检索结果-南通市图书馆

Detections of mefA, ermB, and mphA Macrolides Resistant Genes in Bacteria Isolated from Covid-19 Patients from Selected Health Facilities in Ibadan, Nigeria

引用

Advances in Microbiology 2023年第2期13卷 106-117页

作者： florence Bamigbola Toyosi Raheem Muinat Fowora Felicia Adesina Department of Biological Sciences Lead City University Ibadan Oyo State Nigeria Molecular Biology and Biotechnology Department Nigerian Institute of Medical Research Yaba Lagos Nigeria

Background: COVID-19 is a disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Epidemiological data indicated that bacterial complications in COVID-19 would decrease clearance rate of the infecting agent and increase mortality rate. Macrolides such as Azithromycin are usually administered to COVID-19 patients as palliative treatments. Currently, a considerable number of bacterial strains have developed resistance to various antibiotics, especially macrolides. Resistance is reported to be due to possession of mefA, ermB, and mphA genes by Gram positive and Gram negative bacteria. Therefore, this study determined antibiotic resistance patterns and identify mefA, ermB and mphA macrolide-resistant genes in bacterial pathogens isolated from COVID-19 cases in Ibadan, Nigeria. Methods: 400 Nasopharyngeal samples were collected from symptomatic cases before antibiotic medication;structured questionnaires were administered to collect socio-demographic data of participants. Samples were cultured on Blood, Chocolate, MacConkey and Mannitol salt agar at 37°C for 48 hrs. Bacterial identification was performed using VITEK 2.0 ID cards and API 20E for Gram positive and negative bacteria respectively. Antibiotic Susceptibility Testing was performed using Kirby Bauer disc diffusion methods and VITEK 2.0 AST card kits. DNA of multidrug resistant bacterial isolates was extracted;resistant genes were determined using a polymerase chain reaction with specific primers. Amplified genes were detected using agarose gel electrophoresis. Results: 240 (60%) had bacterial growth and 97 (22.2%) yielded no growth. From the 240 bacterial isolates, 38 (15.83%) were multi-drug resistant including resistance to macrolides (Azithromycin) 20 (52.63%) of which were positive for either mefA or ermB, and none (0.0%) possess mphA gene;14 (36.8%) isolates had mefA gene, 10 (26.3%) isolates carried ermB gene. Conclusion: Multi-drug bacterial resistance including macrolides and quin

关键词： SARS-CoV-2 Bacterial Co-Infection API 20E VITEK 2.0 and Resistant Genes

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Influences of initial porosity,stress triaxiality and Lode parameter on plastic deformation and ductile fracture

引用

Acta Mechanica Solida Sinica 2017年第5期30卷 493-506页

作者： Ying-Song Ma Dong-Zhi Sun florence Andrieux Ke-Shi Zhang College of Civil Engineering and Architecture Guangxi UniversityKey Lab of Disaster Prevention and Structural SafetyGuangxi Key Lab Disaster Prevention and Engineering SafetyNanning 530004China Department of Mining Engineering Shanxi Datong UniversityDatong 037003China Fraunhofer Institute for Mechanics of Materials IwM Woehlerstrasse 1179108 FreiburgGermany

Local mechanical properties in aluminum cast components are inhomogeneous as a con- sequence of spatial distribution of microstructure, e.g., porosity, inclusions, grain size and arm spacing of secondary dendrites. In this work, the effect of porosity is investigated. Cast components contain voids with different sizes, forms, orientations and distributions. This is approximated by a porosity distribution in the following. The aim of this paper is to in- vestigate the influence of initial porosity, stress triaxiality and Lode parameter on plastic deformation and ductile fracture. A micromechanical model with a spherical void located at the center of the matrix material, called the representative volume element （RVE）, is de- veloped. Fully periodic boundary conditions are applied to the RVE and the values of stress triaxiality and Lode parameter are kept constant during the entire course of loading. For this purpose, a multi-point constraint （MPC） user subroutine is developed to prescribe the loading. The results of the RVE model are used to establish the constitutive equations and to further investigate the influences of initial porosity, stress triaxiality and Lode parameter on elastic constant, plastic deformation and ductile fracture of an aluminum die castin~ alloy.

关键词： Stress triaxialityLode parameterVoidDuctile fractureRVE

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Risk stratification in symptomatic intracranial atherosclerotic disease with conventional vascular risk factors and cerebral haemodynamics

引用

Stroke & Vascular Neurology 2023年第1期8卷 77-85页

作者： Xuan Tian Hui Fang Linfang Lan Hing Lung Ip Jill Abrigo Haipeng Liu Lina Zheng florence S Y Fan Sze Ho Ma Bonaventure Ip Bo Song Yuming Xu Jingwei Li Bing Zhang Yun Xu Yannie O Y Soo Vincent Mok Ka Sing wong Thomas w Leung Xinyi Leng Department of Medicine and Therapeutics The Chinese UniversityHong KongChina Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenanChina Department of Neurology The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina Department of Imaging and Interventional The Chinese UniversityHong KongChina Research Centre of Intelligent Healthcare Faculty of Health and Life ScienceCoventry UniversityCoventryUK Department of Neurology Nanjing University Medical School Affiliated Nanjing Drum Tower HospitalNanjingJiangsuChina Department of Radiology Nanjing University Medical School Affiliated Nanjing Drum Tower HospitalNanjingJiangsuChina

Background and purpose Symptomatic intracranial atherosclerotic stenosis(sICAS)is associated with a considerable risk of recurrent stroke despite contemporarily optimal medical *** of luminal stenosis in sICAS and its haemodynamic significance quantified with computational fluid dynamics(CFD)models were associated with the risk of stroke *** aimed to develop and compare stroke risk prediction nomograms in sICAS,based on vascular risk factors and these *** Patients with 50%-99%sICAS confirmed in CT angiography(CTA)were *** vascular risk factors were *** of luminal stenosis in sICAS was dichotomised as moderate(50%-69%)and severe(70%-99%).Translesional pressure ratio(PR)and wall shear stress ratio(wSSR)were quantified via CTA-based CFD modelling;the haemodynamic status of sICAS was classified as normal(normal PR&wSSR),intermediate(otherwise)and abnormal(abnormal PR&wSSR).All patients received guideline-recommended medical *** developed and compared performance of nomograms composed of these variables and independent predictors identified in multivariate logistic regression,in predicting the primary outcome,recurrent ischaemic stroke in the same territory(SIT)within 1 *** Among 245 sICAS patients,20(8.2%)had *** D2H2A nomogram,incorporating diabetes,dyslipidaemia,haemodynamic status of sICAS,hypertension and age≥50 years,showed good calibration(P for Hosmer-Lemeshow test=0.560)and discrimination(C-statistic 0.73,95%CI 0.60 to 0.85).It also had better performance in risk reclassification and provided larger net benefits in decision curve analysis,compared with nomograms composed of conventional vascular risk factors only,and plus the severity of luminal stenosis in *** analysis in patients with anterior-circulation sICAS showed similar *** The D2H2A nomogram,incorporating conventional vascular risk factors and the haemodynamic significance of sICAS a

关键词： intracranial otherwise stratification

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effects of meteorological conditions and topography on the bioaccumulation of PAHs and metal elements by native lichen(Xanthoria parietina)

引用

Journal of Environmental Sciences 2021年第11期33卷 193-205页

作者： Julien Dron Aude Ratier Annabelle Austruy Gautier Revenko florence Chaspoul Emmanuel wafo Institutécocitoyen pour la Connaissance des Pollutions Fos-sur-MerFrance Aix Marseille Université Avignon UniversitéCNRS UMR-7263IRD-237IMBEMarseilleFrance Aix Marseille Université INSERM U-1261SSAIRBAMCTMarseilleFrance Universitéde Lyon UniversitéLyon 1CNRS UMR-5558LBBEVilleurbanneFrance

The bioaccumulation of PAHs and metal elements in the indigenous lichens Xanthoria parietina was monitored during two years at a quarterly frequency,in 3 sites of contrasted anthropic *** impact of the meteorological factors(temperature,relative humidity,rainfall,wind speed)was first estimated through principal component analysis,and then by stepwise multilinear regressions to include wind *** pollutants levels reflected the proximity of atmospheric emissions,in particular from a large industrial *** humidity and mild temperatures,and in a lower extent low wind speed and rainfall,also favored higher concentration *** contributions of these meteorological aspects became minor when including wind direction,especially when approaching major emission *** bioaccumulation integration time towards meteorological variations was on a seasonal basis(1–2 months)but the wind direction and thus local emissions also relied on a longer time scale(12 months).This showed that the contribution of meteorological conditions may be prevalent in remote places,while secondary in polluted areas,and should be definitely taken into account regarding long-term lichen biomonitoring and inter-annual *** the same time,a quadruple sampling in each site revealed a high homogeneity among supporting tree species and *** resulting uncertainty,including sampling,preparation and analysis was below 30%when comfortable analytical conditions were ***,the occurrence of unexpected events such as a major forest fire,permitted to evaluate that this type of short,although intense,events did not have a strong influence on PAH and metals bioaccumulation by lichen.

关键词： Indigenous lichen Biomonitoring Climate Seasonal impacts Sampling uncertainties Integration time

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The Involvement of Lipids in Alzheimer's Disease

引用

Journal of Genetics and Genomics 2014年第5期41卷 261-274页

作者： wei Ling florence Lim Ian James Martins Ralph Nigel Martins School of Medical Sciences Edith Cowan University Centre of Excellence in Alzheimer's Disease Research and Care McCusker Foundation for Alzheimer's Disease Research Inc. Suite 22 Hollywood Medical Centre School of Psychiatry and Clinical Neurosciences The University of Western Australia

It has been estimated that Alzheimer＇s disease （AD）, the most common form of dementia, will affect approximately 81 million individuals by 2040. To date, the actual cause and cascade of events in the progression of this disease have not been fully determined. Furthermore, there is currently no definitive blood test or simple diagnostic method for AD. Considerable efforts have been put into proteomic approaches to develop a diagnostic blood test, but to date these efforts have not been successful. More recently, there has been a stronger focus on lipidomic studies in the hope of increasing our understanding of the underlying mechanisms leading to AD and developing an AD blood test. It is well known that the strongest genetic risk factor for AD is the e4 variant of apolipoprotein E （APOE）. Evidence suggests that the ApoE protein, a major lipid transporter, plays a key role in the pathogenesis of AD, and its role in both normal and aberrant lipid metabolism warrants further extensive investigation. Here, we review ApoE-lipid interactions, as well as the roles that lipids may play in the pathogenesis of AD.

关键词： Alzheimer's disease Lipids ApoE Oxysterols Inflammation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Is the soil seed bank a reliable source for passive restoration of bush-cleared semi-arid rangelands of South Africa?

引用

Ecological Processes 2020年第1期9卷 1-16页

作者： Mthunzi Mndela Casper Ignacio Madakadze florence Nherera-Chokuda Sikhalazo Dube University of Pretoria P/Bag X20HatfieldPretoria 0028South Africa Agricultural Research Council APIP/Bag X02IrenePretoria 0062South Africa

Background:Bush clearing of encroached rangelands is crucial for restoration of herbaceous cover and *** after bush clearing depends largely on the soil seed bank(SSB)size and *** assess the potential of the SSB to facilitate post-clearing herbaceous restoration,we examined the SSB density,composition and diversity and similarity between SSB and aboveground vegetation(AGV).Methods:The study was conducted in semi-arid rangelands of Maseding and Kgomokgomo in North-west Province of South *** each rangeland,all woody plants in three 1250 m^(2) plots were cut using saws and loppers,with the stumps treated with *** observations were conducted in cleared and uncleared *** samples were collected at three depths(0-10,10-20 and 20-30 cm)in each microsite in April(pretreatment),August,October and December 2016 and in April and August *** was assessed using seedling emergence method,whereas pre-and post-clearing surveys of AGV were conducted in February 2016 and 2017,***:Cleared microsites had significantly(pwith grasses accounting for higher densities than other plant functional groups in the upper 0-10 *** grasses(Aristida congesta ***,Brachiaria eruciformis and Tragus berteronianus)and invasive forbs(Bidens pilosa and Schkuhria pinnata)dominated the SSB in cleared microsites at Maseding,whereas succulents(Portulaca spp.)and pioneer grasses(*** and Urochloa mosambicensis)were abundant at Kgomokgomo in August *** and AGV were dissimilar until December 2016;thereafter,similarity increased significantly(pwas highest in August 2016 and April 2017 at Maseding,but

关键词： Bush clearing Seed bank density Seed bank diversity Sørensen’s coefficient

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Soil Amendments Improved Tomato Growth, Yield and Soil Properties

引用

American Journal of Plant Sciences 2022年第7期13卷 960-971页

作者： Gabriel Ddamulira Alex Malaala Alfred Otim Nakityo florence Mcebisi Maphosa National Crops Resource Research Institute Kampala Uganda Makerere University Kampala Kampala Uganda Lupane State University Lupane Zimbabwe

Different soil amendments have varying effects on crop growth, yield and soil properties. The study evaluated the effect of poultry manure, inorganic fertilizer (NPK), and biochar-based fertilizer (organo-yield) on tomato growth, yield and post-cropping soil properties. The experiment was laid out in a Randomized Complete Block Design (RCBD) with three replications. Data on tomato growth and yield were collected and soils were tested before and after the cropping seasons. Analysis of variance was performed on the data and the effect of soil amendments on tomato growth and yield was determined. The effect of soil amendments on post-production soil properties was tested by comparing soil properties before and after the cropping seasons with published critical values. Results showed that all amendments increased the growth and yield of tomato significantly (P 0.05) compared to the control (without soil amendments). Plant height was higher in plots applied with soil amendments as compared to the control, while stem girth was highest in poultry-manured plots. Poultry manure and organo-yield applied plants exhibited high tomato fruit number and yield compared to control plots. In terms of soil properties, poultry manure and organo-yield improved the soil’s physical and chemical properties. Organo-yield decreased the soil bulk density and increased the pH from 4.8 to 5.5, while, application of NPK only increased calcium content in the soil. The findings confirmed that soil amendments applied increased tomato growth, and yield and also improved soil bulky density and pH.

关键词： Organo-Yield Poultry Manure NPK Soil

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genome sequencing reveals the role of rare genomic variants in Chinese patients with symptomatic intracranial atherosclerotic disease

引用

Stroke & Vascular Neurology 2022年第3期7卷 182-189页

作者： Mengmeng Shi Xinyi Leng Ying Li Zihan Chen Ye Cao Tiffany Chung Bonaventure YM Ip Vincent HL Ip Yannie OY Soo florence SY Fan Sze Ho Ma Karen Ma Anne Y Y Chan Lisa wC Au Howan Leung Alexander Y Lau Vincent CT Mok Kwong wai Choy Zirui Dong Thomas w Leung Department of Obstetrics and Gynaecology The Chinese University of Hong KongHong KongChina Key Laboratory for Regenerative Medicine Ministry of Education(Shenzhen Base)Shenzhen Research InstituteThe Chinese University of Hong KongShenzhenChina Hong Kong Hub of Paediatric Excellence The Chinese University of Hong KongHong KongChina Department of Medicine and Therapeutics The Chinese University of Hong KongPrince of Wales HospitalHong KongChina Department of Paediatrics The Chinese University of Hong KongHong KongChina The Chinese University of Hong Kong-Baylor College of Medicine Joint Center For Medical Genetics The Chinese University of Hong KongHong KongChina

Objectives The predisposition of intracranial atherosclerotic disease(ICAD)to East Asians over Caucasians infers a genetic basis which,however,remains largely *** prevalence of vascular risk factors(VRFs)in Chinese over Caucasian patients who had a stroke,and shared risk factors of ICAD with other stroke subtypes indicate genes related to VRFs and/or other stroke subtypes may also contribute to *** Unrelated symptomatic patients with ICAD were recruited for genome sequencing(GS,60-fold).Rare and potentially deleterious single-nucleotide variants(SNVs)and small insertions/deletions(InDels)were detected in genome-wide and correlated to genes related to VRFs and/or other stroke *** aneuploidies,copy number variants(CNVs)and chromosomal structural rearrangements were also ***,candidate genes were used for pathway and gene ontology enrichment *** Among 92 patients(mean age at stroke onset 61.0±9.3 years),GS identified likely ICAD-associated rare genomic variants in 54.3%(50/92)of ***-eight patients(52.2%,48/92)had 59 rare SNVs/InDels reported or predicted to be deleterious in genes related to VRFs and/or other stroke *** of the 59 rare variants were identified in local subjects without ICAD(n=126).31 SNVs/InDels were related to conventional VRFs,and 28 were discovered in genes related to other stroke *** study also showed that rare CNVs(n=7)and structural rearrangement(a balanced translocation)were potentially related to ICAD in 8.7%(8/92)of ***,candidate genes were significantly enriched in pathways related to lipoprotein metabolism and cellular lipid catabolic *** Our GS study suggests a role of rare genomic variants with various variant types contributing to the development of ICAD in Chinese patients.

关键词： patients metabolism intracranial

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Painting image browser applying an associate-rule-aware multidimensional data visualization technique

引用

Visual Computing for Industry,Biomedicine,and Art 2020年第1期3卷 18-30页

作者： Ayaka Kaneko Akiko Komatsu Takayuki Itoh florence Ying wang Ochanomizu University 2-1-1 OtsukaBunkyo-ku1128610 TokyoJapan CSIRO Julius Ave.2113 North RydeNSWAustralia

Exploration of artworks is enjoyable but often time *** example,it is not always easy to discover the favorite types of unknown painting *** is not also always easy to explore unpopular painting works which looks similar to painting works created by famous *** paper presents a painting image browser which assists the explorative discovery of user-interested painting *** presented browser applies a new multidimensional data visualization technique that highlights particular ranges of particular numeric values based on association rules to suggest cues to find favorite painting *** study assumes a large number of painting images are provided where categorical information(e.g.,names of artists,created year)is assigned to the *** presented system firstly calculates the feature values of the images as a preprocessing *** the browser visualizes the multidimensional feature values as a heatmap and highlights association rules discovered from the relationships between the feature values and categorical *** mechanism enables users to explore favorite painting images or painting images that look similar to famous painting *** case study and user evaluation demonstrates the effectiveness of the presented image browser.

关键词： Painting image Multi-dimensional data visualization Association rule

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effects of Health Record Computerization in the Context of the COVID-19 Pandemic in Burundi’ Hospitals: Propensity Score Matching

引用

Open Journal of Epidemiology 2022年第3期12卷 245-260页

作者： florence Munezero Charles J. Sossa Glele Yolaine Ahanhanzo Leodegal Bazira National Institute of Public Health Department of Research Bujumbura Burundi University of Abomey-Calavi Regional Institute of Public Health Ouidah Benin Faculty of Medicine University of Burundi Bujumbura Burundi

Introduction: A great number of software are currently used to digitalize the patient records in order to optimize the quality of services offered to patients. The objective of this study was to evaluate the effects of Electronic Health Records use in Burundi’s hospitals, taking into account the COVID-19 pandemic context. Methods: This was a quasi-experimental study based on difference in difference method. Ten district hospitals were included in the study, five of them had the Electronic Health Records and five of which did not yet have the Electronic Health Records. The hospital’s control group were chosen using the propensity score matching method. The period before the project’s implementation was 2014 and the period after were 2019 and 2020. Results: After 5 years of the Electronic Health Record’s implementation, the results showed an increase in outpatient consultation (70%), deliveries (more than 100%), caesarean sections (56%) and major surgeries (43%) indicators. The overall quality score of hospitals’ care had a regressive effect of 37% and the income from performance-based funding had an increase by 31%. The indicators which were affected by the context of the COVID-19 pandemic were especially outpatient consultation, caesarian section, income from performance-based funding decreased by 3%, 5% and 20% respectively. Conclusion: The effects of Electronic Health Records use are effective. As the COVID-19 pandemic impacted the hospital’s indicators negatively, the resilient strategies alongside the potential shocks are recommended.

关键词： Effects Health Record Computerization COVID-19 Hospitals Propensity Score Matching

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：