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Potentials of marine natural products against malaria, leishmaniasis, and trypanosomiasis parasites: a review of recent articles

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Infectious Diseases of Poverty 2021年第1期10卷 95-96页

作者： Justus Amuche nweze floren.e n.mbaoji Yan-Ming Li Li-Yan Yang Shu-Shi Huang Vincent n.Chigor emmanuel A.eze Li-Xia Pan Ting Zhang Deng-Feng Yang Guangxi Key Laboratory of Marine natural Products and Combinatorial Biosynthesis Chemistry National Engineering Research Center of Non-Food Biorefi neryState Key Laboratory of Non-Food Biomass and Enzyme TechnologyGuangxi Academy of SciencesNanning 530007GuangxiPeople's Republic of China nation al Institute of Parasitic Diseases Chinese Center for Disease Control and PreventionWHO Collaborating Center for Tropical DiseasesNatio nal Center for Inter national Research on Tropical DiseasesKey Laboratory of Parasite and Vector Biology of the Chinese Ministry of HealthShanghai 200025People's Republic of China Full list of author information is available at the end of the article

Background:Malaria and neglected communicable protozoa parasitic diseases,such as leishmaniasis,and trypanosomiasis,are among the otherwise called diseases for neglected communities,which are habitual in underprivileged populations in developing tropical and subtropical regions of Africa,Asia,and the *** of the currently available therapeutic drugs have some limitations such as toxicity and questionable efficacy and long treatment period,which have encouraged *** have prompted many researchers to focus on fin ding new drugs that are safe,effective,and affordable from marine environ *** aim of this review was to show the diversity,structural scaffolds,in-vitro or in-vivo efficacy,and recent progress made in the discovery/isolation of marine natural products(MnPs)with potent bioactivity against malaria,leishmaniasis,and *** text:We searched PubMed and Google scholar using Boolean Operators(AnD,OR,and nOT)and the combination of related terms for articles on marine natural products(MnPs)discovery published only in english language from January 2016 to June *** nine articles reported the isolation,identification and antiparasitic activity of the isolated compounds from marine environment.A total of 125 compounds were reported to have been isolated,out of which 45 were newly isolated *** compounds were all isolated from bacteria,a fungus,sponges,algae,a bryozoan,cnidarians and soft *** recent years,great progress is being made on anti-malarial drug discovery from marine organisms with the isolation of these potent ***,some of these promising antikinetoplastid MnPs have potency better or similar to conventional drugs and could be developed as both antileishmanial and antitrypanosomal ***,very few of these MnPs have a pharmaceutical destiny due to lack of the following:sustainable production of the bioactive compounds,stan da rd efficient screening methods,knowledge of the me

关键词： Marine natural products neglected tropical diseases Anti-trypanosoma Anti-leishmania Anti-plasmodia Protozoa parasites

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Antimicrobial and antispasmodic activity of leaf extract and fractions of Stachytarpheta cayennensis

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Asian Pacific Journal of Tropical Medicine 2010年第3期3卷 189-192页

作者： Okoye TC Akah PA Okoli CO ezike AC mbaoji Fn Department of Pharmacology & Toxicology Faculty of Pharmaceutical SciencesUniversity of Nigeria

Objective:To investigate the antimicrobial activity of the methanol leaf extract(Me),n-hexane fraction(HF),ethylacetate fraction(eF) and methanol fraction(MF),of Stachytarpheta cayennensis ***(verbenaceae) as well as to ascertain the antispasmodic effects of the Me and the various fractions(HF,eF and MF) on acetylcholine(Ach) and histamine(H) induced contractions on isolated guinea pig ***:The in vitro agar well diffusion method was used for the antimicrobial studies while the isolated tissue method was employed for the antispasmodic test. Organisms used were all clinical isolates of Bacillus subtilis,Staphylococcus aureus,Pseudomonas aeruginosa,Salmonella paratyphi,Candida albicans and Aspergillus ***:The extract and fractions exhibited dose dependent inhibition against all the bacteria tested and also exhibited insignificant antifungal activity against Candida albicans and Aspergillus *** minimum inhibitory concentration(MIC) of the extract and fractions(mg/mL) on Bacillus subtilis, Staphylococcus aureus,Pseudomonas aeruginosa and Salmonella paratyphi respectively were Me 5.62,14.12,22.38,2.11;eF 1.25,6.30,9.40,9.40 and MF 3.98,8.81,39.80,*** n-hexane fraction exhibited MIC of 1.07 mg/mL against only Bacillus *** extract and fractions exhibited significant(Pe dependent attenuation of contractions induced by acetylcholine and histamine on isolated guinea pig *** of the extract and fractions(μg/mL) which evoked 50%inhibition of maximal response exhibited by Ach were Me 0.64,HF 0.16,eF 0.08 and MF 0.15,while that of histamine included Me 5.12,HF 0.16,eF 0.04 and MF *** phytochemical studies on the extract and fractions indicated the presence of carbohydrates,alkaloids,saponins,flavonoids,steroids and ***: The extract and fractions of Stachytarpheta cayennensis possessed both antibacterial and antispasmodic effects confirming the claimed use in folkloric medicine

关键词： Antimicrobial Antispasmodic Stachytarpheta cayennensis Acetylcholine Histamine

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