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Daclatasvir plus asunaprevir in treatment-na?ve patients with hepatitis C virus genotype 1b infection

World Journal of Gastroenterology 2018年第12期24卷 1361-1372页

作者： Lai Wei Fu-Sheng Wang Ming-Xiang Zhang Ji-Dong Jia Alexey A Yakovlev Wen Xie Eduard Burnevich Jun-Qi Niu Yong Jin Jung Xiang-Jun Jiang Min Xu Xin-Yue Chen Qing Xie Jun Li Jin-Lin Hou Hong Tang Xiao-guang Dou Yash Gandhi Wen-Hua Hu fiona McPhee Stephanie Noviello Michelle Treitel Ling Mo Jun Deng Peking University People’s Hospital and Peking University Hepatology Institute Beijing 100044China Qingdao Municipal Hospital Qingdao 266011Shandong ProvinceChina Guangzhou No.8 People’s Hospital Guangzhou 510060Guangdong ProvinceChina Beijing Youan Hospital Capital Medical UniversityBeijing 100069China Shanghai Ruijin Hospital Jiaotong University School of MedicineShenyang 200025Liaoning ProvinceChina TheFirst Affiliated Hospital with Nanjing Medical University Nanjing 210029Jiangsu ProvinceChina Hepatology Unit Nanfang HospitalSouthern Medical UniversityGuangzhou 510515Guangdong ProvinceChina West China Hospital Sichuan UniversityChengdu 610041Sichuan ProvinceChina China Medical University Shengjing HospitalShenyang 110004Liaoning ProvinceChina Bristol-Myers Squibb PrincetonNJ 08540United States Bristol-Myers Squibb WallingfordCT 06492United States 302 Military Hospital of China Beijing 100039China Bristol-Myers Squibb Shanghai 200040China the Sixth People’s Hospital of Shenyang Shenyang 110006Liaoning ProvinceChina Beijing Friendship Hospital Capital Medical UniversityBeijing 100050China Saint-Petersburg State Healthcare Institution'Clinical Infectious Hospital n.a.S.P.Botkin’ Saint-Petersburg 191167Russia Beijing Ditan Hospital Capital Medical UniversityBeijing 100015China I.M.Sechenov First Moscow State Medical University Moscow 119991Russia The First Hospital of Jilin University Jilin 1300021Jilin ProvinceChina SMG-SNU Boramae Medical Center Seoul 07061South Korea

AIM To assess daclatasvir plus asunaprevir(d UAL) in treatment-na?ve patients from China's Mainland, Russia and South Korea with hepatitis C virus(HCV) genotype 1 b infection. METHODS Patients were randomly assigned(3:1) to receive 24 wk of treatment with d UAL(daclatasvir 60 mg once daily and asunaprevir 100 mg twice daily) beginning on day 1 of the treatment period(immediate treatment arm) or following 12 wk of matching placebo(placebodeferred treatment arm). The primary endpoint was a comparison of sustained virologic response at posttreatment week 12(SVR12) compared with the historical SVR rate for peg-interferon plus ribavirin(70%) among patients in the immediate treatment arm. The first 12 wk of the study were blinded. Safety was assessed in d UAL-treated patients compared with placebo patients during the first 12 wk(doubleblind phase), and during 24 wk of d UAL in both arms *** In total, 207 patients were randomly assigned to immediate(n = 155) or placebo-deferred(n = 52) treatment. Most patients were Asian(86%), female(59%) and aged < 65 years(90%). Among them, 13% had cirrhosis, 32% had IL28 B non-CC genotypes and 53% had baseline HCV RNA levels of ≥ 6 million IU/m L. Among patients in the immediate treatment arm, SVR12 was achieved by 92%(95% confidence interval: 87.2-96.0), which was significantly higher than the historical comparator rate(70%). SVR12 was largely unaffected by cirrhosis(89%), age ≥ 65 years(92%), male sex(90%), baseline HCV RNA ≥ 6 million(89%) or IL28 B non-CC genotypes(96%), although SVR12 was higher among patients without(96%) than among those with(53%) baseline NS5 A resistanceassociated polymorphisms(at L31 or Y93 H). during the double-blind phase, aminotransferase elevations were more common among placebo recipients than among patients receiving d UAL. during 24 wk of d UAL therapy(combined arms), the most common adverse events(≥ 10%) were elevated alanine aminotransferase and upper respiratory tract infection; emergent

关键词： Asunaprevir Daclatasvir Direct-acting antiviral Chronic hepatitis C Liver disease NS3 NS5A Genotype 1b

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肿瘤恶性转化与C/EBPβ和STAT3基因相关(英文)

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中华神经外科疾病研究杂志 2010年第1期9卷 22-22页

作者： Maria Stella Carro Wei Keat Lim Mariano Javier Alvarez Robert J. Bollo Evan Y. Snyder Erik P. Sulman Sandrine L. Anne fiona Doetsch Howard Colman Anna Lasorella Ken Aldape Andrea Califano Antonio Iavarone

The inference of transcriptional networks that regulate transitions into physiological or pathological cellular states remains a central challenge in systems biology. A mesenchymal phenotype is the hallmark of tumour aggressiveness in human malignant glioma,but the regulatory programs responsible for implementing the associated molecular signature are largely unknown. Here we show that reverse-engineering and an unbiased interrogation of a glioma-specific regulatory network reveal the transcriptional module that activates expression of mesenchymal genes in malignant glioma. Two transcription factors (C/EBPβ and STAT3) emerge as synergistic initiators and master regulators of mesenchymal transformation. Ectopic co-expression of C/EBPβ and STAT3 reprograms neural stem cells along the aberrant mesenchymal lineage,whereas elimination of the two factors in glioma cells leads to collapse of the mesenchymal signature and reduces tumour aggressiveness. In human glioma,expression of C/EBPβ and STAT3 correlates with mesenchymal differentiation and predicts poor clinical outcome. These results show that the activation of a small regulatory module is necessary and sufficient to initiate and maintain an aberrant phenotypic state in cancer cells.

关键词：脑瘤细胞分子生理学临床分析

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临床试验数据共享声明国际医学期刊编辑委员会统一要求

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英国医学杂志中文版 2017年第7期20卷 365-366页

作者： Darren B Taichman Peush Sahni Larry Peiperl Christine Laine Astrid James Sung-Tae Hong Abraham Haileamlak Laragh Gollogly fiona Godlee Frank A Frizelle Fernando Florenzano Jeffrey M Drazen Howard Bauchner Christopher Baethge Deutsches Arzteblatt Joyce Backus 季媛媛不详中华医学杂志英文版编辑部

国际医学期刊编辑委员会（ICMJE）认为，由于临床试验参与者处于研究风险之中，我们有伦理义务来负责任地共享干预性临床试验产生的原始数据。2016年1月，ICMJE发表了1项关于临床试验数据共享的提案，旨在帮助创造共享去标识个体患者数... 详细信息

国际医学期刊编辑委员会（ICMJE）认为，由于临床试验参与者处于研究风险之中，我们有伦理义务来负责任地共享干预性临床试验产生的原始数据。2016年1月，ICMJE发表了1项关于临床试验数据共享的提案，旨在帮助创造共享去标识个体患者数据的常态化环境。迄今，应我们的反馈要求，ICMJE收到了很多来自个人和团体的意见。

关键词：临床试验数据数据共享期刊编辑工作

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临床试验数据共享声明

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中国医院院长 2017年第16期13卷 27-28页

作者： Darren B Taichman Peush Sahni Anja Pinborg Larry Peiperl Christine Laine Astrid James Sung-Tae Hong Abraham Haileamlak Laragh Gollogly fiona Godlee Frank A Frizelle Fernando Florenzano Jeffrey M Drazen Howard Bauchner Christopher Baethge Joyce Backus 季媛媛

国际医学期刊编辑委员会（ICMJE）认为，由于临床试验参与者处于研究风险之中，我们有伦理义务来负责任地共享干预性临床试验产生的原始数据。2016年1月，ICMJE发表了一项关于临床试验数据共享的提案，旨在帮助创造共享去标识个体患者... 详细信息

国际医学期刊编辑委员会（ICMJE）认为，由于临床试验参与者处于研究风险之中，我们有伦理义务来负责任地共享干预性临床试验产生的原始数据。2016年1月，ICMJE发表了一项关于临床试验数据共享的提案，旨在帮助创造共享去标识个体患者数据的常态化环境。

关键词：数据共享临床试验国际医学期刊编辑委员会原始数据干预性

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Trees as hotspots:Using forests,trees,and agroforestry to foster diverse sustainable landscapes

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Circular Agricultural Systems 2022年第1期2卷 30-37页

作者： Vincent Gitz Jianchu Xu Yuanchang Lu Elaine Springgay Illias Animon Razan Khalifa Al Mubarak Robert Nasi Tony Simons Ranjit Barthakur Ren Wang Jianrong Su Fergus Sinclair Eduardo Somarriba Dossa G.O.Gbadamassi Ramni Jamnadass Christopher JKettle Dengpan Bu Anja Gassner Yves Laumonier Mi Zhou Himlal Baral Fangyuan Hua Peter AMinang Yufu Guo Michael Allen Brady Yanxia Li Peter Mortimer Bin Yang Heng Gui fiona Worthy Deli Zhai Huafang Chen Huili Li Yufang Su Alexandre Meybeck Fabio Ricci CIFOR-ICRAF Bogor 16115Indonesia Center for Mountain Futures Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China CIFOR-ICRAF China Program World AgroforestryKunming 650201China State Key Laboratory of Animal Nutrition Institute of Animal SciencesChinese Academy of Agricultural SciencesBeijing 100081China Research Institute of Forest Resource Information Techniques Chinese Academy of ForestryBeijing 100091China Food and Agriculture Organization of the United Nations(FAO) Rome 00153Italy Food and Agriculture Organization of the United Nations(FAO) Bangkok 10200Thailand Mohamed bin Zayed Species Conservation Fund Abu Dhabi 131112United Arab Emirates Balipara Foundation GuwahatiAssam 781024India China National Gene Bank Shenzhen 518083China Research Institute of Resource Insects Chinese Academy of ForestryKunming 650233China World Agroforestry Centre(ICRAF) United Nations AvenueGigiriP.O.Box 30677-00100NairobiKenya CATIE Turrialba 30501Costa Rica Xishuangbanna Tropical Botanical Garden Chinese Academy of SciencesMengla 666303China Bioversity International Rome 00153Italy Global Landscapes Forum CIFOR gmbHCharles-de-Gaulle-Straße 553113 BonnGermany Institute of American and Oceania Study Chinese Academy of International Trade and Economic CooperationMinistry of CommerceBeijingChina Institute of Ecology Peking UniversityBeijing 100871China National Forestry and Grassland Administration Beijing 100714China International Network for Bamboo and Rattan(INBAR) Beijing 100102China Yunnan University Kunming 650500China Editorial Office of Biological Science Institute of BotanyChinese Academy SciencesBeijing 100093China

Forests,trees,and agroforestry(FTA)are ecosystem *** exemplify the contributions of biodiversity to sustainable and resilient landscapes,green circular economy and to sustainable agriculture and food systems for healthy ***,most research on these topics have been performed separately and lack *** International FTA-Kunming Conference'Forests,trees and agroforestry for diverse sustainable landscapes'22nd–24th June 2021,focused on these contributions,brought together scientists NGOs,and policy makers to further the understanding of tree diversity;provided a communication platform for scientists to share their research results;evaluated the role of tree diversity in agroecology and circular agriculture;assessed benefits of landscape restoration;and explored applied research in mountain ecosystems and food *** goals were to gather evidence that ground the design of solutions that can contribute to the implementation of the post 2020 Global Biodiversity Framework and towards the UN Food Systems Summit,and the overall implementation of the *** paper summarizes the outcomes of the international FTA Conference in Kunming 2021 and points out the highlights of research involved in six major themes.

关键词： landscape sustainable diverse

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