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Relationship between adipose tissue dysfunction, vitamin D deficiency and the pathogenesis of non-alcoholic fatty liver disease

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World Journal of Gastroenterology 2017年第19期23卷 3407-3417页

作者： flavia a cimini Ilaria Barchetta Simone Carotti Laura Bertoccini Marco G Baroni Umberto Vespasiani-Gentilucci Maria-Gisella Cavallo Sergio Morini Department of Experimental Medicine Sapienza University of Rome Laboratory of Microscopic and Ultrastructural Anatomy(CIR) Faculty of MedicineUniversity Campus Bio-Medico Internal Medicine and Hepatology University Campus Bio-Medico

Non-alcoholic fatty liver disease(NAFLD)is the most common chronic liver disease *** pathogenesis is complex and not yet fully *** the years many studies have proposed various pathophysiological hypotheses,among which the currently most widely accepted is the"multiple parallel hits"*** to this model,lipid accumulation in the hepatocytes and insulin resistance increase the vulnerability of the liver to many factors that act in a coordinated and cooperative manner to promote hepatic injury,inflammation and *** these factors,adipose tissue dysfunction and subsequent chronic low grade inflammation play a crucial *** studies have shown that vitamin D exerts an immune-regulating action on adipose tissue,and the growing wealth of epidemiological data is demonstrating that hypovitaminosis D is associated with both obesity and ***,given the strong association between these conditions,current findings suggest that vitamin D may be involved in the relationship between adipose tissue dysfunction and *** purpose of this review is to provide an overview of recent advances in the pathogenesis of NAFLD in relation to adipose tissue dysfunction,and in the pathophysiology linking vitamin D deficiency with NAFLD and adiposity,together with an overview of the evidence available on the clinical utility of vitamin D supplementation in cases of NAFLD.

关键词：脂肪质的织物机能障碍维生素 D 非酒精的脂肪肝疾病脂肪变性非酒精的 steatohepatitis 肥胖 Adipokines

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Overview of studies of the vitamin D/vitamin D receptor system in the development of non-alcoholic fatty liver disease

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World Journal of Gastrointestinal Pathophysiology 2019年第2期10卷 11-16页

作者： flavia Agata cimini Ilaria Barchetta Simone Carotti Sergio Morini Maria Gisella Cavallo Department of Experimental Medicine Sapienza University of RomeRome I-00161Italy Department of Medicine and Surgery Laboratory of Microscopic and Ultrastructural AnatomyUniversity Campus Bio-Medico of RomeRome I-00128Italy

Non-alcoholic fatty liver disease(NAFLD)is the most common chronic liver disease in the *** is known to be associated with obesity,type 2 diabetes,metabolic syndrome and increased cardiovascular events:for these reasons,it is becoming a global public health problem and represents an important challenge in terms of prevention and *** mechanisms behind the pathogenesis of NAFLD are multiple and have not yet been completely unraveled;consequently,at moment there are not effective *** the past few years a large body of evidence has been assembled that attributes an important role in hepatic aberrant fat accumulation,inflammation and fibrosis,to the vitamin D/vitamin D receptor(VD/VDR)axis,showing a strong association between hypovitaminosis D and the diagnosis of ***,the data currently available,including clinical trials with VD supplementation,still provides a contrasting *** purpose of this editorial is to provide an overview of recent advances in the pathogenesis of NAFLD in relation to VD/*** on recent data from literature,we focused in particular on the hypothesis that VDR itself,independently from its traditional ligand VD,may have a crucial function in promoting hepatic fat *** might also offer new possibilities for future innovative therapeutic approaches in the management of NAFLD.

关键词： Vitamin D Vitamin D receptor Non-alcoholic fatty liver disease Type 2 diabetes

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