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Identification of Early Nuclear Target Genes of Plastidial Redox Signals that Trigger the Long- Term Response of Arabidopsis to Light Quality Sh∽ts

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Molecular Plant 2015年第8期8卷 1237-1252页

作者： Lars Dietzel Christine Glaeer Monique Liebers Stefan Hiekel florence courtois Olaf Czarneckit Hagen Schlicke Yan Zubo Thomas Borner Klaus Mayer Bernhard Grimm Thomas Pfannschmidt Department of Plant Physiology Institute of General Botany and Plant Physiology Friedrich-Schiller-University of Jena Domburger Strasse 159 07743 JenaGermany MIPS/IBI Helmholtz Zentrum MGnchen German Research Center for Environmental Health (GmbH) Ingolst~dter Landstrasse 1 85764 Neuherberg Germany Institute of Biology/Plant Physiology Humboldt-University Berlin Philippstrasse 13 Building 12 10115 Berlin Germany Institute of Biology Genetics Humboldt-University Berlin Chausseestrasse 117 10115 Berlin Germany present address: Institut fer Molekulare Biowissenschaften Pflanzliche Zellphysiologie Max-von-Laue-Strasse 9 Biozentrum Goethe-Universit~t Frankfurt 60438Frankfurt am Main Germany Present address: Zentrum fur Molekulare Biologie an der Universitat zu Heidelberg (ZMBH) Im Neuenheimer Feld 282 69120 Heidelberg Germany present address: Universite Grenoble-Alpes F-38000 Grenoble France Present address: CNRS UMR5168 F-38054 Grenoble France present address: CEA iRTSV Laboratoire de Physiologie Cellulaire & Vgetale F-38054 Grenoble France Present address: INRA USC1359 F-38054 Grenoble France Present address: Plant Reproductive Biology Group Department of Physiology and Ceil-Biology Leibniz Institute of Rant Genetics and Crop Plant Research (IPK)OT Gatersleben Corrensstrasse 3 D-06466 Stadt Seeland Germany present address: KWS Saat AG Grimsehlstrasse 31 37555 Einbeck Germany present address: Dartmouth College Department of Biological Sciences Ufe Sciences Center 78 College Street Hanover NH 03755 USA

Natural illumination conditions are highly variable and because of their sessile life style, plants are forced to acclimate to them at the cellular and molecular level. Changes in light intensity or quality induce changes in the reduction/oxidation （redox） state of the photosynthetic electron chain that acts as a trigger for compen- satory acclimation responses comprising functional and structural adjustments of photosynthesis and metabolism. Such responses include redox-controlled changes in plant gene expression in the nucleus and organelles. Here we describe a strategy for the identification of early redox-regulated genes （ERGs） in the nucleus of the model organism Arabidopsis thaliana that respond significantly 30 or 60 min after the generation of a reduction signal in the photosynthetic electron transport chain. By comparing the response of wild-type plants with that of the acclimation mutant stn7, we could specifically identify ERGs. The results reveal a significant impact of chloroplast redox signals on distinct nuclear gene groups including genes for the mitochondrial electron transport chain, tetrapyrrole biosynthesis, carbohydrate metabolism, and signaling lipid synthesis. These expression profiles are clearly different from those observed in response to the reduction of photosynthetic electron transport by high light treatments. Thus, the ERGs identified are unique to redox imbalances in photosynthetic electron transport and were then used for analyzing potential redox-responsive cis-elements, trans-factors, and chromosomal regulatory hot spots. The data identify a novel redox-responsive element and indicate extensive redox control at transcriptional and chromosomal levels that point to an unprecedented impact of redox signals on epigenetic processes.

关键词： plastidial redox signaling,early redox-regulated gene Arabidopsis thaliana Molecular Plant

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A common metabolomic signature is observed upon inoculation of rice roots with various rhizobacteria

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Journal of Integrative Plant Biology 2020年第2期62卷 228-246页

作者： Marine Valette Marjolaine Rey florence Gerin Gilles Comte florence Wisniewski-Dyé Universite de Lyon Universite Lyon1Ecologie MicrobienneCNRS UMR-5557INRA UMR-1418VetAgroSup43 boulevard du 11 novembre 191869622 VilleurbanneFrance

Plant growth-promoting rhizobacteria(PGPR),whose growth is stimulated by root exudates,are able to improve plant growth and *** those,bacteria of the genus Azospirillum were shown to affect root secondary metabolite content in rice and maize,sometimes without visible effects on root *** studies also revealed that expression of several genes involved in stress and plant defense was affected,albeit with fewer genes when a strain was inoculated onto its original host ***,we investigated,via a metabolic profiling approach,whether rice roots responded differently and with gradual intensity to various PGPR,isolated from rice or not.A common metabolomic signature of nine compounds was highlighted,with the reduced accumulation of three alkylresorcinols and increased accumulation of two hydroxycinnamic acid amides(HCAA),identified as N-p-coumaroylputrescine and *** was accompanied by the increased transcription of two genes involved in the N-feruloylputrescine biosynthetic ***,exposure to a rice bacterial pathogen triggered a reduced accumulation of these HCAA in roots,a result contrasting with previous reports of increased HCAA content in leaves upon pathogen *** of HCAA,that are potential antimicrobial compounds,might be considered as a primary reaction of plant to bacterial perception.

关键词： PGPR various rhizobacteria root exudates

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An update on biomarkers of potential benefit with bevacizumab for breast cancer treatment: Do we make progress?

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Chinese Journal of Cancer Research 2019年第4期31卷 586-600页

作者： Xu Liang Huiping Li florence Coussy Celine Callens florence Lerebours Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of Breast OncologyPeking University Cancer Hospital&InstituteBeijing 100142China Department of Medical Oncology Institut CuriePSL Research UniversityParis 75005France Pharmacogenomic Unit Department of GeneticsCurie InstitutePSL Research UniversityParis 75005France Department of Medical Oncology Institut CurieRené Huguenin HospitalSaint-Cloud 92210France

As the first monoclonal antibody against vascular endothelial growth factor(VEGF), bevacizumab(BEV) is a definitely controversial antiangiogenic therapy in breast cancer. The initial excitement over improvements in progression-free survival(PFS) with BEV was tempered by an absence of overall survival(OS) benefit and serious adverse effects. Missing targeted population urged us to identify the predictive biomarkers for BEV efficacy. In this review we focus on the research in breast cancer and provide recent investigations on clinical, radiological,molecular and gene profiling markers of BEV efficacy, including the new results from randomized phase III clinical trials evaluating the efficacy of BEV in combination with comprehensive biomarker analyses. Current evidences indicate some predictive values for genetic variants, molecular imaging, VEGF pathway factors or associated factors in peripheral blood and gene profiling. The current challenge is to validate those potential biomarkers and implement them into clinical practice.

关键词： Bevacizumab efficacy biomarker breast cancer

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Advances in spinal cord injury:insights from non-human primates

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Neural Regeneration Research 2024年第11期19卷 2354-2364页

作者： Gaetan Poulen florence E.Perrin University of Montpellier INSERMEPHEMontpellierFrance Department of Neurosurgery Gui de Chauliac HospitalMontpellier University Medical CenterMontpellierFrance Institut Universitaire de France(IUF) ParisFrance

Spinal cord injury results in significant sensorimotor deficits,currently,there is no curative treatment for the symptoms induced by spinal cord *** and pre-clinical research on spinal cord injury relies on the development and characterization of appropriate animal *** models should replicate the symptoms observed in human,allowing for the exploration of functional deficits and investigation into various aspects of physiopathology of spinal cord ***-human primates,due to their close phylogenetic association with humans,share more neuroanatomical,genetic,and physiological similarities with humans than ***,the responses to spinal cord injury in nonhuman primates most likely resemble the responses to traumatism in *** this review,we will discuss nonhuman primate models of spinal cord injury,focusing on in vivo assessments,including behavioral tests,magnetic resonance imaging,and electrical activity recordings,as well as ex vivo histological ***,we will present therapeutic strategies developed in non-human primates and discuss the unique specificities of non-human primate models of spinal cord injury.

关键词： behavior cellular analysis non-human primates spinal cord injury tissue analysis

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Rehabilitation following spinal cord injury:how animal models can help our understanding of exercise-induced neuroplasticity

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Neural Regeneration Research 2019年第3期14卷 405-412页

作者： Kristina Loy florence M.Bareyre Institute of Clinical Neuroimmunology Ludwig-Maximilians Universitat Munchen Munich Cluster of Systems Neurology (SyNergy)

Spinal cord injury is a devastating condition that is followed by long and often unsuccessful recovery after trauma. The state of the art approach to manage paralysis and concomitant impairments is rehabilitation, which is the only strategy that has proven to be effective and beneficial for the patients over the last decades. How rehabilitation influences the remodeling of spinal axonal connections in patients is important to understand, in order to better target these changes and define the optimal timing and onset of training. While clinically the answers to these questions remain difficult to obtain, rodent models of rehabilitation like bicycling, treadmill training, swimming, enriched environments or wheel running that mimic clinical rehabilitation can be helpful to reveal the axonal changes underlying motor recovery. This review will focus on the different animal models of spinal cord injury rehabilitation and the underlying changes in neuronal networks that are improved by exercise and rehabilitation.

关键词： remodeling exercise wheel running treadmill detour circuit propriospinal neuron corticospinal tract raphespinal tract reticulospinal tract activity recovery central nervous system

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Semaphorin7A:its role in the control of serotonergic circuits and functional recovery following spinal cord injury

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Neural Regeneration Research 2022年第5期17卷 959-962页

作者： Julie Fourneau florence M.Bareyre Institute of Clinical Neuroimmunology Ludwig-Maximilians Universität MünchenMunichGermany Munich Cluster of Systems Neurology(SyNergy) MunichGermany

Serotonin is a monoamine neurotransmitter synthetized in various populations of brainstem *** the spinal cord,descending serotonergic projections regulate postural muscle tone,locomotion and rhythm and coordination of movements via the Central Pattern *** a spinal cord injury,serotonergic projections to the lumbar spinal cord,where the Central Pattern Generators are located,are interrupted resulting in devastating locomotor impairments and changes in the expression and activation of serotonin and its spinal *** molecular cues that control the precise patterning and targeting of serotonergic inputs onto Central Pattern Generator networks in healthy animals or after injury are still *** our recent research work,we have been particularly interested in Semaphorin7A,which belongs to the Semaphorins family involved in guiding growing axons and controlling plasticity of synaptic *** this review,we discuss the role of Semaphorin7A signaling as an important molecular actor that instructs the patterning of serotonin inputs to spinal Central Pattern Generator *** show that Semaphorin7A controls the wiring of descending serotonin axons in the spinal *** results reveal that mistargetting of serotonin fibers in the spinal cord is compensated in healthy uninjured Semaphorin7A deficient mice so that their gross locomotion proceeds *** also demonstrate that when the system is challenged with a spinal lesion,the pattern of post-injury serotonin expression is significantly altered in Semaphorin7A deficient mice with specific ectopic targeting of serotonin fibers in the lumbar spinal *** mechanisms in place in uninjured Semaphorin7A deficient mice are lost and injured Semaphorin7A deficient mice exhibit a worsening of their post-injury locomotor *** findings identify Semaphorin7A as a critical determinant of serotonergic circuit formation in healthy or spinal cord injured mice.

关键词： central pattern generator guidance molecule locomotion recovery rewiring semaphorin7A serotonergic patterning serotonin spinal cord injury

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Heterogeneous Trends of Precipitation Extremes in Recent Two Decades over East Africa

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Journal of Meteorological Research 2021年第6期35卷 1057-1073页

作者： Zacharia florence MTEWELE Xiyan XU Gensuo JIA Key Laboratory of Regional Climate-Environment for Temperate East Asia Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China University of Chinese Academy of Sciences Beijing 100049China Physics Department University of Dares SalaamDares Salaam P.O.Box 35063Tanzania

East Africa is so vulnerable to the impacts of precipitation extremes varying from frequent floods to prolonged ***,systematic regional assessment of precipitation extremes across seasons has received little attention,and most previous studies of precipitation extremes have employed many indices and sparse gauge observations giving marginalized *** this study,we use three precipitation extreme indices to examine the intensity of the highest single-day rainfall record(rx1day),prevalence of very heavy rainfalls(r30mm),and persistence of successive wet days(cwd)at both annual and seasonal scales over recent two decades(1998-2018)based on the Tropical Rainfall Measuring Mission(TRMM)Multisatellite Precipitation Analysis *** results show that the most intensive and frequent precipitation extremes are noticeable from January to May across the areas extending from Madagascar to the Tanzanian coastal *** areas also exhibit patches of significant increasing trends in frequency,duration,and intensity of precipitation extremes annually and ***,significant declines in frequency and intensity of precipitation extremes are observed from western Ethiopia to Congo-Uganda,especially in *** October-December season witnesses higher interannual variability amounting to overall weak and less significant *** subregional assessment shows overall declining intensity and frequency of precipitation extremes in northern part of the study *** wetness duration increased,with persistence of moderate wet days and slight reduction of severe *** study unveils higher susceptibility of the East African region to the widely observed hotspots of precipitation extremes posing threats to food security,water resource,and human *** region should consider upscaling irrigation schemes in addition to planning resilient and supportive infrastructures to withstand the upsurging precipitation extremes,especially al

关键词： precipitation extremes East Africa extreme indices Tropical Rainfall Measuring Mission(TRMM) climate extremes

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Regulation of axonal remodeling following spinal cord injury

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Neural Regeneration Research 2015年第10期10卷 1555-1557页

作者： Anne Jacobi florence M.Bareyre Institute of Clinical Neuroimmunology Ludwig-Maximilians Universit?t München Munich Cluster of Systems Neurology (Sy Nergy)

Central nervous system injuries,such as spinal cord injury（SCI）,are a leading cause of disability in young *** generally have severe clinical consequences and often lead to loss of motor or sensory input below the s... 详细信息

关键词： Regulation of axonal remodeling following spinal cord injury STAT FGFR Figure CST

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Use of longitudinal magnetic resonance imaging in preclinical models of spinal cord injury

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Neural Regeneration Research 2019年第5期14卷 771-772页

作者： Harun Najib Noristani florence Evelyne Perrin INSERM U1198 University of Montpellier

Spinal cord injury(SCI)is a distressing event with grave socio/economic consequences to our *** response following SCI involves blood-spinal cord barrier breakdown,neuroinflammation and formation of a glial scar that altogether govern the feasibility of spontaneous axonal re-growth and limited functional *** advances in understanding SCI pathophysiology have been achieved using numerous transgenic mouse lines developed in different ***,there are inherent strain differences that affect inflammation,gliosis,axon regeneration and ultimately functional recovery after SCI.

关键词： Spinal cord injury(SCI) spinal cord injury

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Extension of Flow Behaviour and Damage Models for Cast Iron Alloys with Strain Rate Effect

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Chinese Journal of Mechanical Engineering 2024年第3期37卷 297-310页

作者： Chuang Liu Dongzhi Sun Xianfeng Zhang florence Andrieux Tobias Gersterc School of Mechanical Engineering Nanjing University of Science and TechnologyNanjing 210094China Fraunhofer Institute for Mechanics of Materials(IWM) 79108 FreiburgGermany Fraunhofer Institute for High Speed Dynamics Ernst-Mach-Institute(EMI)79104 FreiburgGermany

Cast iron alloys with low production cost and quite good mechanical properties are widely used in the automotive *** study the mechanical behavior of a typical ductile cast iron(GJS-450)with nodular graphite,uni-axial quasi-static and dynamic tensile tests at strain rates of 10^(-4),1,10,100,and 250 s^(-1)were carried *** order to investigate the influence of stress state on the deformation and fracture parameters,specimens with various geometries were used in the *** strain curves and fracture strains of the GJS-450 alloy in the strain rate range of 10^(-4)to 250 s^(-1)were obtained.A strain rate-dependent plastic flow model was proposed to describe the mechanical behavior in the corresponding strain-rate *** available damage model was extended to take the strain rate into account and calibrated based on the analysis of local fracture *** with the proposed plastic flow model and the damage model were conducted to observe the deformation and fracture *** results show that the strain rate has obviously nonlinear effects on the yield stress and fracture strain of GJS-450 *** predictions with the proposed plastic flow and damage models at various strain rates agree well with the experimental results,which illustrates that the rate-dependent plastic flow and damage models can be used to describe the mechanical behavior of cast iron alloys at elevated strain *** proposed plastic flow and damage models can be used to describe the deformation and fracture analysis of materials with similar properties.

关键词： Dynamic behavior of materials Strain rate dependency Damage model Voce model Cast iron

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