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世界核心医学期刊文摘（神经病学分册） 2005年第11期1卷 57-57页

作者： Elkind M.S.V. flint a.c. Scia.c. R.R. Sa.c. R.L. 刘凯 Dr.Neurological Institute 710 West 168th Street New York NY 10032 United States

Background: 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (statins), the most frequently used lipid-lowering agents (LLAs) have neuroprotective effects in rodent models of ischemic stroke. The authors hypothesized that patients with ischemic stroke taking LLAs would have better outcomes than patients not taking LLAs. Methods: The Northern Manhattan Study is a population-based study designed to determine stroke incidence and prognosis in a multiethnic, urban population. Northern Manhattan residents age 40 years or older diagnosed with their first ischemic stroke were eligible. Patients or their proxies were interviewed regarding medications being taken at home before stroke onset. The NIH Stroke Scale was used to assess stroke severity, categorized as mild (≤5), moderate (6 to 13), or severe (≥14), and the Barthel Index at 6 months to assess functional outcome. clinical worsening in hospital was recorded by trial neurologists. Odds ratios and 95%cIs for association of LLA use and stroke severity, mortality, and functional outcome were ca.c.lated using logistic regression. Results: Of 650 patients, 57 (8.8%) were taking LLAs. The majority (90.9%) of LLA users were taking a statin. clinical worsening in hospital occurred less frequently among patients taking LLAs at stroke onset (6.3%vs 18.2%; p=0.04). Ninety day mortality was lower in those taking LLAs (1.8%vs 10.6%, p=0.03). The proportion of patients with severe stroke among those taking LLAs was not lower (10.7%vs 16.8%, p=0.39). conclusion: Patients taking lipid-lowering agents (LLAs) at the time of an ischemic stroke may have lower poststroke mortality and a lower risk of worsening during hospitalization. Prospective studies are warranted to determine whether LLAs, and statins in particular, have neuroprotective properties or other beneficial effects in acute ischemic stroke.

关键词：缺血性卒中降脂类药物卒中发作神经保护作用他汀类药物城市人群神经科医师还原酶抑制剂比值比可信区间

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cross-scale modeling of surface temperature and tree seedling establishment in mountain landscapes

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Ecological Processes 2013年第1期2卷 313-327页

作者： John R Dingman Lynn c Sweet Ian Mccullough Frank W Davis Alan flint Janet Franklin Lorraine E flint Earth Resea.c. Institute University of California Santa BarbaraSanta BarbaraCA 93106USA U.S.Geological Survey California Water Science CenterSacramentoCA 95819USA Bren School of Environmental Science&Management University of California Santa BarbaraSanta BarbaraCA93106USA School of Geographical Sciences and Urban Planning Arizona State UniversityTempeAZ85287USA

Introduction:Estimating surface temperature from above-ground field measurements is important for understanding the complex landscape patterns of plant seedling survival and establishment,processes which occur at heights of only several ***,future climate models predict temperature at 2 m above ground,leaving ground-surface microclimate not well ***:Using a network of field temperature sensors and climate models,a ground-surface temperature method was used to estimate microclimate variability of minimum and maximum *** lapse rates were derived from field temperature sensors and distributed across the landscape capturing differences in solar radiation and cold air drainages modeled at a 30-m spatial ***:The surface temperature estimation method used for this analysis successfully estimated minimum surface temperatures on north-facing,south-facing,valley,and ridgeline topographic settings,and when compared to measured temperatures yielded an R2 of 0.88,0.80,0.88,and 0.80,*** surface temperatures generally had slightly more spatial variability than minimum surface temperatures,resulting in R2 values of 0.86,0.77,0.72,and 0.79 for north-facing,south-facing,valley,and ridgeline topographic ***-Poisson regressions predicting recruitment of Quercus kelloggii(black oak)seedlings from temperature variables were significantly improved using these estimates of surface temperature compared to air temperature modeled at 2 ***:Predicting minimum and maximum ground-surface temperatures using a downscaled climate model coupled with temperature lapse rates estimated from field measurements provides a method for modeling temperature effects on plant *** methods could be applied to improve projections of species’range shifts under climate *** of complex topography can provide intricate microclimates that may allow species to redistribute locally as climate

关键词： Black oak climate change Generalized linear models Microclimate Topography Spatial scale Surface temperature

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On Propagation of convergence

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Analysis in Theory and Applications 2000年第1期16卷 36-40页

作者： Mehrdad Simkani (Department of Mathematics The University of Michigan-flint flint, Michigan 48502 - 1950 USA) The University of Michigan-flint USA

We discuss some classical theorems and some recent results in the field of complex approximation from the viewpoint of propagation of convergence. We also prove a theorem on propagation of convergence in c2.

关键词： oscillatory integral operator multiplier singularity

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数据环主干网

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1988年

作者： (英)D.c.·弗林特

来源：南通市图书馆图书汇雅图书（南通市图书馆... 评论

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每日注射一次的人GLP-1类似物利拉鲁肽的药代动力学和药效动力学(血糖,胃排空,能量摄入)之间的关系

每日注射一次的人GLP-1类似物利拉鲁肽的药代动力学和药效动力学(...

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中华医学会第十次全国内分泌学学术会议

作者： A.flint c.HINDSBERGER Novo Nordisk A/S SφborgDenmark

目的:本试验的目的是评价利拉鲁肽的血药浓度与血糖、胃排空及能量摄入的关系。方法:该试验为随机、安慰剂对照、双盲、交叉试验,共18名2型糖尿病患者入组。利拉鲁肽的起始剂量为每日0.6mg,每周增加0.6mg直至1.8mg。检测利拉鲁肽稳定状...

目的:本试验的目的是评价利拉鲁肽的血药浓度与血糖、胃排空及能量摄入的关系。方法:该试验为随机、安慰剂对照、双盲、交叉试验,共18名2型糖尿病患者入组。利拉鲁肽的起始剂量为每日0.6mg,每周增加0.6mg直至1.8mg。检测利拉鲁肽稳定状态血药浓度(即每种剂量连续使用一周后),评价其与

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白缘象甲(在美国)

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植物检疫 1982年第6期 15-16页

作者： c.L.Metcalf W.P.flint 周永淑

白缘象甲 Pantomorus leucoloma(Boheman)属鞘翅目,象虫科。成虫灰色,头长,体长1/2英寸,侧缘带有暗淡色白条。一株寄主上可多至二百至三百头,或在地上爬动。取食多种大田和园艺作物的茎基、主根或播下的种子。幼虫白色,无足,小型,长达1/... 详细信息

白缘象甲 Pantomorus leucoloma(Boheman)属鞘翅目,象虫科。成虫灰色,头长,体长1/2英寸,侧缘带有暗淡色白条。一株寄主上可多至二百至三百头,或在地上爬动。取食多种大田和园艺作物的茎基、主根或播下的种子。幼虫白色,无足,小型,长达1/2英寸,春天大量幼虫为害,造成植物变黄,枯萎和死亡。尽管这种昆虫不能飞,但因其卵产在植物的许多部位上,当这些植物作为商品而转移时,卵就被带到

关键词：象甲幼虫白缘美国美利坚合众国北美洲

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液氦自动输送系统

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低温与特气 1984年第2期2卷 42-43页

作者： E．B．flint L.c.Jenkins R．W．Guernsey 顾荣而王玉杰不详光明所杭州制氧机研究所

术文介绍研究用小型杜瓦(50升)液氦自动输送系统，该系统设备简单，输液安全、可靠。

关键词：自动输送系统液氦系统设备输液

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Analyses of oligodontia phenotypes and genetic etiologies

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International Journal of Oral Science 2021年第3期13卷 323-332页

作者： Mengqi Zhou Hong Zhang Heather camhi Figen Seymen Mine Koruyucu Yelda Kasimoglu Jung-Wook Kim Hera Kim-Berman Ninna M.R.Yuson Paul J.Benke Yiqun Wu Feng Wang Yaqin Zhu James P.Simmer Jan c-c.Hu Dental Resea.c. Laboratory University of Michigan School of DentistryAnn ArborMIUSA Department of Second Dental center Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineCollege of StomatologyShanghai Jiao Tong UniversityNational Center for StomatologyNational Clinical Research Center for Oral DiseasesShanghai Key Laboratory of StomatologyShanghaiChina Department of General Dentistry Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineCollege of StomatologyShanghai Jiao Tong UniversityNational Center for StomatologyNational Clinical Research Center for Oral DiseasesShanghai Key Laboratory of StomatologyShanghaiChina Orthodontic and Pediatric Dentistry University of Michigan School of Dentistry1011N.University AveAnn ArborMIUSA Mott children’s Health center 806 Tuuri Place FlintMIUSA Department of Pedodontics Faculty of DentistryIstanbul UniversityIstanbulTurkey Department of Molecular Genetics&Dental Resea.c. Institute School of Dentistry Seoul National UniversitySeoulKorea Department of Pediatric Dentistry&Dental Resea.c. Institute School of Dentistry Seoul National UniversitySeoulKorea Department of Paediatric Dentistry Women’s and Children’s HospitalNorth AdelaideSAAustralia Department of Medical Genetics Joe DiMaggio Children’s HospitalHollywoodFLUSA Department of Oral Implantology Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineCollege of StomatologyShanghai Jiao Tong UniversityNational Center for StomatologyNational Clinical Research Center for Oral DiseasesShanghai Key Laboratory of StomatologyShanghaiChina

Oligodontia is the congenital absence of six or more teeth and comprises the more severe forms of tooth *** genes have been implicated in the etiology of tooth agenesis,which is highly variable in its clinical *** purpose of this study was to identify associations between genetic mutations and clinical features of oligodontia *** online systematic sea.c. of papers published from January 1992 to June 2021 identified 381 oligodontia.c.ses meeting the eligibility criteria of causative gene mutation,phenotype description,and radiographic ***,ten families with oligodontia were recruited and their genetic etiologies were determined by whole-exome sequence *** identified a novel mutation in WNT10a.c.99_105dup)and eight previously reported mutations in WNT10a.c.433 G>a.c.682 T>a.c.318 c>G;c.511.c>T;c.321 c>A),EDAR(c.581 c>T),and LRP6(c.1003 c>T,c.2747 G>T).collectively,20 different causative genes were implicated among those 393 cases with *** each causative gene,the mean number of missing teeth per case and the frequency of teeth missing at each position were ***–phenotype correlation analysis indicated that molars agenesis is more likely linked to PAX9 mutations,mandibular first premolar agenesis is least associated with PAX9 mutations.

关键词： clinical congenital likely

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利拉鲁肽对2型糖尿病受试者进食高脂饮食后甘油三脂(TG)和载脂蛋白B48(ApoB48)的抑制作用

利拉鲁肽对2型糖尿病受试者进食高脂饮食后甘油三脂(TG)和载脂蛋...

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中华医学会第十一次全国内分泌学学术会议

作者： KJELD HERMANSEN TINE AGGERHOLM BAEDAL MARIA DüRING ANNA PIETRASZEK LENE SUNDAHL MORTENSEN KNUD ERIK BAcH KNUDSEN ANNE flint Arhus University Hospital Arhus CDenmark Novo Nordisk A/S BagsvrdDenmark Arhus University FoulumTjeleDenmark

目的:比较1.8 mg利拉鲁肽在达到稳态状态下和安慰剂对餐后血脂水平的作用。方法:本试验为交叉设计,患有2型糖尿病(T2DM)的受试者(n=20,53-73岁,BMI 24-39 kg/m

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control of Glyphosate-Resistant Giant Ragweed (Ambrosia trifida L.) with Isoxaflutole and Metribuzin Tankmix

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American Journal of Plant Sciences 2016年第6期7卷 916-927页

作者： Scott Ditschun Nader Soltani Darren E. Robinson François J. Tardif Allan c. Kaastra Peter H. Sikkema Department of Plant Agriculture University of Guelph Guelph Canada University of Guelph Ridgetown campus Ridgetown Canada Bayer crop Science canada Guelph Canada

Five field trials were conducted over a two-year period (2013, 2014) to determine the control of glyphosate-resistant (GR) giant ragweed with isoxaflutole (IFT) and metribuzin (MTZ) applied alone and in combination. Treatments were designed to assess the dose response of an IFT plus MTZ tank-mix as well as each chemical applied alone to classify the response using flint’s adaptation of colby’s equation. Two factor factorial experiments were performed in the growth room to a.c.rtain the response of IFT versus glyphosate, IFT versus MTZ, and IFT plus MTZ versus glyphosate on single plants. Field experiments evaluated the control of GR giant ragweed with IFT plus MTZ in tank-mix in a 1:4 ratio. The rate of IFT plus MTZ for 80% control of GR giant ragweed at 4 and 8 weeks after application (WAA) was 518 (104 g a.i. ha-1 IFT + 414 g a.i. ha-1 MTZ) and 631 g a.i. ha-1 (126 g a.i. ha-1 IFT + 505 g a.i. ha-1 MTZ), respectively. A rate of 668 and 467 g a.i. ha-1 was required to reduce GR giant ragweed density and biomass by 80%, respectively. Field experiments evaluating the control of GR giant ragweed with tank-mixes of IFT plus MTZ, where glyphosate was a.c.nstant tank-mix partner, were mostly synergistic. However, the low tank-mix rate (52.5 + 210 g a.i. ha-1) had an additive response for GR giant ragweed biomass reduction. When tested in the greenhouse and growth room, glyphosate susceptible (GS) giant ragweed showed some antagonism with glyphosate and isoxaflutole tank-mixes at rates less than commercial field rates. GR giant ragweed showed an additive response across all treatments in the growth room. Greenhouse experiments evaluating IFT versus MTZ and IFT plus MTZ versus glyphosate revealed all tank-mix treatments to be synergistic at 2 WAA.

关键词： Additive Antagonistic Giant Ragweed Glyphosate Herbicide Resista.c. Soybean Synergistic Yield

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