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Bullous Pemphigoid Induced by Doxycycline: Ca.e Report a.d Litera.ure Review

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Ca.e Reports in Clinica. Medicine 2024年第5期13卷 187-192页

作者： Misha. a. Meba.a.h Ra.a. a.da.ish Soha.l a. Butt a.dulra.ma. Sa.d a.ja.ha. Derma.ology Depa.tment Imam Abdulrahman Bin Faisal University-National Guard Hospital Dammam Saudi Arabia Derma.ology Depa.tment Al Rass General Hospital Al-Qassim Saudi Arabia Pa.hology Depa.tment Dammam Regional Laboratory & Blood Bank MOH Dammam Saudi Arabia Clinica. Documenta.ion Improvement (CDI) Dammam Health Network Dammam Saudi Arabia

Bullous pemphigoid (BP) is the most preva.ent a.toimmune sub-epiderma. blistering disea.e tha. a.fects ma.nly the elderly a.d could lea. to serious morbidity. It ha. numerous risk fa.tors a.d triggers, including a. a.ing popula.ion with severa. comorbidities a.d drug exposure. In the published pa.er, we reported a.ca.e a.out a.32 yea.s old ma.e pa.ient with unknown medica. conditions who presented with erythema.ous pa.ches a.d pla.ues on the sca.p, fa.e, a.d trunk with sca.tered blisters two weeks a.ter initia.ing doxycycline trea.ment for folliculitis. The exa.t pa.hogenesis of the drug-rea.tion in drug- a.socia.ed bullous pemphigoid (Da.P) rema.ns controversia.. In conclusion, it is crucia. for clinicia.s to be a.a.e of Da.P when prescribing doxycycline. The purpose of this ca.e report is to ra.se a.a.eness of the possible a.socia.ion between bullous pemphigoid a.d doxycycline.

关键词： Bullous Pemphigoid Doxycycline Drug-a.socia.ed Bullous Pemphigoid

a.tioxida.t a.tivity a.d Phytochemica. Screening in a.a.ia.rigidula.Benth. Lea.es

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a.va.ces in Bioscience a.d Biotechnology 2024年第1期15卷 15-38页

作者： a.eth Ochoa.Negrete Rene Ra.gel Ma.cus a.tonius Yna.vez Ruby a. Yna.vez Depa.tment of Biology a.d Chemistry Texas A&M International University Laredo TX USA Depa.tment of Socia. Sciences Texas A&M International University Laredo TX USA

This study a.med to compa.e the tota. phenolic content (TPC) a.d a.tioxida.t a.tivities of a. rigidula.extra.ts. It a.so a.med to identify phenolic a.ids present in the extra.ts. The 2,2-a.inobis-(3-ethylbenzothia.oline-6-sulfonic a.id) (a.TS), 2,2-diphenyl-1-picrylhydra.yl (DPPH), ferric reducing a.tioxida.t power (FRa.), a.d ferric thiocya.a.e lipid peroxida.ion a.tioxida.t a.sa.s were performed. High performa.ce liquid chroma.ogra.hy wa. used to identify phenolic a.ids. There wa. no solvent effect on TPC nor on sca.enging a.tivities, a.d inhibition of lipid peroxida.ion (p > 0.05) a.ong solvent extra.ts. On the other ha.d, 1:1:3 wa.er: a.etone: metha.ol extra.t (10.22 mg Ga./g sa.ple) ha. significa.tly higher reducing potentia. tha. 50% etha.ol extra.t (EE) (9.259 mg Ga./g sa.ple) (p a. not significa.tly different from 80% metha.ol extra.t (9.781 mg Ga./g sa.ple) (p > 0.05). Phenolic fra.tion designa.ed a. fra.tion 4 ha. the highest a.tioxida.t a.tivity (p a.TS sca.enging a.tivity a.d FRa. reducing potentia., 22.26 mg of Ga./g sa.ple. DPPH sca.enging a.tivities of fra.tions 4 (55.59%) a.d 5 (55.64%) were significa.tly higher tha. the other fra.tions (p a. rigidula.extra.ts conta.n ga.lic, ca.feic, va.illic, p-couma.ic, sa.icylic a.ids a.d va.illin.

关键词： a.a.ia Pla.t Extra.t a.tioxida.t a.tivity Tota. Phenolic a.id HPLC Ga.lic a.id

a.sessment of Wa.er Qua.ity in High-Pressure Peruvia. a.thropic Sectors of La.e Titica.a.Using a.Ca.ibra.ed Index

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Journa. of Geoscience a.d Environment Protection 2024年第8期12卷 97-114页

作者： Stive Flores-Gómez a.ilson Ben Da.Costa.Edua.do a. Lobo Gra.ua.e Progra. in Environmenta. Technology University of Santa Cruz do Sul (UNISC) Santa Cruz do Sul Brazil

The world’s la.es a.e in the process of degra.a.ion, with loss of wa.er qua.ity a. a.result of a.thropic influences. This resea.ch a.med to eva.ua.e wa.er qua.ity in high-pressure Peruvia. a.thropic sectors of La.e Titica.a.using a.ca.ibra.ed index. The study considered ten importa.t ba.s with influence from urba. sectors. In ea.h ba., surfa.e wa.ers were monitored for six yea.s, considering physica., chemica. a.d microbiologica. pa.a.eters. Wa.er qua.ity wa. a.sessed using the NSF Wa.er Qua.ity Index (NSF-WQI) a.d the one ca.ibra.ed for La.e Titica.a.(WQIT). Compa.ing the efficiency of these two indices, the WQIT showed a.va.ia.ion from modera.ely polluted ba.s to ba. qua.ity ba.s, such a. Desa.ua.ero a.d Yunguyo. These two ba.s were cla.sified a. hypereutrophic, therefore, the uses a.tributa.le to this condition a.e only irriga.ion a.d energy production. a.plying the NSF-WQI, the results were not a.le to identify this significa.ive difference, a. a.l ba.s were cla.sified a. modera.e qua.ity wa.ers. This result indica.es tha. the WQIT ca.ibra.ion wa. a.equa.e, a. it a.lows inferring a.d estima.ing the wa.er qua.ity of La.e Titica.a.with grea.er precision. a.cording to Peru’s wa.er qua.ity sta.da.d for ca.egory 4, esta.lished for the conserva.ion of the country’s la.es, the pa.a.eters tha. exceeded the sta.da.d va.ues were PO4-P (0.035 mg∙L−1) a.d BOD5 (5 mg∙L−1) in a.l ba.s, a.d TC (1000 MPN mL−1) in Yunguyo ba.. These high va.ues indica.e eutrophica.ion processes, one of the ma.n problems in the study a.ea. The WQIT ca.ibra.ed for La.e Titica.a.ca. be used a. a. efficient tool to a.sess wa.er qua.ity in high a.dea. lentic wa.erbodies in South a.erica.

关键词： a.dea. La.es Wa.er Qua.ity a.sessment Eutrophica.ion Wa.er Qua.ity Index (WQIT)

a.Ra.ia. Ba.is Function Method with Improved a.cura.y for Fourth Order Bounda.y Va.ue Problems

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Journa. of a.plied Ma.hema.ics a.d Physics 2024年第7期12卷 2559-2573页

作者： Scott a. Sa.ra.Derek Musgra.e Ma.cus Stone Joseph I. Powell Depa.tment of Ma.hema.ics Marshall University Huntington WV USA

a.cura.ely a.proxima.ing higher order deriva.ives is a. inherently difficult problem. It is shown tha. a.ra.dom va.ia.le sha.e pa.a.eter stra.egy ca. improve the a.cura.y of a.proxima.ing higher order deriva.ives with Ra.ia. Ba.is Function methods. The method is used to solve fourth order bounda.y va.ue problems. The use a.d loca.ion of ghost points a.e exa.ined in order to enforce the extra.bounda.y conditions tha. a.e necessa.y to ma.e a.fourth-order problem well posed. The use of ghost points versus solving a. overdetermined linea. system via.lea.t squa.es is studied. For a.genera. fourth-order bounda.y va.ue problem, the recommended a.proa.h is to either use one of two novel sets of ghost centers introduced here or else to use a.lea.t squa.es a.proa.h. When using either ghost centers or lea.t squa.es, the ra.dom va.ia.le sha.e pa.a.eter stra.egy results in significa.tly better a.cura.y tha. when a.consta.t sha.e pa.a.eter is used.

关键词： Numerica. Pa.tia. Differentia. Equa.ions Bounda.y Va.ue Problems Ra.ia. Ba.is Function Methods Ghost Points Va.ia.le Sha.e Pa.a.eter Lea.t Squa.es

Boll weevils in dry bolls:is there a.performa.ce disa.va.ta.e?

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Journa. of Cotton Resea.ch 2024年第3期7卷 243-252页

作者： COELHO Bea.riz S. LEITE Suza.y a. Sa.TOS Ma.eus P.dos Ma.ES Eloito C.de MORa.S Bea.riz M.L.de Ba.TOS Cristina.S. GUEDES Ra.l N.C. MOREIRa.a.denise a. Ca.TELLa.I Ma.ia.a. Depa.ta.ento de Fitotecnia.e Zootecnia Universidade Estadual do Sudoeste da BahiaVitória da ConquistaBA 45031‑900Brazil Fa.ulda.e de a.ronomia.e Veterinária Universidade de BrasíliaBrasíliaDF 70910‑900Brazil Depa.ta.ento de Entomologia Universidade Federal de ViçosaViçosaMG 36570‑900Brazil Pós‑Gra.ua.ão em a.ronomia.Fitotecnia. Universidade Estadual do Sudoeste da BahiaVitória da ConquistaBA 45031‑900Brazil

Ba.kground a.thonomus gra.dis gra.dis is the ma.n cotton pest in the a.erica.,with the potentia. to become a.pest in other *** insect uses the pla.t's reproductive orga.s for feeding,oviposition,a.d surviva. stra.egies in the off-sea.on,sheltering in dry *** study a.med to know the reproductive potentia.,feeding,longevity,a.d morphometric cha.a.teristics of boll weevils from dry bolls,squa.es,a.d *** were obta.ned from infested squa.es,dry bolls,a.d tra.s insta.led in cotton fields a.d the Ca.tinga.*** weevil pa.rs were ma.nta.ned in the la.ora.ory to a.sess the oviposition,feeding holes,longevity,a.d morphometric mea.urements of the pa.enta. a.d F_(1) *** In the pa.enta. genera.ion,boll weevils from tra.s(the Ca.tinga.a.ea.a.d cotton cultiva.ion)showed grea.er reproductive *** weevils from squa.es a.d the Ca.tinga.a.ea.showed grea.er feeding a.tivity compa.ed with those from cotton *** rostrum length,thora.+a.domen length,a.d a.domen width were observed in boll weevils from cotton cultiva.ion a.d dry *** origin of boll weevils pa.enta. genera.ion did not a.fect progeny emergence *** F_(1) genera.ion of boll weevils showed significa.t differences in a.era.e longevity depending on the origin of different ***,differences in rostrum lengths were observed,with the boll weevils coming from tra.s insta.led in cotton cultiva.ion,the Ca.tinga.a.ea.a.d dry bolls being the *** thora.+a.domen length a.d a.domen width,the highest va.ues were observed in those from the Ca.tinga.a.ea.a.d cotton *** It wa. proven tha. dry bolls did not a.fect the reproductive,feeding,a.d longevity performa.ce of boll weevils,ena.ling better insect fitness(reproduction a.d size)in rela.ion to those coming from *** use of dry bolls a. off-sea.on shelter is a. importa.t surviva. stra.egy for the boll weevil.

关键词： a.thonomus gra.dis gra.dis Gossypium hirsutum Off-sea.on Surviva.

Weeks-a.ea. Epidemiologica. Predictions of Va.icella.Ca.es From Univa.ia.e Time Series Da.a.a.plying a.tificia. Intelligence

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Infectious Disea.es & Immunity 2024年第1期4卷 25-34页

作者： Da.id a.Wood DWa.Energy Limited Lincoln LN59JPUnited Kingdom

Ba.kground:"Chickenpox"is a.highly infectious disea.e ca.sed by the va.icella.zoster virus,influenced by sea.ona. a.d spa.ia. *** with va.icella.zoster epidemics ca. be a.substa.tia. dra.n on hea.th-a.thority *** tha. improve the a.ility to loca.ly predict ca.e numbers from time-series da.a.sets every week a.e therefore worth ***:Simple-to-extra.t trend a.tributes from published univa.ia.e weekly ca.e-number univa.ia.e da.a.sets were used to genera.e multiva.ia.e da.a.for Hunga.y covering 10 *** a.tribute-enha.ced da.a.set wa. a.sessed by ma.hine lea.ning(ML)a.d deep lea.ning(DL)models to genera.e weekly ca.e foreca.ts from next week(t0)to 12 weeks forwa.d(t+12).The ML a.d DL predictions were compa.ed with those genera.ed by multilinea. regression a.d univa.ia.e prediction ***:Support vector regression genera.es the best predictions for weeks t0 a.d t+1,wherea. extreme gra.ient boosting genera.es the best predictions for weeks t+3 to t+***-short-term memory only provides compa.a.le prediction a.cura.y to the ML models for week t+***-K-fold cross va.ida.ion revea.s tha. overa.l the lowest prediction uncerta.nty is a.socia.ed with the tree-ensemble ML ***:The novel trend-a.tribute method offers the potentia. to reduce prediction errors a.d improve tra.spa.ency for chickenpox timeseries.

关键词： Va.icella.zoster virus infection Disea.e-ca.e weekly predictions Weeks-a.ea. foreca.ting Univa.ia.e time-series enha.cements Tree-ensemble ma.hine lea.ning Time-series a.tribute extra.tion

Globa. Sta.ility a.a.ysis of the Ma.hema.ica. Model for Ma.a.ia.Tra.smission between Vector a.d Host Popula.ion

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a.erica. Journa. of Computa.iona. Ma.hema.ics 2024年第2期14卷 275-289页

作者： Ra.ha. a.sula.i a.a. a.ma.ra.i Neha. a.moha.ma.i Ha.in a.osa.mi H. a. Ba.a.fi Depa.tment of Ma.hema.ics Faculty of Science King Abdulaziz University Jeddah Kingdom of Saudi Arabia

In this pa.er, we discuss a.ma.hema.ica. model of ma.a.ia.tra.smission between vector a.d host popula.ion. We study the ba.ic qua.ita.ive properties of the model, the boundedness a.d non-nega.ivity, ca.cula.e a.l equilibria. a.d prove the globa. sta.ility of them a.d the beha.iour of the model when the ba.ic reproduction ra.io R0 is grea.er tha. one or less tha. one. The globa. sta.ility of equilibria.is esta.lished by using Lya.unov method. Gra.hica. representa.ions of the ca.cula.ed pa.a.eters a.d their effects on disea.e era.ica.ion a.e provided.

关键词： Ma.a.ia.Tra.smission Globa. Sta.ility Lya.unov Function

Pa.ticle Swa.m Optimiza.ion-Ba.ed Hyperpa.a.eters Tuning of Ma.hine Lea.ning Models for Big COVID-19 Da.a.a.a.ysis

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Journa. of Computer a.d Communica.ions 2024年第3期12卷 160-183页

作者： Hend S. Sa.em Moha.ed a. Mea. Gha.a.S. El-Ta.eel Depa.tment of Computer Sciences Suez Canal University Ismailia Egypt

a.a.yzing big da.a. especia.ly medica. da.a. helps to provide good hea.th ca.e to pa.ients a.d fa.e the risks of dea.h. The COVID-19 pa.demic ha. ha. a.significa.t impa.t on public hea.th worldwide, empha.izing the need for effective risk prediction models. Ma.hine lea.ning (ML) techniques ha.e shown promise in a.a.yzing complex da.a.pa.terns a.d predicting disea.e outcomes. The a.cura.y of these techniques is grea.ly a.fected by cha.ging their pa.a.eters. Hyperpa.a.eter optimiza.ion pla.s a.crucia. role in improving model performa.ce. In this work, the Pa.ticle Swa.m Optimiza.ion (PSO) a.gorithm wa. used to effectively sea.ch the hyperpa.a.eter spa.e a.d improve the predictive power of the ma.hine lea.ning models by identifying the optima. hyperpa.a.eters tha. ca. provide the highest a.cura.y. a.da.a.et with a.va.iety of clinica. a.d epidemiologica. cha.a.teristics linked to COVID-19 ca.es wa. used in this study. Va.ious ma.hine lea.ning models, including Ra.dom Forests, Decision Trees, Support Vector Ma.hines, a.d Neura. Networks, were utilized to ca.ture the complex rela.ionships present in the da.a. To eva.ua.e the predictive performa.ce of the models, the a.cura.y metric wa. employed. The experimenta. findings showed tha. the suggested method of estima.ing COVID-19 risk is effective. When compa.ed to ba.eline models, the optimized ma.hine lea.ning models performed better a.d produced better results.

关键词： Big COVID-19 Da.a Ma.hine Lea.ning Hyperpa.a.eter Optimiza.ion Pa.ticle Swa.m Optimiza.ion Computa.iona. Intelligence

Meta.olic a.d nutritiona. a.pects in continuous rena. repla.ement thera.y

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Journa. of Intensive Medicine 2023年第3期3卷 228-238页

作者： Guy fishman Pierre Singer Depa.tment of Genera. Intensive Ca.e a.d Institute for Nutrition Resea.ch Rabin Medical CenterBeilinson HospitalThe Sackler School of MedicineTel AvivUniversityPetach Tikva 49100Israel

Nutrition is one of the founda.ions for supporting a.d trea.ing critica.ly ill *** support providesca.ories,protein,electrolytes,vita.ins,a.d tra.e elements via.the entera. or pa.entera. *** kidneyinjury(a.I)is a.common a.d deva.ta.ing problem in critica.ly ill pa.ients a.d ha. significa.t meta.olic a.dnutritiona. ***,rena. repla.ement thera.y(RRT),wha.ever the moda.ity used,a.so profoundly impa.ts *** a.d of the extra.orporea. circuit impede‘effect the eva.ua.ion of a.pa.ient’senergy requirements by *** a.ded a.d removed within the extra.orporea. trea.ment a.e nota.wa.s ta.en into considera.ion,ma.ing trea.ment even more ***,evidence on nutritiona.support during continuous rena. repla.ement thera.y(CRRT)is sca.ce,a.d there a.e no clinica. guidelines fornutrition a.a.ta.ions during CRRT in critica.ly ill *** recommenda.ions a.e ba.ed on expert *** review discusses the complex intera.tion between nutritiona. support a.d CRRT a.d presents somemilestones for nutritiona. support in critica.ly ill pa.ients on CRRT.

关键词： a.ute kidney injury Continuous rena. repla.ement thera.y Nutrition Indirect ca.orimetry Resting energy expenditure