检索结果-南通市图书馆

Regulator of G protein signaling 6 mediates exercise-induced recovery of hippocampal neurogenesis,learning,and memory in a mouse model of Alzheimer’s disease

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第10期20卷 2969-2981页

作者： Mackenzie M.Spicer Jianqi Yang Daniel Fu Alison N.DeVore Marisol Lauffer Nilufer S.Atasoy Deniz Atasoy Rory A.fisher Department of Neuroscience and Pharmacology University of Iowa Carver College of MedicineIowa CityIAUSA Iowa Neuroscience Institute University of Iowa Carver College of MedicineIowa CityIAUSA Interdisciplinary Graduate Program in Molecular Medicine University of Iowa Carver College of MedicineIowa CityIAUSA Neural Circuits and Behavior Core University of Iowa Carver College of MedicineIowa CityIAUSA

Hippocampal neuronal loss causes cognitive dysfunction in Alzheimer’s *** hippocampal neurogenesis is reduced in patients with Alzheimer’s *** stimulates adult hippocampal neurogenesis in rodents and improves memory and slows cognitive decline in patients with Alzheimer’s ***,the molecular pathways for exercise-induced adult hippocampal neurogenesis and improved cognition in Alzheimer’s disease are poorly ***,regulator of G protein signaling 6(RGS6)was identified as the mediator of voluntary running-induced adult hippocampal neurogenesis in ***,we generated novel RGS6fl/fl;APP_(SWE) mice and used retroviral approaches to examine the impact of RGS6 deletion from dentate gyrus neuronal progenitor cells on voluntary running-induced adult hippocampal neurogenesis and cognition in an amyloid-based Alzheimer’s disease mouse *** found that voluntary running in APP_(SWE) mice restored their hippocampal cognitive impairments to that of control *** cognitive rescue was abolished by RGS6 deletion in dentate gyrus neuronal progenitor cells,which also abolished running-mediated increases in adult hippocampal *** hippocampal neurogenesis was reduced in sedentary APP_(SWE) mice versus control mice,with basal adult hippocampal neurogenesis reduced by RGS6 deletion in dentate gyrus neural precursor ***6 was expressed in neurons within the dentate gyrus of patients with Alzheimer’s disease with significant loss of these RGS6-expressing ***,RGS6 mediated voluntary running-induced rescue of impaired cognition and adult hippocampal neurogenesis in APP_(SWE) mice,identifying RGS6 in dentate gyrus neural precursor cells as a possible therapeutic target in Alzheimer’s disease.

关键词： adult hippocampal neurogenesis Alzheimer’s disease dentate gyrus exercise learning/memory neural precursor cells regulator of G protein signaling 6(RGS6)

FIXED POINT THEOREMS FOR MAPPINGS SATISFYING IMPLICIT RELATION ON TWO COMPLETE AND COMPACT METRIC SPACES

在线全文

学校读者我要写书评

暂无评论

Applied Mathematics and Mechanics(English Edition) 2006年第9期27卷 1217-1222页

作者： Abdlkrim Aliouche Brian fisher Department of Mathematics University of Lari Ben M'Hidi Oum EI Bouaghi 04000 Algria Department of Mathematics University of Leicester Leicester LE1 7RHU. K.

First, the implicit relations were given. A common fixed point theorem was proved for two mappings satisfying implicit relation functions. A further fixed point theorem was proved for mappings satisfying implicit rela... 详细信息

关键词： complete metric space compact metric space fixed Points implicit relation

Are claudin-5 tight-junction proteins in the blood-brain barrier porous?

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2020年第10期15卷 1838-1839页

作者： David fisher Shireen Mentor Department of Medical Biosciences University of the Western CapeBellvilleCape TownSouth Africa School of Health Professions University of MissouriColumbiaMOUSA

The capillaries of the brain are particularly special,as they are not simply conduits for blood,but are primarily responsible to ensure that the neurons function in a strictly regulated homeostatic *** endothelial cells(BECs)express a plethora of ion channels on its luminal and abluminal surfaces,namely:potassium(K^+)channels(i.e.,Kir2 and Kv1),chloride(Cl^)/bicarbonate(HCO3^–)channels,as well as a number of ion-solute exchangers(Redzic et al.,2011).

关键词： porous potassium solute

Psychological and social aspects of infertility in men： an overview of the evidence and implications for psychologically informed clinical care and future research

在线全文

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2012年第1期14卷 121-129,179页

作者： Jane RW fisher Karin Hammarberg Jean Hailes Research Unit School of PubLic Health and Preventive Medicine Monash University Clayton Vic. 3168 Australia

Research concerning the psychosocial aspects of infertility and infertility treatment focuses more often on women than men. The aim of this review was to synthesize the English-language evidence related to the psychological and social aspects of infertility in men and discuss the implications of these reports for clinical care and future research. A structured search identified 73 studies that reported data concerning the desire for fatherhood and the psychological and social aspects of diagnosis, assisted reproductive technology （ART） treatment and unsuccessful treatment among men with fertility difficulties. The studies are diverse in conceptualisation, design, setting and data collection, but the findings were reasonably consistent. These studies indicated that fertile and infertile childless men of reproductive age have desires to experience parenthood that are similar to those of their female counterparts; in addition, diagnosis and initiation of treatment are associated with elevated infertility-specific anxiety, and unsuccessful treatment can lead to a state of lasting sadness. However, rates of clinically significant mental health problems among this patient population are no higher than in the general population. Infertile men who are socially isolated, have an avoidant coping style and appraise stressful events as overwhelming, are more vulnerable to severe anxiety than men without these characteristics. Men prefer oral to written treatment information and prefer to receive emotional support from infertility clinicians rather than from mental health professionals, self-help support groups or friends. Nevertheless, structured, facilitated psycho-educational groups that are didactic but permit informal sharing of experiences might be beneficial. There are gaps in knowledge about factors governing seeking, persisting with and deciding to cease treatment; experiences of invasive procedures; parenting after assisted conception; adoption and infertility-related

关键词： assisted reproductive technologies male infertility psychologically-informed clinical care psychosocial aspects

Octopamine enhances learning

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

National Science Review 2024年第6期11卷 82-83页

作者： Yvette E.fisher Department of Molecular and Cell Biology and Helen Wills Neuroscience Institute University of California

Across the animal kingdom, diverse monoamines actuate and modulate neural circuit function. However, measuring the rapid dynamics of these neuromodulators at cellular resolution has historically presented significant ... 详细信息

关键词： learning enhances octopamine

Micro RNA in inflammatory bowel disease: Translational research and clinical implication

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2015年第43期21卷 12274-12282页

作者： Kurt fisher Jingmei Lin Department of Pathology and Laboratory Medicine Indiana University School of Medicine

Idiopathic inflammatory bowel disease(IBD) predominantly includes ulcerative colitis and Crohn's disease. The pathogenesis of IBD is complex and not completely understood. Micro RNAs belong to a class of noncoding small RNAs that post-transcriptionally regulate gene expression. Unique micro RNA expression profiles have been explored in IBD. In this review,we focus on the unique micro RNA expression pattern in both tissue and peripheral blood from IBD patients and emphasize the potential diagnostic and therapeutic applications. The discovery of micro RNAs has contributed to our understanding of IBD pathogenesis and might lead to clinical advance in new therapeutics.

关键词： Inflammatory bowel disease Ulcerative colitis Croh

Simple weighing lysimeters for measuring evapotranspiration and developing crop coefficients

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Agricultural and Biological Engineering 2012年第3期5卷 35-43页

作者： Daniel K.fisher Crop Production Systems Research Unit USDA-ARSStonevilleMS38776USA

Knowledge of cotton crop evapotranspiration(ET)is important in scheduling irrigations,optimizing crop production,and modeling ET and crop *** ability to measure,estimate,and predict ET and cotton crop water requirements can result in better satisfying the crop’s water needs and improving water use *** lysimeters have been used for many years to measure and study water use,and to develop crop-coefficient functions necessary in estimating *** weighing lysimeters,consisting of a steel outer tank and inner tank,electronic loadcell assemblies,and a PVC drain system,were designed,constructed,and *** lysimeter cost approximately US$1700(in 2001)in materials,required two people and 40 hours of labor to construct,and were installed by two people using minimal excavation and hand *** ET data for cotton were collected from 2003 to 2006 to quantify cotton water-use and to develop crop coefficient *** water use ranged generally from 2 to 8 mm/*** water-use patterns varied considerably among growing seasons due to variable environmental and crop-growth conditions,making determination of an“average”crop-coefficient function difficult.

关键词： weighing lysimeter evapotranspiration crop coefficient water use efficiency cotton

THE SCENERY FLOW FOR GEOMETRIC STRUCTURES ON THE TORUS: THE LINEAR SETTING

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Annals of Mathematics,Series B 2001年第4期22卷 427-470页

作者： P.ARNOUX A.M.fisher InstitutdeMathematiquesdeLuminy（UPR9016） 163AvenuedeLuminycase90713288MarseilleCedex9France. DeptMatIME-USP CaixaPostal66281CEP05315-970SaoPauloBrazil.

The authOrs define the scenery flow of the torus. The flow space is the union of all flat 2- dimensional tori of area 1 with a marked direction (or equivalently the union of all tori with a quadratic differential of norm 1). This is a 5-dimensional space, and the flow acts by following individual points under an extremal deformation of the quadratic differential. The authors define associated horocycle and translation flows; the latter preserve each torus and are the horizontal and vertical flows of the corresponding quadratic differential. The scenery flow projects to the geodesic flow on the modular surface, and admits, for each orientation preserving hyperbolic toral automorphism, an invariant 3-dimensional subset on which it is the suspension flow of that map. The authors first give a simple algebraic definition in terms of the group of affine maps of the plane, and prove that the flow is Anosov. They give an explicit formula for the first-return map of the flow on convenient cross-sections. Then, in the main part of the paper, the authors give several different models for the flow and its cross-sections, in terms of : stacking and rescaling periodic tilings of the plane; symbolic dynamics: the natural extension of the recoding of Sturmian sequences, or the S-adic system generated by two substitutions; zooming and subdividing quasi-periodic tilings of the real line, or aperiodic quasicrystals of minimal complexity; the natural extension of two-dimensional continued fractions; induction on exchanges of three intervals; rescaling on pairs of transverse measure foliations on the torus, or the Teichmuller flow on the twice-punctured torus.

关键词： Modular surface Continued fractions Sturmian sequences Plane tilings Teichmuller flow Substitution dynamical system

Photodynamic therapy in the treatment of intracranial gliomas:A review of current practice and considerations for future clinical directions

在线全文

学校读者我要写书评

暂无评论

Journal of Innovative Optical Health Sciences 2015年第1期8卷 40-59页

作者： Carl J.fisher Lothar Lilge Department of Medical Biophysics University of Toronto Princess Margaret Cancer Centre 101 College StRm.15-710 TorontoON M5G 1L7 University Health Network Princess Margaret Cancer Centre 101 College St Rm.15-310TorontoON M5G 1L7

Invasive grade III and IV maliguant gliomas remain difficult to treat with a typical survival time post-diagnosis hovering around 16 months with only minor extension thereof seen in the past decade,whereas some improvements have been obtained towards five-year survival rates for which completeness of resection is a *** techniques such as fluorescence guided resection(FGR)and photodynamic therapy(PDT)are promising adjuvant techniques to in-crease the tumor volume reduction *** has been used in combination with surgical resection or alternatively as standalone treat ment strategy with some sucoess in extending the median survival time of patients compared to surgery alone and the current standard of *** document reviews the outcome of past clinical trials and highlights the general shift in PDT therapeutic *** also looks at the current approaches for interstitial PDT and research options into increasing PDT's glioma treatment fficacy through exploiting both physical and biological based approaches to maximize PDT selectivity and therapeutic index,particularly in brain adjacent to tumor(BAT).Potential reasons for failing to demonstrate a significant survival advantage in prior PDT clinical trials will become evident in light of the improved understanding of glioma biology and PDT dosimetry.

关键词： Oncology brain tumour photodynamic dose therapeutic index photofin aminolu-velinic acid