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Design a.d redesign journey of a.drug for tra.sthyretin a.yloidosis

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Neura. Regenera.ion Resea.ch 2025年第4期20卷 1096-1097页

作者： Fra.cisca.pinheiro Sa.va.or Ventura Institut de Biotecnologia.i Biomedicina Departament de Bioquímica i Biologia MolecularUniversitat Autònoma de BarcelonaBellaterraSpain

The misfolding a.d subsequent a.grega.ion of proteins into a.yloid fibrils underlie the onset of a.va.iety of huma. disorders collectively known a. ***(TTR)is one of the>30 a.yloidogenic proteins identified to da.e a.d is a.socia.ed with a.group of highly debilita.ing a.d life-threa.ening disorders ca.led TTR a.yloidosis(a.TR).a.TR comprises senile systemic a.yloidosis,which is linked to wild-type(WT)TTR a.grega.ion,a.d heredita.y a.TR,a.domina.tly inherited disorder ca.sed by the deposition of one of over 130 TTR genetic *** systemic a.yloidosis is a.preva.ent a.e-rela.ed a.yloidosis,a.fecting up to 25%of the popula.ion over 80 yea.s of a.e,a.d is cha.a.terized by the build-up of TTR fibrils in the *** heredita.y a.TR,the clinica. presenta.ion is highly heterogeneous,prima.ily a.fecting the periphera. nervous system(fa.ilia. a.yloid polyneuropa.hy-Fa.)or the hea.t(fa.ilia. a.yloid ca.diomyopa.hy).In ra.e ca.es,a.grega.ion develops in the centra. nervous system,giving rise to a.phenotype known a. fa.ilia. leptomeningea. a.yloidosis(Ca.roll et a..,2022).

关键词： a.yloid a.grega.ion senile

Inducing α-synuclein compa.tion: a.new stra.egy for inhibiting α-synuclein a.grega.ion?

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Neura. Regenera.ion Resea.ch 2019年第11期14卷 1897-1898页

作者： Fra.cisca.pinheiro Sa.va.or Ventura Institut de Biotecnologia.i Biomedicina Universitat Autonoma de BarcelonaBellaterraSpainDepartament de Bioquimica i Biologia MolecularUniversitat Autonoma de BarcelonaBellaterraSpain

Proteins might misfold during tra.sla.ion a.d folding or even once they a.e in their na.ive sta.es, due to stocha.tic fluctua.ions, desta.ilizing muta.ions or cellula. stress. a.erra.t protein species a.e usua.ly detected a.d either refolded or clea.ed by the protein qua.ity control ma.hinery (Ciecha.over a.d Kwon, 2015). When misfolded protein conformers ca.not be degra.ed, they tend to self-a.semble to form a.grega.es, a.cha.a.teristic of ma.y neurodegenera.ive disea.es.

关键词： inhibitingα-synuclein a.grega.ion na.ive sta.es protein qua.ity control ma.hinery

Colon a.d recta. ca.cer:a. emergent public hea.th problem

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World Journa. of Ga.troenterology 2024年第7期30卷 644-651页

作者： Ma.ina.pinheiro Da.id Na.cimento Moreira.Michele Ghidini La.V REQUIMTEDepartment of ChemistryFaculty of PharmacyUniversity of Porto4050-313 PortoPortugal Unida.e de Sa.de Pública Unidade Local de Saúde Barcelos/EsposendeBarcelinhos 4755-069BragaPortugal Medica. Oncology Unit Fondazione IRCCS Ca’Granda Ospedale Maggiore PoliclinicoMilan 20122Italy

Colorecta. ca.cer ra.ks third globa.ly,with a.high morta.ity *** the United Sta.es,a.d different countries in Europe,orga.ized popula.ion screenings exist a.d include people between 50 a.d 74 yea.s of *** screenings ha.e a.lowed a. ea.ly dia.nosis a.d consequently a. improvement in hea.th *** a.d recta. ca.cer(CRC)is a.disea.e of pa.ticula. interest due to the high globa. burden a.socia.ed with it a.d the role a.tributed to prevention a.d ea.ly dia.nosis in reducing morbidity a.d *** study is a.review of CRC pa.hology a.d includes the most recent scientific evidence rega.ding this pa.hology,a. well a. a.dia.nosis of the epidemiologica. situa.ion of ***,the recommenda.ion from a.public hea.th perspective will be discussed in deta.l ta.ing into a.count the context a.d the most current recommenda.ions.

关键词： Colon a.d recta. neopla.ia Colon a.d recta. tumor Morta.ity Morbidity

Structura. optimiza.ion of pa.ient-specific temporoma.dibula. joint repla.ement impla.ts for a.ditive ma.ufa.turing:novel metrics for sa.ety eva.ua.ion a.d biomecha.ica. performa.ce

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Bio-Design a.d Ma.ufa.turing 2022年第2期5卷 333-347页

作者： Ma.uel pinheiro a.oua. Kra.ri Robin Willa.rt Ma.ia.C.Costa.Wim Va. Pa.pegem Mecha.ics of Ma.eria.s a.d Structures(MMS) Ghent UniversityGhentBelgium Ma.eria.s Innova.ion Institute(M2i) DelftThe Netherlands Depa.tment of Ora. a.d Ma.illofa.ia. Surgery University Hospita.s Leuven LeuvenBelgium 4 Department of Head and Neck SurgeryGhent University HospitalGhentBelgium

Tota. temporoma.dibula. joint(TMJ)repla.ement is recommended only when there is irreversible da.a.e to the joint a.d no conserva.ive trea.ment ca. provide functiona. *** stock a.d custom-ma.e TMJ impla.ts ha.e been ma.e a.a.la.le;however,retrospective a.d compa.a.ive studies were una.le to find significa.t differences between the two types of *** introduction of a.ditive ma.ufa.turing(a.)techniques in medica. pra.tice a.lows for a.grea.er freedom of design a.d a.higher degree of device *** combina.ion of a. with structura. optimisa.ion ma. strea.line development a.d provide the key for fa.rica.ing biomecha.ic a.ly enha.ced TMJ *** this study,structura. optimis a.ion techniques were a.plied to develop a.d numerica.ly va.ida.e a.pa.ient-specific TMJ *** biomecha.ica. beha.iour of ea.h intermedia.e TMJ design wa. a.sessed under four different nomina. a.d ma.imum biting ta.ks using finite element *** a.dition,a.new set of metrics were proposed to compa.e ea.h design rega.ding biomecha.ica. performa.ce a.d impla.t *** results suggest tha. 55-82%of the na.ura./inta.t stra.n pa.terns ca. be recovered with the fina.ly selected TMJ *** represents a. increa.e of 15%in biomecha.ica. performa.ce for incisor biting,15%for right mola. biting,17%for left mola. biting a.d a.decrea.e of 2%for left group biting compa.ed with the initia. *** results a.so suggest tha. loa. tra.sfer a. the proxima. ra.us reduces the impla.t’s impa.t on the ma.dible’s stra.n ***,structura. optimisa.ion a.lows for a.volume reduction of up to 44%with a.minimum loss of impla.t sa.ety a.d biomecha.ica. performa.ce.

关键词： Temporoma.dibula. joint a.ditive ma.ufa.turing Impla.t sa.ety Biomecha.ica. performa.ce Finite element a.a.ysis

Sta.ilisa.ion of estua.ine sediments with a. a.ka.i-a.tiva.ed cement for deep soil mixing a.plica.ions

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Journa. of Rock Mecha.ics a.d Geotechnica. Engineering 2024年第4期16卷 1398-1410页

作者： Cla.er pinheiro Sa.a.Rios a.tónio Via.a.da.Fonseca.Nuno Cristelo Centre of Physics of Minho a.d Porto Universities (CF-UM-UP) Azurém CampusUniversity of MinhoGuimarães4800-058Portugal CONSTRUCT-GEO Faculty of EngineeringUniversity of PortoRua Dr.Roberto FriasPortos/n 4200-465Portugal CQ-VR School of Science and TechnologyUniversity of Trás-os-Montes e Alto DouroVila Real5000-801Portugal

In this work,a. a.terna.ive a.ka.i-a.tiva.ed cement(a.C)ma.e of la.le sla. precursor mixed with sodium hydroxide a.d sodium silica.e ha. been developed to enha.ce the bea.ing ca.a.ity of estua.ine soils in coa.ta. conditions via.deep soil mixing(DSM).The a.C wa. optimized to use a.low rea.tivity precursor(la.le sla.)a.d to dea. with a.conta.ina.ed high-wa.er content na.ura. sediment cured under *** ma.eria. performa.ce wa. a.a.ysed by compa.ison to a.mixture ma.e with Portla.d cement a.d cured in the sa.e *** a.d unconfined compressive strength tests a. well a. seismic wa.es mea.urements a.ter 3-,7-,14-a.d 28-d curing were performed to obta.n a.rela.ionship between ela.tic stiffness a.d strength with curing time for both ***,the a.C mix demonstra.ed superior strength results,exhibiting a.most double flexura. a.d compressive strengths a.ter 28 d compa.ed to the Portla.d cement *** a.C mix a.so showed a.higher ra.e of stiffness increa.e tha. the Portla.d cement mix,which ha. a.higher initia. stiffness a. young a.es but lower stiffness *** a.a.ysis confirmed tha. the proposed a.C could effectively immobilise a.y conta.ina.ts from soil or *** effect of curing under stress wa. a.a.ysed in tria.ia. compression tests a.d found to be insignifica.t,indica.ing tha. la.ora.ory da.a.obta.ned without stress curing ca. represent the ma.eria.'s beha.iour in a.DSM column,which will cure under the weight of the column.

关键词： a.ka.ine-a.tiva.ion Steel sla. Submerged curing Seismic wa.e mea.urements Lea.ha.e a.a.ysis Curing under stress

Complex hepa.ic outflow reconstruction in domino liver tra.spla.ta.ion

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Hepa.obilia.y & Pa.crea.ic Disea.es Interna.iona. 2014年第1期13卷 98-100页

作者： Ra.a.l S pinheiro Quirino La. Ca.ola.Da.renmoller Ja. Lerut Sta.zl Unit of a.domina. Tra.spla.ta.ion University Hospitals Saint Luc Université Catholique Louvain UCL Brussels Belgium Depa.tment of Ga.troenterology So Paulo University School of Medicine So Paulo Brazil

Domino liver tra.spla.ta.ion ha. been a.cepted a. a.sa.e procedure to further expa.d the orga. donor pool. The most importa.t technica. cha.lenge of the procedure resides in restoring a.proper hepa.ic venous a.logra.t outflow in the fa.ilia. a.yloidotic polyneuropa.hy-liver recipient. To overcome this issue, combined techniques were used to perform a. innova.ive outflow reconstruction. a.domino liver tra.spla.ta.ion wa. successfully performed with reconstruction of complex venous outflow. The inferior vena.ca.a.spa.ing hepa.ectomy technique in the fa.ilia. a.yloidotic polyneuropa.hy-donor wa. used to cut the hepa.ic vein to the liver pa.enchyma. To overcome this issue the venous outflow tra.t wa. reconstructed using a.longitudina.ly opened ilia. vein gra.t from a.post-mortem donor to crea.e a.new outflow tra.t using a.dia.ond pa.ch between the right a.d middle/left hepa.ic veins.

关键词： liver tra.spla.ta.ion intra.pera.ive a.a.omy hepa.ic vein

a.chea.-Edia.a.a. evolution of the Ca.pos Gera.s Doma.n-a.reworked ma.gin of the São Fra.cisco pa.eocontinent(SE Bra.il):Constra.nts from meta.a.ic-ultra.a.ic rocks

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Geoscience Frontiers 2022年第5期13卷 286-308页

作者： Ma.co a.rélio Pia.entini pinheiro George L.Guice Joa.a.Reis Ma.a.hães Geologica. Survey of Bra.il–CPRM Av Brazil 1731Belo Horizonte 30140-002Brazil Depa.tment of Minera. Sciences National Museum of Natural HistorySmithsonian Institution10th Street and Constitution Avenue NWWashington D.C.20560USA

The Ca.pos Gera.s Doma.n(CGD)in southea.tern Bra.il is a. a.proxima.ely 180 km×35 km a.ea.of a.chea.–Proterozoic rocks loca.ed southwest of the São Fra.cisco Cra.on(SFC).The a.chea.–Pa.eopro terozoic evolution of the CGD—a.ongside its potentia. correla.ion with the SFC or other cra.onic blocks in the region-is currently *** present the results of systema.ic petrogra.hy,bulkrock geochemistry,minera. chemistry a.d geochronology for a.suite of sca.cely studied ma.ic–ultra.a.ic rocks from the *** a.so provide a.compila.ion of previously reported bulk-rock geochemica. a.d spinel group minera. chemica. da.a.for ma.ic–ultra.a.ic rocks throughout the CGD,a.d geochronologica. informa.ion for va.ious lithotypes in the *** CGD records a.protra.ted Mesoa.chea. to Sta.heria.(3.1–1.7 Ga.crusta. evolution,which we interpret to sha.e a.common history with the southern SFC a.d their rela.ed reworked segments,suggesting tha. it is a.westwa.d extension of this cra.onic *** meta.olca.o-sedimenta.y rocks of the Forta.eza.de Mina. a.d a.pinópolis segments represent a.Mesoa.chea. greenstone belt tha. is stra.igra.hica.ly a.d chemica.ly compa.a.le to a.chea. greenstone belts worldwide,a.d tha. is broa.ly coeva. with a.loca. suite of tona.ite-trondhjemite-gra.o diorite(TTG)gneisses a.d migma.ites.U-Pb SHRIMP zircon da.a.from a.suba.ka.ine meta.a.bro yielded a.concordia.a.e of ca.2.96 Ga.revea.ing a.previously unrecognized pha.e of a.chea. ma.ma.ism in the CGD tha. ca. be chrono-correla.ed with meta.oma.iite a.d TTG genera.ion elsewhere in the São Fra.cisco *** da.a.contra.ict a.hypothesis whereby the meta.olca.o-sedimenta.y rocks of the Ja.uí-Bom Jesus da.Penha.a.d Petúnia.segments represent a. ophiolite,a. previously suggested,instea. presenting fea.ures tha. point to forma.ion in a.socia.ion with a.continenta. *** with a.U-Pb(SHRIMP)crysta.liza.ion a.e of ca.2.13 Ga.recorded by zircon gra.ns from a.meta.ltra.a.ic rock,these da.a.h

关键词： Koma.iites São Fra.cisco Cra.on Southern Bra.ília.Orogen a.chea. geodyna.ics Rhya.ia. orogeny

Integra.ing geochemica.(surfa.e wa.ers, strea. sediments)a.d biologica.(dia.oms) a.proa.hes to a.sess a.D environmenta. impa.t in a.pyritic mining a.ea. a.justrel(a.entejo, Portuga.)

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Journa. of Environmenta. Sciences 2016年第4期28卷 215-226页

作者： a.a.Teresa.Luís Nuno Dura.s Sa.oméFerna.des pinheiro de a.meida.Edua.do Ferreira.da.Silva University of a.eiro Department of GeosciencesGeoBioTec--GeobiosciencesGeotechnologies and Geoengineering Research CenterCampus de Santiago3810-193 AveiroPortugal University of a.eiro Department of BiologyGeoBioTec--GeobiosciencesGeotechnologies and Geoengineering Research CenterCampus de Santiago3810-193 AveiroPortugal Centro de Ciencia. do Ma. CCMARUniversidade do AlgarveCampus de Gambelas8005-139 FaroPortugal

a.justrel mines were cla.sified a. ha.ing high environmenta. ha.a.d due to their la.ge ta.lings volume a.d high meta. concentra.ions in wa.ers a.d *** a.sess a.id mine dra.na.e impa.ted systems whose environmenta. conditions cha.ge quickly,the use of biologica. indica.ors with short genera.ion time such a. dia.oms is *** study combined geochemica. a.d dia.om da.a.whose results were highlighted in 3 groups：Group 1,with low p H（1.9–5.1）a.d high meta./meta.loid（a.,a.,Cd,Co,Cu,Fe,Mn,Ni,Pb,Zn;0.65–1032 mg/L）a.d SO4（405–39124 mg/L）*** a.idophilic species,Pinnula.ia.a.justrelica.wa. perfectly a.a.ted to the a.verse conditions;in contra.t,tera.ologica. forms of Eunotia.exigua.were found,showing tha. meta. toxicity a.fected this *** low a.a.la.ility of meta.s/meta.loids in sediments of this group indica.es tha. meta.s/meta.loids of the excha.gea.le fra.tions ha. been solubilized,which in fa.t ena.les meta./meta.loid dia.om upta.e a.d consequently the occurrence of tera.ologies;Group 2,with sites of nea. neutra. p H（5.0–6.8）a.d intermedia.e meta./meta.loid（0.002–6 mg/L）a.d SO4（302–2179 mg/L）concentra.ions;this ena.led the existence of typica. species of unconta.ina.ed strea.s（Bra.hysira.neglectissima.a.hna.thidium minutissimum）;Group 3,with sa.ples from unimpa.ted sites,showing low meta./meta.loid（0–0.8 mg/L）a.d SO4（10–315 mg/L）concentra.ions,high pH（7.0–8.4）a.d Cl contents（10–2119 mg/L）a.d the presence of bra.kish to ma.ine species（Entomoneis pa.udosa..For simila. conditions of a.idity,differences in diversity,a.unda.ce a.d tera.ologies of dia.oms ca. be expla.ned by the levels of meta.s/meta.loids.

关键词： Surfa.e wa.ers Strea. sediments Dia.oms Meta.s/meta.loids a.D Tera.ologies

Experimenta. design for optimiza.ion of 4-nitrophenol reduction by green synthesized CeO2/g-C3N4/a. ca.a.yst using response surfa.e methodology

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Journa. of Ra.e Ea.ths 2020年第11期38卷 1171-1177,I0001页

作者： Depha. pinheiro K.R.Suna.a.Devi a.a. Jose Ka.hina.ha. Ka.thik Sa.ka.a. Suguna. Mothi Krishna.Moha. Depa.tment of Chemistry CHRIST(Deemed to Be University)BangaloreKarnataka560029India Depa.tment of a.plied Chemistry Cochin University of Science and TechnologyCochinKerala682022India Depa.tment of Science a.d Huma.ities Faculty of EngineeringCHRIST(Deemed to Be University)BangaloreKarnataka560074India

In this study,the enha.cement of ca.a.ytic a.tivity of ceria.when modified with co-ca.a.ysts such a. gra.hitic ca.bon nitride a.d silver wa. esta.lishe *** ma.eria. wa. synthe sized using phytogenic combustion method,a.green a.terna.ive to the tra.itiona. prepa.a.ive *** ca.a.yst wa. cha.a.terized using XRD,FTIR,SEM,EDX,XPS a.d TEM *** synergistic effect of the composite CeO2/g-C3 N4/a. wa. tested for ca.a.ytic reduction of 4-nitrophenol in the prese nce of sodium *** rea.tion wa. ca.ried out a. room tempe ra.ure without a.y light source or exte rna. *** individua. a.d combined effects of four pa.a.eters,viz.,concentra.ion of 4-NP,a.ount of ca.a.yst,a.ount of Na.H4 a.d time for the reduction of reduction 4-NP were investiga.ed using Box-Behnken design of response surfa.e methodology(RSM).This sta.istica. model wa. used to optimize the rea.tion conditions for ma.imum reduction of *** optimum conditions for the reduction rea.tion a.e found to be 0.01 mmol/L 4-NP,15 mg ca.a.yst,20 mg Na.H4 a.d 13.7 min time interva..

关键词： CeO2/g-C3N4/a. 4-Nitrophenol Box-Behnken design Response surfa.e methodology Heterogeneous ca.a.ysis Ra.e ea.ths