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Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal J.Goldschmidt-Clermont Aisha Khan George Jimsheleishvili Patricia Graham Adriana brooks Risset Silvera Alexander J.P.Goldschmidt Damien D.Pearse W.Dalton Dietrich Allan D.Levi James D.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FDA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of Dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

The tortuous path of lactate shuttle discovery:From cinders and boards to the lab and ICU

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Journal of Sport and Health Science 2020年第5期9卷 446-460页

作者： George A.brooks Exercise Physiology Laboratory Department of Integrative BiologyUniversity of California BerkeleyCA 94720-3140USA

Once thought to be a waste product of oxygen limited(anaerobic)metabolism,lactate is now known to form continuously under fully oxygenated(aerobic)*** shuttling between producer(driver)and consumer cells fulfills at least 3 purposes;lactate is:(1)a major energy source,(2)the major gluconeogenic precursor,and(3)a signaling *** Lactate Shuttle theory is applicable to diverse fields such as sports nutrition and hydration,resuscitation from acidosis and Dengue,treatment of traumatic brain injury,maintenance of glycemia,reduction of inflammation,cardiac support in heart failure and following a myocardial infarction,and to improve ***,dysregulated lactate shuttling disrupts metabolic flexibility,and worse,supports *** production in cancer(the Warburg effect)is involved in all main sequela for carcinogenesis:angiogenesis,immune escape,cell migration,metastasis,and self-sufficient *** history of the tortuous path of discovery in lactate metabolism and shuttling was discussed in the 2019 American College of Sports Medicine Joseph *** Lecture in Orlando,FL.

关键词： Anaerobic metabolism Exercise Glycolysis Oxidative metabolism Warburg Effect

An overview of patterns and trends in nursing publications from the People's Republic of China

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Frontiers of Nursing 2020年第2期7卷 111-118页

作者： fiona Timmins School of Nursing and Midwifery Trinity College DublinDublin D02 T283Ireland

Objective:To explore patterns and trends in nursing publications from the People's Republic of ***:Using the Scopus online database,the author performed two searches in August *** first search identified all items in the category of nursing affiliated to China,and the second search identified publications from China within one specific nursing *** author used a theoretical framework to provide a more in-depth understanding of patterns and trends within these ***:The number of articles categorized as nursing,with listed authorship in China,within the Scopus database was 17,*** majority of published papers were categorized as ***-ranking Chinese universities,such as Peking University and Fudan University,scored high in terms of several publications listed within the *** categorized as nursing,the most common source titles that are mostly high-ranking journals did not feature the high-ranking nursing *** authors were generally not affiliated with nursing *** analysis of one of the top-ranking nursing journals,the Journal of Nursing Management,featured top Chinese universities and consistent nursing *** authors were found to have lower h-indices than international nursing ***:There has been a steady increase year by year in publications categorized as nursing from China since 2009,with the majority of published papers categorized as *** is clear evidence of scholarly activity in nursing in China,both in the published literature and anecdotally in ***,nursing scholars need to do more to increase dissemination and ensure that nursing professors are leading and driving nursing research,although in a multidisciplinary *** is also a need for increased exposure of Chinese nursing scholarship in high-ranking nursing journals.

关键词： nurse nursing research publication dissemination

Translating science to inform global policy on physical activity

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Journal of Sport and Health Science 2018年第1期7卷 3-4页

作者： fiona Bull Surveillance and Population Based Prevention Prevention of Noncommunicable Disease World Health Organization School of Human Science The University of Western Australia

Regular physical activity(PA)provides well established multiple health benefits and can improve physical,mental,and social health for people of all *** 2004,the World Health Organization(WHO)launched the first global strategy on diet and PA,1which urged all countries to implement a set of recommended policy actions to increase levels of ***

关键词：物理科学翻译乐观主义健康催化剂 PA 宽度

Applied biodiversity science in China in the global context

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National Science Review 2021年第7期8卷 62-65页

作者： Thomas M.brooks Xinsheng Zhang International Union for Conservation of Nature

In 2021, the city of Kunming in Yunnan Province, China,will host the fifteenth meeting of Conference of Parties of the Convention on Biological Diversity. The meeting is expected to be the pivotal moment at which the world’s governments agree on a new ‘Post-2020 Global Biodiversity Framework’(https://***/conferences/post2020). The framework is anticipated to be structured around a small number of outcome goals for 2050—a compelling case has been made that these should include explicit goals for ecosystems, species,genetic diversity and the contributions which nature makes to people [1].

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Birthplace is not a determinant of colorectal adenomas

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World Journal of Gastroenterology 2014年第26期20卷 8606-8611页

作者： fiona Tran Jenn Hian Koo Department of Gastroenterology and Hepatology Liverpool Hospital Department of Gastroenterology The University of New South Wales

AIM: To examine the impact of the patient’s birthplace on the prevalence of colonic polyps and histopathological subtypes.

关键词： Ethnicity Polyps Adenomas Advanced adenomas Colorectal cancer

Does digit ratio （2D：4D） predict penile length？

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Asian Journal of Andrology 2011年第5期13卷 667-668页

作者： Denise brooks McQuade Department of Biology Skidmore College SaratogaSprings NY 12866 USA

Now advertized in at least one locale as the ＇sexy ratio＇ with the caption, ＇Your hands give away your hotness＇（http：//***/ #!5794008; accessed 3 May 2011）, an online summary of a recent study linking facial attractiveness to the ratio of the index and ring fingers1 indicates that digit ratio （2D：4D） research has reached mainstream culture. Digit ratio, most commonly the ratio of the index to ring fingers in humans, is sexually dimorphic （males have lower values than females） with greater differences on their right hand.

关键词： Acute lymphocytic leukaemia Cancer microenvironment Myeloproliferative disease

The“Great Flood”of 1926:environmental change and post-disaster management in British Malaya

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Ecosystem Health and Sustainability 2016年第11期2卷 10-18页

作者： fiona Williamson Asia Research Institute 10 Kent Ridge CrescentNational University of Singapore119260Singapore

This paper is an historical case study of a major flood that occurred in British Malaya in *** focuses on two key ***,that the magnitude and subsequent impacts of the flood were exacerbated by contemporary industrial,agricultural,and hydraulic ***,that this event pushed the British colonial government toward improving their land and river management strategies over the following *** article draws on recent research arguing the importance of an historical approach to disaster,as it enables greater insight into a disaster’s causes and long-term political,social,and environmental *** on December 1926-a month of especially severe flooding likely linked to La Niña-this article will explore how those inundations became disastrous because of man-made changes enacted on the local *** will consider the sequential effect of the inundations,from their immediate to medium-term impact on the environment,to subsequent government-led flood mitigation *** viewing the mid-1920s floods as a catalyst for change,with the benefit of hindsight,it is also possible to assess how far these changes were positive or negative.

关键词： British Malaya disaster environment floods history hydraulic governance.

Post-industrial Economic Restructuring and Wage Inequality in Urban China, 2003-2015: A Sectoral Perspective

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Chinese Geographical Science 2020年第3期30卷 516-531页

作者： YANG fiona Fan HU Fox Zhiyong WANG Yuhua School of Geography and Planning Sun Yat-sen UniversityGuangzhou 510275China Department of Asian and Policy Studies The Education University of Hong KongHong Kong 999077China College of Water Conservancy and Civil Engineering China Agricultural UniversityBeijing 100083China

Income inequality in urban China has attracted growing attention from China’s urban researchers and policy makers. Whereas many studies have interrogated the pattern and process of the income gap in Chinese cities undergoing the institutional transformation from plan to market, relatively little is known about how such unequal distribution of income is related to China’s ongoing structural transformation toward a post-industrial economy. Drawing on a decomposition methodology based on the Theil index, this study aimed to address this lacuna through an empirical investigation of China’s urban wage inequality from a sectoral perspective. Our empirical study identified the low-wage manufacturing sector and the high-wage producer services sector as the two biggest contributors to urban wage inequality in China. Urban wage inequality within the producer services was found to be caused by the spatial concentration of a disproportionate number of high-paying jobs in a few developed, high-tier city-regions on the eastern coast. Our empirical findings have important implications for the formulation of policies to address the income inequality that plagues China’s continuing urbanization.

关键词： wage inequality post-industrial economy economic restructuring producer service urban China