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Factors associated with DAA virological treatment failure and resistance-associated substitutions description in HIV/HCV coinfected patients

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World Journal of Hepatology 2018年第11期10卷 856-866页

作者： Dominique Salmon Pascale Trimoulet Camille Gilbert Caroline Solas Eva Lafourcade Julie Chas Lionel Piroth Karine Lacombe Christine Katlama Gilles Peytavin Hugues Aumaitre Laurent Alric Franoois Boué Philippe Morlat Isabelle Poizot-Martin Eric Billaud Eric Rosenthal Alissa Naqvi Patrick Miailhes firouzé bani-sadr Laure Esterle Patrizia Carrieri Franoois Dabis Philippe Sogni Linda Wittkop 无 Assistance Publique des Hopitaux de Paris Hopitaux Universitaires Paris CentreHopital Hotel DieuUnitédes Maladies infectieuses et tropicalesParis 75004France Université Paris Descartes Sorbonne Paris CitéParis 75006France Trimoulet CHU de BordeauxHopital PellegrinLaboratoire de VirologieBordeaux 33000France Trimoulet CNRS-UMR 5234Microbiologie fondamentale et PathogénicitéUniversitéde BordeauxBordeaux 3000France Philippe Morlat Laure EsterleFrancois DabisLinda WittkopUniv.BordeauxISPEDInsermBordeaux Population Health Research Centerteam MORPH3EUSUMR 1219CIC-EC 1401Bordeaux F-33000France APHM Hopital La TimoneLaboratoire de Pharmacocinétique et ToxicologieMarseille 13005France Centre Hospitalier Universitaire de Dijon Département d'InfectiologieDijon cedex 21079France INSERM-CIC 1342 Universitéde Bourgogne Dijon 21000France Assistance Publique des Hopitaux de Paris GHUEP site Saint-AntoineServices Maladies infectieuses et tropicalesParis 75011France UniversitéPierre et Marie Curie UMR S1136Institut Pierre Louis d' Epidémiologie et de SantéPubliqueParis 75646France UniversitéParis-Sorbonne Paris 75005France Assistance Publique des Hopitaux de Paris Hopital PitiéSalpêtrière Services Maladies infectieuses et tropicalesParis 75013France Assistance Publique des Hopitaux de Paris Hopital Bichat-Claude BernardLaboratoire de PharmacologieParis 75877France IAME UMR 1137Sorbonne Paris CitéINSERMUniversitéParis DiderotParis 75890France Centre Hospitalier de Perpignan Service Maladies infectieuses et tropicalesPerpignan 66000Franc Centre Hospitalier Universitaire de Toulouse Hopital PurpanService Médecine interne-Pole DigestifToulouse 31300France UMR 152 IRD UniversitéToulouseⅢ Paul SabatierToulouse 31330France Hopital Antoine-Béclère Assistance Publique des Hopitaux de ParisUniversitéParis SudService Médecine interne et immunologieClamart 92140France Centre Hospitalier Universitaire de Bordeaux Service de médecine interneHopital Saint-AndréBordeaux 33000France Uni

AIMTo describe factors associated with treatment failure and frequency of resistance-associated substitutions （RAS）.METHODSHuman immunodefciency virus （HIV）/hepatitis C virus （HCV） coinfected patients starting a first direct-acting antiviral （DAA） regimen before February 2016 and included in the French ANRS CO13 HEPAVIH cohort were eligible. Failure was defned as：（1） non-response [HCV-RNA remained detectable during treatment, at end of treatment （EOT）]; and （2） relapse （HCV-RNA suppressed at EOT but detectable thereafter）. Sequencing analysis was performed to describe prevalence of drug class-specifc RAS. Factors associated with failure were determined using logistic regression *** 559 patients, 77% had suppressed plasmaHIV-RNA 〈 50 copies/mL at DAA treatment initiation41% were cirrhotic, and 68% were HCV treatmentexperienced. Virological treatment failures occurred in22 patients and were mainly relapses （17, 77%） thenundefined failures （3, 14%） and non-responses （29%）. Mean treatment duration was 16 wk overall. Posttreatment NS3, NS5A or NS5B RAS were detected in10/14 patients with samples available for sequencinganalysis. After adjustment for age, sex, ribavirin useHCV genotype and treatment duration, low platelecount was the only factor signifcantly associated with ahigher risk of failure （OR： 6.5; 95%CI： 1.8-22.6）. CONCLUSIONOnly 3.9% HIV-HCV coinfected patients failed DAAregimens and RAS were found in 70% of those failingLow platelet count was independently associated withvirological failure.

关键词： Human immunodeficiency virus Hepatitis C virus Direct-acting antiviral Treatment virological failure Resistant associated mutations

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Assessment of electrostatic discharge sensitivity of nitrogen-rich heterocyclic energetic compounds and their salts as high energy-density dangerous compounds:A study of structural variables

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Defence Technology（防务技术） 2024年第9期39卷 15-22页

作者： Mohammad Hossein Keshavarz Sedigheh Heydari bani Reza Bakhtiari Seyyed Hesamodin Hosseini Faculty of Applied Sciences Malek Ashtar University of TechnologyIsfahan 177415875Iran

Nitrogen-rich heterocyclic energetic compounds(NRHECs)and their salts have witnessed widespread synthesis in recent *** substantial energy-density content within these compounds can lead to potentially dangerous explosive reactions when subjected to external stimuli such as electrical ***,developing a reliable model for predicting their electrostatic discharge sensitivity(ESD)becomes *** study proposes a novel and straightforward model based on the presence of specific groups(-NH_(2) or-NH-,-N=N^(+)-O^(-)and-NNO_(2),-ONO_(2) or-NO_(2))under certain conditions to assess the ESD of NRHECs and their salts,employing interpretable structural *** a comprehensive dataset comprising 54 ESD measurements of NRHECs and their salts,divided into 49/5 training/test sets,the model achieves promising *** Root Mean Square Error(RMSE),Mean Absolute Error(MAE),and Maximum Error for the training set are reported as 0.16 J,0.12 J,and 0.5 J,***,the ratios RMSE(training)/RMSE(test),MAE(training)/MAE(test),and Max Error(training)/Max Error(test)are all greater than 1.0,indicating the robust predictive capabilities of the *** presented model demonstrates its efficacy in providing a reliable assessment of ESD for the targeted NRHECs and their salts,without the need for intricate computer codes or expert involvement.

关键词： Electrostatic discharge sensitivity Heterocyclic energetic compounds containing azole compound Interpretable structural parameter Safety

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Enhancing Human Action Recognition with Adaptive Hybrid Deep Attentive Networks and Archerfish Optimization

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Computers, Materials & Continua 2024年第9期80卷 4791-4812页

作者： Ahmad Yahiya Ahmad bani Ahmad Jafar Alzubi Sophers James Vincent Omollo Nyangaresi Chanthirasekaran Kutralakani Anguraju Krishnan Department of Accounting and Finance Faculty of BusinessMiddle East UniversityAmman11831Jordan Faculty of Engineering Al-Balqa Applied UniversitySalt19117Jordan Department of Mathematics Kongunadu College of Engineering and Technology(Autonomous)TholurpattiTrichy621215India Department of Computer Science and Software Engineering Jaramogi Oginga Odinga University of Science and TechnologyBondo210-40601Kenya Department of Electronics and Communication Engineering Saveetha School of EngineeringSaveetha Institute of Medical and Technical SciencesChennai602105India Department of Electronics and Communication Engineering Saveetha Engineering College(Autonomous)Chennai602105India Department of Computer Science and Engineering Kongunadu College of Engineering and Technology(Autonomous)TholurpattiTrichy621215India

In recent years,wearable devices-based Human Activity Recognition(HAR)models have received significant *** developed HAR models use hand-crafted features to recognize human activities,leading to the extraction of basic *** images captured by wearable sensors contain advanced features,allowing them to be analyzed by deep learning algorithms to enhance the detection and recognition of human *** lighting and limited sensor capabilities can impact data quality,making the recognition of human actions a challenging *** unimodal-based HAR approaches are not suitable in a real-time ***,an updated HAR model is developed using multiple types of data and an advanced deep-learning ***,the required signals and sensor data are accumulated from the standard *** these signals,the wave features are *** the extracted wave features and sensor data are given as the input to recognize the human *** Adaptive Hybrid Deep Attentive Network(AHDAN)is developed by incorporating a“1D Convolutional Neural Network(1DCNN)”with a“Gated Recurrent Unit(GRU)”for the human activity recognition ***,the Enhanced Archerfish Hunting Optimizer(EAHO)is suggested to fine-tune the network parameters for enhancing the recognition *** experimental evaluation is performed on various deep learning networks and heuristic algorithms to confirm the effectiveness of the proposed HAR *** EAHO-based HAR model outperforms traditional deep learning networks with an accuracy of 95.36,95.25 for recall,95.48 for specificity,and 95.47 for precision,*** result proved that the developed model is effective in recognizing human action by taking less ***,it reduces the computation complexity and overfitting issue through using an optimization approach.

关键词： Human action recognition multi-modal sensor data and signals adaptive hybrid deep attentive network enhanced archerfish hunting optimizer 1D convolutional neural network gated recurrent units

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Enhancement in Bioavailability of CurCousin^®, A Minor Metabolite from Curcuma longa by Addition of BioPerine^® —A Pharmacokinetic Study

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Journal of Biosciences and Medicines 2024年第2期12卷 282-293页

作者： Muhammed Majeed Kalyanam Nagabhushanam Sarang bani Anjali Pandey Smitha Thazhathidath Sami-Sabinsa Group Limited Bengaluru India Sabinsa Corporation New Jersey USA

In recent years, metabolic syndrome has been a growing health concern across the world. The role of nutraceuticals and functional foods in this area has a significant place due to the adverse effects of contemporary modes of treatment. CurCousin® is a nutritional ingredient containing bioactive Calebin A, (analog of Curcumin) with self-affirmed GRAS status. CurCousin® has been a clinically studied dietary supplement ingredient with a positive impact on body weight, lipid levels and metabolic health. Bioenhancers play an important role in increasing the bioavailability of the active in turn enhancing efficacy as well as reducing the dosage required to achieve the therapeutic effect. This study investigated the possible pharmacokinetic interaction between CurCousin® at two different doses (2.25 and 4.5 mg/kg) in the presence and absence of BioPerine® (0.27 mg/kg), a natural bioenhancer in Sprague-Dawley rats. The results revealed that the addition of BioPerine® into CurCousin® (2.25 mg/kg) half the dose when administered enhances the bioavailability and was equipotent to CurCousin® (4.5 mg/kg) double the dose without BioPerine®. Thus, leading to future clinical studies to evaluate its improved pharmacological efficacy as well as reduced therapeutic dosage.

关键词： Metabolic Health Bioavailability Pharmacokinetics CurCousin® BioPerine® Calebin A

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Therapeutic and regenerative potential of different sources of mesenchymal stem cells for cardiovascular diseases

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BIOCELL 2024年第4期48卷 559-569页

作者： YARA ALZGHOUL HALA J.bani ISSA AHMAD K.SANAJLEH TAQWA ALABDUH FATIMAH RABABAH MAHA AL-SHDAIFAT EJLAL ABU-EL-RUB FATIMAH ALMAHASNEH RAMADA R.KHASAWNEH AYMAN ALZU’BI HUTHAIFA MAGABLEH Department of Basic Medical Sciences Faculty of MedicineYarmouk UniversityIrbidJordan

Mesenchymalstemcells(MSCs)*** the internal cardiac microenvironment to facilitate their immunomodulatory and differentiation abilities,which are essential to restore heart *** can be easily isolated from different sources,including bone marrow,adipose tissues,umbilical cord,and dental *** from various sources differ in their regenerative and therapeutic abilities for cardiovascular *** this review,we will summarize the therapeutic potential of each MSC source for heart diseases and highlight the possible molecular mechanisms of each source to restore cardiac function.

关键词： Bone marrow mesenchymal stem cells Adipose tissue mesenchymal stem cells Dental pulp stem cells Umbilical cord mesenchymal stem cells Cardiomyocytes Regeneration Myocardial infarction Mesenchymal stem cells Differentiation Immunomodulation

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Simultaneous portal vein thrombosis and splenic vein thrombosis in a COVID-19 patient:A case report and review of literature

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World Journal of Clinical Cases 2024年第18期12卷 3561-3566页

作者： Binyamin Ravina Abramowitz Michael Coles Ayse Aytaman bani Chander-Roland Daniel Anthony DiLeo Department of Gastroenterology and Hepatology SUNY Downstate Health Sciences UniversityBrooklynNY 11203United States Department of Gastroenterology and Hepatology Brooklyn Campus of the Veterans Affairs New York Harbor Healthcare SystemBrooklynNY 11209United States

BACKGROUND It is well-described that the coronavirus disease 2019(COVID-19)infection is associated with an increased risk of thrombotic *** there have been many cases of pulmonary emboli and deep vein thrombosis in these patients,reports of COVID-19 associated portal vein thrombosis(PVT)have been *** present a unique case of concomitant PVT and splenic artery thrombosis in a COVID-19 *** SUMMARY A 77-year-old-male with no history of liver disease presented with three days of left-sided abdominal *** week earlier,the patient was diagnosed with mildly symptomatic COVID-19 and was treated with nirmatrelvir/*** exam revealed mild right and left lower quadrant tenderness,but was otherwise *** laboratory findings included white blood cell count 12.5 K/μL,total bilirubin 1.6 mg/dL,aminoaspartate transferase 40 U/L,and alanine aminotransferase 61 U/*** tomography of the abdomen and pelvis revealed acute PVT with thrombus extending from the distal portion of the main portal vein into the right and left *** noted was a thrombus within the distal portion of the splenic artery with resulting splenic *** workup including prothrombin gene analysis,factor V Leiden,cardiolipin antibody,and JAK2 mutation were all *** with enoxaparin was initiated,and the patient’s pain *** was discharged on *** It is quite uncommon for PVT to present simultaneously with an arterial thrombotic occlusion,as in the case of our *** thrombotic manifestations are classically linked to hypercoagulable states including malignancy and hereditary and autoimmune *** infections such as Epstein-Barr virus,cytomegalovirus,viral hepatitis,and COVID-19 have all been found to increase the risk of splanchnic venous occlusions,including *** our patient,prompt abdominal imaging led to early detection of thrombus,early treatment,and an exce

关键词： COVID-19 Thromboembolism Portal vein thrombosis Splenic artery thrombosis Anticoagulation Lovenox Thrombotic complication Case report

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Impact of Rainfall Temporal Heterogeneity on Relationship between Curve Number and Rainfall Depth in the Zagros Mountain Region,Iran

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Journal of Mountain Science 2015年第3期12卷 689-698页

作者： Hassan REZAEI-sadr Water Resources Department Nahrab Parseh Consulting Engineers Company

The impact of temporal variation of rainfall on the relationship between rainfall and catchment response is investigated in a catchment with high temporally variable rainfalls and a high percentage of permeable soils in the southwest of ***-nine storm events are classified into two classes, High Temporal heterogeneous(HT) and Low Temporal heterogeneous(LT) events using the variogram technique and the storm events of each class are analyzed to detect the relationship between Curve Number(CN) and rainfall depth. It is found that there is not a similar correlation between CN values and rainfall depths for both temporally variable classes, and hence, two different responses can be observed in the catchment according to rainfall temporal heterogeneities. For HT events, a complacent behavior is detected in which the CNs decline as rainfall depth increases while a different response, violent behavior, is observed for LT events in which the CNs rise and asymptotically approach a constant value with increasing storm size. This considerable difference between CN-P relationships derived from the two temporally variable classes of rainfall is attributed to the provocation of different runoff generation mechanisms, infiltration-excess and saturation-excess caused by rainfall temporal heterogeneities. Moreover, the results support the validity of variogram technique to classify storm events into two LT and HT classes.

关键词： Asymptotic approach Curve Numbermethod Infiltration-excess Rainfall temporalvariation Saturation-excess Variogram technique

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Nonlocality and Multipartite Entanglement in Asymptotically Flat Space-Times

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Communications in Theoretical Physics 2016年第1期65卷 17-22页

作者： Shahpoor Moradi firouz Amiri Department of Physics Razi University Kermanshah Iran Department of Physics Khorram Abad Branch Islamic Azad University Iran

We study the Bell's inequality and multipartite entanglement generation for initially maximally entangled states of free Dirac field in a non inertial frame and asymptotically flat Robertson–Walker *** two qubit case,we show that the Bell's inequality always is violated as measured by the accelerated observers which are in the causally connected *** the other hand,for those observers in the causally disconnected regions inequality is not violated for any values of *** generated three qubit state from two qubit state due to acceleration of one parties has a zero *** a three qubit state,the inequality violated for measurements done by both causally connected and disconnected *** GHZ state with non zero 3-tangle,in accelerated frame,transformed to a four qubit state with vanishing 4-tangle *** the other hand,for a W-state with zero 3-tangle,in non inertial frame,transformed to a four qubit state with a non-zero 4-tangle acceleration *** an expanding space-time with asymptotically flat regions,for an initially maximally entangled state,the maximum value of violation of Bell's inequality in the far past decreased in the far future due to cosmological particle *** some initially maximally entangled states,the generated four qubit state due to expansion of space-time,has non vanishing 4-tangle.

关键词： Bell's inequality multiparticle entanglement accelerated frames expanding space-time

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Dynamic Modeling and Closed-loop Control of Hybrid Grid-connected Renewable Energy System with Multi-input Multi-output Controller

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Journal of Modern Power Systems and Clean Energy 2021年第1期9卷 94-103页

作者： Mahdi Salimi Fereshteh Radmand Mansour Hosseini firouz the Department of Electrical Engineering Ardabil BranchIslamic Azad UniversityArdabilIran

In this study, a novel approach for dynamic modeling and closed-loop control of hybrid grid-connected renewable energy system with multi-input multi-output(MIMO) controller is proposed. The studied converter includes two parallel DC-DC boost converters, which are connected into the power grid through a single-phase H-bridge inverter. The proposed MIMO controller is developed for maximum power point tracking of photovoltaic(PV)/fuel-cell(FC) input power sources and output power control of the grid-connected DC-AC inverter. Considering circuit topology of the system, a unique MIMO model is proposed for the analysis of the entire system. A unique model of the system includes all of the circuit state variables in DCDC and DC-AC converters. In fact, from the viewpoint of closed-loop controller design, the hybrid grid-connected energy system is an MIMO system. The control inputs of the system are duty cycles of the DC-DC boost converters and the amplitude modulation index of DC-AC inverters. Furthermore, the control outputs are the output power of the PV/FC input power sources as well as AC power injected into the power grid. After the development of the unique model for the entire system, a decoupling network is introduced for system input-output linearization due to inherent connection of the control outputs with all of the system inputs. Considering the decoupled model and small signal linearization, the required linear controllers are designed to adjust the outputs. Finally, to evaluate the accuracy and effectiveness of the designed controllers, the PV/FC based grid-connected system is simulated using the MATLAB/Simulink toolbox.

关键词： Multi-input multi-output(MIMO)converter maximum power point tracking grid-connected inverter conversion function matrix

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Pathogenesis of columnar-lined esophagus

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World Journal of Gastroenterology 2006年第10期12卷 1521-1528页

作者： Kamal E bani-Hani Bayan K bani-Hani Department of Surgery Faculty of Medicine Jordan University of Science and TechnologyIrbidJordan

Since its initial description, the pathogenesis of the columnar-lined esophagus （CLE） has been surrounded by many controversies. The first controversy is related to the existence of the condition itself. The second controversy centers on whether the CLE is a congenital or an acquired condition. In this article, we review the congenital and acquired theories of development of CLE and discuss the various factors in acquisition of CLE. The bulk of evidence in the literature suggests that CLE is an acquired condition.

关键词： Barrett's esophagus Risk factors Esophageal adenocarcinoma Pathogenesis Reflux esophagitis Gastroesophageal reflux

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