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Inhibitory Effect of the Essential Oil from Hyptis suaveolens （L.） Poit on the Growth and Aflatoxins Synthesis of Aspergillus flavus

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Journal of Life Sciences 2013年第3期7卷 276-281页

作者： Ana Carolina Pessoa Moreira Egberto Santos carmo Paulo Alves Wanderley Evandro Leite de Souza Edeltrudes de Oliveira lima Department of Pharmaceutical Sciences Federal University of Paraiba Joao Pessoa 58051-900 Brazil Academic Unit of Health Federal University of Campina Grande Cuitd 58175-000 Brazil Department of Agriculture Federal University of Paraiba Bananeiras 58220-000 Brazil Laboratory of Food Microbiology Department of Nutrition Federal University of Paraiba Joao Pessoa 58051-900 Brazil

H. suaveolens （L.） Poit has been used in folk medicine revealing a wide pharmacological potential. This study aimed to evaluate the efficacy of the essential oil from 11. suaveolens leaves in inhibiting the growth of A. flavus LM257 and synthesis of aflatoxins Bl and B2. The essential oil at 20, 40 and 80 laL/mL strongly reduced the biomass and spore germination ofA. flavus. A 100% inhibition was found at 40 μL/mL and 80μL/mL, while at 20 μL/mL the growth depressed over 50% for both tested parameters. The essential oil at all assayed concentrations totally inhibited the production of aflatoxin B1 and B2. From these results, the essential oil from 11. suaveolens leaves may be considered as an alternative and effective inhibitor ofA. flavus, in addition to offer some protective effect to the production of aflatoxins.

关键词： Hyptis suaveolens essential oil Aspergillusflavus mycotoxins inhibitory effect.

源自巴西野生动物的毒液、毒素及其衍生物：药物开发的重要来源(英文)

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生理学报 2015年第3期67卷 261-270页

作者： flavia De Marco Almeid Adriano Monteiro de Castro Pimentat Monica Cristina Oliveiral Maria Elena De lima 米纳斯吉拉斯联邦大学药学院医药部制药技术实验室巴西米纳斯吉拉斯州贝洛奥里藏特31270-901 米纳斯吉拉斯联邦大学生物科学研究所生化和免疫学系动物毒液和毒素实验室巴西米纳斯吉拉斯州贝洛奥里藏特31270-901

在药物研发领域,野生动物的毒液正被广泛研究,许多基于毒液组分的研究以生物技术应用和专利申请形式被报道。巴西拥有丰富的生物多样性,公布的科研论文和专利申请数量显示了该资源是多么重要。本文报道了一份研究最透彻的巴西有毒动物... 详细信息

在药物研发领域,野生动物的毒液正被广泛研究,许多基于毒液组分的研究以生物技术应用和专利申请形式被报道。巴西拥有丰富的生物多样性,公布的科研论文和专利申请数量显示了该资源是多么重要。本文报道了一份研究最透彻的巴西有毒动物物种清单及从2000年到2013年的专利申请情况,包括源自巴西有毒物种的毒液成份、毒素及其衍生物。分析了涉及物种的数据、产品类型与发明者的国籍。55个专利申请涉及8个种属,响尾蛇、南美巨蝮蛇、矛头蝮蛇、斜蛛占其中78%。其余22%的专利来自巴西游走蛛、巴西金幽灵蝎、巴西捕鸟蛛、叶水蛙的毒液研究。大多数的发明(42%)包括抗癌、免疫调节剂或抗菌的药物,13%的发明为抗毒血清和疫苗,11%为降压成分,9%为镇痛及抗炎成分,其它25%为一些技术和试剂盒。巴西发明家占专利申请比重的49%,而其它国家如美国、德国、俄罗斯和法国同样发表了巴西动物毒液、毒素或衍生物的专利。虽然巴西拥有着大多数有毒物种的专利,但这些专利主要属于其学校和研究机构,药物工业在这方面依然薄弱。迄今为止,在世界范围内,已将巴西的有毒物种运用于药物研发,但大多数的物种可否作为研发的重要工具,仍然需要作进一步的勘探。

关键词：专利申请有毒物种毒液毒素药物研发

Why Sustainable Porous Carbon Should be Further Explored as Radar-Absorbing Material? A Comparative Study with Different Nanostructured Carbons

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Journal of Renewable Materials 2024年第10期12卷 1639-1659页

作者： Alan F.N.Boss Manuella G.C.Munhoz Gisele Amaral-Labat Rodrigo G.A.lima Leonardo I.Medeiros Nila C.F.L.Medeiros Beatriz C.S.Fonseca flavia L.Braghiroli Guilherme F.B.Lenz e Silva Department of Metallurgical and Materials Engineering University of de São PauloAvenida Mello MoraesCidade UniversitáriaSão PauloSP 05508-030Brazil Coordination of Applied Research and Technological Development National Institute for Space ResearchAvenida dos AstronautasJardim da GranjaSão Josédos CamposSP 12227-010Brazil Department of Exact and Technological Sciences Santa Cruz State UniversityRodovia Jorge Amadokm16IlhéusBA 45662900Brazil Institut de recherche sur les forêts Universitédu Québec en Abitibi-TémiscamingueRouyn-Noranda445 Bd de l’UniversitéRouyn-NorandaQC J9X 5E4Canada

Radar Absorbing Materials(RAM)are a class of composites that can attenuate incident electromagnetic waves to avoid radar *** carbon allotropes that have the potential to be used as RAM are either carbon nano-tubes(CNTs),graphene,carbon black(CB)and ultimately,sustainable porous carbon(SPC).Here,black wattle bark waste(following tannin extraction)was used as a sustainable source to produce SPC made from biomass *** was characterized and used as afiller for a silicone rubber matrix to produce aflexible *** elec-tromagnetic performance of this composite was compared with composites made with commercial CB and CNT through reflection loss(RL),where-10 dB is equivalent to 90%of *** composites were evaluated in single-layer,double-layer,and as radar absorbing structures(RAS)with the aim of improving their effective absorption bandwidth(EAB)performances and a reduction in *** CNT composite presented a RL of-26.85 dB at 10.89 GHz and an EAB of 2.6 GHz with a 1.9 mm thickness,while the double-layer structures using CNT and SPC provided a RL of-19.74 dB at 10.75 GHz and an EAB of 2.51 ***,the double-layer structures are~42%cheaper than the composite using only CNT since less material is ***,the largest EAB was achieved with a RAS using SPC,reaching~2.8 GHz and a RL of-49.09 dB at 10.4 ***,SPC made of black wattle bark waste can be a competitive,alternative material for use as RAM and RAS since it is cheaper,sustainable,and suitable for daily life uses such as absorbers for anechoic chambers,sensors,and elec-tromagnetic interference shields for electronics,wallets,vehicles,and others.

关键词： Microwave absorption material tannin waste dielectric constant carbon composite reflectivity

Child Oncology and Hospital Recreation

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Journal of Cancer Therapy 2019年第2期10卷 157-165页

作者： Conceicao de Maria lima Nascimento Erenice Conceicao de Almeida Barbosa Brunna Rafaella do carmo Silva Karoline Queiroz Martins Almeida de Araújo Gilzandra Lira Dantas Florencio Ana Carla Gomes Canário Paulo Francisco de Almeida Neto FCU Sao PauloBrazil UFRN NatalBrazil UNINASSAU NatalBrazil FAK FortalezaBrazil UFPB Joao PessoaBrazil UFSC FlorianópolisBrazil SBOC Sao PauloBrazil

Introduction: Hospital Recreation (HR) aims to reduce disasters caused by hospital admission. Objectives: To expose the behavior of children in cancer treatment (CA) during HR, and to verify which recreational activities generate the most adherence. Methods: The research is an experimental clinical trial of a non-probabilistic and intentional sample, with a quantitative and qualitative approach. Participants were 43 children (both sexes), with CA, admitted to the Pediatric Hospital Oncology Center—PHOC. The mean age of the children in fact was 7.5 years, and the data of mean and standard deviation between parenthood confer with the data of the results found during the research. The study lasted 12 weeks, with 38 sessions lasting 3 hours. Using games of activity: cognitive, manipulative, perceptive, creative and cooperative. Inclusion criteria: 1) being hospitalized in the PHOC, of the city of Natal;2) being released by the medical team to participate in the activities. Children who were on special care in the ICU were excluded from the study. The behavior of the children was evaluated by the observation matrix proposed by Urie Bonfenbrenner, approached by Krebs and Koller. At the end of the research, an interview was made with patients about the HR experience. Results: In the subjects the molecular behavior showed relevance of ~50%, and the cooperative of ~80% in relation to HR, and the cognitive activities showed an adhesion index of ~90%. Conclusion: The participants showed greater adherence in the cognitive activities, and the predominance of the molecular behavior in relation to hospital recreation, highlighting the cooperative behavior among the individuals. In this way, the activities of HR can complement conventional medical treatment.

关键词： Ludic Activity Hospital Children Recreation Playful Cancer

Intense Exercise in the Quality of Life of Breast Cancer Survivors:A Meta-Analysis

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Journal of Cancer Therapy 2019年第12期10卷 895-907页

作者： Paulo Francisco de Almeida Neto Erenice Conceicao de Almeida Barbosa Karoline Queiroz Martins Almeida de Araujo Tatianny de Macedo Cesario Brunna Rafaella do carmo Silva Thiago Gil Vieira de Figueiredo lima Nelson Carvas Junior Ana Carla Gomes Canario Federal University of Rio Grande do Norte UFRNNatalRNBrazil Brazilian Society of Clinical Oncology SBOCSao PauloSPBrazil Mauricio of Nassau University Center UNINASSANatalRNBrazil Institute of Medical Assistance to the state public servant IAMSPESao PauloSPBrazil Federal University of Paraíba UFPBJoao PessoaPBBrazil

The treatment of breast cancer (BC) leaves emotional and functional sequels affecting the quality of life (QOL) of the survivors. We aim to investigate, intense exercises in the rehabilitation of BC survivors. Using the systematic search model in the PubMed databases;Lilacs Bireme and Scielo. Meta-Analysis used the Meta package implemented in software R (version 3.3.2) p < 0.05. We selected 29 articles, and after reading in the Integra, we excluded 27 texts being included in the meta-analysis only 2. In the QOL, the heterogeneity in the emotional function showed a difference of 75%, in the social function 36% and in the physics 32%. Using intense exercises in BC survivors during rehabilitation improves overall QOL, muscle structure, and preserves functional capacity.

关键词： Breast Cancer High-Intensity Exercises High-Intensity Intermittent Exercise Women’s Health

Isotopic and geochemical constraints for a Paleoproterozoic accretionary orogen in the Borborema Province,NE Brazil:Implications for reconstructing Nuna/Columbia

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Geoscience Frontiers 2022年第5期13卷 267-285页

作者： Lauro Cézar M.de Lira Santos Geysson A.Lages Fabrício A.Caxito Elton L.Dantas Peter A.Cawood Haroldo M.lima Felipe Jda Cruz lima Departamento de Geologia Universidade Federal de PernambucoAv.da ArquiteturaCidade UniversitáriaRecifePEBrazil Serviço Geológico do Brasil-CPRM Av.SulAfogadosRecifePEBrazil CPMTC Instituto de GeociênciasUniversidade Federal de Minas GeraisAv.Pres.Antônio CarlosPampulhaBelo HorizonteMGBrazil Instituto de Geociências Universidade de BrasíliaCampus Universitário Darcy RibeiroAsa NorteBrasíliaDFBrazil School of Earth Atmosphere and EnvironmentMonash UniversityWellington RdClaytonVIC 3800Australia Departamento de Geologia Universidade Federal do CearáCampus do PiciParquelândiaFortalezaCEBrazil

The Alto MoxotóTerrane of the Borborema Province presents a wide exposure of Paleoproterozoic crust,but unlike other continental blocks of South America,its orogenic history is strongly obliterated by late Neoproterozoic *** isotopic and geochemical studies were conducted in mafic-ultramafic(Fazenda carmo Suite)and granitic-gneissic rocks(Riacho do Navio Suite)within the *** former present zircon U-Pb crystallization ages at ca.2.13 Ga,whereas Sm-Nd data suggests a juvenile origin via melting of early Paleoproterozoic to Archean peridotitic *** data for these rocks are compatible with tholeiitic magmas with some degree of crustal contamination and trace element distribution points to a continental-arc related setting interpreted as remnants of the early stages of *** contrast,the Riacho do Navio Suite was emplaced at ca.2.08 Ga and has highly negativeεNd(t)values indicating crustal *** suite displays calc-alkali to alkali-calcic and ferroan geochemical signatures compatible with Cordilleran *** addition,trace-element distribution as well as discriminant diagrams suggest that the precursor magmas were generated during the later stages of a continental arc or in a syn-collisional *** on our results,we suggest that the studied units might represent missing pieces of a Paleoproterozoic accretionary orogen that formed the crustal framework of the Alto MoxotóTerrane,and that this represents a block associated with assembly of the Nuna/Columbia supercontinent,which is now largely hidden within the Neoproterozoic orogenic belts of West Gondwana.

关键词： Paleoproterozoic accretionary-collisional event Early orogenic and syn-collisional magmatism Paleoproterozoic inlier within West Gondwana Nuna/Columbia Supercontinent

Risk factors associated with inflammatory bowel disease: A multicenter case-control study in Brazil

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World Journal of Gastroenterology 2020年第25期26卷 3611-3624页

作者： Valéria Cristina Loureiro Salgado Ronir Raggio Luiz Neio Lucio Fernandes Boéchat Isabella Sued Leao Bianca do carmo Schorr JoséMiguel Luz Parente Daniela Calado lima Eduardo Santos Silveira Júnior Genoile Oliveira Santana Silva Neogélia Pereira Almeida Andrea Vieira Maria Luiza Queiroz de Bueno Júlio Maria Chebli érika Ruback Bertges Luísa Martins da Costa Brugnara Columbano Junqueira Neto Stefania Burjack Gabriel Campbell Luana Letiza Discacciati Joao Paulo Silva Cézar Tiago Nunes Gilaad G Kaplan Cyrla Zaltman Division of Gastroenterology Department of Internal MedicineClementino Fraga Filho HospitalFederal University of Rio de JaneiroRio de Janeiro 21940-230Brazil Institute for Studies in Public Health Federal University of Rio de JaneiroRio de Janeiro 21940-230Brazil Multidisciplinary Research Laboratory Clementino Fraga Filho HospitalInstitute of Thoracic DiseasesFaculty of MedicineFederal University of Rio de JaneiroRio de Janeiro 21940-230Brazil Division of Gastroenterology Department of Internal MedicineHospital UniversityFaculty of MedicineFederal University of PiauíPiauí64049-550Brazil Almeida Division of GastroenterologyInflammatory Bowel Disease Outpatient ClinicRoberto Santos General Hospital(HGRS)of the Bahia State Department of HealthBahia 40110-060Brazil Division of Gastroenterology Inflammatory Bowel Disease Outpatient ClinicIrmandade Santa Casa da Misericórdia of São PauloSão Paulo 01221020Brazil Division of Gastroenterology Department of Internal MedicineHospital UniversityFaculty of MedicineFederal University of Juiz de ForaMinas Gerais 36036-247Brazil Division of Gastroenterology Inflammatory Bowel Disease Outpatient ClinicFederal District Base HospitalBrasília 70330-150Brazil Gastrointestinal Physiology Institute of Nutritional ScienceNestle Research CenterLausanne 1000Switzerland Departments of Medicine and Community Health Sciences University of CalgaryCalgary T2N4Z6Canada

BACKGROUND The etiology of inflammatory bowel disease(IBD)is unknown,but it is believed to be *** hygiene hypothesis proposes that better hygiene conditions would lead to less infectious disease during childhood and favor the development of immune-mediated *** To test the hygiene hypothesis in IBD by assessing the environmental risk factors associated with IBD development in different regions of Brazil with diverse socioeconomic development *** A multicenter case-control study was carried out with 548 Crohn’s disease(CD)and 492 ulcerative colitis(UC)outpatients and 416 healthy controls,from six IBD centers within different Brazilian states at diverse socioeconomic development stages.A semi-structured questionnaire with 87 socioeconomic and environmental questions was *** regression model was created to assess the odds ratio(OR)with P value and 95%confidence intervals(CI).RESULTS Predictive variables for both diseases(CD and UC)were women[odd ratios(OR)=1.31;OR=1.69],low monthly family income(OR=1.78;OR=1.57),lower number of cohabitants(OR=1.70;OR=1.60),absence of vaccination(OR=3.11;OR=2.51),previous history of bowel infections(OR=1.78;OR=1.49),and family history of IBD(OR=5.26;OR=3.33).Associated risk factors for CD were age(18-39 years)(OR=1.73),higher educational level(OR=2.22),absence of infectious childhood diseases(OR=1.99).The UC predictive variables were living in an urban area(OR=1.62),inadequate living conditions(OR=1.48)and former smokers(OR=3.36).Appendectomy was a risk factor for CD(OR=1.58)with inverse association with UC(OR=4.79).Consumption of treated and untreated water was associated with risk of CD(OR=1.38)and UC(OR=1.53),*** This is the first examining environmental exposures as risk factors for inflammatory bowel disease in *** of the variables associated with disease risk support the role of the hygiene hypothesis in IBD development.

关键词： Crohn’s disease Ulcerative colitis Risk factors Environmental factors Hygiene hypothesis

Biotechnological Potential of Endophytic Bacteria to Improve the Micropropagated Seedling of Variety RB92579 Sugarcane(Saccharum officinarum L.)

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Advances in Microbiology 2018年第11期8卷 859-873页

作者： Maria do carmo Silva Barreto Márcia do Vale Barreto Figueiredo Márcia Vanusa da Silva Arnóbio Gon?alves de Andrade José de Paula de Oliveira Clébia Maria Alves Almeida Livia Caroline Alexandre de Araújo Odemar Vicente dos Reis Junior Manoel Urbano Ferreira Junior Antonio Félix da Costa Vera Lucia de Menezes lima Departamento de Bioquímica Centro de Biociências Universidade Federal de Pernambuco Recife Brazil Laboratório de Biologia do Solo Instituto Agron&#244 mico de Pernambuco Recife Brazil Departamento de Química Universidade Federal Rural de Pernambuco Recife Brazil Centro de Tecnologias Estratégicas do Nordeste Recife Brazil

Endophytic bacteria may influence agricultural production in several ways, including promoting plant growth. Two experiments were conducted in order to evaluate the combination of endophytic bacteria from the Brazilian Northeast region aims at the commercial introduction of the inoculation of these bacteria in micropropagated sugarcane plants using a temporary immersion bioreactor. One experiment was done in tubes with sterile commercial substrate, and the other was done in pots with soil;both were installed in a greenhouse. A mixed inoculation was performed in six inoculated endophytic diazotrophic bacteria in micropropagated sugarcane plants, variety RB92579. In the experiment with soil, the mixed inoculation significantly increased the shoot dry matter of plants without the addition of nitrogen fertilizer. However, the accumulation of total-N in the tissues showed no significant differences between treatments with and without nitrogen fertilization. The evaluation of micropropagated seedlings showed no increases in the parameters tested. The results showed that the response of inoculation in temporary immersion bioreactor micropropagation is possible, and that the application of homologous strains may have contributed to a better response by the interaction of endophytic bacteria with sugarcane RB92579. Further studies should be conducted to improve the methodology, which indicates a great potential to optimize this process on a commercial scale.

关键词： Biological Nitrogen Fixation Meristem Culture Diazotrophic Bacteria Endophytes Micropropagation

The Aging Bladder in Females Evaluated by Urodynamics

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Open Journal of Urology 2017年第3期7卷 54-64页

作者： M. C. de Albuquerque Neto Leslie Clifford Noronha Araujo Thome Decio Pinheiro Barros Junior Joao Luiz Amaro flavia Cristina Morone Pinto Fabio de Oliveira Vilar Salvador Vilar Correia lima Urologic Department Clinical Hospital Federal University of Pernambuco UFPE Recife Brazil Urologic Service Botucatu Medical School Paulista State University UNESP Botucatu Brazil Postgraduate Program in Surgery Department of Surgery Center for Health Sciences Federal University of Pernambuco UFPE Recife Brazil

Aim: To determine whether bladder functions deteriorate with age. Methods: Data contained in electronic medical record (INFOMED?) were used in this institutional retrospective review. Analysis was done on the urodynamic studies in women over 18 years old conducted between May 2011 and November 2015. Patients with previous history of pelvic surgery or radiotherapy, neurological disease, vaginal prolapse greater than grade I, congenital urogenital malformations, urinary obstructive disease, diabetes, or the use of any medication that could interfere with bladder function were excluded from the analysis. The urodynamic parameters analyzed were the Maximum Cystometric Capacity (MCC), Voiding Volume (VV), Maximum Flow (Qmax), Bladder Compliance (BC), Detrusor Pressure at Maximum Flow (PdetQmax), Bladder Contractility Index (BCI), Bladder Voiding Efficiency (BVE) and Post-Void Residual Urine Volume (PVR). Patients were further stratified in five groups according to age (A—18 to 40;B—41 to 50;C—51 to 60;D—61 to 70;E—over 70 years old). Results: Out of 3103 urodynamic studies analyzed, 719 were eligible for the study. The average age of patients was 49.3 (+13.2) years old and in all evaluated parameters, statistically significant correlation between age and decline of bladder function was obtained (p Conclusions: This study showed a decline in bladder storage function (reduction in MCC and BC) and in bladder emptying function (reduction in Qmax, PdetQmax, VV, BCI and BVE with an increase in PVR) with age.

关键词： Aging Urinary Bladder Diseases Urinary Bladder Neurogenic Overactive Urodynamics