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Treatment for paraganglioma with stereotactic radiotherapy

World Journal of Clinical Cases 2024年第16期12卷 2729-2737页

作者： antonio Pontoriero Paola Critelli Marco Zeppieri Filippo flavio Angileri Tamara Ius Radiation Oncology Unit Department of BiomedicalDental Science and Morphological and Functional ImagesUniversity of MessinaMessina 98125Italy Department of Ophthalmology University Hospital of UdineUdine 33100Italy Neurosurgery Unit Department of BiomedicalDental Science and Morphological and Functional ImagesUniversity of MessinaMessina 98125Italy Neurosurgery Unit Head-Neck and NeuroScience DepartmentUniversity Hospital of UdineUdine 33100Italy

BACKGROUND Paragangliomas(PG)are rare neoplasms of neuroendocrine origin that tend to be highly vascularized,slow-growing,and usually *** date,common treatment options are surgical resection(SR),with or without radiation therapy(RT),and a watch-and-wait *** To evaluate the local control and effectiveness of exclusive fractionated stereotactic RT(FSRT)treatment in unresectable PG(uPG).METHODS We retrospectively evaluated patients with uPG(medically inoperable or refused SR)treated with FSRT with a Cyberknife System(Accuray Incorporated,Sunnyvale,California).Toxicity and initial efficacy were *** From May 2009 to January 2023,6 patients with a median age of 68(range 20-84)were treated with *** median delivered dose was 21 Gy(range 20-30 Gy)at a median isodose line of 75.5%(range 70%-76%)in 4 fractions(range 3-5 fractions).The median volume was 13.6 mL(range 12.4-65.24 mL).The median cumulative biological effective dose and equivalent dose in 2-Gy fractions were 70 Gy and 37.10 Gy *** of origin involved were the timpa-nojugular glomus(4/6),temporal bone,and cervical *** 1 of the 6 patients,the follow-up was insufficient;5 of 6 patients showed a 5-year overall survival and 5-year progression-free survival of 100%.We observed negligible toxicities during and after *** majority of patients showed stable symptoms during *** 1 patient developed spine *** Our preliminary results on this small cohort of patients suggest that FSRT could be an effective and safe alternative to SR.

关键词： Unresectable paraganglioma Fractionated stereotactic radiation therapy Cyberknife Neurosurgery Metastasis

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Simulated Experiments for Teaching Mutually-Coupled Circuits CAD Techniques Using Analytic and Finite Element Solutions

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Journal of Electromagnetic Analysis and Applications 2017年第11期9卷 183-202页

作者： antonio flavio Licariao Nogueira Vitor Horbe Pereira da Costa Rodolfo Lauro Weinert Santa Catarina State University JoinvilleBrazil

The paper describes an approach to teaching mutually-coupled circuits CAD techniques to undergraduate students pursuing a degree course in electrical engineering or physics, and explains how a series of simulated experiments may be incorporated into the existing subjects. The simulated experiments make use of a two-dimensional open-access software based on the finite-element method. At the laboratory meetings, the students learn how to set up field problems for solution, and how to examine the results. Simulation tasks based on three axisymmetric open-boundary problems are used to introduce different numeric techniques to compute inductance and magnetic forces. The paper takes the reader to a step-by-step simulation journey, and provides all the basic elements required for further exploration of axially-symmetric systems.

关键词： Electromagnetic Engineering Education Finite Element Method Inductance Magnetic Forces Simulation Software

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Simulated Experiments for Teaching CAD Techniques Using Analytic and Finite Element Solutions of Electromagnetic Two-Dimensional Problems with Longitudinal Symmetry

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Journal of Electromagnetic Analysis and Applications 2019年第6期11卷 79-99页

作者： antonio flavio Licariao Nogueira Rodolfo Lauro Weinert Leonardo Jose Amador Salas Maldonado Santa Catarina State University JoinvilleBrazil

The paper describes an approach to teaching low-frequency electromagnetic CAD techniques to undergraduate students pursuing a degree course in electrical engineering. The simulated experiments make use of a two-dimensional open-access software based on the finite-element method. At the laboratory meetings, the problems are initially solved analytically. Upon this, students learn how to create the numeric model and how to define the sequence of field problems that lead to the required solution. Simulation tasks based on a force-producing electromagnet are used to introduce numeric techniques to determine magnetic field distribution, evaluation of energy storage and generation of magnetic forces. The nature of the magnetic force generated in the air gaps of the C-core electromagnet is explained in detail. Magnetic forces are calculated by the classical and weighted versions of the method of Maxwell stress tensor. The paper provides all the basic elements required for further exploration of devices with longitudinal symmetry.

关键词： Actuators Electromagnetic Engineering Education Energy Storage Finite Element Method Magnetic Forces

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Inguinal Hernia Repair with Local Anesthesia in the Outpatient—10 Year Experience

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International Journal of Clinical Medicine 2014年第12期5卷 644-649页

作者： flavio antonio de Sa Ribeiro Baltazar de Araujo Fernandes Joao Pedro de Araujo Simoes Correa Surgery of UNIFESO TeresopolisBrazil Hospital Federal de Bonsucesso Rio de JaneiroBrazil General Surgery Service Hospital Geral de BonsucessoRio de JaneiroBrazil

Objective: To demonstrate the feasibility of inguinal hernia repair with local anesthesia in an out-patient regime, with safety, efficacy and short learning curve. Methods: We prospectively evaluated 1186 patients undergoing inguinal hernia repair under local anesthesia on an outpatient basis between November 2004 and March 2014. Of the total number of hernias surgically treated in this period, 755 were operated on the right, 394 on the left and 37 bilateral. We used clinical, surgical and psychosocial criteria for inclusion in the procedure. The parameters for exclusion were complex, irreducible or recurrent hernia, obesity (BMI greater than 30 kg/m2), patient’s refusal and psychiatric disorder. All patients underwent elective surgery and were analyzed regarding surgical outcome, complications and hospital stay. Results: All operations were completed successfully. In no case there was a need to change the anesthetic method. Surgical time was similar to that conducted with other methods of anesthesia and there were no cases of adverse effects of local anesthetics. Intra-operative complications amounted to approximately 2.64%. There was no need for hospital admissions greater than 24 hours. Conclusion: The procedure is feasible and causes no perioperative significant pain, is safe, can be performed by residents under supervision, has satisfactory patient acceptance and complications similar to those observed in a conventional herniorrhaphy, allowing lower time and cost of hospitalization and faster access to treatment.

关键词： Inguinal Hernia/Surgery Local Anesthesia Ambulatory Surgical Procedures

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This pain drives me crazy:Psychiatric symptoms in women with interstitial cystitis/bladder pain syndrome

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World Journal of Psychiatry 2024年第6期14卷 954-984页

作者： Marianna Mazza Stella Margoni Giuseppe Mandracchia Guglielmo Donofrio Alessia Fischetti Georgios D Kotzalidis Giuseppe Marano Alessio Simonetti Delfina Janiri Lorenzo Moccia Ilaria Marcelli Greta Sfratta Domenico De Berardis Ottavia Ferrara Evelina Bernardi antonio Restaino Francesco Maria Lisci antonio Maria D'Onofrio Caterina Brisi Flavia Grisoni Claudia Calderoni Michele Ciliberto Andrea Brugnami Sara Rossi Maria Chiara Spera Valeria De Masi Ester Maria Marzo Francesca Abate Gianluca Boggio Maria Benedetta Anesini Cecilia Falsini Anna Quintano Alberto Torresi Miriam Militenda Giovanni Bartolucci Marco Biscosi Sara Ruggiero Luca Lo Giudice Giulia Mastroeni Elisabetta Benini Luca Di Benedetto Romina Caso Francesco Pesaresi Francesco Traccis Luca Onori Luca Chisari Leonardo Monacelli Mariateresa Acanfora Eleonora Gaetani Monia Marturano Sara Barbonetti Elettra Specogna Francesca Bardi Emanuela De Chiara Gianmarco Stella Andrea Zanzarri flavio Tavoletta Arianna Crupi Giulia Battisti Laura Monti Giovanni Camardese Daniela Chieffo antonio Gasbarrini Giovanni Scambia Gabriele Sani Department of Neurosciences Fondazione Policlinico Universitario A Gemelli IRCCSUniversita Cattolica del Sacro CuoreRome 00168Italy Department of Psychiatry UniversitàCattolica del Sacro CuoreRome 00168Italy Department of Neurosciences Section of PsychiatryFondazione Policlinico Universitario Agostino Gemelli IRCCSUniversitàCattolica del Sacro CuoreRome 00168Italy Mental Health NHSASL 4 TeramoTeramo 64100Italy Medical and Surgical Sciences UniversitàCattolica del Sacro CuoreRome 00168Italy Division of Gynecologic Oncology UniversitàCattolica del Sacro CuoreRome 00168Italy UOS Psicologia Clinica Governo ClinicoFondazione Policlinico Universitario Agostino Gemelli IRCCSRome 00168Italy CEMAD Digestive Disease Center Fondazione Policlinico Universitario A.Gemelli-IRCCSRome 00168Italy Department of Woman and Child Health Catholic UniversityRome 00168Italy UOC Psichiatria Clinica e d’Urgenza Dipartimento di Scienze Dell’InvecchiamentoNeurologicheOrtopediche e Della Testa-colloFondazione Policlinico Universitario Agostino Gemelli IRCCSRome 00168Italy

BACKGROUND Interstitial cystitis/bladder pain syndrome(IC/BPS)is an at least 6-mo noninfectious bladder inflammation of unknown origin characterized by chronic suprapubic,abdominal,and/or pelvic *** the term cystitis suggests an inflammatory or infectious origin,no definite cause has been *** occurs in both sexes,but women are twice as much *** To systematically review evidence of psychiatric/psychological changes in persons with IC/*** Hypothesizing that particular psychological characteristics could underpin IC/BPS,we investigated in three databases the presence of psychiatric symptoms and/or disorders and/or psychological characteristics in patients with IC/BPS using the following strategy:("interstitial cystitis"OR"bladder pain syndrome")AND("mood disorder"OR depressive OR antidepressant OR depression OR depressed OR hyperthymic OR mania OR manic OR rapid cyclasterisk OR dysthymiasterisk OR dysphoriasterisk).RESULTS On September 27,2023,the PubMed search produced 223 articles,CINAHL 62,and the combined PsycLIT/PsycARTICLES/PsycINFO/Psychology and Behavioral Sciences Collection search *** on *** produced 14 studies,of which none had available *** were peer-reviewed articles reporting psychiatric/psychological symptoms in patients with IC/BPS,i.e.63 articles spanning from 2000 to October *** studies identified depression and anxiety problems in the IC/BPS population,along with sleep problems and the tendency to *** Psychotherapies targeting catastrophizing and life stress emotional awareness and expression reduced perceived pain in women with IC/*** concepts should be considered when implementing treatments aimed at reducing IC/BPS-related pain.

关键词： Interstitial cystitis/bladder pain syndrome Psychiatric symptoms Psychological symptoms Catastrophizing Anxiety Depression

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Prevalence of Giardia duodenalis among dogs seized by the Center for Control of Zoonoses (CCZ) of the city of Lages, Santa Catarina, Brazil

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Health 2013年第1期5卷 119-124页

作者： Rosileia Marinho Quadros Paulo Henrique Exterckotter Weiss Geison Willian Ezequiel Renato Batista Tamanho Geanice Lepo Marcio Rodrigues da Silva Carlos Roberto Joao da Silva Junior flavio antonio Pacheco de Araujo Luiz Claudio Miletti Universidade do Estado de Santa Catarina LagesBrazil

The knowledge of the epidemiology of parasitic infections in stray and domestic animals, especially of its incidence and prevalence, is fundamental to adopting effective prophylactic measures. Stray dogs play an important role in environmental contamination favoring the transmission cycle of zoonotic agents. Among the parasitic infections that affect humans, Giardia duodenalis is the most common intestinal protozoa and was designated as a re-emerging infectious disease. This study aimed to determine the prevalence of G. duodenalis in dogs siezed by the Center for Control of Zoonoses (CCZ) of the city of Lages, Santa Catarina, Brazil using two diagnostic techniques. In 357 stool samples analysed, the prevalence of G. duodenalis cysts was 5.3% (19/357) and 4.8% (17/357) detected by floatation and sedimentation techniques, respecttively. No correspondence between gender and age was found among the methods used for analyzing the infected dogs in this study. Our data suggested that two diagnostic techniques should be used in a complementary way to ensure that false negatives are not neglected.

关键词： Giardia Duodenalis Dogs Zoonoses Brazil

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Simultaneous Measurements of Rainfall Intensity, Low Energy Neutrons and Gamma Radiation in Sao Jose Dos Campos, SP, Brazil

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Journal of Environmental Science and Engineering(B) 2013年第11期2卷 643-647页

作者： Marcelo Pego Gomes Inacio Malmonge Martin Mauro Angelo Alves Bogos Nubar Sismanoglu Marco antonio S. Ferro Marcos Pinto flavio antonio IAE (Institute of Aeronautics and Space) Sao Josedos Campos 1222 6900 Brazil Physics Department ITA (the Technological Institute of Aeronautics) Sao Jose dos Campos 1222 8900 Brazil

The article aims to study the possible correlation between the presence and intensity of rainfall X- and γ-radiation and low energy neutrons at one specific location in Sao Jose dos Campos, SP, Brazil. Monitoring of these parameters was carried out from end February to half of June 2013 just in Physics Department of ITA (Technological Institute of Aeronautics). By correlating the data of measurements of intensity of X and γ-radiations with the rainfall it has been found that this meteorological parameter had a significant influence on the background of these radiation profile. A possible reason for this fact is associated with the presence of radon gas in the environment that is dragged to the surface during the occurrences of local rainfall. In relation neutrons, it was possible to note that the rainfall has small influence on this parameter measures.

关键词：降雨强度低能中子同步测量 γ射线 SP 巴西低能量航空航天技术

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Diagnostic performance of endoscopic ultrasound-guided tissue acquisition of splenic lesions:systematic review with pooled analysis

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Gastroenterology Report 2022年第1期10卷 356-362页

作者： Andrea Lisotti Stefano Francesco Crino` Benedetto Mangiavillano Anna Cominardi Andrew Ofosu Nicole Brighi flavio Metelli Rocco Maurizio Zagari antonio Facciorusso Pietro Fusaroli Gastroenterology Unit Hospital of ImolaUniversity of BolognaImolaItaly Department of Medicine Gastroenterology and Digestive Endoscopy UnitThe Pancreas InstituteUniversity Hospital of VeronaVeronaItaly Gastrointestinal Endoscopy Unit Humanitas—Mater Domini CastellanzaVareseItaly Gastroenterology and Hepatology Stanford UniversityStanfordCAUSA Department of Medical Oncology IRCSS Istituto Romagnolo per lo Studio dei Tumori(IRST)“Dino Amadori”MedolaItaly Department of Medical and Surgical Sciences—DIMEC University of BolognaBolognaItaly Department of Surgical and Medical Sciences Section of GastroenterologyUniversity of FoggiaFoggiaItaly

Background Focal splenic lesions are usually incidentally discovered on radiological *** percutaneous tissue acquisition(TA)under trans-abdominal ultrasound guidance is a well-established technique for obtaining cyto-histological diagnosis of focal splenic lesions,endoscopic ultrasound(EUS)-guided TA has been described in several studies,reporting different safety and *** aimwas to assess the pooled safety,adequacy,and accuracy of EUS-TA of splenic *** A comprehensive review of available evidence was conducted at the end of November *** studies including more than five patients and reporting about the safety,adequacy,and accuracy of EUS-TA of the spleen were *** Six studies(62 patients)were identified;all studies have been conducted using fine-needle aspiration(FNA)*** specimen adequacy and accuracy of EUS-TA for spleen characterization were 92.8%[95%confidence interval(CI),86.3%–99.3%]and 88.2%(95%CI,79.3%–97.1%),*** pooled incidence of adverse events(six studies,62 patients)was 4.7%(95%CI,0.4%–9.7%).Conclusion EUS-FNA of the spleen is a safe technique with high diagnostic adequacy and *** EUS-guided approach could be considered a valid alternative to the percutaneous approach for spleen TA.

关键词： biopsy cancer lymphoma metastasis leukemia

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Non-Intrusive Elastic Query Processing in the Cloud

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Journal of Computer Science & Technology 2013年第6期28卷 932-947页

作者： Ticiana L. Coelho da Silva Mario A. Nascimento Jose antonio F. de Macedo flavio R. C. Sousa Javam C. Machado Department of Computing Federal University of Ceara Fortaleza Ceara Brazil Department of Computing Science University of Alberta Edmonton Alberta T6G 2E8 Canada

Cloud computing is a very promising paradigm of service-oriented computing. One major benefit of cloud computing is its elasticity, i.e., the system＇s capacity to provide and remove resources automatically at runtime. For that, it is essential to design and implement an efficient and effective technique that takes full advantage of the system＇s potential flexibility. This paper presents a non-intrusive approach that monitors the performance of relational database management systems in a cloud infrastructure, and automatically makes decisions to maximize the efficiency of the provider＇s environment while still satisfying agreed upon ＂service level agreements＂（SLAs）. Our experiments conducted on Amazon＇s cloud infrastructure, confirm that our technique is capable of automatically and dynamically adjusting the system＇s allocated resources observing the SLA.

关键词： elasticity query processing non-intrusive service level agreement

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An Inchworm-inspired Robot Based on Modular Body, Electronics and Passive Friction Pads Performing the Two-anchor Crawl Gait

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Journal of Bionic Engineering 2018年第5期15卷 820-826页

作者： flavio Moreira Anthony Abundis Michael Aguirre Justin Castillo Pranav A. Bhounsule Robotics and Motion Laboratory Department of Mechanical Engineering The University of Texas at San Antonio One UTSA Circle San Antonio rX78249 USA

We have created an inchworm robot capable of the two-anchor crawl gait on level ground and inclined plane. The main novelty is in the design of the inchworm：（1） three-part body that is 3D printed and actuated by two servo motors to allow a looping and lengthening action, （2） passive friction pads to anchor the feet, each of which may be disengaged using a servo motor actuated lever arm, and （3） modular body and electronics. The robot is about 2 feet （61 cm） in length, has a mass of about 4 kg, and uses an open-loop controller to achieve steady crawling gait. The inchworm robot achieved a speed of 2.54 *** on level ground as well as on an incline plane of 19~. The energy usage as measured by the Mechanical Cost of Transport （a non-dimensional number defined as the energy used per unit weight per unit distance moved） is 3.34. Our results indicate that simple robotic designs that copy the basic features of natural organisms provide a promising alternative over conventional wheeled robots.

关键词： inchworm bioinspiration two-anchor crawl gait 3D printing sliding locomotion cost of transport

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