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Role of Transparent Exopolymer Particles on Phytoplankton Dynamics in a Subtropical Estuary,Cananeia-Iguape(Sp,Brazil)

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Open Journal of Marine Science 2012年第1期2卷 25-32页

作者： Jose Juan Barrera-Alba Gleyci Aparecida Oliveira Moser Sonia Maria flores Gianesella flávia marisa prado saldanha-correa Departamento de Biologia Marinha Universidade Federal do Rio de JaneiroRio de JaneiroBrazil Faculdade de Oceanografia Universidade do Estado do Rio de JaneiroRio de JaneiroBrazil Instituto Oceanográfico Universidade de Sao PauloSao PauloBrazil

Transparent Exopolymer Particles (TEP) has a known crucial role in vertical fluxes of carbon in the ocean and has been intensively studied in the last decade. Nevertheless, few studies have considered horizontal fluxes of TEP. These fluxes arise prominently between estuaries and the coast, where its importance is associated to the predominant horizontal transport. This is due both to the low density of the TEP agglomerate generated in low density waters of continental origin, and to the fact that the main component of the advective transport at estuarine regions is the horizontal one. In this study, the significance of TEP in the particulate matter exchange between estuary and coast was analyzed in the estuarine lagoon system of Cananéia-Iguape (southeast coast of Brazil). TEP, total seston (TS), organic seston (OS) and chlorophyll a (Chl.a) were analyzed over complete tidal cycles, during the dry and rainy seasons both at spring and neap tides. Horizontal fluxes and net transport rates of these variables were also calculated. TEP concentrations (max. 4991 μg Xeq/L) were almost one order of magnitude higher during the rainy season. TEP horizontal transport rates as high as 1.8 g Xeq. m/s were observed at the northern inlet of the system. In terms of particulate carbon, it represents 32.7 g TEP-C m/s or 4% of the OS transport rates. Our study quantifies the advective transport of TEP and their importance in particulate matter exchange between a subtropical estuarine system and the adjacent coastal region. Our results contribute to the knowledge of exopolimer particles dynamics in subtropical estuarine systems, and their relationship to phyto-plankton biomass and particulate matter.

关键词： Cananéia-Iguape Estuarine Lagoon System Phytoplankton Biomass Carbon flux

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Analyzing the Wind-Dominant Electricity Market under Coexistence of Regulated and Deregulated Power Trading

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Energy Engineering 2024年第8期121卷 2093-2127页

作者： Yirui Li Dongliang Xiao Haoyong Chen Weijun Cai Josue Campos do prado School of Electric Power South China University of TechnologyGuangzhou510641China School of Engineering and Computer Science Washington State University VancouverVancouver98686USA School of Automation Guangdong University of TechnologyGuangzhou510006China

Currently,both regulated and deregulated power trading exist in China’s power system,which has caused imbalanced funds in the electricity *** this paper,a simulation analysis of the electricity market with wind energy resources is conducted,and the calculation methods of unbalanced funds are investigated *** detail,the calculation formulas of unbalanced funds are illustrated based on their definition,and a two-track electricity market clearing model is ***,the concept of the dual-track system is explained,and the specific calculation formulas of various types of unbalanced funds are ***,considering the renewable energy consumption,the market clearing model based on DC power flow is constructed and solved;by combining fitting methods of mid-and long-term curves,the unbalanced funds are calculated based on clearing results and formulas.

关键词： Dual-track system electricity market renewable energy unbalanced funds

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The effect of abiotic stresses on plant C:N:P homeostasis and their mitigation by silicon

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The Crop Journal 2024年第2期12卷 340-353页

作者： Milton Garcia Costa Renato de Mello prado Luiz Fabiano Palaretti Jonas Pereira de Souza Júnior Department of Agricultural Production Science School of Agricultural and Veterinarian SciencesSão Paulo State UniversityJaboticabalBrazil

In crop plants, various environmental stresses affect the balance of carbon, nitrogen, and phosphorus(C:N:P), leading to biochemical and physiological alterations and reductions in yield. Silicon(Si) is a beneficial element that alleviates plant stress. Most studies involving silicon have focused on physiological responses, such as improvements in photosynthetic processes, water use efficiency, and antioxidant defense systems. But recent research suggests that stressed plants facing either limited or excessive resources(water, light, nutrients, and toxic elements), strategically employ Si to maintain C:N:P homeostasis, thereby minimizing biomass losses. Understanding the role of Si in mitigating the impact of abiotic stresses on plants by regulating C:N:P homeostasis holds great potential for advancing sustainable agricultural practices in crop production. This review presents recent advances in characterizing the influence of environmental stresses on C:N:P homeostasis, as well as the role of Si in preserving C:N:P equilibrium and attenuating biological damage associated with abiotic stress. It underscores the beneficial effects of Si in sustaining C:N:P homeostasis and increasing yield via improved nutritional efficiency and stress mitigation.

关键词： Nutritional stoichiometry Elemental stoichiometry Beneficial element Environmental stresses Nutritional efficiency Carbon use efficiency Agricultural sustainability

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Potential of Bamboo Species Guadua trinii and Guadua angustifolia for Nanocellulose Production

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Journal of Renewable Materials 2024年第9期12卷 1541-1555页

作者： Agatha E.R.prado Gárate Fernando E.Felissia María Cristina Area Teresa Suirezs María Evangelina Vallejos Círculo de Investigación del Bambú Universidad Nacional Agraria La Molina(UNALM)Lima15026Perú Instituto de Materiales de Misiones(IMAM) Universidad Nacional de Misiones(UNaM)Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET)Facultad de Ciencias ExactasQuímicas y Naturales(FCEQYN)Programa de Celulosa y Papel(PROCyP)Posadas3300Argentina Instituto de Materiales de Misiones(IMAM) Universidad Nacional de Misiones(UNaM)Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET)Facultad de Ciencias Forestales(FCF)Eldorado3380Argentina

Non-traditional lignocellulosic materials are a significant resource for producing high-value products,including *** work studied the nanocellulose obtention from chemical pulps of the two fast-growing bamboo species,Guadua trinii,and Guadua *** pulps were produced by soda-anthraquinone(S)pulping from both autohydrolysis-pretreated(H)and unpretreated bamboo ***-pretreated(SHP)and unpretreated soda-anthraquinone(AQ)(SP)pulps were characterized by yield,Kappa number,alpha,beta,and gamma cellulose,degree of polymerization,water retention value,and *** nanocellulose was produced by a sequential chemical oxidation treatment(2,2,6,6-tetramethylpiperidine-1-oxyl,TEMPO reagent)and mechanical *** was characterized by carboxylic group content and *** results revealed that autohydrolysis pretreatment resulted in a higher hemicelluloses extraction in *** contrast,the pulping yield of unpretreated samples was higher for ***,and the soda-AQ pulps from this species exhibited better delignification than the autohydrolysis-pretreated *** crystallinity index values of the obtained pulps were high(>80%),and the alpha-cellulose contents were *** viscosities of the aqueous nanocellulose suspensions were higher for the nanocellulose solutions obtained from the unpretreated soda-AQ ***,nanocellulose from *** unpretreated soda-AQ pulps had a higher rate of carboxylic *** results of this work are significant in assessing the potential of both bamboo species as a source of high-value products within the biorefinery framework because the viscosities of the aqueous nanocellulose suspensions depend on the size and shape of *** has significant importance for industrial unit operations and potential applications.

关键词： Natural fiber Guadua angustifolia Guadua trinii soda-anthraquinone pulp nanocellulose

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Effect of resistance training volume on body adiposity,metabolic risk,and inflammation in postmenopausal and older females:Systematic review and meta-analysis of randomized controlled trials

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Journal of Sport and Health Science 2024年第2期13卷 145-159页

作者： Paulo Ricardo prado Nunes Pamela Castro-e-Souza Anselmo Alves de Oliveira Bruno de Freitas Camilo Gislaine Cristina-Souza Lucio Marques Vieira-Souza Marcelo Augusto da Silva Carneiro Department of Body and Human Movement Minas Gerais State University(UEMG)37902-092 PassosMGBrazil University Center of Planalto de Araxa(UNIARAXA) 38180-129 AraxaMGBrazil Physical Activity Health and Ageing Research Group(GPASE)Minas Gerais State University(UEMG)37902-092 PassosMGBrazil Exercise and Nutrition Research Group(GPEN) Minas Gerais State University(UEMG)37902-092 PassosMGBrazil Sport Sciences and Physical Exercise Study and Research Group(GEPCEEX) Minas Gerais State University(UEMG)37902-092 PassosMGBrazil Metabolism Nutrition and Exercise LaboratoryPhysical Education and Sport CenterLondrina State University(UEL)86050-070 LondrinaPRBrazil Postgraduate Program in Physical Education Federal University of Sergipe(UFS)49107-230 Sao CristovaoSEBrazil

Purpose:This meta-analytical study aimed to explore the effects of resistance training(RT) volume on body adiposity,metabolic risk,and inflammation in postmenopausal and older ***:A systematic search was performed for randomized controlled trials in PubMed,Scopus,Web of Science,and *** controlled trials with postmenopausal and older females that compared RT effects on body adiposity,metabolic risk,and inflammation with a control group(CG) were *** reviewers selected the studies,extracted the data,and performed the risk of bias and certainty of the evidence(Grading of Recommendations,Assessment,Development,and Evaluation(GRADE)) *** body and abdominal adiposity,blood lipids,glucose,and C-reactive protein were included for meta-analysis.A random-effects model,standardized mean difference(Hedges’ g),and 95% confidence interval(95%CI) were used for ***:Twenty randomized controlled trials(overall risk of bias:some concerns;GRADE:low to very low) with overweight/obese postmenopausal and older females were *** groups were divided into low-volume RT(LVRT,~44 sets/week) and high-volume RT(HVRT,~77 sets/week).Both RT groups presented improved body adiposity,metabolic risk,and inflammation when compared to ***,HVRT demonstrated higher effect sizes than LVRT for glucose(HVRT=-1.19;95%CI:-1.63 to-0.74;LVRT=-0.78;95%CI:-1.15 to-0.41) and C-reactive protein(HVRT=-1.00;95%CI:-1.32 to-0.67;LVRT=-0.34;95%CI,-0.63 to-0.04)) when compared to ***:Compared to CG,HVRT protocols elicit greater improvements in metabolic risk and inflammation outcomes than LVRT in overweight/obese postmenopausal and older females.

关键词： C-reactive protein Fat mass Lipid profile Menopause Strength training

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Expanding the Boundaries of the Chemical Space of DNA Methyltransferase 1 Modulators

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Computational Molecular Bioscience 2024年第1期14卷 1-16页

作者： Massyel S. Martínez-Cortés Diana L. prado-Romero José L. Medina-Franco DIFACQUIM Research Group Department of Pharmacy School of Chemistry Universidad Nacional Autónoma de México Avenida Universidad 3000 Mexico City México

DNA methyltransferase 1 (DNMT1), one of the main epigenetic targets, is involved in the duplication of the DNA methylation pattern during replication, and it is essential for proper mammalian development. Small molecule DNMT1 modulators are attractive for biochemical epigenetic studies and have the potential to become drugs. So far, more than five hundred small molecules have been reported as DNMT1 inhibitors. However, only a limited number of DNMT1 activators have been disclosed because, at least in part, DNMT1 activators are typically regarded as negative data in virtual screening campaigns or optimization projects. This manuscript aims to report the chemical structures and biological activity of small molecules that increase the enzymatic activity of DNMT1. Results of the biochemical experimental assays are discussed. It was found that small molecule activators have a large variety of chemical scaffolds but share pharmacophore features. Visual analysis of the chemical space and multiverse based on molecular fingertips supported that activators are structurally diverse. This is the first report of eight small molecules that increase the enzymatic activity of DNMT1 by more than 400% in an enzymatic-based assay. The outcome warrants further investigation of the epigenetic activity of the compounds in a counter-screen assay, e.g., cell-based and in vivo context.

关键词： Chemical Multiverse Chemoinformatics Epigenetics Pharmacophore Hypothesis Small Molecules

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The Use of Insulin Negatively Impacts the Mortality of Severe COVID-19 in Patients with Type 2 Diabetes—A Systematic Review

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Journal of Diabetes Mellitus 2024年第3期14卷 166-176页

作者： Caio F. Biolcatti Marcela R. Simoes Thais P. prado Milena Monfort-Pires Licio A. Velloso Obesity and Comorbidities Research Center Campinas Brazil Turku PET Centre University of Turku Turku Finland National Institute of Science and Technology on Neuroimmunomodulation Campinas Brazil

Obesity and type 2 diabetes are among the most important risk factors for severe coronavirus disease-19. Some studies have suggested that the use of insulin as a therapeutic agent to treat hyperglycemia and the metabolic abnormalities associated with type 2 diabetes during the acute phase of severe coronavirus disease-19 could have a negative impact on the disease’s progression;however, there is no consensus on this issue. Here, we performed a systematic review in an attempt to answer this important question. We included 29 articles published from December 2019 to August 2023, which reported the outcomes of 3,070,657 patients with severe coronavirus disease-19 that had the diagnosis of diabetes and were treated with either insulin or other glucose-reducing agents. The results show that using insulin as a pharmacological intervention to treat type 2 diabetes in patients with severe coronavirus disease-19 increases the likelihood of mortality by 193%.

关键词： SARS-CoV2 Obesity Inflammation Metabolism Glucose

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Evaluation of the Antibacterial and Antifungal Capacity of Nanoemulsions Loaded with Synthetic Chalcone Derivatives Di-Benzyl Cinnamaldehyde and Benzyl 4-Aminochalcone

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Journal of Renewable Materials 2024年第2期12卷 285-304页

作者： flavia Oliveira Monteiro da Silva Abreu Taysse Holanda Joice Farias do Nascimento Henety Nascimento Pinheiro Rachel Menezes Castelo Hélcio Silva dos Santos Thais Benincá Patrícia da Silva Malheiros Júlio César Sousa prado Raquel de Oliveira Fontenelle Maria Madalena de Camargo Forte Natural Polymers Laboratory PPGCNState University of CearáFortaleza60.714.903Brazil Polymeric Materials Laboratory PPGE3MFederal University of Rio Grande do SulPorto Alegre91501-970Brazil Natural Product Chemistry Laboratory PPGCNState University of CearáFortaleza60.714.903Brazil Food Hygiene and Microbiology Laboratory PPGCTAFederal University of Rio Grande do SulPorto Alegre91501-970Brazil Microbiology Laboratory Medicine SchoolFederal University of CearáSobral62010-560Brazil

With the increase in antimicrobial resistance,it has become necessary to explore alternative approaches for combating and preventing ***-cinnamaldehyde(CNM)and Benzyl4-amino(B4AM)are bioactive compounds derived from chalcones but with restricted solubility in aqueous *** can enhance the solubility of compounds and can be a promising alternative in the development of novel antimicrobials,with reduced side effects and prolonged *** objective of this study was to evaluate the stability of oil-in-water nanoemulsions loaded with two distinct types of chalcones at two different dosages,to propose a stable formulation with antimicrobial *** showed that nanoemulsions presented high encapsulation efficiency,low polydispersity index(PDI)and particle size below 200 nm,indicating that emulsification was a suitable method for nanoemulsion *** with higher dosages exhibited significant antimicrobial effects when compared to free chalcones and positive ***,B4AM nanoemulsions at higher dosages showed expressive activity against Salmonella minnesota,with a 420%greater inhibitory response compared to the free form and showing equivalence to the positive *** nanoemulsions showed excellent inhibitory activity at the highest dosage,equivalent to the positive control against *** and Staphylococcus *** greater number of conjugated bonds in CNM increased the antimicrobial activity in comparison with B4AM,and the formation of nanometric domains enhanced the bioavailability,being a promising alternative for antimicrobial applications.

关键词： Polysaccharide nanoemulsions S.aureus S.minnesota chalcones alginate

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Increased CO2 Levels during the First Half of Incubation at High Altitude Modifies Embryonic Development of Fertile Leghorn Breeder Eggs

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Food and Nutrition Sciences 2024年第7期15卷 524-547页

作者： Marco A. Juárez-Estrada Erik I. López-Ruiz Sonia López-Cordova Guillermo Tellez-Isaias Omar F. prado-Rebolledo Departamento de Medicina y Zootecnia de Aves Facultad de Medicina Veterinaria y Zootecnia Universidad Nacional Autnoma de Mxico Ciudad de Mxico Mxico Department of Poultry Science Division of Agriculture University of Arkansas Fayetteville USA Facultad de Medicina Veterinaria y Zootecnia Universidad de Colima Tecomn Mxico

The exchange of oxygen (O2) and carbon dioxide (CO2) within an incubator has a significant impact on embryonic development (ED) and hatching processes. This study examines the influence of non-ventilation (NV) conditions during the first ten days of incubation at high altitudes on Leghorn hens hatching eggs. Five hundred four hatching eggs were equally divided into three treatment groups and placed in twelve incubators (R = 4). The first group was subjected to standard ventilated conditions (V) during the setting phase. The ventilation inlet holes of the remaining incubators in the NV treatments were closed with either micropore (M) or polypropylene (P) tape, referred to as NVM and NVP groups, respectively. These two different airtight settings were intended to allow for a gradual rise in CO2 naturally generated by the embryos. Results indicate that carbon dioxide concentration gradually increased during the first half of incubation, reaching 1.42% in the NVM group and 1.20% in the NVP group, while the V condition group remained at 0.15%. From 10 days of incubation onwards, normal V conditions were restored in all incubators. The highest hatchability of fertile eggs (HFE) was shown by the NVP group (55.7%), followed by the V (52.6%) and NVM (38.6%) groups. The NVP group showed a greater yolk-free body mass (YFBM) from 10 days of incubation until the hatch basket transfer. NV conditions during the first 10 days of incubation at high altitude produced higher YFBM with gradually decreasing yolk sac mass. In comparison to the NVM and V conditions, the particular NVP condition showed a beneficial impact on the quality of hatched chicks. Sustaining NVP condition (1.2% of CO2) throughout the first half of incubation at high altitude generated the optimal environment in the incubator ensuring the best hatchability results. This study highlights how important it is for hatchery managers to recognize the influence of low O2 and high levels of CO2 on the development trajectori

关键词： Non-Ventilation Hypercapnia Hypoxia Egg Mass Loss Hatchability Embryonic Mortality Hatchling Chick Quality

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How nerve-sparing technique has been applied to radiotherapy？

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Asian Journal of Andrology 2016年第6期18卷 898-899页

作者： Kris prado Arnold I Chin Department of Urology UCLA Los Angeles CA 90095 USA Broad Stem Cell Research Center UCLA Los Angeles CA 90095 USA Jonsson Comprehensive Cancer Center UCLA Los Angeles CA 90095 USA

The introduction of nerve-sparing technique is one of the most significantadvances in the surgical treatment of prostate cancer and heralded a shift from a curing cancer at all-cost model to a curing cancer and preser... 详细信息

关键词： PROSTATE-CANCER SEXUAL FUNCTION RADIATION IMPOTENCE MRI

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