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Chronic myeloid leukemia-from the Philadelphia chromosome to specific target drugs:A literature review

World Journal of Clinical Oncology 2021年第2期12卷 69-94页

作者： Mariana miranda Sampaio Maria Luísa Cordeiro Santos Hanna Santos Marques Vinícius Lima de Souza Gonçalves Glauber Rocha Lima Araújo Luana Weber Lopes Jonathan Santos Apolonio Camilo Santana silva Luana Kauany de SáSantos Beatriz Rocha Cuzzuol Quézia Estéfani silva Guimarães Mariana Novaes Santos Breno Bittencourt de Brito Filipe Antônio França da silva Márcio Vasconcelos Oliveira Cláudio Lima Souza Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil Campus Vitória da Conquista Universidade Estadual do Sudoeste da BahiaVitória da Conquista 45083-900BahiaBrazil

Chronic myeloid leukemia(CML)is a myeloproliferative neoplasm and was the first neoplastic disease associated with a well-defined genotypic anomaly―the presence of the Philadelphia *** advances in cytogenetic and molecular assays are of great importance to the diagnosis,prognosis,treatment,and monitoring of *** discovery of the breakpoint cluster region(BCR)-Abelson murine leukemia(ABL)1 fusion oncogene has revolutionized the treatment of CML patients by allowing the development of targeted drugs that inhibit the tyrosine kinase activity of the BCR-ABL *** kinase inhibitors(known as TKIs)are the standard therapy for CML and greatly increase the survival rates,despite adverse effects and the odds of residual disease after discontinuation of *** therapeutic alternatives,the subsequent TKIs lead to faster and deeper molecular remissions;however,with the emergence of resistance to these drugs,immunotherapy appears as an alternative,which may have a cure potential in these *** this background,this article aims at providing an overview on CML clinical management and a summary on the main targeted drugs available in that context.

关键词： Chronic myeloid leukemia Breakpoint cluster region-Abelson murine leukemia Immunotherapy Tyrosine kinase inhibitors Philadelphia chromosome Diagnosis

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The Potential of Activated Carbon in the Treatment of Water for Human Consumption, a Study of the State of the Art and Its Techniques Used for Its Development

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Advances in Bioscience and Biotechnology（生命科学与技术进展） 2021年第6期

作者： Adenes Teixeira alves Dimas José Lasmar Ires Paula de Andrade miranda Jamal da silva Chaar Jardson dos Santos Reis

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Relationship between Th17 immune response and cancer

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World Journal of Clinical Oncology 2021年第10期12卷 845-867页

作者： Hanna Santos Marques Breno Bittencourt de Brito Filipe Antônio França da silva Maria Luísa Cordeiro Santos Júlio César Braga de Souza Thiago Macêdo Lopes Correia Luana Weber Lopes Nayara silva de Macêdo Neres Rafael Santos dantas miranda Dórea Anna Carolina Saúde dantas Lorena Lôbo Brito Morbeck Iasmin Souza Lima Amanda alves de Almeida Maiara Raulina de Jesus Dias Fabrício Freire de Melo Campus Vitória da Conquista Universidade Estadual do Sudoeste da BahiaVitória da Conquista 45083-900BahiaBrazil Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil

Cancer is the second leading cause of death worldwide and epidemiological projections predict growing cancer mortality rates in the next *** has a close relationship with the immune system and,although Th17 cells are known to play roles in the immune response against microorganisms and in autoimmunity,studies have emphasized their roles in cancer *** Th17 immune response profile is involved in several types of cancer including urogenital,respiratory,gastrointestinal,and skin *** type of immune response exerts pro and antitumor functions through several mechanisms,depending on the context of each tumor,including the protumor angiogenesis and exhaustion of T cells and the antitumor recruitment of T cells and neutrophils to the tumor *** other factors,the paradoxical behavior of Th17 cells in this setting has been attributed to its plasticity potential,which makes possible their conversion into other types of T cells such as Th17/Treg and Th17/Th1 ***(IL)-17 stands out among Th17-related cytokines since it modulates pathways and interacts with other cell profiles in the tumor microenvironment,which allow Th17 cells to prevail in ***,the IL-17 is able to mediate pro and antitumor processes that influence the development and progression of various cancers,being associated with variable clinical *** understanding of the relationship between the Th17 immune response and cancer as well as the singularities of carcinogenic processes in each type of tumor is crucial for the identification of new therapeutic targets.

关键词： Cancer Immune response Th17 cells Interleukin-17 Tumor microenvironment Pathophysiology

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Feasibility to Convert the NuScale SMR from UO2 to a Mixed (U, Th)O2 Core:A Parametric Study of Fuel Element—Seed-Blanket Concept

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World Journal of Nuclear Science and Technology（核科学与技术国际期刊） 2023年第2期

作者： Giovani Laranjo de Stefani Diego Manoel Enedino Gonçalves Cesar Raitz Marcelo V. da silva Caio Július César miranda Rodrigues da Cunha

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Correction to“Performance of a serological IgM and IgG qualitative test for COVID-19 diagnosis:An experimental study in Brazil”

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World Journal of Experimental Medicine 2023年第3期13卷 47-49页

作者： Fabrício Freire de Melo Lilian Martins Oliveira Diniz JoséNélio Januário João Fernando Gonçalves Ferreira Rafael Santos dantas miranda Dórea Breno Bittencourt de Brito Hanna Santos Marques Fabian Fellipe Bueno Lemos Marcel silva Luz Samuel Luca Rocha Pinheiro Gifone Aguiar Rocha Dulciene Maria de Magalhães Queiroz Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil Departamento de Pediatria Universidade Federal de Minas GeraisBelo Horizonte 30130-100Minas GeraisBrazil Departamento de Clínica Médica Universidade Federal de Minas GeraisBelo Horizonte 30130-100Minas GeraisBrazil Laboratory of Research in Bacteriology Universidade Federal de Minas GeraisBelo Horizonte 30130-100Minas GeraisBrazil Laboratory of Bacteriology Faculdade de MedicinaUniversidade Federal de Minas GeraisBelo Horizonte 30130-100Brazil Campus Vitória da Conquista Universidade Estadual do Sudoeste da BahiaVitória da Conquista 45029-094BahiaBrazil

Correction to“Freire de Melo F,Martins Oliveira Diniz L,Nélio Januário J,Fernando Gonçalves Ferreira J,Dórea RSDM,de Brito BB,Marques HS,Lemos FFB,silva Luz M,Rocha Pinheiro SL,de Magalhães Queiroz *** of a serological IgM and IgG qualitative test for COVID-19 diagnosis:An experimental study in *** J Exp Med 2022;12(5):100-103[PMID:36196438 DOI:10.5493/wjem.v12.i5.100]”.In this article,we identified an issue with the“Acknowledgments”***,we then provide a recognition section for our supporting institutions.

关键词： Correction COVID-19 serological testing Serologic tests Rapid diagnostic

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Measurement of Ξcc++ production in pp collisions at s1/2=13 TeV

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Chinese Physics C 2020年第2期44卷 13-23页

作者： R.Aaij C.Abellán Beteta T.Ackernley B.Adeva M.Adinolfi H.Afsharnia C.A.Aidala S.Aiola Z.Ajaltouni S.Akar P.Albicocco J.Albrecht F.Alessio M.Alexander A.Alfonso Albero G.Alkhazov P.Alvarez Cartelle A.A.alves Jr S.Amato Y.Amhis L.An L.Anderlini G.Andreassi M.Andreotti F.Archilli A.Artamonov M.Artuso K.Arzymatov E.Aslanides M.Atzeni B.Audurier S.Bachmann J.J.Back S.Baker V.Balagura W.Baldini A.Baranov R.J.Barlow S.Barsuk W.Barter M.Bartolini F.Baryshnikov J.M.Basels G.Bassi V.Batozskaya B.Batsukh A.Battig A.Bay M.Becker F.Bedeschi I.Bediaga A.Beiter L.J.Bel V.Belavin S.Belin V.Bellee K.Belous I.Belyaev G.Bencivenni E.Ben-Haim S.Benson S.Beranek A.Berezhnoy *** D.Berninghoff H.C.Bernstein C.Bertella E.Bertholet A.Bertolin C.Betancourt F.Betti M.O.Bettler Ia.Bezshyiko S.Bhasin J.Bhom M.S.Bieker S.Bifani P.Billoir A.Bizzeti M.Bjørn M.P.Blago T.Blake F.Blanc S.Blusk D.Bobulska V.Bocci O.Boente Garcia T.Boettcher A.Boldyrev A.Bondar N.Bondar S.Borghi M.Borisyak M.Borsato J.T.Borsuk T.J.V.Bowcock C.Bozzi M.J.Bradley S.Braun A.Brea Rodriguez M.Brodski J.Brodzicka A.Brossa Gonzalo D.Brundu E.Buchanan A.Buonaura C.Burr A.Bursche A.Butkevich J.S.Butter J.Buytaert W.Byczynski S.Cadeddu H.Cai R.Calabrese L.Calero Diaz S.Cali R.Calladine M.Calvi M.Calvo Gomez P.Camargo Magalhaes A.Camboni P.Campana D.H.Campora Perez A.F.Campoverde Quezada L.Capriotti A.Carbone G.Carboni R.Cardinale A.Cardini I.Carli P.Carniti K.Carvalho Akiba A.Casais Vidal G.Casse M.Cattaneo G.Cavallero S.Celani R.Cenci J.Cerasoli M.G.Chapman M.Charles Ph.Charpentier G.Chatzikonstantinidis M.Chefdeville V.Chekalina C.Chen S.Chen A.Chernov S.-G.Chitic V.Chobanova S.Cholak M.Chrzaszcz A.Chubykin P.Ciambrone M.F.Cicala X.Cid Vidal G.Ciezarek F.Cindolo P.E.L.Clarke M.Clemencic H.V.Cliff J.Closier J.L.Cobbledick V.Coco J.A.B.Coelho J.Cogan E.Cogneras L.Cojocariu P.Collins T.Colombo A.Comerma-Montells A.Contu N.Cooke G.Coombs S.Coquereau G.Corti C.M.Costa Sobral B.Couturier D.C.Craik J.Crkovska A.Crocombe M.Cruz Torres R.Currie C.L.da silva E.dall'Occo J.dalseno C.D' Centro Brasileiro de Pesquisas Físicas(CBPF) Rio de JaneiroBrazil Universidade Federal do Rio de Janeiro(UFRJ) Rio de JaneiroBrazil Center for High Energy Physics Tsinghua UniversityBeijingChina School of Physics State Key Laboratory of Nuclear Physics and Technology Peking UniversityBeijingChina University of Chinese Academy of Sciences BeijingChina Institute Of High Energy Physics(IHEP) BeijingChina Institute of Particle Physics Central China Normal UniversityWuhanHubeiChina Univ.Grenoble Alpes Univ.Savoie Mont BlancCNRSIN2P3-LAPPAnnecyFrance UniversitéClermont Auvergne CNRS/IN2P3LPCClermont-FerrandFrance Aix Marseille Univ CNRS/IN2P3CPPMMarseilleFrance LAL Univ.Paris-SudCNRS/IN2P3UniversitéParis-SaclayOrsayFrance LPNHE Sorbonne UniversitéParis Diderot Sorbonne Paris CitéCNRS/IN2P3ParisFrance I.Physikalisches Institut RWTH Aachen UniversityAachenGermany Fakultät Physik Technische Universität DortmundDortmundGermany Max-Planck-Institut für Kernphysik(MPIK) HeidelbergGermany Physikalisches Institut Ruprecht-Karls-Universität HeidelbergHeidelbergGermany School of Physics University College DublinDublinIreland INFN Sezione di Bari BariItaly INFN Sezione di Bologna BolognaItaly INFN Sezione di Ferrara FerraraItaly INFN Sezione di Firenze FirenzeItaly INFN Laboratori Nazionali di Frascati FrascatiItaly INFN Sezione di Genova GenovaItaly INFN Sezione di Milano-Bicocca MilanoItaly INFN Sezione di Milano MilanoItaly INFN Sezione di Cagliari MonserratoItaly INFN Sezione di Padova PadovaItaly INFN Sezione di Pisa PisaItaly INFN Sezione di Roma Tor Vergata RomaItaly INFN Sezione di Roma La Sapienza RomaItaly Nikhef National Institute for Subatomic Physics AmsterdamNetherlands Nikhef National Institute for Subatomic Physics and VU University Amsterdam AmsterdamNetherlands Henryk Niewodniczanski Institute of Nuclear Physics Polish Academy of Sciences KrakówPoland AGH-University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakówPoland Nationa

The production of ■baryons in proton-proton collisions at a centre-of-mass energy of √s = 13 TeV is measured in the transverse-momentum range 4data used in this measuremen... 详细信息

The production of ■baryons in proton-proton collisions at a centre-of-mass energy of √s = 13 TeV is measured in the transverse-momentum range 4data used in this measurement correspond to an integrated luminosity of 1.7fb^-1,recorded by the LHCb experiment during *** ratio of the ■ production cross-section times the branching fraction of the■→∧^+cK^-π^+ π^+decay relative to the prompt ∧^+c production cross-section is found to be(2.22±0.27±0.29)×10^-4,assuming the central value of the measured lifetime,where the first uncertainty is statistical and the second systematic.

关键词： doubly charmed baryons hadron production QCD

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Search for the doubly charmed baryon ■

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Science China(Physics,Mechanics & Astronomy) 2020年第2期63卷 8-22页

作者： R.Aaij C.Abellán Beteta T.Ackernley B.Adeva M.Adinolfi H.Afsharnia C.A.Aidala S.Aiola Z.Ajaltouni S.Akar P.Albicocco J.Albrecht F.Alessio M.Alexander A.Alfonso Albero G.Alkhazov P.Alvarez Cartelle A.A.alves Jr S.Amato Y.Amhis L.An L.Anderlini G.Andreassi M.Andreotti F.Archilli J.Arnau Romeu A.Artamonov M.Artuso K.Arzymatov E.Aslanides M.Atzeni B.Audurier S.Bachmann J.J.Back S.Baker V.Balagura W.Baldini A.Baranov R.J.Barlow S.Barsuk W.Barter M.Bartolini F.Baryshnikov G.Bassi V.Batozskaya B.Batsukh A.Battig V.Battista A.Bay M.Becker F.Bedeschi I.Bediaga A.Beiter L.J.Bel V.Belavin S.Belin N.Beliy V.Bellee K.Belous I.Belyaev G.Bencivenni E.Ben-Haim S.Benson S.Beranek A.Berezhnoy *** D.Berninghoff H.C.Bernstein E.Bertholet A.Bertolin C.Betancourt F.Betti M.O.Bettler Ia.Bezshyiko S.Bhasin J.Bhom M.S.Bieker S.Bifani P.Billoir A.Birnkraut A.Bizzeti M.Bjφrn M.P.Blago T.Blake F.Blanc S.Blusk D.Bobulska V.Bocci O.Boente Garcia T.Boettcher A.Boldyrev A.Bondar N.Bondar S.Borghi M.Borisyak M.Borsato J.T.Borsuk T.J.V.Bowcock C.Bozzi S.Braun A.Brea Rodriguez M.Brodski J.Brodzicka A.Brossa Gonzalo D.Brundu E.Buchanan A.Buonaura C.Burr A.Bursche J.S.Butter J.Buytaert W.Byczynski S.Cadeddu H.Cai R.Calabrese S.Cali R.Calladine M.Calvi M.Calvo Gomez A.Camboni P.Campana D.H.Campora Perez L.Capriotti A.Carbone G.Carboni R.Cardinale A.Cardini P.Carniti K.Carvalho Akiba A.Casais Vidal G.Casse M.Cattaneo G.Cavallero R.Cenci J.Cerasoli M.G.Chapman M.Charles Ph.Charpentier G.Chatzikonstantinidis M.Chefdeville V.Chekalina C.Chen S.Chen A.Chernov S.-G.Chitic V.Chobanova M.Chrzaszcz A.Chubykin P.Ciambrone M.F.Cicala X.Cid Vidal G.Ciezarek F.Cindolo P.E.L.Clarke M.Clemencic H.V.Cliff J.Closier J.L.Cobbledick V.Coco J.A.B.Coelho J.Cogan E.Cogneras L.Cojocariu P.Collins T.Colombo A.Comerma-Montells A.Contu N.Cooke G.Coombs S.Coquereau G.Corti C.M.Costa Sobral B.Couturier D.C.Craik J.Crkovska A.Crocombe M.Cruz Torres R.Currie C.L.da silva E.dall'Occo J.dalseno C.D'Ambrosio A.danilina P.d'Argent A.davis O.De Aguiar Francisco K.De Bruyn S.De Capua M Centro Brasileiro de Pesquisas Fisicas(CBPF) Rio de JaneiroBrazil Universidade Federal do Rio de Janeiro(UFRJ) Rio de JaneiroBrazil Center for High Energy Physics Tsinghua UniversityBeijingChina School of Physics State Key Laboratory of Nuclear Physics and Technology Peking UniversityBeijingChina University of Chinese Academy of Sciences BeijingChina Institute Of High Energy Physics(IHEP) BeijingChina Institute of Particle Physics Central China Normal UniversityWuhanHubeiChina Univ.Grenoble Alpes Univ.Savoie Mont BlancCNRSIN2P3-LAPPAnnecyFrance Universite Clermont Auvergne CNRS/IN2P3LPCClermont-FerrandFrance Aix Marseille Univ CNRS/IN2P3CPPMMarseilleFrance LAL Univ.Paris-SudCNRS/IN2P3Universite Paris-SaclayOrsayFrance LPNHE Sorbonne Universite Paris Diderot Sorbonne Paris Cite CNRS/IN2P3ParisFrance I.Physikalisches Institut RWTH Aachen UniversityAachenGermany Fakultat Physik Technische Universitat DortmundDortmundGermany Max-Planck-Institut für Kernphysik(MPIK) HeidelbergGermany Physikalisches Institut Ruprecht-Karls-Universitat HeidelbergHeidelbergGermany School of Physics University College DublinDublinIreland INFN Sezione di Bari BariItaly INFN Sezione di Bologna BolognaItaly INFN Sezione di Ferrara FerraraItaly INFN Sezione di Firenze FirenzeItaly INFN Laboratori Nazionali di Frascati FrascatiItaly INFN Sezione di Genova GenovaItaly INFN Sezione di Milano-Bicocca MilanoItaly INFN Sezione di Milano MilanoItaly INFN Sezione di Cagliari MonserratoItaly INFN Sezione di Padova PadovaItaly INFN Sezione di Pisa PisaItaly INFN Sezione di Roma Tor Vergata RomaItaly INFN Sezione di Roma La Sapienza RomaItaly Nikhef National Institute for Subatomic Physics AmsterdamNetherlands Nikhef National Institute for Subatomic Physics and VU University Amsterdam AmsterdamNetherlands Henryk Niewodniczanski Institute of Nuclear Physics Polish Academy of Sciences KrakowPoland AGH-University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakowPoland Natio

A search for the doubly charmed baryon ■^+cc is performed through its decay to theΛ^+c K^-π^+ final state,using proton-proton collision data collected with the LHCb detector at centre-of-mass energies of 7,8 and 13 *** data correspond to a total integrated luminosity of 9 fb^-*** significant signal is observed in the mass range from 3.4 to 3.8 GeV/c^*** limits are set at 95%credibility level on the ratio of the ■^+cc production cross-section times the branching fraction to that ofΛ^+c and ■^++cc *** limits are determined as functions of the ■^+cc mass for different lifetime hypotheses,in the rapidity range from 2.0 to 4.5 and the transverse momentum range from 4 to 15 GeV/c.

关键词： charmed baryons limits on production of particles charmed quarks experimental tests

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