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世界核心医学期刊文摘（神经病学分册） 2005年第7期1卷 38-39页

作者： Correale J. fiol m. 朱光明 Raul Carrea Inst. for Neurol. Res. FLEN I Montaneses 2325 (1428) Buenos Aires Argentina Dr.

Objective: To study immunologic alterations in patients with neuromyelitis opt ica (NmO). methods: The authors studied 8 patients with NmO together with 16 hea lthy subjects, 16 patients with relapsing remitting multiple sclerosis (RRmS), a nd16 patients with secondary progressive mS (SPmS), matched for age and sex, as controls. Because recent histopathologic studies have demonstrated that active N mO lesions consist of perivascular immunoglobulin (Ig) deposition and eosinophil in filtration, IL-5, IL-6, IL-12, IgG, and Igm production by anti-myelin oli godendrocyte glycoprotein (mOG) mononuclear cells in peripheral blood and CSF we re selected for study using ELISPOT. Eotaxin-2 (Eo-2) and eotaxin-3 (Eo-3)le vels were also assessed using ELISA and eosinophil cationic protein (ECP) levels by radioimmunoassay. Results: mOG specific responses in CSF showed significant increase in IL-5,IL-6, IgG, and Igm secreting cells in NmO patients compared w ith patients with RRmS, SPmS and healthy subjects. Interestingly,numbers of Igm secreting cells were significantly higher than identical specificity IgG secreti ng ones. moreover,CSF Eo-2, Eo-3, and ECP levels were also significantly highe r in NmO patients compared to all three control ***-mOG IL-12 sec reting cells were increased in CSF and peripheral blood from NmO, RRmS, and SPmS patients when compared to healthy subjects. Conclusions: These observations suggest that neu romyelitis optica is associated with amajor humoral immune response (particularl y anti-mOG Igm production) and eosinophil activation present exclusively in CSF .

关键词：视神经脊髓炎嗜酸性粒细胞体液免疫髓鞘免疫球蛋白 eosinophil 健康受试者 myelin Eotaxin IgG

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地中海膳食干预研究中来自胆碱通路的血浆代谢物与心血管病风险的关系

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中华高血压杂志 2017年第12期25卷 1108-1108页

作者：黄洁叶鹏 Guasch-Ferré m Hu FB Ruiz-Canela m Bulló m Toledo E Wang DD Corella D Gómez-Gracia E fiol m Estruch R Lapetra J Fitó m Arós F Serra-majem L Ros E Dennis C Liang L Clish CB martínez-González mA Salas-Salvadó J

血浆甜菜碱水平以及胆碱代谢水平与主要心血管病终点之间的联系仍不清楚。研究者评估了胆碱通路的代谢物与偶发心血管病风险以及地中海膳食干预的潜在调节效应之间的相关性。

关键词：心血管病膳食干预代谢物地中海胆碱风险血浆通路

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Serum Adiponectin levels in Different Phenotypes of Polycystic Ovary Syndrome

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Open Journal of Endocrine and metabolic Diseases 2012年第4期2卷 125-131页

作者： Carolina Fux Otta Paula Szafryk de mereshian Raquel Kaplan Gabriel Santino Iraci Silvia Ojeda José Ochoa Andrés Albrecht Natalia Filipone marta fiol de Cuneo Cátedra de Farmacología Aplicada Facultad de Ciencias Médicas Universidad Nacional de Córdoba (UNC) Córdoba Argentina Cátedra de Fisiología Humana Facultad de Ciencias Médicas Universidad Nacional de Córdoba (UNC) Córdoba Argentina Departamento de Endocrinología y Diabetes Hospital Universitario de Maternidad y Neonatología (HUM y N) Córdoba Argentina Diangus Diagnóstico por imágenes docencia e investigación Córdoba Argentina Grupo de Probabilidad y Estadística Facultad de Matemática Astronomía y Física (UNC) Córdoba Argentina Laboratorio mEGA Rafaela Santa Fe

Objectives: to evaluate and compare serum adiponectin levels in different phenotypes of polycystic ovary syndrome (PCOS) and to investigate their correlation with endocrine and metabolic parameters. material and methods: we studied 5 groups of patients: A (n = 20): H (hyperandrogenism) + O (oligoanovulation) + P (polycystic ovary) [classic phenotype];B (n = 17): H + O [classic phenotype but normal ovaries];C (n = 15): H + P [Ovulatory phenotype];D (n = 17): O + P [Normoandrogenic phenotype];and E (n = 16) control group. Body mass index, waist circumference, waist/hip ratio, blood pressure and hirsutism were evaluated. Serum concentrations of adiponectin, insulin, Creactive protein, SHBG, androgens and lipids were measured. Oral glucose tolerance test was performed. Results: there were no differences between the groups in terms of age and BmI. Total cholesterol, LDL-C and triglyceride levels were higher in phenotype A than in C (P P = 0.03). HOmA-IR, insulin and glucose/insulin ratio were significantly higher in phenotypes A and D vs C and E (P P P m concentrations vary according to the phenotypic expression of PCOS. Our results suggest that adiponectin could be used as a biochemical marker to identify phenotypes at increased metabolic risk.

关键词： Polycystic Ovary Syndrome Phenotypes Adiponectin

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心电图判断急性下壁心梗时右冠状动脉闭塞部位的新标准

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国外医学（心血管疾病分册） 2005年第3期32卷 192-192页

作者： fiol m 张小雷（摘）崔炜（校）

该研究评估了新的ECG诊断标准的价值，即在Ⅰ导联及aVL导联ST段压低的总和以及ST段在V1导联的变化，来判断急性下后壁心梗的病人右冠状动脉闭塞的部位。

关键词：右冠状动脉闭塞急性下壁心梗闭塞部位标准导联ST段压低心电图 V1导联后壁心梗 ECG

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