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高质量发展背景下提升二级公立医院行政办公室创新管理效能的思考

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中国卫生产业 2024年第8期21卷 250-252,256页

作者：杨宇卓王倩塔拉北京四季青医院北京100097

行政办公室作为公立医院重要的行政职能管理部门,具有传达落实各项制度与决策、工作协调、调研、监督管理、服务患者等多项基础职能,是公立医院各类重大工作部署与落实中具有内外上下协调联动的中枢部门,但在实际工作过程中却存在一定... 详细信息

行政办公室作为公立医院重要的行政职能管理部门,具有传达落实各项制度与决策、工作协调、调研、监督管理、服务患者等多项基础职能,是公立医院各类重大工作部署与落实中具有内外上下协调联动的中枢部门,但在实际工作过程中却存在一定的管理漏洞,如管理方法陈旧、管理流程存在漏洞等。在高质量发展背景下,公立医院对行政办公室的职能与工作水平也有了更高的要求,要求其需充分依托科室优势,重视人才培养,加强沟通以及建设优质服务团队、提升服务质量等,注重细节管理抓住机会弥补医院劣势,促进办公室重点工作职能的完善与转变,更好地为医院高质量发展提供帮助。

关键词：高质量发展二级公立医院行政办公室管理效能职能转变

Kinetic modeling of high-temperature oxidation of pure Mg

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Journal of Magnesium and Alloys 2020年第3期8卷 819-831页

作者： Sa Ma Fangzhou Xing Na ta Lijun Zhang State Key Laboratory of Powder Metallurgy Central South UniversityChangshaHunan 410083P.R.China Max-Planck-Institut fiir Eisenforschung GmbH Max-Planck-Straβe 140237DusseldorfGermany

A variety of experimental tracer diffusivities of Mg and O in magnesium oxide available in the literature were first *** mobilities including bulk and short-circuit diffusion of Mg and O were then obtained by means of the CALPHAD(Calculation of Phase Diagram)***,the diffusion-controlled kinetic model of oxidation in a gas-MgO-Mg environment was developed based on the moving boundary model and Fick's law,coupling with the modified thermodynamic description of MgO.A mathematical expression for parabolic rate constant kp of the oxide scale was derived for magnesia and correlated with the thermodynamic and diffusion kinetic *** evaluated kp results were in line with the experimental ***,the oxidation process of pure magnesium at 673 K was model-predicted,and the predicted evolution of the oxide thicknesses agreed very well with the experimental *** was indicated that the grain boundaries diffusion of magnesium cations predominated the high temperature oxidation process.

关键词： MgO Diffusion Oxidation Atomic mobility CALPHAD Wagner's model

Functional,chemical,and sensorial properties of gluten-free fermented instant soup powders developed by use of mung bean and drum drying process

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Food Bioscience 2022年第3期47卷 1070-1081页

作者： Bilge taşkın NazlıSavlak Department of Food Engineering Faculty of EngineeringManisa Celal Bayar University45140YunusemreManisaTurkey

There is a potent demand to develop novel gluten-free food alternatives that are nutritious and ***-free instant fermented soup powder was developed by partial substitution of rice flour with mung bean *** of drum drying conditions;feed moisture(45–65%),drum rotating speed(0.6–2.2 rpm),and steam pressure(75–95 psi)on functional,chemical,sensorial,and morphological properties of soup powders were *** powders exhibited high protein content(20.52–22.62%)and remarkable amounts of dietary fibers(2.63–3.94%),total phenolics(2.23–3.64μg GAE/g),and antioxidant capacities(DPPH:6.28–9.96μmol TEAC/g,FRAP:26.02–42.88μmol/g).The instant structure of the soup powder was provided by water solubility(17.93–23.14%),water absorption(3.20–4.20 g/g),and gelatinization degree(82.92–97.60%)analyses,as well as SEM appearances and DSC *** conditions were determined as 57.55%feed moisture,1.00 rpm rotating speed,and 91.27 psi steam *** instant soup powders had enhanced chemical,functional and bioactive properties,and can be used practically in daily and social life by celiac patients or gluten sensitive *** bean was proven to be a valid option for novel application opportunities in gluten-free systems.

关键词： Gluten-free Antioxidant activity Mung bean Optimization Instant soup Drum drying Quality characteristics

Study on the dynamic behavior of herringbone gear structure of marine propulsion system powered by double-cylinder turbines

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Science China(Technological Sciences) 2022年第3期65卷 611-630页

作者： XU JiangHai JIAO ChunXiao ZOU DongLin ta Na RAO ZhuShi State Key Laboratory of Mechanical System and Vibration Institute of VibrationShock and NoiseShanghai Jiao Tong UniversityShanghai 200240China Collaborative Innovation Center for Advanced Ship and Deep-Sea Exploration Shanghai 200240China

Propulsion systems powered by double-cylinder turbines(DCT)are widely used in large-scale ***,the nonlinear instability leads to hidden dangers associated with the safe operation,and there is a lack of theoretical and systematic research on this *** on the gear transmission principle and non-Newtonian thermal elastohydrodynamic lubrication(EHL)theory,a torsional model of a two-stage herringbone system forced by unsymmetrical load is *** nonlinear and time-varying factors of meshing friction,meshing stiffness,and gear pair backlash are included in the model,and multiple meshing states,including single-and double-sided impact are *** nonlinear phenomena of the dynamic system are explored and the effects of the unsymmetrical load on the system stability are *** results indicate that the stability of the gear system is improved,and that the back-sided impact gradually disappears with the increases of load ratio between the two inputs and the input load ***,it is found that the gear pairs on the low-load side experience more severe vibration than those on the high-load ***,the stability of the gear pairs decreases along the power transmission path of the multistage gear *** results of this research will be useful when making predictions of the stability of such systems and in the optimization of the load parameters.

关键词： DCT propulsion system DI-SO herringbone gears unsymmetrical load nonlinear instability mechanism

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可编织、可穿戴的宽带聚合物超声换能器

Science China Materials 2024年第8期67卷 2653-2660页

作者：邹君逸郭星奕吴家琦徐冬梅许凯亮陈培宁他得安彭慧胜 State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular Science Institute of Fiber Materials and DevicesLaboratory of Advanced MaterialsFudan UniversityShanghai 200438China Department of Biomedical Engineering Yiwu Research Institute and Shanghai Poda Medical Technology Co.Ltd.Fudan UniversityShanghai 200438China

新兴的物联网技术推动了可穿戴健康监测设备的快速发展.目前,医学超声技术在严重慢性疾病的长时间监测方面具有广阔的应用前景.然而,商用超声探头一般都是刚性的,需要手持,难以满足医疗可穿戴设备对柔性化、小型化和舒适性的要求.本文... 详细信息

新兴的物联网技术推动了可穿戴健康监测设备的快速发展.目前,医学超声技术在严重慢性疾病的长时间监测方面具有广阔的应用前景.然而,商用超声探头一般都是刚性的,需要手持,难以满足医疗可穿戴设备对柔性化、小型化和舒适性的要求.本文提出了一种可编织、可穿戴的聚合物超声换能器,该换能器由匹配层、背衬层和压电层组成.聚合物压电材料的带宽(93%)是压电陶瓷的7倍,并且可以承受超过10,000次的弯曲和扭曲变形.该传感器能监测颈动脉血液流速,心脏血液流速和心脏血管的血管厚度,并具有与商用探头相当的信噪比.它的宽带特性(3.68–10.08 MHz)使其能通过调整频率来监测不同的组织.可编织超声换能器可以制成纤维形式,并编织成透气织物,在不牺牲穿戴舒适性的情况下进行实时血管监测.

关键词：血液流速超声换能器可穿戴设备超声探头扭曲变形匹配层慢性疾病压电材料

Glutamic acid decarboxylase 65-positive autoimmune encephalitis presenting with gelastic seizure, responsive to steroid: A case report

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World Journal of Clinical Cases 2021年第19期9卷 5325-5331页

作者： Camerdy Yue Yang Sheng-ta Tsai Department of Neurology China Medical University HospitalTaichung 404332Taiwan

BACKGROUND Anti-glutamic acid decarboxylase(GAD)antibody is known to cause several autoimmune-related *** most known relationship is that it may cause type I *** addition,it was also reported to result in several neurologic syndromes including stiff person syndrome,cerebellar ataxia,and autoimmune *** ago,isolated epilepsy associated with anti-GAD antibody was first ***,the association between temporal lobe epilepsy and anti-GAD antibody has been ***,with improvements in examination technique,many more autoimmune-related disorders can be diagnosed and treated easier than in the *** SUMMARY A 44-year-old female Asian with a history of end-stage renal disease(without diabetes mellitus)under hemodialysis presented with diffuse abdominal *** initial diagnosis was peritonitis complicated with sepsis and paralytic *** peritonitis was treated and she recovered well,but seizure attack was noticed during *** clinical impression was gelastic seizure with the presentation of frequent smiling,head turned to the right side,and eyes staring without focus;the duration was about 5–10 *** lobe epilepsy was recorded through electroencephalogram,and she was later diagnosed with anti-GAD65 antibody positive autoimmune *** seizure was treated initially with several anticonvulsants but with poor ***,she showed excellent response to intravenous methylprednisolone pulse *** consciousness returned to normal,and no more seizures were recorded after 5 d of intravenous methylprednisolone *** In any case presenting with new-onset epilepsy,in addition to performing routine brain imaging to exclude structural lesion and cerebrospinal fluid studies to exclude common etiologies of infection and inflammation,checking the autoimmune profile has to be *** the practice of modern medicine,autoimmune-related disorders are relatively treatab

关键词： Anti-GAD antibody GAD65 antibody Autoimmune encephalitis Gelastic seizure Electroencephalogram Case report

CCT各亚基在甲状腺癌中的表达及其对患者临床预后、肿瘤微环境和化疗药物敏感性的影响

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中国肿瘤生物治疗杂志 2024年第9期31卷 895-906页

作者：施晓辉白云峰塔拉白银宝顾佳慧内蒙古自治区人民医院肿瘤中心甲状腺肿瘤外科内蒙古呼和浩特010000 内蒙古科技大学包头医学院研究生院内蒙古包头014000

目的:探究含t-复合物1的伴侣蛋白(CCT)的8个亚基在甲状腺癌(TC)组织中的表达及其与TC分期、患者预后、免疫细胞浸润、免疫检查点表达和化疗药物敏感性的相关性。方法:采用TCGA数据库数据分析CCT各亚基在TC组织和癌旁组织中的表达;用TCG... 详细信息

目的:探究含t-复合物1的伴侣蛋白(CCT)的8个亚基在甲状腺癌(TC)组织中的表达及其与TC分期、患者预后、免疫细胞浸润、免疫检查点表达和化疗药物敏感性的相关性。方法:采用TCGA数据库数据分析CCT各亚基在TC组织和癌旁组织中的表达;用TCGA数据库数据分析CCT各亚基表达与TC患者预后的关系;用GSEA法分析CCT各亚基的生物学功能;用TCGA和TIMER2.0数据库数据分析CCT各亚基表达与肿瘤微环境、免疫细胞浸润、化疗药物敏感性、免疫检查点表达的相关性。结果:数据库数据分析显示,在TC组织中CCT3、CCT7和CCT8 mRNA均呈高表达(P<0.01或P<0.001),而CCT1、CCT2、CCT5和CCT6B mRNA均呈低表达(P<0.01或P<0.001);CCT3、CCT6B、CCT8 mRNA的表达与T分期有关联(P<0.05或P<0.01)、CCT6B mRNA的表达与淋巴结转移有关联(P<0.01),CCT5 mRNA的表达与远处转移有关联(P<0.05),CCT6B可能是TC患者OS的独立预后生物标志物;CCT各亚基mRNA表达主要富集于移植物排斥、补体和干扰素-γ等信号通路;CCT各亚基mRNA低表达组TC组织的基质、免疫和综合评分均显著高于高表达组(P<0.05或P<0.01或P<0.001);CCT各亚基mRNA表达与TC的基质评分、免疫评分和综合评分均呈负相关(均P<0.01);CCT各亚基mRNA的表达与CD8+T细胞和巨噬细胞浸润均呈正相关(均P<0.05),多数CCT亚基(CCT6B和CCT7除外)的mRNA表达与中性粒细胞的浸润呈正相关(P<0.05或P<0.01或P<0.001),而CCT3、4、7、8mRNA的表达与CD4+T细胞浸润呈负相关(均P<0.05);与低表达组比较,大多数CCT亚基mRNA高表达的TC患者对索拉非尼、乐伐替尼、达拉非尼、曲美替尼、凡德他尼和卡博替尼等化疗药物的IC50均明显升高(P<0.05或P<0.01或P<0.001);TC组织中CCT各亚基mRNA的表达与PD-1、PD-L1、PD-L2、CTLA4、CD80和CD86表达均有明显关联(P<0.05或P<0.01或P<0.001)。结论:CCT复合物可能通过影响肿瘤微环境促进TC的发生发展,进而影响患者预后,其可成为难治性TC诊断和免疫治疗的潜在靶点。

关键词：甲状腺癌 CCT复合物预后免疫细胞浸润药物敏感性

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近40 a昆仑山北麓典型河流生态基流时空特征

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长江科学院院报 2024年第1期41卷 44-51页

作者：胡可可何建村赵健塔依尔苏里坦中国科学院新疆生态与地理研究所荒漠与绿洲生态国家重点实验室乌鲁木齐830011 中国科学院大学资源与环境学院北京100049 新疆维吾尔自治区水利厅水资源规划研究所乌鲁木齐830000

生态基流是河流生态系统健康稳定的关键,对于水资源缺乏的干旱区内陆河流尤为重要。以昆仑山北麓克里雅河、尼雅河与车尔臣河3条典型季节性内陆河为研究对象,选取1978—2014年流域水文数据,利用QP法、Tennant法、近10 a最枯月平均流量法... 详细信息

生态基流是河流生态系统健康稳定的关键,对于水资源缺乏的干旱区内陆河流尤为重要。以昆仑山北麓克里雅河、尼雅河与车尔臣河3条典型季节性内陆河为研究对象,选取1978—2014年流域水文数据,利用QP法、Tennant法、近10 a最枯月平均流量法和Texas法4种水文学方法,计算确定河流生态基流并据此分析其时空分异特征与影响因素。结果表明:Tennant法更适合昆仑山北麓河流生态基流计算。从时间变化来看,3条河生态基流年内最大值均出现在7月份,最小值均出现在1月份;年生态基流最大值均出现在2010年左右,最小值在1980年前后,分别以1.378、0.653、3.066 m^(3)/s·(10 a)^(-1)的速度增加。3条河流生态基流空间分布,春季表现为车尔臣河>克里雅河>尼雅河,夏季和秋季均表现为克里雅河>车尔臣河>尼雅河,且同一河流波动变化明显,不同河流之间变化差异不显著(p>0.05)。影响生态基流年内时空差异的主要因素分别是气温、降水和人类活动,其中以车尔臣河流域气温、降水与生态基流的相关性最强,相关系数r分别为0.876、0.917。考虑生态基流时空分布与流域气候变化特征,综合提出3条河流年内各月生态基流管控目标。研究结果可为昆仑山北麓河流生态保护与水资源管理调度提供参考。

关键词：生态基流时空特征 Tennant法管控目标昆仑山北麓

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Co_3O_4 nanosheets:synthesis and catalytic application for CO oxidation at room temperature

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Science China Chemistry 2014年第6期57卷 873-880页

作者： LV YongGe LI Yong ta Na SHEN WenJie State Key Laboratory of Catalysis Dalian Institute of Chemical PhysicsChinese Academy of Sciences

Hexagonal β-Co(OH)2 nanosheets with edge length of 50 nm and thickness of 10 nm were hydrothermally synthesized with the aid of *** calcination at 350°C in air,the β-Co(OH)2 nanosheets was converted into Co3O4 nanosheets with a similar *** analyses during the calcination process identified that the β-Co(OH)2 precursor was initially dehydrated to HCoO2 and subsequently transferred into *** being applied to catalyze CO oxidation at room temperature,the Co3O4 nanosheets exhibited a higher activity than the conventional spherical *** was perhaps related to the partial exposure of the{112}planes over the Co3O4 *** porous structure generated during the calcination process also provided significant amounts of surface defects,which might contribute to the enhanced catalytic activity as well.

关键词： Co3O4 nanosheets CO oxidation morphology-dependence nanocatalysis