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Journal of Bionic Engineering 2018年第5期15卷 820-826页

作者： flavio moreira Anthony Abundis Michael Aguirre Justin Castillo Pranav A. Bhounsule Robotics and Motion Laboratory Department of Mechanical Engineering The University of Texas at San Antonio One UTSA Circle San Antonio rX78249 USA

We have created an inchworm robot capable of the two-anchor crawl gait on level ground and inclined plane. The main novelty is in the design of the inchworm：（1） three-part body that is 3D printed and actuated by two servo motors to allow a looping and lengthening action, （2） passive friction pads to anchor the feet, each of which may be disengaged using a servo motor actuated lever arm, and （3） modular body and electronics. The robot is about 2 feet （61 cm） in length, has a mass of about 4 kg, and uses an open-loop controller to achieve steady crawling gait. The inchworm robot achieved a speed of 2.54 *** on level ground as well as on an incline plane of 19~. The energy usage as measured by the Mechanical Cost of Transport （a non-dimensional number defined as the energy used per unit weight per unit distance moved） is 3.34. Our results indicate that simple robotic designs that copy the basic features of natural organisms provide a promising alternative over conventional wheeled robots.

关键词： inchworm bioinspiration two-anchor crawl gait 3D printing sliding locomotion cost of transport

Impact characterization on thin structures using machine learning approaches

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Chinese Journal of Aeronautics 2024年第2期37卷 30-44页

作者： flavio DIPIETRANGELO Francesco NICASSIO Gennaro SCARSELLI Department of Engineering for Innovation University of SalentoLecce 73100Italy

Machine learning algorithms are trained and compared to identify and to characterise the impact on typical aerospace panels of different *** activities are conducted to build a proper impacts’*** regression algorithm and artificial neural network are applied and optimised to panels without stringer to test their capability to identify the ***,the algorithms are applied to panels reinforced with stringers that represent a significant increase of complexity in terms of dynamic features of the system to test:the focus is not only on the impact position’s detection but also on the event’s *** the identification of the best algorithm,the corresponding machine learning model is deployed on an ARM processor minicomputer,implementing an impact detection system,able to be installed on board an aerial vehicle,making it a smart aircraft equipped with an artificial intelligence decision-making system.

关键词： Artificial neural network Impact localisation Machine learning Polynomial regression Structural health monitoring

Breeding phase and outcome determine space use in European rollers Coracias garrulus prior to migration

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Current Zoology 2024年第2期70卷 137-149页

作者： flavio Monti Sanja Barisic Sebastian Cannarella Davor Cikovic Vesna Tutis JelenaKralj Carlo Catoni aUniversity of Siena Department of Physical SciencesEarth and EnvironmentVia Mattioli 453100 SienaItaly Institute of Ornithology Croatian Academy of Sciences and ArtsGunduliceva 24HR-1000 ZagrebCroatia Ornis italica Piazza Crati 1500199 RomeItaly

The breeding period is a demanding and time-constrained phase for migratory bird *** outcome and duration can interact with the extent and duration of post-breeding movements,resulting in individual differences in space use ultimately influencing later stages of the annual *** present space-use and home range estimates during the breeding season for 21 European rollers Coracias garrulus tracked between 2018 and 2022,in Italy and *** high-resolution spatial GPS data coupled with regular nest-box monitoring,we analyzed dif-ferences in space use during the incubation/nestling period versus post-breeding period prior to migration,accounting for the breeding outcome(successful ***).We found that adult movements were strongly reduced during the first phase,whereas increased in the post-breeding phase,especially for failed *** breeders remained in the surroundings of the nest site,whereas unsuccessful ones tended to abandon the nest and visit distant areas(up to 500 km)for long periods(60.5±6.2 days).Breeding outcome did not influence the departure date of autumn migration,suggesting that failed breeders used this period for exploratory movements but not for advancing the onset of *** exploratory movements may be functional to prospect and inform settlement decisions in failed breeders in search of new breeding opportunities and may be particularly important in migratory species,which generally have a limited period to gather information prior to autumn *** study demonstrates the need to investigate seasonal movements in different populations and the potential importance of pros-pectingpost-breeding movements for long-distance migratory species.

关键词： animal movement biologging conservation Coracidae Mediterranean nest-box population monitoring prospecting movements reproduction.

Treatment for paraganglioma with stereotactic radiotherapy

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World Journal of Clinical Cases 2024年第16期12卷 2729-2737页

作者： Antonio Pontoriero Paola Critelli Marco Zeppieri Filippo flavio Angileri Tamara Ius Radiation Oncology Unit Department of BiomedicalDental Science and Morphological and Functional ImagesUniversity of MessinaMessina 98125Italy Department of Ophthalmology University Hospital of UdineUdine 33100Italy Neurosurgery Unit Department of BiomedicalDental Science and Morphological and Functional ImagesUniversity of MessinaMessina 98125Italy Neurosurgery Unit Head-Neck and NeuroScience DepartmentUniversity Hospital of UdineUdine 33100Italy

BACKGROUND Paragangliomas(PG)are rare neoplasms of neuroendocrine origin that tend to be highly vascularized,slow-growing,and usually *** date,common treatment options are surgical resection(SR),with or without radiation therapy(RT),and a watch-and-wait *** To evaluate the local control and effectiveness of exclusive fractionated stereotactic RT(FSRT)treatment in unresectable PG(uPG).METHODS We retrospectively evaluated patients with uPG(medically inoperable or refused SR)treated with FSRT with a Cyberknife System(Accuray Incorporated,Sunnyvale,California).Toxicity and initial efficacy were *** From May 2009 to January 2023,6 patients with a median age of 68(range 20-84)were treated with *** median delivered dose was 21 Gy(range 20-30 Gy)at a median isodose line of 75.5%(range 70%-76%)in 4 fractions(range 3-5 fractions).The median volume was 13.6 mL(range 12.4-65.24 mL).The median cumulative biological effective dose and equivalent dose in 2-Gy fractions were 70 Gy and 37.10 Gy *** of origin involved were the timpa-nojugular glomus(4/6),temporal bone,and cervical *** 1 of the 6 patients,the follow-up was insufficient;5 of 6 patients showed a 5-year overall survival and 5-year progression-free survival of 100%.We observed negligible toxicities during and after *** majority of patients showed stable symptoms during *** 1 patient developed spine *** Our preliminary results on this small cohort of patients suggest that FSRT could be an effective and safe alternative to SR.

关键词： Unresectable paraganglioma Fractionated stereotactic radiation therapy Cyberknife Neurosurgery Metastasis

Two is better than one: combinatorial receptor targeting enhances hepatocellular carcinoma (HCC) therapeutic response

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Hepatobiliary Surgery and Nutrition 2022年第1期11卷 139-142页

作者： Celia Sequera flavio Maina Aix Marseille Univ CNRSDevelopmental Biology Institute of Marseille(IBDM)Turing Center for Living SystemsParc Scientifique de LuminyMarseilleFrance

Finding effective therapies for hepatocellular carcinoma(HCC)is an ongoing challenge for both researchers and *** for new treatment options emerging from in vitro,preclinical,and clinical studies is often tempered by limited patient benefits and associated side effects,tolerated in some cases due to the lack of *** complexity of identifying effective treatment options resides in several features of HCC,notably the extraordinary heterogeneity in molecular alterations among different patients(1-3),the lack of consistent alterations associated with oncogene addictions(4),and a so-called“non-oncogene addiction”by which tumorigenicity results from the action of non-mutated genes(5,6).This complex configuration also prevents identification of unequivocal alterations used to design therapies,as for some other cancer *** HCC treatments are based on the Barcelona Clinic Liver Cancer(BCLC)guidelines according to the stage of lesions among other *** HCC at early stages(30-40%of HCC patients),treatments include lesion resection,liver transplantation,radiofrequency ablation(RFA)and microwave ablation(MWA),achieving a median overall survival(OS)of more than 60 *** HCC at intermediate stages(~20%of HCC patients),the advised treatment is generally transarterial chemoembolization(TACE),achieving an OS of 20 *** HCC at advanced stages(~40%of HCC patients),targeted therapies are the most frequent treatments,leading to an OS of 11 months with most targeted *** HCC at terminal stages,only palliative care is provided(~10%of HCC patients),with less than 3 months OS(7,8).

关键词： alterations hepatocellular treatment

Advancing prognostic precision in hepatocellular carcinoma:a paradigm shift towards machine learning

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Hepatobiliary Surgery and Nutrition 2023年第5期12卷 810-812页

作者： flavio Milana Simone Famularo Guido Torzilli Department of Biomedical Sciences Humanitas UniversityMilanItaly Division of Hepatobiliary and General Surgery Department of SurgeryIRCCS Humanitas Research HospitalMilanItaly

Introduction Hepatocellular carcinoma(HCC)stands as a significant contributor to cancer-related mortality,ranking as the fifth leading cause of cancer-related death(1).In 80%of cases,HCC arises from an underlying liver disease(2).Despite screening programs for at-risk patients,the prognosis for HCC remains even dismal because of late *** only curative options currently available are liver resection for selected cases,and liver ***,the high rate of recurrence after surgery makes the prognosis *** fact,following curative intent resection,the 5-year recurrence is approximately 60%(3),with 5-year survival after recurrence of 35%(4).

关键词： Hepatocellular carcinoma(HCC) machine learning liver resection early recurrence

Editorial on“Perihilar Cholangiocarcinoma-Novel Benchmark Values for Surgical and Oncological Outcomes From 24 Expert Centers”

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Hepatobiliary Surgery and Nutrition 2022年第3期11卷 422-424页

作者： Shivan Sivakumar flavio GRocha Lara Heij Department of Oncology University of OxfordOxfordUK Division of Surgical Oncology Knight Cancer InstituteOregon Health and Science UniversityPortlandORUSA Department of Surgery and Transplantation University Hospital RWTH AachenAachenGermany Institute of Pathology University Hospital RWTH AachenAachenGermany

Cholangiocarcinoma(CCA)is a rare and very aggressive malignancy arising from the biliary *** on the location of the tumor,CCA can be divided in intrahepatic cholangiocarcinoma(iCCA),perihilar cholangiocarcinoma(pCCA)and distal cholangiocarcinoma(dCCA).Many other characteristics differentiate these groups,including pathological features,oncological approach and surgical techniques,which in turn influences patient outcomes.

关键词： hilar carcinoma Surgical

A computer vision system for early detection of anthracnose in sugar mango(Mangifera indica)based on UV-A illumination

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Information Processing in Agriculture 2023年第2期10卷 204-215页

作者： Leonardo Ramırez Alberto Carlos Eduardo Cabrera Ardila flavio Augusto Prieto Ortiz Facultad de Ingenierı´a Universidad Nacional de ColombiaBogota´D.C.111321Colombia

The present work describes the development of a computer vision system for the early detection of anthracnose in sugar mango based on Ultraviolet A illumination(UV-A).Anthracnose,a disease caused by the fungus Colletotrichum sp,is commonly found in the fruit of sugar mango(Mangifera indica).It manifests as surface defects including black spots and is responsible for reducing the quality of the ***,it decreases its commercial *** more detail,this study poses a system that begins with image acquisition under white and ultraviolet ***,it proposes to analyze the Red,Green and Blue color information(R,G,B)of the pixels under two types of illumination,using four different methods:RGB-threshold,RGB-Linear Discriminant Analysis(RGBLDA),UV-LDA,and *** analysis produces an early semantic segmentation of healthy and diseased areas of the mango *** results showed that the combination of the linear discriminant analysis(LDA)and UV-A light(called UV-LDA method)in sugar mango images allows early detection of ***,this method achieves the identification of the disease one day earlier than by an expert with respect to the scale of anthracnose severity implemented in this work.

关键词： Sugar mango Anthracnose LDA UV-A light Grading Image processing

Cell extrusion in development and cancer,what MARCKS the difference for epithelial integrity?

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BIOCELL 2022年第3期46卷 639-644页

作者： LUCÍA VELOZ SANTIAGO A.BOSCH GONZALO APARICIO flavio R.ZOLESSI Sección Biología Celular Facultad de CienciasUniversidad de la RepúblicaMontevideoCP 11400Uruguay Institut Pasteur de Montevideo MontevideoCP 11400Uruguay Sección Biofísica y Biología de Sistemas Facultad de CienciasUniversidad de la RepúblicaMontevideoCP 11400Uruguay

Cell extrusion is an active mechanism to eliminate non-viable or supernumerary cells in healthy *** also plays a role in carcinogenesis,both in tumor growth(apical extrusion)and metastasis(basal extrusion).Embryonic tissues like the neuroepithelium,on the other hand,present rates of proliferation comparable to that of carcinomas,without the occurrence of cell ***,the downregulation or phosphorylation of actinmodulating proteins like MARCKS,causes extensive neuroepithelial apical cell *** changes in MARCKS proteins phosphorylation and expression have also been correlated to carcinogenesis,we propose here an integrated model for their functions in epithelial integrity.

关键词： Epithelial-mesenchymal plasticity Carcinoma Neurulation Neuroepithelium Phosphorylation

Development of waste-to-energy through integrated sustainable waste management:the case of ABREN WtERT Brazil towards changing status quo in Brazil

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Waste Disposal and Sustainable Energy 2023年第3期5卷 295-308页

作者： Yuri Schmitke Almeida Belchior Tisi flavio Arantes Matos Maria Luisa N.M.Carneiro Waste to Energy Research and Technology Council—WtERT Brasil Distrito FederalBrasília71316-109Brazil Waste to Energy Research and Technology Council—WtERT Brasil Ribeirão PretoSão PauloBrazil Waste to Energy Research and Technology Council—WtERT Brasil Rio de JaneiroBrazil

In the context of circular economy,it is known that once waste is generated,it should be subject to proper treatment for recovering material or energy before being *** countries worldwide,especially developing countries such as Brazil,have been struggling to effectively apply sustainable waste management in municipalities and still rely on dumpsites and unsuitable ***,a weak legal framework,lack of financial resources and poor infra-structure as well as pressure from organizations profiting from the expansion of landfills are some factors contributing to the preservation of the negative status quo:the“landfill culture”.Material recovery,i.e.,recycling and composting,is applied to less than 5%of Brazilian municipal waste,while 95%is disposed of in landfills or *** this context,ABREN WtERT(Waste-to-Energy Research and Technology Council)Brazil was created in 2019 as the first permanent organization formed to promote the development of energy and material recovery from waste focused on the waste-to-energy(WTE)*** this paper,the strategy proposed and implemented by the organization towards changing the status quo in Brazil through an integrated sustainable waste management approach is *** proposed strategy integrates the concepts of Sustainability and Circular Economy for minimizing landfill disposal(avoiding methane emissions)and maximizing material/energy *** others,the approach focuses on changing the public opinion regarding thermal treatment facilities,mainly incinerators,which has been wrongly linked to pollution,excessive public expenditures and considered a harm to the recycling *** activities performed by ABREN include engaging public and private institutions,enhancing education,leading the publication of research and business studies,gathering industry members and academy experts,as well as creating strategic alliances with players around the *** a result,within a few years,major

关键词： Integrated Sustainable Waste Management(ISWM) Waste-to-energy(WTE) Municipal solid waste(MSW) Energy recovery