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Prevalence of Human Leukocyte Antigen HLA-B*5701 in HIV-1 Infected Individuals in Brazil

Open Journal of Genetics 2014年第1期4卷 56-62页

作者： Claudinéia de Araújo Cristina Valetta de Carvalho Miriam Estela de Souza Freire Amanda Yamaguti Ivens Cuiabano Scaff Fernando José de Souza flávia galindo silvestre silva Ricardo Sobhie Diaz Ismael Dale Cotrim Guerreiro da silva Department of Gynecology Molecular Gynecology Laboratory Federal University of S&atildeo Paulo S&atildeo Paulo Brazil State Department of Health of Mato Grosso Cuiabá Brazil Unirondon University Cuiabá Brazil Infectious Diseases Division Federal University of Mato Grosso Cuiabá Brazil Imunogenetics Laboratory General University Hospital Cuiabá Brazil

This study was designed to establish the prevalence of HLA-B*5701 at HIV-1 infected individuals in Brazil. A total of 517 consecutive individuals were followed in this study from February 2009 through July 2011. The presence of HLA-B*5701 was determined by Nested-PCR with HLA-B*57 and HLA-B*5701 sequence-specific primers (PCR-SSP). The expression of HLA-B*57 was negative in the 385 (74.5%) and positive in the 103 (19.9%) of infected individuals. Among these, the expression of HLA-B5701 was positive in the 29 (5.6%) of individuals. No demographic or ethnic differences were found between HLA-B*57/HLA-B*5701 HIV-1 negative patients, with a prevalence of Caucasians (57.1%) individuals. During the period of study, 68 patients were submited to an abacavir contain- ing regimen. The HLA-B*5701 allele was observed in 7 (10.3%) patients, with a significant incidence of Hypersensitivity reactions at 4 of them (p < 0.001). Conclusions: Although Brazilian population consists of a mixture of individuals of Caucasian, African and Native American genetic background, prevalence of HLA-B*5701 in this population is similar to the one found in pure Caucasians.

关键词： Immunogenetics Human Immunodeficiency Virus HLA-B*5701 Antigen Human Abacavir

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Redefining Commercial Bus Models in Brazil

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Journal of Civil Engineering and Architecture 2012年第5期6卷 557-573页

作者： Artur Carlos de Morais Maria Luiza Bastos da silva e galindo Heitor Pereira do Nascimento Wilier Luciano Carvalho Marcos Fleming Balieiro Alves and Joaquim Jose Guilherme de Aragao

Currently, Brazilian buses are divided in three categories： city buses, intercity buses and coaches. That categorization results from the understanding that citizens only need to move around urban perimeters. However, the current bus models available do not fully meet legal demands or cater for all of society＇s demands. Rural workers and students that live in rural areas also must be conveyed in buses and minibuses. Municipal and state directives prohibit employers to convey them in improper vehicles, such as trucks. Social demands, on the other hand, can be i[llustrated by federal and state programs that provide vehicles to transport students who dwell in rural settings. Accordingly, this paper proposes a new categorization of bus models available in the Brazilian market, which should account for the unique local operating conditions rural buses face, instead of only considering the type of service they provide. Further, a purpose-built vehicle is suggested i[n order to cater for the needs of rural workers and students. Rural students represent, in average, five million rural school bus riders.

关键词： Bus models rural matters rural vehicle category.

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Any Hamiltonian System Is Locally Equivalent to a Free Particle

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World Journal of Mechanics 2012年第5期2卷 246-252页

作者： Elizabeth galindo-Linares Esperanza Navarro-Morale Gilberto silva-Ortigoza Román Suárez-Xique Magdalena Marciano-Melchor Ramón silva-Ortigoza Edwin Román-Hernández CIDETEC-IPN. Departamento de Posgrado. área de Mecatrónica. Unidad Profesional Adolfo López Mateos. C.P. México D.F. México Facultad de Ciencias Físico Matemáticas de la Benemérita Universidad Autónoma de Puebla Apartado Postal Puebla Pue. México Universidad del Istmo Departamento de Matemáticas Aplicadas Cd. Universitaria Tehuantepec Oax. México

In this work we use the Hamilton-Jacobi theory to show that locally all the Hamiltonian systems with n degrees of freedom are equivalent. That is, there is a canonical transformation connecting two arbitrary Hamiltonian systems with the same number of degrees of freedom. This result in particular implies that locally all the Hamiltonian systems are equivalent to that of a free particle. We illustrate our result with two particular examples;first we show that the one-dimensional free particle is locally equivalent to the one-dimensional harmonic oscillator and second that the two-dimensional free particle is locally equivalent to the two-dimensional Kepler problem.

关键词： Hamiltonian System Canonical Transformation

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Multiomic investigation of Sugarcane mosaic virus resistance in sugarcane

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The Crop Journal 2023年第6期11卷 1805-1815页

作者： Ricardo JoséGonzaga Pimenta Alexandre Hild Aono Roberto Carlos Villavicencio Burbano Marcel Fernando da silva Ivan Antônio dos Anjos Marcos Guimarães de Andrade Landell Marcos Cesar Gonçalves Luciana Rossini Pinto Anete Pereira de Souza Centre for Molecular Biology and Genetic Engineering University of CampinasCampinasBrazil Gustavo galindo Velasco Campus Littoral Polytechnic Superior SchoolGuayaquilEcuador Advanced Centre for Technological Research in Sugarcane Agribusiness Agronomic Institute of CampinasRibeirão PretoBrazil Plant Protection Research Centre Biological InstituteSão PauloBrazil Department of Plant Biology Institute of BiologyUniversity of CampinasCampinasBrazil

Sugarcane mosaic virus(SCMV)is the main etiological agent of sugarcane mosaic disease,which affects sugarcane and other grass *** the extensive characterization of quantitative trait loci controlling resistance to SCMV in maize,the genetic basis of this trait in sugarcane is largely ***,a genome-wide association study was performed and machine learning coupled with feature selection was used for genomic prediction of resistance to SCMV in a diverse sugarcane *** single-nucleotide polymorphisms(SNPs)explained up to 29.9%of the observed phenotypic variance and a 73-SNP set predicted resistance with high accuracy,precision,recall,and F1 scores(the harmonic mean of precision and recall).Both marker sets were validated in additional sugarcane genotypes,in which the SNPs explained up to 23.6%of the phenotypic variation and predicted resistance with a maximum accuracy of 69.1%.Synteny analyses suggested that the gene responsible for the majority of SCMV resistance in maize is absent in sugarcane,explaining why this major resistance source has not been identified in this ***,using sugarcane RNA-Seq data,markers associated with resistance to SCMV were annotated,and a gene coexpression network was constructed to identify the predicted biological processes involved in *** network allowed the identification of candidate resistance genes and confirmed the involvement of stress responses,photosynthesis,and the regulation of transcription and translation in resistance to *** results provide a practical marker-assisted breeding approach for sugarcane and identify target genes for future studies of SCMV resistance.

关键词： Saccharum SCMV GWAS Machine learning RNA-Seq

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吡罗喜康引起的固定性药疹

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世界核心医学期刊文摘（皮肤病学分册） 2005年第2期1卷 55-55页

作者： galindo E.C. Buj'an J.J.G. silva J.M.G. 张宪旗 Department ofDermatology Hospital JuanCanalejo C/Xubias deArriba 84 15006ACoru.na Spain

The pathogenetic mechanism of fixed drug eruption (FDE) is still unknown. One of the most common causes of FDE is the use of nonsteroidal antiinflammatory drugs (NSAIDs). Oxicams are in the NSAID group and piroxicam is one of the most used of these drugs. FDE caused by piroxicam is rare but a few cases have been reported. Patch tests are useful for diagnosing some cases of FDE; they give variable results on previously affected skin while no reaction appears on unaffected skin. Some cases of cross-sensitivity among piroxicam and other substances have been reported. We report two new cases of FDE due to piroxicam with negative patch test on normal skin and positive results on affected skin.

关键词：固定性药疹皮肤斑贴试验吡罗昔康交叉过敏抗感染药 NSAID 发病机制

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