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The Role of Human Herpesvirus 8 Molecular Characterization in the Management of HIV Infected Patients Diagnosed with Malignancies Associated with Its Infection

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World Journal of AIDS 2013年第3期3卷 221-230页

作者： Martínez Pedro Ariel Kourí Vivian Blanco Orestes Capó Virginia Abad Yoandra Alemán Yoan Verdasquera Denis Jiménez Narciso Caballero Iraida fleites gilberto Ugarte Yaumara Calderón Odalys álvarez Alina Ulrich Hengge Institute of Tropical Medicine “Pedro Kourí” (IPK) Autopista Novia del Mediodía Habana Cuba

Despite the progress has been reached with Human herpesvirus 8 (HHV-8) research, there are gaps in the knowledge of viral induced oncogenesis. The aim of the present study was to identify possible associations between HHV-8 subtypes, HHV-8 loads and clinical manifestations of HIV infected patients diagnosed with different malignancies associated with HHV-8 infection. Forty six HIV-1 infected individuals diagnosed with different HHV-8 associated diseases were studied [37 epidemic Kaposi’s sarcoma (KS), 3 pleural effusion lymphoma (PEL);5 peripheral lymphadenopathies (PL);1 Hodgkin’s lymphoma (HL);1 non Hodgkin’s lymphoma (NHL)]. HHV-8 loads were determined by quantitative real time PCR (qRT-PCR) whilst HHV-8 subtypes were determined by open-reading frame (ORF)-K1 gen genotyping. HHV-8 subtypes B, A, C, A5 and E were exhibited by 31.8%, 23.4%, 19.1%, 17% and 8.5% of the studied patients, respectively. The median HHV-8 viral load did not differ between subtypes (p > 0.05) but HHV-8 viral loads were significantly higher in PEL than in epidemic KS lesion or lymph nodes (p = 0.04). Subtype B was detected in 60% of patients with B cell lymphoma (NHL, PEL and HL) whereas subtype E was only detected in patients with epidemic KS diagnosis. Our data suggest that HHV-8 DNA quantification instead of subtype identification could be used as a surrogate marker for monitoring its infection, not only in epidemic KS patients but also in HIV infected individuals with lymphoproliferative disorders.

关键词： Human Herpesvirus 8 or Kaposi’s Sarcoma-Associated Herpesvirus Real Time PCR Subtypes Lymphoproliferative Disorders Cuban HIV/AIDS

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Internal mammary artery harvesting with its distal end occluded

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Chinese Medical Journal 2019年第11期132卷 1385-1386页

作者： Yoandy Lopez-de la Cruz Yolepsis Quintero-fleites Department of Cardiovascular Surgery Santa Clara Cardiac Center Santa Clara Villa Clara 50200 Cuba

To the Editor:We have read with great interest the comment of Chen et al"What can we learn from cases of internal mammary artery damage in coronary artery bypass graft ", The advice that the authors propose in relation to the internal mammary artery (IMA) harvesting is very useful because they are based on a 20-year experience in more than 10,000 patients.

关键词： coronary artery mammary Lesion of internal mammary artery

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Exploring the Role of Nutraceuticals (Red Yeast Rice) in Secondary Prevention: A New Pathway Can Be Opened

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World Journal of Cardiovascular Diseases 2022年第1期12卷 24-29页

作者： Santiago de Dios Eduardo Fernandez Carrion Javier Antona Makoshi Juan Jose Parra Fuertes Hector fleites Eduardo Zatarain Jose Luis Zamorano Gomez Department of Cardiology Hospital Universitario de la Zarzuela Madrid Spain Department of Maths Universidad Complutense Madrid Spain Department of Cardiology Hospital Conde Valle-Suchil Madrid Spain Department of Cardiology Hospital 12 de Octubre Madrid Spain Department of Cardiology Hospital Gregorio Mara&ntilde ón Madrid Spain

Background: Long-term survival in acute coronary syndrome has increased steadily in the last decades. Follow-up studies developed in this patient clearly reveal that they are at risk of suffering a new event, placing them in a new stage, secondary prevention. Assuming this increased risk, the control target of their cardiovascular risk factors become more ambitious. In this field, control of Cholesterol levels, particularly LDL-C, has arisen as a priority objective in patients with coronary arterial disease. In this sense, management of dyslipidemia guidelines, recently recognises the role of functional food, highlighting among them is the Red Yeast Rice (RYR). The aim of the study is to establish the potential role of functional food, in secondary prevention, while determining its additional capacity to reduce LDL-C in patients that despite optimal classic treatment (maximum tolerated dose of stain plus Ezetimibe) is still out of control objectives. Results and Discussion: 88 patients were included and after 3 months of tr

关键词： Lipids Nutraceuticals Coronary Artery Disease Secondary Prevention

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