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Fabrication of 3D air-core MEMS inductors for very-highfrequency power conversions

Microsystems & Nanoengineering 2018年第1期4卷 509-517页

作者： Hoa Thanh Le Io Mizushima Yasser Nour Peter Torben Tang Arnold Knott Ziwei Ouyang flemming jensen Anpan Han National Center for Micro-and Nanofabrication DanchipTechnical University of Denmark2800 Kongens LyngbyDenmark Department of Electrical Engineering Technical University of Denmark2800 Kongens LyngbyDenmark IPU Nils Koppels Allé2800 Kongens LyngbyDenmark

We report a fabrication technology for 3D air-core inductors for small footprint and very-high-frequency power *** process is scalable and highly generic for fabricating inductors with a wide range of geometries and core *** demonstrate spiral,solenoid,and toroidal inductors,a toroidal transformer and inductor with advanced geometries that cannot be produced by wire winding *** inductors are embedded in a silicon substrate and consist of through-silicon vias and suspended *** inductors fabricated with 20 and 25 turns and 280-350μm heights on 4-16 mm2 footprints have an inductance from 34.2 to 44.6 nH and a quality factor from 10 to 13 at frequencies ranging from 30 to 72 *** air-core inductors show threefold lower parasitic capacitance and up to a 140% higher-quality factor and a 230% higher-operation frequency than silicon-core inductors.A 33 MHz boost converter mounted with an air-core toroidal inductor achieves an efficiency of 68.2%,which is better than converters mounted with a Si-core inductor(64.1%).Our inductors show good thermal cycling stability,and they are mechanically stable after vibration and 2-m-drop tests.

关键词： MEMS inductor PwrSoC TSVs very high frequency 3D

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Axial force measurement for esophageal function testing

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World Journal of Gastroenterology 2009年第2期15卷 139-143页

作者： flemming H Gravesen Peter Funch-jensen Hans Gregersen Asbjφrn Mohr Drewes Mech-Sense Department of Gastroenterology Aalborg Hospital Aalborg Denmark Center for Sensory-Motor Interaction (SMI) Department of Health Science and Technology Aalborg University DK-9000 Aalborg Denmark Department of Surgical Gastroenterology L rhus University Hospital rhus Denmark

The esophagus serves to transport food and fluid from the pharynx to the stomach. Manometry has been the "golden standard" for the diagnosis of esophageal motility diseases for many decades. Hence, esophageal function is normally evaluated by means of manometry even though it reflects the squeeze force (force in radial direction) whereas the bolus moves along the length of esophagus in a distal direction. Force measurements in the longitudinal (axial) direction provide a more direct measure of esophageal transport function. The technique used to record axial force has developed from external force transducers over in-vivo strain gauges of various sizes to electrical impedance based measurements. The amplitude and duration of the axial force has been shown to be as reliable as manometry. Normal, as well as abnormal, manometric recordings occur with normal bolus transit, which have been documented using imaging modalities such as radiography and scintigraphy. This inconsistency using manometry has also been documented by axial force recordings. This underlines the lack of information when diagnostics are based on manometry alone. Increasing the volume of a bag mounted on a probe with combined axial force and manometry recordings showed that axial force amplitude increased by 130% in contrast to an increase of 30% using manometry. Using axial force in combination with manometry provides a more complete picture of esophageal motility, and the current paper outlines the advantages of using this method.

关键词：轴向力牵引力压力测量法运动性蠕动食管疾病

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MicroRNA-126 and epidermal growth factor-like domain 7 predict recurrence in patients with colon cancer treated with neoadjuvant chemotherapy

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Cancer Drug Resistance 2019年第3期2卷 885-896页

作者： Torben Frøstrup Hansen Anting Liu Carlsen Julia Tanas Tanassi Ole Larsen flemming Brandt Sørensen Lars Henrik jensen Anders Jakobsen Danish Colorectal Cancer Center South Vejle HospitalInstitute of Regional Health ResearchUniversity of Southern DenmarkVejle 7100Denmark Department of Autoimmunology and Biomarkers Statens Serum InstitutCopenhagen 2300Denmark Department of Congenital Disorders Statens Serum InstitutCopenhagen 2300Denmark Department of Oncology Herlev HospitalHerlev 2730Denmark University Institute of Pathology Aarhus University Hospitaland department of Clinical MedicineUniversity of AarhusAarhus 8200Denmark

Aim:Neoadjuvant chemotherapy may represent a shift in the treatment of locally advanced colon *** angiogenic couple has-microRNA-126(miRNA-126)and epidermal growth factor-like domain 7(EGFL7)are transcribed from the same gene and regulates all aspects of angiogenesis and may influence the ability of tumor cells to *** aim was to analyze the relationship between miRNA-126 and EGFL7 and disease recurrence in patients with locally advanced colon cancer treated with neoadjuvant ***:This study included 71 patients from a phase II study all planned for three cycles of capecitabine and oxaliplatin before *** was sampled at baseline and right before and after the *** miRNA-126 was analysed by RT-qPCR and a quantitative immunoassay was used for the analyses of ***:The rates of 5-year disease-free survival(DFS)and overall survival(OS)were 80%and 85%,*** level of circulating miRNA-126 before the operation predicts recurrence,P=*** patients with values below and above the median the recurrence rate was 31%and 4%,*** results applied to EGFL7.A combined estimate identified a subgroup of patients(25 of 71)with no recurrence and a 5-year DFS and OS rate of 100%,***:MicroRNA-126 and EGFL7 are predictors for disease recurrence in patients with locally advanced colon cancer treated with neoadjuvant chemotherapy and may assist in selection of adjuvant chemotherapy.

关键词： Chemotherapy colon cancer epidermal growth factor-like domain 7 microRNA-126

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Effect of Gastrointestinal Protease Digestion on Bioactivity of Marine Peptides

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Journal of Agricultural Science and Technology(B) 2014年第1期4卷 74-84页

作者： Ida-Johanne jensen Lisa Lystbek Andersen Carlo Gunnar Ossum Greta Jakobsen Cristian De Gobba Sabeena Farvin Koduvayur Habeebullah Inez Johansson Else Hoffmann Edel Oddny Elvevoll flemming Jessen Henrik Hauch Nielsen Faculty of Bioscience Fisheries and Economics Norwegian College of FisheO Science UniversiO of Tromso Tromso 9037Norway Division ofIndustrial Food Research National Food Institute DTU-Food Technical University qf Denmark Lyngby DK-2800Denmark Department of Biology Cell and Developmental Biology Universitv of Copenhagen Copenhagen 2100 Denmark Marinova ApS Adelvej 11 Lem St. 6940 Denmark Department of Food Science University o[Copenhagen Frederiksberg C 1958 Denmark

Focus in nutritional science has turned towards components in, or added to, foods that may possess health beneficial activities beyond the classical nutritional value, namely functional food. Bioactive peptides are examples of such components. In vitro studies on bioactivities have mainly been executed without concerning subsequent digestion after intake and the aim of this work was hence to investigate how the in vitro antioxidative, antihypertensive and caspase activating activities of peptides are affected by digestion with gastrointestinal (GI) proteases. Five different fish protein hydrolysates were chosen to study the effect of in vitro digestion on bioactivity. The protein concentration decreased in all samples during digestion and the molecular weight distribution of the peptides shifted towards lower values. Thus, in vitro digestion with GI proteases resulted in a further degradation of the peptides obtained by hydrolysis. The antihypertensive effect increased in all samples after digestion with GI proteases whereas the antioxidative capacity decreased. The effect on the caspase activity depended on the proteases used in the preparation of hydrolysates. In conclusion, the caspase activity and antihypertensive activity are maintained during digestion with GI proteases, while the antioxidative capacity seems to be reduced.

关键词：生物活性肽体外消化肠蛋白酶海洋肽胃肠道 caspase 蛋白水解物抗氧化能力

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