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Striatins and STRIPAK complex partners in clinical outcomes of patients with breast cancer and responses to drug treatment

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中国癌症研究:英文版 2023年第4期35卷 365-385页

作者： Amber Xinyu Li Jimmy Jianyuan Zeng Tracey A Martin Lin Ye fiona ruge Andrew J Sanders Elyas Khan QPing Dou Eleri Davies Wen G Jiang Cardiff China Medical Research Collaborative Division of Cancer and GeneticsCardiff University School of MedicineHeath ParkCardiff CF144XNUK School of Natural and Social Science University of GloucestershireFrancis Close HallCheltenham GL504AZUK Karmanos Cancer Institute Department of OncologySchool of MedicineWayne State UniversityDetroit MI 48201USA Wales Breast Center Cardiff and Vales University Health BoardUniversity Llandough HospitalCardiff CF642XXUK

Objective: Striatins(STRNs) family, which contains three multi-domain scaffolding proteins, are cornerstones of the striatins interacting phosphatase and kinase(STRIPAK) complex. Although the role of the STRIPAK complex in cancer has become recognized in recent years, its clinical significance in breast cancer has not been fully ***: Using a freshly frozen breast cancer tissue cohort containing both cancerous and adjacent normal mammary tissues, we quantitatively evaluated the transcript-level expression of all members within the STRIPAK complex along with some key interacting and regulatory proteins of STRNs. The expression profile of each molecule and the integrated pattern of the complex members were assessed against the clinical-pathological factors of the patients. The Cancer Genome Atlas(TCGA) dataset was used to evaluate the breast cancer patients’ response to chemotherapies. Four human breast cancer cell lines, MDA-MB-231, MDA-MB-361, MCF-7, and SKBR-3, were subsequently adopted for in vitro ***: Here we found that high-level expressions of STRIP2, calmodulin, CCM3, MINK1 and SLMAP were respectively associated with shorter overall survival(OS) of patients. Although the similar pattern observed for STRN3, STRN4 and a contrary pattern observed for PPP2CA, PPP2CB and PPPR1A were not significant, the integrated expression profile of STRNs group and PPP2 group members constitutes a highly significant prognostic indicator for OS [P<0.001, hazard ratio(HR)=2.04, 95% confidence interval(95% CI), 1.36-3.07] and disease-free survival(DFS)(P=0.003, HR=1.40, 95% CI, 1.12-1.75). Reduced expression of STRN3 has an influence on the biological functions including adhesiveness and migration. In line with our clinical findings, the breast cancer cells responded to STRN3 knockdown with changes in their chemo-sensitivity, of which the response is also breast cancer subtype ***: Our results suggest a possible role of the STRIPAK complex

关键词： Striatins STRN3 STRIPAK breast cancer prognosis chemo-resistance

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Understanding Urban Vitality from the Economic and Human Activities Perspective:A Case Study of Chongqing,China

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Chinese Geographical Science 2024年第1期34卷 52-66页

作者： YANG fiona Fan LIN Geng LEI Yubing WANG Ying YI Zheng School of Geography and Planning Sun Yat-sen UniversityGuangzhou510006China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Zhuhai519100China Chongqing Planning and Design Institute Chongqing401147China

The literature on urban vitality tends to focus on the built *** paper argues that some important processes in shaping vitality may be overlooked without examining the intensity and diversity of economic and human *** newly developed spatial big data and adopting the methods of multi-indicator measurement and spatial analysis methods,we analyzed the pattern of urban vitality in Chongqing,a provincial city in western China and,on this basis,evaluated the creation and maintenance of urban vitality from the economic and human activities *** findings indicate that the impacts of economic and human activities are positive and *** the three intensity and diversity indicators,economic intensity and population density show an effect on urban vitality stronger than that of economic ***,economic diversity has the strongest superposition or interactive effect,and is thus an important foundation *** positive effect of population density on urban vitality is largely a result of Chongqing’s jobs-housing *** case of Chongqing highlights the importance of topographic features,historical inheritance,large-scale migration,and cultural activities in shaping the distinctive vitality pattern of a *** study contends that the creation and maintenance of urban vitality can not be fully explained without incorporating the impacts of economic and human *** contributes to a comprehensive measurement of urban vitality and enriches its connotations.

关键词： urban vitality economic diversity economic intensity population density Chongqing,China

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A marathon,not a sprint:Increasing population physical activity as a legacy of sports mega-events

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Journal of Sport and Health Science 2024年第6期13卷 732-735页

作者： fiona C.Bull Paul J.Simpson Physical Activity Unit Department of Health PromotionWorld Health OrganizationGeneva CH-1211Switzerland The BMJ London WC1H 9JPUK

*** matters The withdrawal of Australia as hosts for the Commonwealth Games in 2026 demonstrates that large international sporting events are more than just sporting mastery,medals,and *** also matters.1 The cost of hosting a major international tournament is eye-wateringly *** governments need to show that the billions of dollars of investment deliver a return beyond sporting glory to justify the resources that are spent.

关键词： return dollar sport

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Extreme Weather Disruptions and Emergency Preparedness Among Older Adults in Ohio: An Eight-County Assessment

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International Journal of Disaster Risk Science 2024年第2期15卷 213-225页

作者： Smitha Rao fiona C.Doherty Anthony Traver Marisa Sheldon Emma Sakulich Holly Dabelko‑Schoeny College of Social Work The Ohio State UniversityColumbusOH 43210USA Age Friendly Innovation Center College of Social WorkThe Ohio State UniversityColumbusOH 43210USA College of Public Health The Ohio State UniversityColumbusOH 43210USA

The disproportionate risks and impacts of climate change and extreme weather on older adults are increasingly evident. While especially true in disaster-prone areas, human-caused climate change introduces an element of uncertainty even in previously identified “safe” regions such as the Midwestern United States. Using a cumulative disadvantage and vulnerability-informed framework and descriptive statistics from multiple data sources, this article provides an overview of climate impacts, vulnerabilities, and county-level characteristics, focusing on older adults living in Central Ohio. A comparative multiple-case study methodology was used to triangulate regionally representative primary and secondary data sources to examine state and county-level measures of vulnerability, emergency preparedness, and disruptions caused by extreme weather among older adults across eight counties in Central Ohio. Seventy-eight percent of older adults in the sample reported being prepared for emergencies per Federal Emergency Management Agency guidelines. Older adults in Union County reported the highest rates of preparedness, while those in Fayette County reported the lowest. County-level rates of disruption of life activities by extreme weather ranged widely. Among the most rural in the region, Fayette County emerged as uniquely disadvantaged, with the lowest median income, the most vulnerable across multiple social vulnerability dimensions, and the most reported disruptions to life activities from extreme weather. County profiles offer a snapshot of existing vulnerabilities, socioeconomic conditions, special needs, preparedness, and current disruptions among older adults in the region and can inform resource mobilization across community and policy contexts.

关键词： Disaster preparedness Extreme weather Midwestern United States Older adults Regional assessment Social vulnerability

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BIKAS:Bio-Inspired Knowledge Acquisition and Simulacrum-A Knowledge Database to Support Multifunctional Design Concept Generation

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Data Intelligence 2024年第2期6卷 531-558页

作者： Pavan Tejaswi Velivela Yaoyao fiona Zhao Department of Mechanical Engineering McGill UniversityQuebecCanada H3A 0G4

A detailed acquisition,analysis,and representation of biological systems exhibiting different functions is required to develop unique bio-inspired multifunctional conceptual designs and *** paper presents BIKAS:Bio-inspired Knowledge Acquisition and Simulacrum,a knowledge database of biological systems exhibiting various functionalities,developed based on case-based bio-inspired examples from *** knowledge database represents the biological features,their characteristics,and the function exhibited by the biological feature as a combination of its integrated structure and structural ***,this knowledge database is utilized by the Expandable Domain Integrated Design(xDID)model that works on classifying,mapping,and representing biological features into their respective geometric designations called *** combination of features from the Domains results in the generation of multifunctional conceptual *** addition,Meta-level design factors are proposed to aid designers in filtering the biological features and their respective functions having a similar structural strategy,thus aiding designers in rapidly selecting and emulating biological functions.

关键词： Bio-inspired design(BID) Knowledge database Conceptual design Multifunctional bio-inspired design Agile innovation

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微波处理对大米储藏过程中脂质变化的影响

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食品科学 2024年第4期45卷 247-256页

作者：曹汝鸽武小晖黄文达天津科技大学食品科学与工程学院食品营养与安全国家重点实验室天津300457 天津凯涛奇食品有限公司天津301799

为揭示微波处理前后大米储藏过程中脂类的变化规律,本实验对不同品种大米(津稻919、超北2号和稻花香2号)进行微波处理(850 W,50 s),并于不同条件下储藏3个月,评价其脂肪酶、脂肪氧化酶、过氧化物酶、过氧化氢酶活力,脂肪酸值、过氧化值... 详细信息

为揭示微波处理前后大米储藏过程中脂类的变化规律,本实验对不同品种大米(津稻919、超北2号和稻花香2号)进行微波处理(850 W,50 s),并于不同条件下储藏3个月,评价其脂肪酶、脂肪氧化酶、过氧化物酶、过氧化氢酶活力,脂肪酸值、过氧化值、羰基值、水分分布及挥发性成分的变化。结果表明:微波处理可以有效降低大米的水分活度,改变大米籽粒微观结构,灭活各脂肪酶。微波处理后储藏期间津稻919、超北2号和稻花香2号大米脂肪酶、脂肪氧化酶、过氧化物酶、过氧化氢酶活性分别平均下降了54.03%、71.11%、95.94%和46.04%。即使在37℃高温储藏90 d时,不同品种大米脂肪酸值、过氧化值和羰基值增加依然不明显,分别增加了0.716~1.436 mg/100 g、2.859~6.734 mmol/kg和3.697~5.308 mmol/kg。说明微波处理能有效钝化大米各脂肪酶活性,减少大米脂质水解氧化过程游离脂肪酸和氢过氧化物的产生,进而降低挥发性醛酮类物质的生成量,大大延缓大米储藏过程中的品质劣变。

关键词：大米微波处理储藏脂肪酶脂肪氧化

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M2型巨噬细胞与GKT137831对肝星状细胞氧化应激的影响

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中华肝脏病杂志 2024年第3期32卷 201-207页

作者：孙儒阁李静申风俊山西医科大学第一医院消化内科太原030001 山西医科大学太原030001

目的探讨还原型烟酰胺腺嘌呤二核苷酸磷酸氧化酶4(NOX4)抑制剂GKT137831与M2型巨噬细胞对大鼠肝星状细胞(HSC)系(HSC-T6)氧化应激指标NOX4、核因子E2相关因子2(Nrf2)和血红素加氧酶1(HO-1)的影响。方法分离大鼠骨髓巨噬细胞,用白细胞介... 详细信息

目的探讨还原型烟酰胺腺嘌呤二核苷酸磷酸氧化酶4(NOX4)抑制剂GKT137831与M2型巨噬细胞对大鼠肝星状细胞(HSC)系(HSC-T6)氧化应激指标NOX4、核因子E2相关因子2(Nrf2)和血红素加氧酶1(HO-1)的影响。方法分离大鼠骨髓巨噬细胞,用白细胞介素(IL)-4诱导其分化为M2巨噬细胞表型。选5μg/L转化生长因子β1(TGF-β1)激活HSC-T6,采用细胞计数(CCK-8)法检测5~80μmol/L浓度梯度下NOX4抑制剂GKT137831刺激活化的大鼠HSC-T6细胞48 h后细胞增殖情况,选定最适药物浓度。分单独培养HSC组(对照组)、TGF-β1刺激组、TGF-β1+GKT137831刺激组、共同培养M2型巨噬细胞+HSC组、M2型巨噬细胞+TGF-β1刺激组、M2型巨噬细胞+TGF-β1+GKT137831刺激组,后5组为实验组。采用DCFH-DA探针法检测各组细胞活性氧(ROS)产生水平,采用qRT-PCR法和蛋白质印迹法检测各组HSC细胞NOX4、α-平滑肌肌动蛋白(α-SMA)、Nrf2和HO-1水平。两组数据间的比较采用t检验,多组间比较行One-way ANOVA法分析。结果TGF-β1刺激后细胞内ROS显著升高,各组细胞ROS相对水平分别为1.03±0.11、3.88±0.07、2.90±0.08、0.99±0.06、3.30±0.05、2.21±0.11,F=686.1,P=0.001;NOX4、α-SMA、Nrf2、HO-1 mRNA和蛋白表达显著升高(P<0.05),加入GKT137831后,ROS及NOX4、α-SMA mRNA和蛋白表达较TGF-β1刺激组降低(P<0.05),Nrf2和HO-1 mRNA及蛋白表达升高(P<0.05)。共培养组中TGF-β1刺激后HSC产生的ROS与NOX4、α-SMA mRNA及蛋白表达较单独培养组中TGF-β1刺激后显著降低(P<0.05),而Nrf2和HO-1 mRNA及蛋白表达显著升高(P<0.05),加入GKT137831后,共同培养组中ROS与NOX4、α-SMA mRNA及蛋白表达较单独培养组进一步降低(P<0.05),而Nrf2和HO-1 mRNA及蛋白表达进一步升高(P<0.05)。结论NOX4抑制剂GKT137831能降低HSC中ROS及NOX4、α-SMA水平和升高Nrf2、HO-1水平;M2型巨噬细胞共培养后辅助GKT137831降低HSC中ROS及NOX4、α-SMA水平,升高Nrf2、HO-1水平,调节了氧化应激与抗氧化应激系统间的平衡,从而拮抗纤维化进程。

关键词：肝纤维化肝星状细胞 M2型巨噬细胞氧化应激活性氧

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西伯利亚的俄罗斯化:布里亚特人的语言演变

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西伯利亚研究 2024年第2期51卷 98-109页

作者：敬如歌上海交通大学外国语学院

16世纪,随着俄国不断向东扩张,西伯利亚逐渐同俄语语言文化产生深度关联,进而同化为俄罗斯地理文化空间的一部分。在这一过程中,西伯利亚原住民对俄语的接纳、吸收以及由此引发的民族语言演变,无疑是加速西伯利亚俄罗斯化的重要推力。... 详细信息

16世纪,随着俄国不断向东扩张,西伯利亚逐渐同俄语语言文化产生深度关联,进而同化为俄罗斯地理文化空间的一部分。在这一过程中,西伯利亚原住民对俄语的接纳、吸收以及由此引发的民族语言演变,无疑是加速西伯利亚俄罗斯化的重要推力。聚居于贝加尔湖畔的布里亚特人是西伯利亚本土文化俄罗斯化的历史亲历者。从沙俄时期的西伯利亚开发到苏联时期的扫盲运动、少数族裔文字改造,布里亚特人的民族语言受环境、政策等多重因素的影响而发生改变。步入21世纪,布里亚特人的民族语言危机揭示出西伯利亚少数族裔群体的语言文化构建困境。俄语、布里亚特语之间的非平衡态势既是西伯利亚地区俄罗斯化的历史积累,同时也是语言在流通使用中的发展必然。

关键词：西伯利亚布里亚特人语言演变俄语使用

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颠覆传统设计美国药店寻找新的发展良方

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商业周刊（中文版） 2024年第8期 10-11页

作者： fiona Rutherford 融汐(译) 不详

●美国药店巨头沃尔格林正在颠覆经典的药店设计,将药房从后端移至最前端走进任何一家美国药店,看上去都是一样的:一排排上锁的柜子里摆满了牙膏、洗发水和化妆品。病人在药店的后端排队等候药物,那里的工作人员通常很少,忙碌的药剂师... 详细信息

●美国药店巨头沃尔格林正在颠覆经典的药店设计,将药房从后端移至最前端走进任何一家美国药店,看上去都是一样的:一排排上锁的柜子里摆满了牙膏、洗发水和化妆品。病人在药店的后端排队等候药物,那里的工作人员通常很少,忙碌的药剂师一边忙着咨询,一边忙着接电话。然而这样的做法还是不够。彭博(Bloomberg)最近报道称,美国最大的连锁药店CVS Health Corp.和沃尔格林(Walgreens Boots Alliance Inc.)的利润率正在下降。(后者开始继续尝试出售博姿国际连锁药店。)曾是这两家激烈竞争对手的来德爱公司(RiteAidCorp.)去年10月宣布破产。药店面临的一个关键问题在于店面前端,那里的竞争和通货膨胀使它们盈利难度更大了。

关键词：连锁药店洗发水通货膨胀利润率药剂师排队等候

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欧洲具有广阔的新电商市场

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现代广告 2024年第3期 36-41页

作者： fiona Liu Guillaume Loiseau 陆斌欧洲电商直播协会法国文艺复兴文化传播公司浙江财经大学

fiona Liu女士和Guillaume Loiseau接受本刊专访。他俩介绍,新冠期间欧洲市场已转向电商购物作为正常购买方式。在法国,KOL不是专业的销售人员,不能直接在平台销售产品。直播营销主要是通过促销代码机制重新引流到品牌网站进行交易。

关键词： KOL 促销代码引流品牌网站

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