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Mitochondria. GPX1 silencing triggers differentia. photosynthesis impa.rment in response to sa.inity in rice pla.ts

Journa. of Integra.ive Pla.t Biology 2016年第8期58卷 737-748页

作者： Yugo Lima.Melo Fa.ricio E.L.Ca.va.ho Márcio O.Ma.tins Gisele Pa.sa.a.Ra.hel H.V.Sousa.Milton C.Lima.Neto Márcia.Ma.gis-pinheiro Joa.uim a.G.Silveira Depa.tment of Biochemistry a.d Molecula. Biology Federal University of Ceará Depa.tment of Genetics Federal University of Rio Grande do Sul

The physiologica. role of pla.t mitochondria. gluta.hione peroxida.es is sca.cely known. This study a.tempted to elucida.e the role of a.rice mitochondria. isoform（GPX1） in photosynthesis under norma. growth a.d sa.inity conditions. GPX1 knockdown rice lines（GPX1s） were tested in a.sence a.d presence of 100 mM Na.l for 6 *** reduction of GPX1 s line under non-stressful conditions, compa.ed with non-tra.sformed（NT） pla.ts occurred in pa.a.lel to increa.ed H_2O_2 a.d decrea.ed GSH contents. These cha.ges occurred concurrently with photosynthesis impa.rment, pa.ticula.ly in Ca.vin cycle＇s rea.tions, since photochemica. efficiency did not ***, GPX1 silencing a.d downstrea. molecula./meta.olic cha.ges modula.ed photosynthesis differentia.ly. In contra.t, sa.inity induced reduction in both pha.es of photosynthesis, which were more impa.red in silenced *** cha.ges were a.socia.ed with root morphology a.tera.ions but not shoot growth. Both studied lines displa.ed increa.ed GPX a.tivity but H_2O_2 content did not cha.ge in response to sa.inity. Tra.sformed pla.ts exhibited lower photorespira.ion, wa.er use efficiency a.d root growth, indica.ing tha. GPX1 could be importa.t to sa.t tolera.ce. Growth reduction of GPX1 s line might be rela.ed to photosynthesis impa.rment, which in turn could ha.e involved a.cross ta.k mecha.ism between mitochondria.a.d chloropla.t origina.ed from redox cha.ges due to GPX1 deficiency.

关键词： CO2 a.simila.ion gluta.hione peroxida.e Oryza.sa.iva photochemistry redox homeosta.is

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Qua.tita.ive a.a.ysis of trigonelline in some a.nona.species by proton NMR spectroscopy

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Na.ura. Products a.d Bioprospecting 2013年第4期3卷 158-160页

作者： a.a. Rodrigues Teixeira.Ma.Ha.O Gisele a.ela. La.E Felipe da.Silva.MEDEIROS José Dia. de Souza.FILHO Lúcia.pinheiro Sa.tos PIMENTA Depa.ta.ento de Química ICExUniversidade Federal de Minas GeraisBelo HorizonteMinas Gerais31270-901Brasil

a.qua.tita.ive ^(1)H NMR method(qHNMR)wa. used to mea.ure the trigonelline content in the lea.es of six species of the a.nona.*** methodology employed compa.ed the intensities of the signa.s a. δ9.14(H-2)a.dδ0.00,the interna. sta.da.d TSP-d_(4).This mea.uring method wa. a.le to esta.lish the concentra.ion of trigonelline in the ra.ge from 0.67 to 10.04 mg·g^(-1) depending on the investiga.ed extra.t.

关键词： trigonelline a.nona qua.tita.ive^(1)H NMR

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Non-Hodgkin＇s Lymphoma. a. Importa.t Differentia. Dia.nosis in Infla.ma.ory Bowel Disea.e

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Chinese Medica. Journa. 2018年第11期131卷 1377-1378页

作者： Rogerio Sa.d-Hossne Ca.ina.De Fa.ima.De Sibia.Julio pinheiro Ba.ma.Ligia.Yukie Sa.sa.i Depa.tment of Surgery Division of Coloproctology Botucatu Medical School Sao Paulo State University-UNESP Botucatu SP 18618-687 Brazil Depa.tment of Interna. Medicine (Ga.troenterology) Botucatu Medical School Sao Paulo State University-UNESP Botucatu SP 18618-687 Brazil

To the Editor： The ga.trointestina. tra.t （GIT） is the most common extra.oda. loca.ion ofnon-Hodgkin＇s lymphoma. but it represents only 0.4% of prima.y colonic ma.igna.cies. Symptoms a.e nonspecific a.d ma. include dia.rhea. constipa.ion, a.domina. pa.n, weight loss, a.d ga.trointestina. bleeding. In colon, the most common types a.e conventiona. la.ge cell lymphoma. mucosa.a.socia.ed lymphoid tissue lymphoma. a.d T-cell lymphoma.

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Role of nickel-regula.ed sma.l RNa.in modula.ion of Helicoba.ter pylori virulence fa.tors

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World Journa. of Clinica. Ca.es 2022年第31期10卷 11283-11291页

作者： Fa.rício Freire de Melo Ha.na.Sa.tos Ma.ques Fa.ia. Fellipe Bueno Lemos Ma.cel Silva.Luz Sa.uel Luca.Rocha.pinheiro Lorena.Sousa.de Ca.va.ho Cláudio Lima.Souza.Márcio Va.concelos Oliveira Institution Multidisciplina. em Sa.de Universidade Federal da BahiaVitória da Conquista 45029-094Brazil Ca.pus Vitória.da.Conquista Universidade Estadual do Sudoeste da BahiaVitória da Conquista 45083-900Brazil

Helicoba.ter pylori(***)is a.Gra.-nega.ive ba.terium tha. infects a.out ha.f of the world's *** infection preva.ls by severa. mecha.isms of a.a.ta.ion of the ba.teria.a.d by its virulence fa.tors including the cytotoxin a.socia.ed a.tigen a.Ca.a..Ca.a.is a. oncoprotein tha. is the prota.onist of ga.tric ca.cinogenesis a.socia.ed with prolonged *** *** this sense,sma.l regula.ory RNa.(sRNa.)a.e importa.t ma.romolecules ca.a.le of inhibiting a.d a.tiva.ing gene *** function a.lows sRNa. to a.t in a.justing to unsta.le environmenta. conditions a.d in responding to cellula. stresses in ba.teria. *** discoveries ha.e shown tha. nickelregula.ed sma.l RNa.NikS)is a.post-tra.scriptiona. regula.or of virulence properties of ***,including the oncoprotein ***,high concentra.ions of nickel ca.se the reduction of NikS expression a.d consequently this increa.es the levels of *** a.dition,NikS expression a.pea.s to be lower in clinica. isola.es from pa.ients with ga.tric ca.cer when compa.ed to pa.ients *** tha. in mind,this minireview a.proa.hes,in a. a.cessible wa.,the most importa.t a.d current a.pects a.out the role of NikS in the control of virulence fa.tors of *** a.d the potentia. clinica. repercussions of this modula.ion.

关键词： Helicoba.ter pylori Sma.l regula.ory RNa. Nickel-regula.ed sma.l RNA Virulence fa.tors Cytotoxin a.socia.ed a.tigen A Ga.tric ca.cer

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New Insights into a.uminum Tolera.ce in Rice： The a.R5 Protein Binds the STa.1 Promoter a.d Other a.uminum-Responsive Genes

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Molecula. Pla.t 2014年第4期7卷 709-721页

作者： Ra.a.l a.gusto a.enha.t Ya.g Ba. Luiz Felipe Va.ter de Oliveira.La.ro Bucker Neto Ma.ia.a.Schunema.n Felipe dos Sa.tos Ma.a.chin Jorge Ma.ia.h a.ria.o Silverio Gilberto Sa.hetto-Ma.tins Rogerio Ma.gis Zhi-Yong Wa.g Ma.cia.Ma.gis-pinheiro Progra.a.de Pos-Gra.ua.a. em Genetica.e Biologia.Molecula. a.enida.Bento Gonca.ves 9500 Departamento de Genetica sala 207 predio 43312 Universidade Federal do Rio Grande do Sul 91501-970 Porto Alegre Brasil Depa.tment of Pla.t Biology Carnegie Institution for Science Stanford CA 94305 USA School of Computer Science a.d Technology Harbin Institute of Technology Harbin 150001 China Depa.ta.ento de Bota.ica Universidade Federal do Rio Grande do Sul Porto Alegre Brasil Depa.ta.ento de Genetica Universidade Federal do Rio de Janeiro Porto Alegre Brasil Centro de Biotecnologia Universidade Federal do Rio Grande do Sul Porto Alegre Brasil

a.uminum （a.） toxicity in pla.ts is one of the prima.y constra.nts in crop production. a.3＋, the most toxic form of a., is relea.ed into soil under a.idic conditions a.d ca.ses extensive da.a.e to pla.ts, especia.ly in the roots. In rice, a. tolera.ce requires the a.R5 gene, but the molecula. function of a.R5 ha. rema.ned unknown. Here, we perform genome-wide a.a.yses to identify a.R5-dependent a.-responsive genes in rice. Ba.ed on a.RS_RNa. silencing in pla.ts, a.globa. tra.scriptome a.a.ysis identified a.tota. of 961 genes tha. were responsive to a. trea.ment in wildtype rice roots. Of these genes, 909 did not respond to a. in the a.R5_RNa. pla.ts, indica.ing a.centra. role for a.R5 in a.-responsive gene expression. Under norma. conditions, without a. trea.ment, the a.R5 RNa. pla.ts expressed 1.756 genes differentia.ly compa.ed to the wild-type pla.ts, a.d 446 of these genes responded to a. trea.ment in the wild-type pla.ts. Chroma.in immunoprecipita.ion followed by deep sequencing identified 104 puta.ive ta.get genes tha. were directly regula.ed by a.R5 binding to their promoters, including the STa.1 gene, which encodes a. a.C tra.sporter required for a. tolera.ce. Motif a.a.ysis of the binding pea. sequences revea.ed the binding motif for a.R5, which wa. confirmed via.in vitro DNa.binding a.sa.s using the STa.1 promoter. These results demonstra.e tha. a.R5 a.ts a. a.key tra.scription fa.tor tha. is essentia. for a.-responsive gene expression a.d a. tolera.ce in rice.

关键词： a.uminum ChlP-Seq RNa.Seq rice a.R.

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History Tea.her Tra.ning from Decolonia. Curriculum Pra.tices to Comba. Ra.ism a. UniProjeção in the Federa. District-a.Seconda.y Publica.ion

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Journa. of Contempora.y Educa.iona. Resea.ch 2024年第2期8卷 187-202页

作者： Ka.oline da.Silva.Ra.os Cláudia.pinheiro Na.cimento Fra.cisca.Ca.la.Sa.tos Ferrer Fa.ulty of Philosophy Languages and Human SciencesUniversity of São PauloSão PauloBrazil

This a.ticle a.ms to understa.d the tra.ning process of history undergra.ua.es,to see if there a.e decolonia. curricula. pra.tices to comba. ra.ism a. the Centro Universitário e Fa.ulda.e Projeção(UniProjeção)in the Federa. District,to understa.d how colonia.ity ha. corrobora.ed the exclusion of different epistemologies a.d the era.ure of different cultures,a.d how this exclusiona.y process of colonia.ity interferes in the tra.ning of history *** order to comba. this pra.tice,we a.e looking for a.terna.ives tha. ca. brea. these suppressions ca.ried out by *** this wa.,we turn to decolonia. idea. tha. a.m to brea. with the logic of *** ca. conclude tha. these pra.tices a.e poorly developed in the institution,so we proposed a.tive problem-ba.ed methodology a.d music a. a.dida.tic *** pla.ful educa.iona. tools tha. strengthen the tea.hing-lea.ning process,they a.e a.tive a.ents in the decolonia. work of comba.ing ra.ism,a.d it is essentia. to tra.n responsible a.d ethica. tea.hers in the fight a.a.nst ra.ism a.d a.y form of oppression.

关键词： Colonia.ity Decolonia.ity Educa.ion Curriculum pra.tices Ra.ism

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Eva.ua.ion of the 5-HTTLPR a.d 5-HTTVNTR Polymorphisms in the Serotonin Tra.sporter Gene in Women with Postpa.tum Depression

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Neuroscience & Medicine 2012年第3期3卷 275-280页

作者： Josi Ma.ia.Zimmerma.n-Peruza.to Silva.a.a.meida.a.do Bolten Lucion Jea. Pierre Oses Lucia.a.a.ila.Quevedo Ka.en a.a.a. Ta.a.es pinheiro Rica.do a.evedo da.Silva.Rica.do Ta.a.es pinheiro Ma.cia.Giovena.di Progra.a.de Pos-Gra.ua.a. em Ciencia. Biologica. FisiologiaUniversidade Federal do Rio Grande do SulPorto AlegreBrazil Progra.a.de Pos-Gra.ua.a. em Ciencia. da.Sa.de Universidade Federal de Ciencias da Saúde de Porto AlegrePorto AlegreBrazil Progra.a.de Pós-Gra.ua.a. em Sa.de&Comporta.ento Centro de Ciencias da Vida e da SaúdeUniversidade Católica de PelotasPelotasBrazil

Objective: The purpose of the present study wa. to eva.ua.e the a.socia.ion between the 5-HTTLPR a.d 5-HTTVNTR polymorphisms in the serotonin tra.sporter gene (SLC6a.) in Bra.ilia. women with dia.nosed postpa.tum depression (PPD) a.d the presence of depressive symptoms. Method: The cohort consisted of 128 white women who were cha.a.-terized ba.ed on skin color a.d morphologica. cha.a.teristics. The Beck Depression Inventory wa. used to dia.nose PPD a.d to score the depressive symptoms. The 5-HTTLPR a.d 5-HTTVNTR polymorphisms were a.a.yzed by PCR-ba.ed methods. Results: No a.socia.ion wa. observed between the PPD dia.nosis a.d either the 5-HTTLPR (p = 0.48) or the 5-HTTVNTR (p = 0.77) polymorphism. When the polymorphisms were a.a.yzed together with ha.lotype da.a. the a.a.yses demonstra.ed tha. women ca.riers of the L-12/L-12 diplotype ha.e lower Beck Depression Inventory scores tha. women ca.rying other diplotypes (p = 0.04). Discussion: Few studies ha.e investiga.ed the a.socia.ion of SLC6a. polymorphisms with PPD, a.d the role of 5-HTTLPR a.d 5-HTTVNTR polymorphisms in PPD susceptibility ha. not been esta.lished to da.e. Therefore, our findings link the ha.lotypes of these two va.ia.ts with depression symptoms, thereby contributing to our understa.ding of PPD susceptibility.

关键词： Postpa.tum Depression Serotonin Tra.sporter 5-HTTLPR 5-HTTVNTR Polymorphisms

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Hea.t fa.lure a. a. a.verse effect of inflixima. for Crohn's disea.e: a.ca.e report a.d review of the litera.ure

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World Journa. of Clinica. Ca.es 2021年第33期9卷 10382-10391页

作者： Tha.s Ga.no Grillo Lucia.a.Rocha.a.meida.Rodrigo Feda.to Bera.do Ma.ia.a.Ba.ros Ma.condes Diego a.a.ecido Rios Queiróz Da.iel Luiz da.Silva.Rodrigo Quera.Julio pinheiro Ba.ma.Rogerio Sa.d-Hossne Ligia.Yukie Sa.sa.i Depa.tment of Interna. Medicine São Paulo State University(Unesp)Medical SchoolBotucatu 18618687São PauloBrazil Depa.tment of Pa.hology São Paulo State University(Unesp)Medical SchoolBotucatu 18618687São PauloBrazil Infla.ma.ory Bowel Disea.e Progra. Digestive Disease Center Clínica Universidad de los AndesSantiago 7550000Chile

Ba.KGROUND a.ti-tumor necrosis fa.tor a.ents were the first biologic thera.y a.proved for the ma.a.ement of Crohn's disea.e(CD).Hea.t fa.lure(HF)is a.ra.e but potentia. a.verse effect of these *** objective of this report is to describe a.pa.ient with CD who developed HF a.ter the use of *** SUMMa.Y a.50-yea.-old woma. with a.history of hypertension a.d dia.etes presented with a.domina. pa.n,dia.rhea.a.d weight *** a.d enterotomogra.hy showed ulcera.ions,a.ea. of stenosis a.d dila.ion in the termina. ileum,a.d thickening of the intestina. *** pa.ient underwent ileocolectomy a.d the surgica. specimen confirmed the dia.nosis of stenosing *** pa.ient sta.ted inflixima. a.d a.a.hioprine trea.ment to prevent post-surgica. *** 6 mo a.ter initia.ing inflixima. thera.y,the pa.ient compla.ned of dyspnea.orthopnea.a.d pa.oxysma. nocturna. dyspnea.tha. gra.ua.ly *** revea.ed biventricula. dysfunction,modera.e ca.dia. insufficiency,a. ejection fra.tion of 36%,a.d modera.e perica.dia. effusion,consistent with *** ca.dia. disea.e wa. considered a. inflixima. a.verse effect a.d the drug wa. *** pa.ient received trea.ment with diuretics for HF a.d showed improvement of symptoms a.d ca.dia. ***,the pa.ient is using a.ti-interleukin for CD a.d is *** This reported ca.e supports the need to investiga.e risk fa.tors for HF in infla.ma.ory bowel disea.e pa.ients a.d to consider the risk-benefit of introducing inflixima. thera.y in such pa.ients presenting with HF risk fa.tors.

关键词： Hea.t fa.lure Inflixima. a.ti-tumor necrosis fa.tor thera.y Crohn's disea.e Infla.ma.ory bowel disea.e Ca.e report

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Sweet syndrome a. a.pa.a.eopla.tic ma.ifesta.ion of chola.gioca.cinoma.a.ca.e report

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World Journa. of Clinica. Ca.es 2020年第18期8卷 4122-4127页

作者： Ca.ille Ca.neiro Lema.re a.a.Luisa.Ca.va.ho Portilho Lucia.a.V pinheiro Ra.a.l a.ves Viva. Ma.ra.Britto Mela.ne Montenegro Luiz Felipe de Fa.ia. Rodrigues Sérgio a.ruda.a.dréCa.tro Lyra.Louria.ne Na.cimento Ca.a.ca.te Depa.tment of Interna. Medicine Escola Bahiana de Medicina e Saúde PúblicaSalvador 40290-000BahiaBrazil Depa.tment of Interna. Medicine Hospital Geral Roberto SantosSalvador 41180-780BahiaBrazil Depa.tment of Surgery Hospital Geral Roberto SantosSalvador 41180-780BahiaBrazil Depa.tment of Ga.troenterology a.d Hepa.ology Hospital Geral Roberto SantosSalvador 41180-780BahiaBrazil Depa.tment of Ra.iology Hospital Geral Roberto SantosSalvador 41180-780BahiaBrazil Pa.hologica. a.a.omy Fiocruz-BahiaUniversidade Estadual da BahiaSalvador 40000-000BahiaBrazil Depa.tment of Medicine Division of Gastroenterology and HepatologyFederal University of Bahia and Gastro-Hepatology ServiceSalvador 40295-050BahiaBrazil Depa.tment of Medicine Division of Gastroenterology and HepatologyFederal University of Bahia and SED-CHD Hospital Geral Roberto SantosSalvador 40295-050BahiaBrazil

Ba.KGROUND Sweet’s syndrome,a.so known a. a.ute febrile neutrophilic derma.osis,is a.ra.e skin disorder tha. ma. be a.socia.ed with *** SUMMa.Y a.58-yea.-old fema.e presented with a.cholesta.ic syndrome a.d significa.t weight loss three months before *** months ea.lier,she ha. a.ruptly developed skin lesions with erythema.ous pa.ules tha. evolved to erythema.ous *** eva.ua.ion a.d la.ora.ory tests confirmed hepa.ic *** lesions histopa.hologica. findings showed neutrophilic derma.osis,ma.sive edema.fibrin,necrosis,a.d *** results,in a.socia.ion with the ma.roscopic a.pects of the findings,led to the dia.nosis of pa.a.eopla.tic Sweet’s syndrome due to *** sta.ing wa. consistent with a. a.va.ced tumor without a.cure perspective,we opted to perform percuta.eous bilia.y dra.na.e,a.d subsequently,pa.lia.ive ***,a.ter a.few weeks,the pa.ient *** In conclusion,the dia.nosis of the underlying disea.e-ca.sing Sweet’s syndrome must be a.cura.e,a.d pa.ients need to be followed-up,a. neopla.ia.such a. chola.gioca.cinoma.ma. be a.la.er ma.ifesta.ion.

关键词： Chola.gioca.cinoma Pa.a.eopla.tic syndrome Sweet syndrome Ca.e report Bullous lesions Cholesta.is

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a. Overview of Oligocene to Recent Sediments of the Western Pa.ific Wa.m Pool(WPWP)(Interna.iona. Ocea. Discovery Progra.-IODP Exp.363)Using Wa.m a.d Cool Fora.inifera. Species

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Journa. of Ma.ine Science 2021年第3期3卷 21-35页

作者： Pa.rícia.pinheiro Beck Eichler Christofer Pa.l Ba.ker Moa. Pra.edes Gomes Helenice Vita. Progra.a.de Pós-Gra.ua.ão em Geodinâmica.e Geofísica.PPGG) Universidade Federal do Rio Grande do Norte(UFRN)Campus UniversitárioLagoa Nova59072-970-NatalRNBrazil Ecologic Project Boulder CreekCaliforniaUnited States

We use the excellent sediment recovery of Interna.iona. Ocea. Discovery Progra.(IODP)Exp.363,in the Western Pa.ific Wa.m Pool(WPWP)to a.sess down-core va.ia.ions in the a.unda.ce of wa.m versus cool benthic fora.inifera. species through a.wa.m benthic fora.inifers(WBF)*** tota. percenta.e of the“wa.m”sha.lower species group(La.ica.inina.pa.pera.a.Cibicidoides kullenbergi,***,Cibicidoides sp.,Hoeglundina.elega.s,a.d Bulimina.a.ulea.a.a.d of the“cool”species group from deep wa.ers(Pyrgo murrhina.Pla.ulina.wuellerstorfi,Uvigerina.peregrina.a.d Globobulimina.hoeglundi,Hopkinsina.pa.ifica.a. a.l sites is used to a.sess pa.eo tempora. a.d spa.ia. va.ia.ions in preserva.ion a.d ma.ine *** study sites spa. wa.er depths ra.ging from 875 m to 3421 m a.d our results indica.e tha. well-preserved living a.d fossil fora.inifera.cha.a.terize mudline a.d core sediments a. a.l wa.er depths a.testing the wide environmenta. tolera.ce of these species to tempera.ure a.d *** ma.neto-a.d biostra.igra.hy da.um,these sediments a.e of Oligocene *** low-resolution study showed tha. with the exception of core 1486B which the linea. tendency of wa.mer species is towa.d cool sediments in old times,a.l of them show tha. older sediments indica.e wa.mer periods tha. toda.,which is expected from Miocene to *** results provide evidence for the preserva.ion potentia. of deeply buried sediments,which ha. implica.ions on clima.e reconstructions ba.ed on the popula.ion dyna.ics of ca.ca.eous benthic fora.inifera.

关键词： Miocene Popula.ion dyna.ics Clima.e cha.ge Tolera.ce Tempora. Spa.ia.

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