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journal of Innovative Optical Health Sciences 2015年第1期8卷 40-59页

作者： Carl j.fisher Lothar Lilge Department of Medical Biophysics University of Toronto Princess Margaret Cancer Centre 101 College StRm.15-710 TorontoON M5G 1L7 University Health Network Princess Margaret Cancer Centre 101 College St Rm.15-310TorontoON M5G 1L7

Invasive grade III and IV maliguant gliomas remain difficult to treat with a typical survival time post-diagnosis hovering around 16 months with only minor extension thereof seen in the past decade,whereas some improvements have been obtained towards five-year survival rates for which completeness of resection is a *** techniques such as fluorescence guided resection(FGR)and photodynamic therapy(PDT)are promising adjuvant techniques to in-crease the tumor volume reduction *** has been used in combination with surgical resection or alternatively as standalone treat ment strategy with some sucoess in extending the median survival time of patients compared to surgery alone and the current standard of *** document reviews the outcome of past clinical trials and highlights the general shift in PDT therapeutic *** also looks at the current approaches for interstitial PDT and research options into increasing PDT's glioma treatment fficacy through exploiting both physical and biological based approaches to maximize PDT selectivity and therapeutic index,particularly in brain adjacent to tumor(BAT).Potential reasons for failing to demonstrate a significant survival advantage in prior PDT clinical trials will become evident in light of the improved understanding of glioma biology and PDT dosimetry.

关键词： Oncology brain tumour photodynamic dose therapeutic index photofin aminolu-velinic acid

Reservoir stress path and induced seismic anisotropy： results from linking coupled fluid-flow/geomechanical simulation with seismic modelling

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Petroleum Science 2016年第4期13卷 669-684页

作者： D.A.Angus Q.j.fisher j.M.Segura j.P.Verdon j.-M.Kendall M.Dutko A.j.L.Crook School of Earth and Environment University of LeedsLeeds UK Formerly School of Earth and Environment University of Leeds Leeds UK Department of Earth Sciences University of Bristol BristolUK Rockfield Software Ltd. Swansea UK Three Cliffs Geomechanics Swansea UK Repsol Madrid Spain ESG Solutions Kingston Canada

We present a workflow linking coupled fluid-flow and geomechanical simulation with seismic modelling to predict seismic anisotropy induced by non-hydrostatic stress changes. We generate seismic models from coupled simulations to examine the relationship between reservoir geometry, stress path and seismic anisotropy. The results indicate that geometry influences the evolution of stress,which leads to stress-induced seismic anisotropy. Although stress anisotropy is high for the small reservoir, the effect of stress arching and the ability of the side-burden to support the excess load limit the overall change in effective stress and hence seismic anisotropy. For the extensive reservoir, stress anisotropy and induced seismic anisotropy are high. The extensive and elongate reservoirs experience significant compaction, where the inefficiency of the developed stress arching in the side-burden cannot support the excess *** elongate reservoir displays significant stress asymmetry,with seismic anisotropy developing predominantly along the long-edge of the reservoir. We show that the link betweenstress path parameters and seismic anisotropy is complex,where the anisotropic symmetry is controlled not only by model geometry but also the nonlinear rock physics model used. Nevertheless, a workflow has been developed to model seismic anisotropy induced by non-hydrostatic stress changes, allowing field observations of anisotropy to be linked with geomechanical models.

关键词： Coupled fluid-flow/geomechanics Reservoir characterization Seismic anisotropy Stress path

Tunable catalytic activity of gadolinium-doped ceria nanoparticles for pro-oxidation of hydrogen peroxide

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Nano Research 2020年第9期13卷 2384-2392页

作者： Anuja Bhalkikar Tai-Sing Wu Tamra j.fisher Anandakumar Sarella Dawei Zhang Yi Gao Yun-Liang Soo Chin Li Cheung Department of Chemistry University of Nebraska-LincolnLincolnNE 68588USA Department of Physics "National Tsing Hua University"Hsinchu 30013TaiwanChina Nebraska Center for Materials and Nanoscience University of Nebraska-LincolnLincolnNEB 68588USA Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China "National Synchrotron Radiation Research Centre" Hsinchu 30076TaiwanChina

We report a study of the roles of gadolinium(lll)(Gd3+)dopants in influencing the catalytic activity of gadolinium-doped ceria nanoparticles towards the pro-oxidation of hydrogen peroxide to hydroxyl *** doped ceria nanoparticles with dopant concentrations of 0.6 wt.%,3 wt.%,and 6 wt.%Gd^3+were synthesized using an ozone-mediated method for tuning their catalytic *** Gd dopants were found to foster an increase in the percentage of Ce^3+ions in the doped ceria *** reaction kinetic study revealed that the relationship between the overall reaction rates and the Gd dopant concentrations in our doped materials followed a volcano-like *** contrast,the apparent activation energy values of these Gd-doped ceria nanoparticles were found to be positively associated with the concentrations of Gd *** overall catalytic activity trend was attributed to the interplay between the promotion and degradation effects of the Gd dopants on the properties of doped ceria nanoparticles.

关键词： ceria cerium oxide gadolinium pro-oxidation hydrogen peroxide hydroxyl radicals ozone

A new challenge for expert witnesses relying on subjective information

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Forensic Sciences Research 2017年第3期2卷 113-114页

作者： Barry A j fisher Crime Lab Los Angeles County Sheriff’s DepartmentIndioCAUSA

Forensic Scientists increasingly face challenges when testifying about pattern evidence.“Pattern evidence”here denotes fingerprint evidence,firearms,tool marks,footwear,tire impressions,handwriting,bite marks,*** question whether experts using only subjec-tive information can provide the court with reliable *** maintain that objective data,meaning statistics,is necessary for the expert to form an opinion in court *** critics have used the depreciatory term“junk science”to suggest that certain forensic science disciplines have little or no validity and should no longer be used.

关键词： maintain lying marks

感知生物多样性、感知声环境、感知自然度和安全感强化了新热带界城市蓝绿空间的恢复力质量和福祉效益

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城市规划学刊 2022年第1期 125-126页

作者： fisher j C IRVINE K N BICKNELL j E 吴双同济大学建筑与城市规划学院

快速城镇化带来的噪声、环境污染和犯罪率上升对城市居民的身心健康形成威胁，而城市中的蓝绿空间已被证明是降低健康风险的良方。“注意力恢复理论（Attention Restoration Theory,ART）”“压力恢复理论（Stress Reduction Theory,SR...

快速城镇化带来的噪声、环境污染和犯罪率上升对城市居民的身心健康形成威胁，而城市中的蓝绿空间已被证明是降低健康风险的良方。“注意力恢复理论（Attention Restoration Theory,ART）”“压力恢复理论（Stress Reduction Theory,SRT）”“亲自然假说（Biophilia）”等几种主流理论解释了蓝绿空间对健康福祉的益处。大量的实证研究验证了这些假说，但生物多样性对人类福祉的促进作用仍不清晰，各种研究中结论的不一致性以及变量测度的差异性使得对现有研究成果的解读变得复杂。

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Crystal structure of PqqB from <i>Pseudomonas putida</i>at 2.2 Åresolution

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journal of Biophysical Chemistry 2012年第2期3卷 206-210页

作者： Moritz Metlitzky Sandra Puehringer Stuart j. fisher Department of Molecular Biology University of Salzburg Salzburg Austria

Pyrroloquinoline quinone (PQQ) is an important redox-active cofactor for many bacterial dehy-drogenases. It's biosynthetic pathway involves six or seven genes, one of which is pqqB. Former studies indicated that the protein encoded by pqqB, namely PqqB, functions as a PQQ transporter. Here we report the crystal structure of PqqB from Pseudomonas putida at 2.2 ? resolution together with functional studies to verify this theory.

关键词： PqqB PQQ Biosynthetic Pathway X-Ray Crystallography

Discovery of Thioether-bridged Cyclic Pentapeptides Binding to Grb2-SH2 Domain with High affinity

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Discovery of Thioether-bridged Cyclic Pentapeptides Binding ...

Exploring Trends in Microcrack Properties of Sedimentary Rocks: An Audit of Dry and Water Saturated Sandstone Core Velocity–Stress Measurements

中国化学会第26届学术年会化学生物分会场

作者： Robert j. fisher Peter P. Roller Laboratory of Protein Chemistry SAIC-Frederick Frederick MD 21702 USA Laboratory of Medicinal Chemistry NCI NIH Frederick MD 21702 USA

Growth factor receptor-bound protein 2 （Grb2） is an essential intracellular adapter protein, consisting of one SH2 domain flanked by two SH3 domains. Grb2-SH2 domain mediates the activation of mitogenic Ras activation pathway through binding to a range of tyrosine-phosphorylated motifs on growth factor receptors such as the epidermal growth factor receptor （EGFR） and erbB2. An aberrant Grb2-depedent Ras activation pathway has been shown to be essential for cellular transformation in a subset of human tumors. Overexpression of Grb2 protein is also related to liver tumorigenesis in mice and human breast cancer cells. Therefore, molecules that can selectively inhibit the linkage of Grb2-SH2 domain to phosphorylated receptors are expected to be useful for the treatment and/or prevention of hyperproliferative diseases such as leukemias, breast and overian cancers. Based upon global modifications, a highly potent peptide ligand 8 was discovered with a Kd=0.36 μM, evaluated by Biacore binding assay.

关键词： Grb2-SH2 domain cyclic peptides G1TE analogs Phosphotyrosine Grb2-SH2 antagonist

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International journal of Geosciences 2012年第4期3卷 822-833页

作者： Doug A. Angus Quentin j. fisher james P. Verdon University of Bristol University of Leeds

Stress dependent rock physics models are being used more routinely to link mechanical deformation and stress perturbations to changes in seismic velocities and seismic anisotropy. In this paper, we invert for the effective non-linear microstructural parameters of 69 dry and saturated sandstone core samples. We evaluate the results in terms of the model input parameters of two non-linear rock physics models: A discrete and an analytic microstructural stress-dependent formulation. The results for the analytic model suggest that the global trend of the initial crack density is lower and initial aspect ratio is larger for the saturated samples compared to the corresponding dry samples. The initial aspect ratios for both the dry and saturated samples are tightly clustered between 0.0002 and 0.001, whereas the initial crack densities show more scatter. The results for the discrete model show higher crack densities for the saturated samples when compared to the corresponding dry samples. With increasing confining stress the crack densities decreases to almost identical values for both the dry and saturated samples. A key result of this paper is that there appears to be a stress dependence of the compliance ratio BN/BT within many of the samples, possibly related to changing microcrack geometry with increasing confining stress. Furthermore, although the compliance ratio BN/BT for dry samples shows a diffuse distribution between 0.4 and 2.0, for saturated samples the distribution is very tightly clustered around 0.5. As confining stresses increase the compliance ratio distributions for the dry and saturated samples become more diffuse but still noticeably different. This result is significant because it reaffirms previous observations that the compliance ratio can be used as an indicator of fluid content within cracks and fractures. From a practical perspective, an overarching purpose of this paper is to investigate the range of input parameters of the microstructural models

关键词： Compliance Ratio Microcrack Properties Saturated Stress Dependent Velocities Ultrasonic

高交联聚乙烯与钴铬合金和陶瓷股骨头匹配使用的磨损和蠕变

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中华骨科杂志 2011年第4期31卷 408-412页

作者： Galvin AL jennings LM Tipper jL Ingham E fisher j 英国利兹大学生物医学工程学院

髋关节骨关节炎患者进行金属对超高分子量聚乙烯（ul tra-high molecular weight polyethylene,UHMWPE）的全髋关节置换是二十世纪最为成功的外科手术之一.据文献报道使用UHMWPE衬垫的骨水泥假体20年成功率达到75%以上[1].

关键词：超高分子量聚乙烯匹配使用钴铬合金股骨头蠕变磨损陶瓷交联

Development of Monodispersed Polymeric Media for Purification and Analysis of Biomacromolecules

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Development of Monodispersed Polymeric Media for Purificatio...