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Development of a Short-Term Ozone Prediction Tool in Campo Grande-MS-Brazil Area Based on Meteorological Variables

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Open Journal of Air Pollution 2014年第2期3卷 42-51页

作者： Amaury de Souza flavio Aristones Hamilton Germano Pavao Widinei Alves Fernandes Institute of Physics Federal University of Mato Grosso do SulCampo GrandeBrazil

The objective of this study was to develop a model to predict the concentration of ozone. The measurements of ozone were conducted at the Federal University of Mato Grosso do Sul. The predictor variables related to climate were supplied by Embrapa Gada de Corte. Analyses of the data show a strong correlation between ozone and wind speed (0.75), humidity (?0.64) and temperature (0.41), as the factors that affect levels of concentration ozone. The observed and predicted values of daily ozone had a correlation coefficient (R) of 0.69.

关键词： Regression Model Meteorology Ozone Prediction

Upper limb embolism as the first manifestation of atrial fibrillation

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Chinese Medical Journal 2014年第8期127卷 1599-1599页

作者： Gabriel Pérez Baztarrica flavio Salvaggio Sandra Zamar Rafael Porcile Department of Cardiology and Physiology Universitary Hospital Universidad Abierta Interamericana Faculty of Medicine Buenos Aires Argentine

To the editor： We present a male patient, 75 years old, admitted to our emergency room with right ann pain for about an hour. The patient had only a history of arterial hypertension. On his physical examination, she had an irregular pulse. The right arm showed hypothermic with cyanotic hand. The right upper limb pulses were not palpable. Her initial electrocardiogram revealed atrial fibrillation with a fast ventricular response.

关键词： THROMBOEMBOLISM

Bisacodyl plus split 2-L polyethylene glycol-citrate-simethicone improves quality of bowel preparation before screening colonoscopy

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World Journal of Gastroenterology 2013年第33期19卷 5493-5499页

作者： flavio Valiante Angelo Bellumat Manuela De Bona Michele De Boni Department of Gastroenterology and Digestive Endoscopy S Maria del Prato Hospital

AIM:To compare the bowel cleansing efficacy,tolerability and acceptability of split 2-L polyethylene glycol(PEG)-citrate-simethicone(PEG-CS)plus bisacodyl(BIS)vs 4-L PEG for fecal occult blood test-positive screening ***:This was a randomised,observer-blind comparative *** hundred and sixty-four subjects underwent screening colonoscopy(mean age 62.5±7.4years,male 61.7%).The primary objective of the study was to compare the bowel cleansing efficacy of the two ***:BIS plus PEG-CS:3 tablets of 5-mg BIS at 16:00,PEG-CS 1-L at 19:00 and 1-L at7:00,4-L PEG:3-L at 17:00,and 1-L at 7:*** was carried out after 11:00,at least 3 h after the completion of bowel *** cleansing was evaluated using the Harefield Cleansing ***:Bowel preparation was successful for 92.8%of subjects in the PEG-CS group and for 92.1%of subjects in the 4-L PEG(RR=1.01;95%CI:0.94-1.08).BIS+PEG-CS was better tolerated than 4-L PEG.A greater rate of patients in the BIS+PEG-CS group had no difficulty and/or were willing to repeat the same preparation compared to split-dose 4-L PEG *** in the BIS+PEG-CS group rated the prep as good or satisfactory in 90.6%as compared to 77%in the 4-L PEG(P=0.003).Subjects receiving BIS+PEGCS stated they fully adhered to instructions drinking all the 2-L solution in 97.1%compared with 87.3%in the4-L PEG(P=0.003).CONCLUSION:BIS plus split 2-L PEG-CS was as effective as but better tolerated and accepted than split4-L PEG for screening *** new procedure may increase the positive attitude and participation to colorectal cancer screening colonoscopy.

关键词： Colonoscopy Colon cleansing Bowel preparations Polyethylene glycol Simethicone Bisacodyl

Co-crystals of non-steroidal anti-inflammatory drugs(NSAIDs):Insight toward formation,methods,and drug enhancement

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Particuology 2021年第5期19卷 227-241页

作者： Andre L.C.S.Nascimento Richard P.Fernandes Maxime D.Charpentier Joop H.ter Horst flavio J.Caires Marius Chorilli Sao Paulo State University(UNESP) School of Pharmaceutical Sciences14800-903 AraraquaraSao PauloBrazil São Paulo State University(UNESP) Institute of Chemistry14800-060 AraraquaraSao PauloBrazil EPSRC Centre for Innovative Manufacturing in Continuous Manufacturing and Crystallisation University of StrathclydeGlasgowUK Sao Paulo State University(UNESP) School of Sciences17033-260 BauruSao PauloBrazil

Pharmaceutical co-crystals have been explored by many researchers as a strategy to optimize physicochemical properties of solid-state *** improvements of solubility,bioavailability,and the reduced tendency for phase transformation occurrence,are factors that highlight benefits of pharmaceutical co-crystals among other solid *** to the Biopharmaceutical Classification System(BCS),non-steroidal anti-inflammatory drugs(NSAIDs)are class Ⅱ drugs,which have low aqueous solubility and therefore co-crystallization has the potential to optimize NSAID product *** this review,we highlight the recent progress made on NSAIDs co-crystals,their co-formers,synthesis,methods and use,while we underline some promising results on in vitro and in vivo co-crystal properties.A celecoxib-tramadol co-crystal reaches phase Ⅲ clinical trials,showing greater analgesic activity than both individual *** aqueous solubility of the co-crystal formed between l-proline and diclofenac is very high in comparison with the pure *** co-crystals with urea and thiourea have an increase of drug release of almost 60%.Co-crystal design brings a new perspective in drug development since the co-former used can also be a biologically active component allowing to combine different anti-inflammatory drugs,which have an incredible spectrum of application due to the analgesic,anti-pyretic and anti-inflammatory properties.

关键词： Pharmaceutical co-crystals NSAIDs Supramolecular synthons Co-crystal discovery Bioavailability

Predicting vasospasm after aneurismal subarachnoid hemorrhage with C reactive protein levels

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Health 2013年第7期5卷 1-6页

作者： flavio RRomero Luis GDucati Marco AZanini Daniele CCataneo Antonio JMCataneo Roberto CGabarra Neurosurgeon at Hospital das Clínicas de Botucatu-UNESP BotucatuBrazil Neurosurgery at Sao Paulo State University Medical School BotucatuBrazil Thoracic Surgery at Sao Paulo State University Medical School BotucatuBrazil

Aim: The interest of inflammatory marker increased in the last years, even in preventing clinical outcome after subarachnoid hemorrhage (SAH). Our objective was to study the relationships between C-reactive protein levels and clinical outcome and the development of cerebral vasospasm after aneurismal SAH. Methods: One hundred adult patients with aneurismal SAH were prospectively evaluated. Glasgow Coma Scale (GCS) score, Hunt and Hess grade, Fisher grade, CT scans, digital subtraction angiography studies, transcranial doppler (TCD) and daily neurological examinations were recorded. Serial serum CRP measurements were obtained on daily between admission and 10th days. Glasgow Outcome Scale (GOS) and the modified Rankin Scale (mRS) were used to predict outcome. Results: A progressive increase in the CRP levels from the admission to the 3rd postictal day was observed, followed by a slow decrease until the 9th day. Hemodynamic changes in TCD were associated with higher serum CRP levels. Patients with lower GCS scores presented with increased CRP levels. Patients with higher Hunt and Hess grades on admission developed significantly higher CRP serum levels. Patients with higher admission Fisher grades showed increased levels of CRP. A statistically significant inverse correlation was established in our series between CRP serum levels and GOS and mRS scores on discharge and CRP levels. Conclusion: Increased CRP levels were strongly associated with poor clinical outcome. CRP levels can predict cerebral vasospasm and delayed ischemic deficits with higher statistic significance. There are relationships between hemodynamic chances in TCD and higher CRP levels.

关键词： Intracranial Vasospasm Subarachnoid Hemorrhage C Protein Intracranial Aneurism

Simulated Experiments for Teaching Mutually-Coupled Circuits CAD Techniques Using Analytic and Finite Element Solutions

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Journal of Electromagnetic Analysis and Applications 2017年第11期9卷 183-202页

作者： Antonio flavio Licariao Nogueira Vitor Horbe Pereira da Costa Rodolfo Lauro Weinert Santa Catarina State University JoinvilleBrazil

The paper describes an approach to teaching mutually-coupled circuits CAD techniques to undergraduate students pursuing a degree course in electrical engineering or physics, and explains how a series of simulated experiments may be incorporated into the existing subjects. The simulated experiments make use of a two-dimensional open-access software based on the finite-element method. At the laboratory meetings, the students learn how to set up field problems for solution, and how to examine the results. Simulation tasks based on three axisymmetric open-boundary problems are used to introduce different numeric techniques to compute inductance and magnetic forces. The paper takes the reader to a step-by-step simulation journey, and provides all the basic elements required for further exploration of axially-symmetric systems.

关键词： Electromagnetic Engineering Education Finite Element Method Inductance Magnetic Forces Simulation Software

Preparation and Microstructural,Structural,Optical and Electro-Optical Properties of La Doped Pmn-Pt Transparent Ceramics

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Optics and Photonics Journal 2012年第3期2卷 157-162页

作者： Fernando Andres Londono Badillo Jose Antonio Eiras flavio Paulo Milton Ducinei Garcia Ferroelectric Ceramics Group Physics DepartmentFederal University of Sao CarlosSao CarlosBrazil

Transparent relaxor ferroelectric ceramics of the system lanthanum modified lead magnesium niobate have been investigated for a variety of electro-optic properties could make these materials alternatives to (Pb,La)(Zr,Ti)O3. However, a study that relates the properties in function stoichiometric formula, it has not been analyzed heretofore. Therefore, in this work the effect of A-site substitution of La+3 in the characterization microstructural, structural, optical and electro-optical on (1-x)[Pb(1-3/2y)Lay(Mg1/3Nb2/3)O3]-xPbTiO3 and (1-z)[(1-x)Pb(Mg1/3Nb2/3)O3+xPbTiO3]+zLa2O3 has been performed. It was observed that the properties according to the stoichiometric formula and the PT had a maximum whose behavior was related to the addition of lanthanum in each stoichiometries.

关键词： Ferroelectric Optics Transmittance Electro-Optical

Verification of Applicability of the Polyurethane Adhesive Based on Castor Oil in the Manufacture of Glued Laminated Bamboo

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Journal of Chemistry and Chemical Engineering 2014年第9期8卷 898-905页

作者： flavio Cardoso Ventura Bruno Perazzelli Farias Ramos Marco Antonio dos Reis Pereira FATEC JAHU Faculty of Technology Jahu Jahu 17212-599 Brazil School of Architecture Arts and Communication Sao Paulo State University Bauru 17033-360 Brazil Department of Mechanical Engineering Sao Paulo State University Bauru 17033-360 Brazil

The current concern with the environment promotes the development of new technologies for production with use of alternative materials, from renewable resources, and changes in production processes, having as main objective the reduction of environmental impact. One of the alternatives for cleaner production is the use of castor oil derivatives instead of non-renewable sources, such as adhesives based on PVA （polyvinyl acetate）, applied in the manufacturing process of glued laminated bamboo. Based on the versatility of the bamboo laminate and the castor oil, and from the perspective of sustainability, this study aims to contribute to the application of new materials and processes, used in the manufacturing industry, by proposing the use of the polyurethane adhesive based on castor oil for glued laminated bamboo manufacturing, which can later be used in the manufacture of several products. To verify the applicability of the polyurethane adhesive based on castor oil in the glued laminated bamboo manufacture, mechanical tests of traction and shearing of the glue sheet were performed in specimens of the said material, and the results were compared with the Cascorez 2590 and Waterbond adhesives. The results showed that the polyurethane adhesive based on castor oil, in the traction test, has superior performance than the Waterbond adhesive and slightly below than the Cascorez 2590 adhesive, but in the shear test, the polyurethane adhesive based on castor oil presented a slightly inferior performance than the other two adhesives used in the comparison.

关键词： Design castor oil glued laminated bamboo sustainable development PVA adhesives.

A universal route to efficient non-linear response via Thomson scattering in linear solids

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National Science Review 2023年第7期10卷 203-212页

作者： Yongzheng Wen flavio Giorgianni Igor Ilyakov Baogang Quan Sergey Kovalev Chen Wang Carlo Vicario Jan-Christoph Deinert Xiaoyu Xiong Joe Bailey Min Chen Alexey Ponomaryov Nilesh Awari Andrea Rovere Jingbo Sun Roberto Morandotti Luca Razzari Gabriel Aeppli Junjie Li Ji Zhou State Key Laboratory of New Ceramics and Fine Processing School of Materials Science and Engineering Tsinghua University Paul Scherrer Institut Helmholtz-Zentrum Dresden-Rossendorf Beijing National Laboratory for Condensed Matter Physics Institute of Physics Chinese Academy of Sciences Institut de Physique école Polytechnique Fédérale de Lausanne (EPFL) Institut National de la Recherche Scientifique (INRS) Centreénergie Matériaux et Télécommunications (EMT) Department of Physics and Quantum Center ETH Zürich

Non-linear materials are cornerstones of modern optics and *** dependence on the intrinsic properties of particular materials,however,inhibits the at-will extension of demanding non-linear effects,especially those second-order ones,to widely adopted centrosymmetric materials(for example,silicon) and te chnologically important burgeoning spectral domains(for example,terahertz frequencies).Here we introduce a universal route to efficient non-linear responses enabled by exciting non-linear Thomson scattering,a fundamental process in electrodynamics that was known to occur only in relativistic electrons in metamaterial composed of linear *** a mechanism modulates the trajectory of charges,either intrinsically or extrinsically provided in solids,at twice the driving frequency,allowing second-harmonic generation at terahertz frequencies on crystalline silicon with extremely large non-linear susceptibility in our proof-of-concept *** offering a substantially material-and frequency-independent platform,our approach opens new possibilities in the fields of on-demand non-linear optics,terahertz sources,strong field light-solid interactions and integrated photonic circuits.

关键词： non-linear optical materials terahertz harmonic generation Thomson scattering magneto-electric coupling metamaterial