检索结果-南通市图书馆

Penetrating keratoplasty in children under 3 years old with congenital corneal opacities

International Journal of Ophthalmology(English edition) 2022年第1期15卷 45-51页

作者： made Susiyanti Burhana mawarasti florence m.manurung Jakarta Eye Center Jakarta 10430Indonesia Department of Ophthalmology Faculty of MedicineUniversitas IndonesiaCipto Mangunkusumo-Kirana HospitalJakarta 10430Indonesia

AIm:To evaluate the graft rejection and visual outcomes after penetrating keratoplasty(PK)in the presence of various congenital corneal opacities in ***:In this retrospective cohort study,children who underwent PK were then followed for 5 *** patient’s medical records were collected from June 2014 until June 2019 and analyzed in December *** patients were children under three years old with congenital corneal opacities with or without microcornea who came to a pediatric ophthalmologist and underwent PK in Jakarta Eye Center(JEC).Beforehand,all children have participated in a thorough evaluation for *** the case of severe microcornea was not advised to undergo *** visual outcomes and graft survival rate were described in *** graft survival plot was presented with Kaplan-meier,while the visual acuity was analyzed using the Wilcoxon signed ranks ***:Sixteen eyes from eleven patients(seven girls and four boys)underwent *** graft survival rate of the first 6,12,and 18 mo later of keratoplasty was 100%,83.3%,and 66.7%,*** overall mean survival time is 22 mo(standard error 2.419),and no significant difference between the patients underwent PK before and after 36 mo of their age(P=0.52).The graft failure was 50%,and postsurgery complications included cataract 43.7%,band keratopathy 12.5%,and scleromalasia 6.25%.Wilcoxon test analysis of visual acuity post keratoplasty was not statistically significant(P=0.34),while overall showed 44%improvements of visual outcome for 5 y of *** a good survival at one year up to 22 mo(83.3%),the visual acuity could be achieved(63%),and showed improvements(44%)during ***:The complications are frequent for pediatric ***,corneal surgery on infants requires careful case selection,adequate pre-operative evaluation,skilled surgery(optical correction),very close cooperation family–physician,intensive post-operation care,and amblyopia management in the

关键词： pediatric penetrating keratoplasty congenital corneal opacities microcornea children

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Evaluation of large language models for the classification of medical device software

引用

Bio-Design and manufacturing 2024年第5期7卷 819-822页

作者： Yu Han Aaron Ceross florence Bourgeois Paulo Savaget Jeroen H.m.Bergmann Department of Engineering Science University of OxfordOld Road CampusOxford OX37QDUK Harvard-mIT Center for Regulatory Science Harvard Medical SchoolBostonMAUSA Computational Health Informatics Program(CHIP) Boston Children’s HospitalBostonMAUSA Department of Technology and Innovation The University of Southern DenmarkOdenseDenmark

Amidst the rapidly expanding integration of large language models(LLms)across various sectors(ranging from everyday applications to specialized fields demanding stringent regulatory adherence),our investigation seeks to determine how well these models can support medical device software *** device classification functions to systematically categorize devices according to their designated use,associated risk levels,and requisite regulatory oversight,thereby providing a structured framework for ensuring safety and efficacy as mandated by regulatory authorities.

关键词： everyday demanding thereby

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Bone marrow mesenchymal stem cells in treatment of peripheral nerve injury

引用

World Journal of Stem Cells 2024年第8期16卷 799-810页

作者： Xiong-Fei Zou Bao-Zhong Zhang Wen-Wei Qian florence mei Cheng Department of Orthopedic Surgery Peking Union Medical College HospitalBeijing 100730China College of Nursing The Ohio State UniversityOhioOH 43210United States

Peripheral nerve injury(PNI)is a common neurological disorder and complete functional recovery is difficult to *** recent years,bone marrow mesenchymal stem cells(BmSCs)have emerged as ideal seed cells for PNI treatment due to their strong differentiation potential and autologous trans-plantation *** review aims to summarize the molecular mechanisms by which BmSCs mediate nerve repair in *** key mechanisms discussed include the differentiation of BmSCs into multiple types of nerve cells to promote repair of nerve *** also create a microenvironment suitable for neuronal survival and regeneration through the secretion of neurotrophic factors,extracellular matrix molecules,and adhesion ***,BmSCs release pro-angiogenic factors to promote the formation of new blood *** modulate cytokine expression and regulate macrophage polarization,leading to ***,BmSCs synthesize and release proteins related to myelin sheath formation and axonal regeneration,thereby promoting neuronal repair and ***,this review explores methods of applying BmSCs in PNI treatment,including direct cell trans-plantation into the injured neural tissue,implantation of BmSCs into nerve conduits providing support,and the application of genetically modified BmSCs,among *** findings confirm the potential of BmSCs in treating ***,with the development of this field,it is crucial to address issues related to BmSC therapy,including establishing standards for extracting,identifying,and cultivating BmSCs,as well as selecting application methods for BmSCs in PNI such as direct transplantation,tissue engineering,and genetic *** these issues will help translate current preclinical research results into clinical practice,providing new and effective treatment strategies for patients with PNI.

关键词： Bone marrow mesenchymal stem cells Peripheral nerve injury Schwann cells myelin sheath Tissue engineering

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Strategic Planning Practices of Hotels in Kenya

引用

Journal of Tourism and Hospitality management 2024年第1期12卷 12-17页

作者： Lilian m.Gikutha florence W.Njau Naghea Jilo Kenya Utalii College NairobiKenya

This study broadens perspectives of strategic planning procedures in hotels by analyzing hotel managers’perspectives on hotel strategy formulation and *** study was a descriptive quantitative study that targeted managers from various Kenyan hotels.180 questionnaires were returned from a sample of 280 hotel managers who had attended management development programs at a hospitality *** primary goal of the study was to analyze two aspects of the strategic planning process:strategy formulation and strategic *** findings revealed that hotels in Kenya have developed methods and are keen on scanning their external ***,with the product offerings being so comparable,competitive analysis played an important role in the *** a unique or specialty offering was not a popular option for most ***-cutting was the most favored strategic inclination to achieve desired *** balanced scorecard was underutilized in the *** managers were involved in the strategic planning process,other lower cadre employees were not,they were provided with the targets for the hotels’organizational goals to be *** findings reveal that with similar products and services,the industry creates a hostile business climate with fierce rivalry and must invest in the most obvious alternative of cost reduction to *** product innovation is not common in this industry for developing a differentiation approach that allows a property to control a market.

关键词： hotels strategy formulation strategic planning

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rehabilitation following spinal cord injury:how animal models can help our understanding of exercise-induced neuroplasticity

引用

Neural Regeneration Research 2019年第3期14卷 405-412页

作者： Kristina Loy florence m.Bareyre Institute of Clinical Neuroimmunology Ludwig-Maximilians Universitat Munchen munich Cluster of Systems Neurology (SyNergy)

Spinal cord injury is a devastating condition that is followed by long and often unsuccessful recovery after trauma. The state of the art approach to manage paralysis and concomitant impairments is rehabilitation, which is the only strategy that has proven to be effective and beneficial for the patients over the last decades. How rehabilitation influences the remodeling of spinal axonal connections in patients is important to understand, in order to better target these changes and define the optimal timing and onset of training. While clinically the answers to these questions remain difficult to obtain, rodent models of rehabilitation like bicycling, treadmill training, swimming, enriched environments or wheel running that mimic clinical rehabilitation can be helpful to reveal the axonal changes underlying motor recovery. This review will focus on the different animal models of spinal cord injury rehabilitation and the underlying changes in neuronal networks that are improved by exercise and rehabilitation.

关键词： remodeling exercise wheel running treadmill detour circuit propriospinal neuron corticospinal tract raphespinal tract reticulospinal tract activity recovery central nervous system

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Semaphorin7A:its role in the control of serotonergic circuits and functional recovery following spinal cord injury

引用

Neural Regeneration Research 2022年第5期17卷 959-962页

作者： Julie Fourneau florence m.Bareyre Institute of Clinical Neuroimmunology Ludwig-Maximilians Universität MünchenMunichGermany munich Cluster of Systems Neurology(SyNergy) MunichGermany

Serotonin is a monoamine neurotransmitter synthetized in various populations of brainstem *** the spinal cord,descending serotonergic projections regulate postural muscle tone,locomotion and rhythm and coordination of movements via the Central Pattern *** a spinal cord injury,serotonergic projections to the lumbar spinal cord,where the Central Pattern Generators are located,are interrupted resulting in devastating locomotor impairments and changes in the expression and activation of serotonin and its spinal *** molecular cues that control the precise patterning and targeting of serotonergic inputs onto Central Pattern Generator networks in healthy animals or after injury are still *** our recent research work,we have been particularly interested in Semaphorin7A,which belongs to the Semaphorins family involved in guiding growing axons and controlling plasticity of synaptic *** this review,we discuss the role of Semaphorin7A signaling as an important molecular actor that instructs the patterning of serotonin inputs to spinal Central Pattern Generator *** show that Semaphorin7A controls the wiring of descending serotonin axons in the spinal *** results reveal that mistargetting of serotonin fibers in the spinal cord is compensated in healthy uninjured Semaphorin7A deficient mice so that their gross locomotion proceeds *** also demonstrate that when the system is challenged with a spinal lesion,the pattern of post-injury serotonin expression is significantly altered in Semaphorin7A deficient mice with specific ectopic targeting of serotonin fibers in the lumbar spinal *** mechanisms in place in uninjured Semaphorin7A deficient mice are lost and injured Semaphorin7A deficient mice exhibit a worsening of their post-injury locomotor *** findings identify Semaphorin7A as a critical determinant of serotonergic circuit formation in healthy or spinal cord injured mice.

关键词： central pattern generator guidance molecule locomotion recovery rewiring semaphorin7A serotonergic patterning serotonin spinal cord injury

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Regulation of axonal remodeling following spinal cord injury

引用

Neural Regeneration Research 2015年第10期10卷 1555-1557页

作者： Anne Jacobi florence m.Bareyre Institute of Clinical Neuroimmunology Ludwig-Maximilians Universit?t München munich Cluster of Systems Neurology (Sy Nergy)

Central nervous system injuries,such as spinal cord injury（SCI）,are a leading cause of disability in young *** generally have severe clinical consequences and often lead to loss of motor or sensory input below the s... 详细信息

关键词： Regulation of axonal remodeling following spinal cord injury STAT FGFR Figure CST

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Plasticity of callosal neurons in the contralesional cortex following traumatic brain injury

引用

Neural Regeneration Research 2023年第6期18卷 1257-1258页

作者： Alexandra Chovsepian Laura Empl florence m.Bareyre Institute of Clinical Neuroimmunology Biomedical Building and Clinic of the Ludwig-Maximilians Universität MünchenMunichGermany

Traumatic brain injury(TBI) represents a significant cause of disability *** creates a vast array of damaging macro-and microscopic changes in the affected brain area(s),ranging from neuronal cell death,changes in structural spine integrity and dynamics to axonal injury and ove rall neuronal circuit disruption,ultimately leading to functional and cognitive deficits in both humans and animal models(N udo,2013).

关键词： injury traumatic cortex

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Traditional Healer’s medicinal Practice Survey and Clinical Evidence Assessment of “YIKI”: An Antimalarial Phytomedicine Recipe from Bobo-Dioulasso, Burkina Faso

引用

Pharmacology & Pharmacy 2024年第7期15卷 248-267页

作者： Zachari Kabre Rakiswende Serge Yerbanga Aminata Fofana Roland Nâg-Tiero meda Anyirekun Fabrice Some Alassane Haro Natacha A. J. A. Boro Fazhira B. Ye Benjamin Kouliga Koama Sami Eric Kam Eliasse Zongo Hadidjatou Belèm Windmi Kagambèga florence Fournet Georges A. Ouedraogo Jean-Bosco Ouedraogo Institut de Recherche en Sciences de la Sant Direction Rgionale de lOuest Bobo-Dioulasso Burkina Faso Laboratoire de Recherche et dEnseignement en Sant et Biotechnologies Animales Universit Nazi BONI Bobo-Dioulasso Burkina Faso Institut des Sciences et Techniques Bobo-Dioulasso Burkina Faso Laboratoire de Recherche en Bactriologie INSP/Centre MURAZ Bobo-Dioulasso Burkina Faso maladies Infectueuses et Vecteurs: Ecologie Gntique Evolution et Contrle (MIVEGEC) Institut de Recherche pour le Dveloppement Universit de Monpellier Montpellier France

YIKI is an antimalarial phytomedicine used by a traditional healer to treat malaria in Bobo-Dioulasso. However, there is no scientific evidence to support its use by local populations. The aim of this study was to identify the medicinal practices of the healer holder of YIKI and assess the clinical evidence of its phytomedicine in the uncomplicated malaria treatment. Ethnomedical survey based on a semi-structured and open questionnaire was conducted from October to December 2019 with the healer. malaria knowledge and diagnosis methods, patient treatment and monitoring, and recipe formulation steps were surveyed. moreover, thick and thin blood smears were taken, haemoglobin levels and temperature of consenting patients were measured before treatment, mid-treatment and at the end of treatment. The survey revealed that the healer has a good knowledge of malaria symptoms and his diagnosis is based on observation and physical examination of patients. The healer’s malaria diagnosis was rudimentary and had accuracy problems, with only 62.79% of malaria cases confirmed by microscopy. The formulation of YIKI and its use to treat malaria follow a standard process for plant harvesting, powder quantities and posology, but do not use any reproducible parameters for dose adjustment. Forty-three patients diagnosed and treated by the healer participated in the study. Laboratory results revealed 27 Plasmodium falciparum infection cases, including 2 with parasitaemia ≥ 200,000 p/µl blood. 25 patients were selected for therapeutic evidence assessment. There was a 48% elimination of parasites, a 28% parasitaemia decrease without complete cure, with gametocytogenesis in some patients, and a 24% parasitaemia increase. Haemoglobin and temperature results suggested that YIKI was not cytotoxic and reduced fever. Encouraging preliminary results have been obtained, but in view of the low number of patients, further YIKI efficacy and toxicity studies will be necessary for patient safety.

关键词： Antimalarial-Phytomedicine Efficacy Traditional Practices Bobo-Dioulasso

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Retinal manifestations of patients with human immun- odeficiency virus, a multiethnics study in malaysia

引用

International Journal of Ophthalmology(English edition) 2011年第6期4卷 641-643页

作者： Loo A.V.P Sujaya S Peyman m florence S Subrayan V Department of Ophthalmology University of Malaya

· AIm: To investigate the fundus findings of patients infected with human immunodeficiency virus (HIV) in correlation to Highly Active Antiretroviral Therapy (HAART) and CD4 count. · mETHODS: Two hundred and two patients of the three major races (Chinese, malay and Indian) in malaysia were recruited in this population-based cross-sectional study. This consisted of confirmed HIV sero-positive patients with HAART treatment (n=95) or without HAART therapy (n=107) from December 2007 to march 2008. They were further classified into the HIV infected group, AIDS related complex (ARC) group and AIDS group. Each group was then subdivided according to their CD4 count. Clinical fundus findings were recorded. · RESULTS: Sixty six patients (32.7%) showed presence of fundus manifestation, majority of which was HIV microangiopathy (89%) and the rest being Cytomegalovirus (CmV) retinitis (11%). The most common fundus lesion was cotton wool spot (34%). There was a higher incidence of fundus manifestation in the non HAART group than the HAART group (P =0.04) and in patients with CD4 count less than 200 cells/ml in both groups (P =0.01). The HAART therapy had remarkably reduced the percentage of fundus manifestation by 20% but CD4 count remains the marker for fundus manifestations. There were no significant differences noted in the retinal manifestation among the different races. (ANOVA, P =0.25). · CONCLUSION: The fundus manifestations were higher in patients with CD4ml and in the non HAART group. Hence the HAART therapy is capable of reducing the incidence of fundus manifestations, however the CD4 count determines the occurrence of fundus manifestations. ·

关键词： HIV fundus manifestations CmV retinitis HAART CD4 count

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：