检索结果-南通市图书馆

Hepatobiliary Surgery and Nutrition 2020年第4期9卷 511-513页

作者： Valentina Cossiga Maria Guarino filomena morisco Nicola Caporaso Gastroenterology Unit Department of Clinical Medicine and SurgeryUniversity of Naples“Federico II”NaplesItaly

Hepatocellular carcinoma(HCC)is the fifth most common cancer and the second most frequent cause of cancer-related death *** C virus(HCV)infection is one of leading cause of cirrhosis,that is the strongest risk factor ... 详细信息

关键词： cancer death cirrhosis

Direct-acting antivirals and hepatocellular carcinoma in chronic hepatitis C: A few lights and many shadows

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2018年第24期24卷 2582-2595页

作者： Maria Guarino Anna Sessa Valentina Cossiga Federica Morando Nicola Caporaso filomena morisco Gastroenterology Unit Department of Clinical Medicine and SurgeryUniversity of Naples Federico Ⅱ

With the introduction of direct-acting antiviral agents(DAA), the rate of sustained virological response(SVR) in the treatment of hepatitis C virus(HCV) has radically improved to over 95%. Robust scientific evidence supports a beneficial role of SVR after interferon therapy in the progression of cirrhosis, resulting in a decreased incidence of hepatocellular carcinoma(HCC). However, a debate on the impact of DAAs on the development of HCC is ongoing. This review aimed to analyse the scientific literature regarding the risk of HCC in terms of its recurrence and occurrence after the use of DAAs to eradicate HCV infection. Among 11 studies examining HCC occurrence, the de novo incidence rate ranged from 0 to 7.4%(maximum follow-up: 18 mo). Among 18 studies regarding HCC recurrence, the rate ranged from 0 to 54.4%(maximum "not well-defined" followup: 32 mo). This review highlights the major difficulties in interpreting data and reconciling the results of the included studies. These difficulties include heterogeneous cohorts, potential misclassifications of HCC prior to DAA therapy, the absence of an adequate control group, short follow-up times and different kinds of follow-up. Moreover, no clinical feature-based scoring system accounts for the molecular characteristics and pathobiology of the tumours. Nonetheless, this review does not suggest that there is a higher rate of de novo HCC occurrence or recurrence after DAA therapy in patients with previous HCV infection.

关键词： hepatocellular carcinoma hepatitis C virus direct-acting antiviral agents occurrence recurrence

Hepatitis B and C virus reactivation in immunosuppressed patients with inflammatory bowel disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2014年第13期20卷 3516-3524页

作者： Stefano Sansone Maria Guarino Fabiana Castiglione Antonio Rispo Francesco Auriemma Ilaria Loperto Matilde Rea Nicola Caporaso filomena morisco Gastroenterology Unit Department of Clinical Medicine and SurgeryUniversity of Naples "Federico II"80131 NaplesItaly

In recent years,a number of case reports and clinical studies have highlighted the risk of hepatitis B and C virus reactivation in patients with inflammatory bowel disease who are treated with immunosuppressive *** cases of viral hepatitis reactivation that have been reported are characterized by a wide range of clinical manifestations,from viremia without clinically relevant manifestations to fulminant life-threatening *** development and dissemination of biological immunosuppressive drugs have led to a significant increase in the number of reports of interest to physicians in a variety of clinical *** this topic,there have been a number of published guidelines and reviews that have collected the available evidence,providing recommendations on prophylactic and therapeutic strategies and methods for monitoring patients at ***,it should be noted that,to date,very few clinical studies have been published,and most of the recommendations have been borrowed from otherclinical *** published studies are mostly retrospective and are based on very heterogeneous populations,using different therapeutic and prophylactic regimens and obtaining conflicting ***,it seems clear that it is desirable to concentrate our efforts on prospective studies,not conducting further reviews of the literature in the continued absence of new evidence.

关键词： Inflammatory bowel disease Biological agents Hepatitis B virus reactivation Hepatitis C virus reactivation Prophylaxis

Sustained virological response: A milestone in the treatment of chronic hepatitis C

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2013年第18期19卷 2793-2798页

作者： filomena morisco Rocco Granata Tommaso Stroffolini Maria Guarino Laura Donnarumma Laura Gaeta Ilaria Loperto Ivan Gentile Francesco Auriemma Nicola Caporaso Dipartimento di Medicina Clinica e Chirurgia Gastroenterology Unit University of Naples "Federico Ⅱ" 80131 Naples Italy Dipartimento di Malattie Infettive e Tropicali University of Rome "La Sapienza" 00161 Rome Italy Dipartimento di Medicina Clinica e Chirurgia Infectious Diseases Unit University of Naples "Federico Ⅱ" 80131 Naples Italy

AIM: To evaluate the long-term eradication of hepatitis C virus (HCV) infection and liver-related complications in chronically infected patients that have achieved sustained virological response. METHODS: One hundred and fifty subjects with chronic hepatitis C (CHC) or cirrhosis and sustained virological response (SVR) between the years of 1989 and 2008 were enrolled in a long-term clinical follow-up study at the Gastrointestinal and Liver Unit of the University Hospital of Naples "Federico Ⅱ". At the beginning of the study, the diagnosis of HCV infection was made on the basis of serum positivity for antibodies to HCV and detection of HCV RNA transcripts, while a diagnosis of chronic hepatitis was formulated using imaging techniques and/or a liver biopsy. SVR was achieved by interferon-based therapy, both conventional and pegylated, with and without ribavirin treatment. The patients were evaluated for follow-up at a median length of 8.6 years, but ranged from 2-19.9 years. Among them, 137 patients had pre-treatment CHC and 13 had cirrhosis. The patients were followed with clinical, biochemical, virological, and ultrasound assessments on a given schedule. Finally, a group of 27 patients underwent a liver biopsy at the beginning of the study and transient elastography at their final visit to evaluate changes in liver fibrosis. RESULTS: The median follow-up was 8.6 years (range 2-19.9 years). HCV RNA remained undetectable in all patients, even in patients who eventually developed liver-related complications, indicating no risk of HCV recurrence. Three liver-related complications were observed: two cases of hepatocellular carcinoma and one case of bleeding from esophageal varices resulting in an incidence rate of 0.23%/person per year. Further, all three complications took place in patients diagnosed with cirrhosis before treatment began. Only one death due to liver-related causes occurred, resulting in a mortality rate of 0.077% person per year. This amounts to a 99.33

关键词： Antiviral therapy Cirrhosis Hepatitis C virus Sustained virological response Fibrosis

Polymorphism AGT2(rs4762)is involved in the development of dermatologic events:Proof-of-concept in hepatocellular carcinoma patients treated with sorafenib

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Hepatology 2022年第7期14卷 1438-1458页

作者： Víctor Sapena Massimo Iavarone Loreto Boix Floriana Facchetti Maria Guarino Marco Sanduzzi Zamparelli Alessandro Granito Esther Samper Mario Scartozzi Josep Corominas Giorgia Marisi Alba Díaz Andrea Casadei-Gardini Laura Gramantieri Pietro Lampertico filomena morisco Ferran Torres Jordi Bruix María Reig Barcelona Clinic Liver Cancer Group Liver UnitHospital Clínic de BarcelonaInstitut d'Investigacions Biomèdiques August Pi SunyerCentro de Investigación Biomédica en Red Enfermedades Hepáticas y DigestivasBarcelona 08036Spain Universidad de Barcelona Barcelona 08036Spain Division of Gastroenterology and Hepatology Foundation Istituto di Ricovero e Cura a Carattere Scientifico di Natura Pubblica Ca’Granda Ospedale Maggiore PoliclinicoMilano 20122Italy Department of Clinical Medicine and Surgery Gastroenterology UnitUniversity of Naples Federico IINaples 80131Italy Gastroenterology and Hepatology Unit Fondazione Istituto di Ricovero e Cura a Carattere Scientifico di Natura Pubblica CàGranda Ospedale Maggiore PoliclinicoUniversity of MilanMilan 20100Italy Department of Clinical Medicine and Surgery Gastroenterology UnitUniversity of Naples"Federico II"Napoli 80100Italy Department of Clinical Medicine and Surgery Gastroenterology and HepatologyFederico II University of NaplesNaples 80131Italy Division of Internal Medicine Hepatobiliary and Immunoallergic DiseasesIstituto di Ricovero e Cura a Carattere Scientifico di Natura Pubblica Azienda Ospedaliero-Universitaria di BolognaBologna 40139Italy Department of Medical and Surgical Sciences University of BolognaBologna 40139Italy Department of Medical Oncology University of CagliariCagliari 45698Italy Biosciences Laboratory Istituto di Ricovero e Cura a Carattere Scientifico di Natura PubblicaIstituto Romagnolo per lo Studio dei Tumori“Dino Amadori”Meldola 47014Italy Department of Pathology Hospital Clínic de BarcelonaUniversitat de BarcelonaBarcelona 08036Spain School of Medicine Vita-Salute San Raffaele UniversityMilan 20132Italy Unit of Oncology UniversitàVita-SaluteIstituto di Ricovero e Cura a Carattere Scientifico di Natura Pubblica-San Raffaele Scientific InstituteMilan 20132Italy Division of Internal Medicine Hepatobiliary and Immunoallergic DiseasesIstituto di Ricovero e Cura a Carattere Scientifico di Natura Pubblica Aziend

BACKGROUND Dermatologic adverse events(DAEs)are associated with a better outcome in patients with hepatocellular carcinoma(HCC)irrespective of the therapeutic agent *** exact mechanisms associated with the development of DAEs are unknown although several studies point to direct toxicity of tyrosine kinase inhibitors(TKIs)to the skin or an immune-mediated reaction triggered by the oncologic *** is the case in other conditions,individual genetic variants may partially explain a higher risk of *** To evaluate the contribution of several gene variants to the risk of developing DAEs in HCC patients treated with *** We first analyzed 27 single-nucleotide polymorphisms(SNPs)from 12 genes selected as potential predictors of adverse event(AE)development in HCC patients treated with sorafenib[Barcelona Clinic Liver Cancer 1(BCLC1)cohort].Three additional cohorts were analyzed for AGT1(rs699)and AGT2(rs4762)polymorphisms-initially identified as predictors of DAEs:BCLC2(n=79),Northern Italy(n=221)and Naples(n=69)cohorts,*** relation between SNPs and DAEs and death were assessed by univariate and multivariate Cox regression models,and presented with hazard ratios and their 95%confidence intervals(95%CI).RESULTS The BCLC1 cohort showed that patients with arterial hypertension(AHT)(HR=1.61;P value=0.007)and/or AGT SNPs had an increased risk of ***,AGT2(rs4762)AA genotype was found to be linked to a statistically significant increased probability of DAEs(HR=5.97;P value=0.0201,AA vs GG)in the Northern Italy cohort by multivariate analysis adjusted for BCLC stage,ECOG-PS,diabetes and *** value of this genetic marker was externally validated in the cohort combining the BCLC1,BCLC2 and Naples cohorts[HR=3.12(95%CI:1.2-8.14),P value=0.0199,AGT2(rs4762)AA vs AG genotype and HR=2.73(95%CI:1.18-6.32)P value=0.0188,AGT2(rs4762)AA vs GG genotype].None of the other gene variants tested were found to be associated with the risk of D

关键词： HCC Early DAE Single-nucleotide polymorphisms AGT1(rs699) AGT2(rs4762),Tyrosine kinase inhibitors

Commentary on “PGT or ICSI? The impression of NGS-based PGT outcomes in nonmosaic Klinefelter syndrome”

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2021年第6期23卷 651-652页

作者： Ermanno Greco filomena Scarselli Giulia Pirastu Private Hospital Villa Mafalda Center for Reproductive Medicine5 Monte delle Gioie St.Rome 00199Italy

Klinefelter syndrome(KS),described for the first time in 1942,is the most common chromosome aneuploidy in men,affecting from 1/500 to 1/1000 newborn males,and it frequently causes *** the majority of cases,KS patients present a nonmosaic karyotype 47,XXY or a mosaic 47,XXY/46,XY karyotipe.1 KS is characterized usually by gynecomastia,small testes,and alteration of germinal epithelium and Sertoli cell.

关键词： epithelium Klinefelter frequent

Linking forest diversity and tree health： preliminary insights from a large-scale survey in Italy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Forest Ecosystems 2018年第2期5卷 151-161页

作者： Filippo Bussotti Matteo Feducci Giovanni Iacopetti filomena Maggino Martina Pollastrini Federico Selvi Department of Agri-Food Production and Environmental Sciences (DISPAA) University of Firenze Piazzale delle Cascine 18- 50144 Florence Italy Department of Statistical Sciences University La Sapienza P.le Aldo Moro 5 00185 Rome Italy

Forest health is currently assessed in Europe （ICP Forests monitoring program）. Crown defoliation and dieback, tree mortality, and pathogenic damage are the main aspects considered in tree health assessment. The worsening of environmental conditions （i.e., increase of temperature and drought events） may cause large-spatial scale tree mortality and forest decline. However, the role of stand features, including tree species assemblage and diversity as factors that modify environmental impacts, is poorly considered. The present contribution reanalyses the historical dataset of crown conditions in Italian forests from ] 997 to 2014 to identify ecological and structural factors that influence tree crown defoliation, highlighting in a special manner the role of tree diversity. The effects of tree diversity were explored using the entire data set through multivariate cluster analyses and on individual trees, analysing the influence of the neighbouring tree diversity and identity at the local （neighbour） level. Preliminary results suggest that each tree species shows a specific behaviour in relation to crown defoliation, and the distribution of crown defoliation across Italian forests reflects the distribution of the main forest types and their ecological equilibrium with the environment. The potentiality and the problems connected to the possible extension of this analysis at a more general level （European and North American） were discussed.

关键词： Cluster analysis Crown defoliation Forest structure ICP Forests Neighbouring trees Tree diversity Tree identity

Oxypropylation of Brazilian Pine-Fruit Shell Evaluated by Principal Component Analysis

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Journal of Renewable Materials 2018年第7期6卷 715-723页

作者： Stephany Cde Rezende João APinto Isabel PFernandes Fernanda VLeimann Maria-filomena Barreiro Laboratory of Separation and Reaction Engineering-Laboratory of Catalysis and Materials(LSRE-LCM) Polytechnic Institute of BragançaBragançaPortugal Programa de Pós-Graduação em Tecnologia de Alimentos(PPGTA) Universidade Tecnológica Federal do Paraná-UTFPR Campus Campo MourãoVia Rosalina Maria Dos Santos1233.CEP 87301-899.Caixa Postal:271Campo Mourão-PR-Brasil Mountain Research Centre(CIMO) Polytechnic Institute of BragançaBragançaPortugal

Pine-fruit shell (PFS) is a lignocellulosic residue derived from the fruit of Araucaria angustifolia, a coniferoustree native of South America, part of a whole vegetation of the Atlantic Forest, found in the South and Southwestof Brazil. In this work PFS will be characterized and used in the production of PFS-based polyols throughoxypropylation. Three series were chosen (PFS/propylene oxide (PO) (w/v, g/mL) of 30/70, 20/80 and 10/90)with four catalyst levels (5%, 10%, 15% and 20%, (w/w, PFS based)). Oxypropylation occurred at moderateconditions of temperature, pressure and time giving rise to liquid polyols with a homopolymer content (PPO)ranging from 4-65%, a hydroxyl number (IOH) between 257-605 mg KOH/g and viscosities (V) varying from0.76 Pa.s to 373.90 Pa.s (20°C) for the series 20/80 and 10/90, while for the series 30/70, the viscosity reachedvalues higher than 500 Pa.s, 20°C. The unreacted PFS (UR) varied between 3.6% and 77.4% (PFS-basis). Afterthe PFS-based polyols production and characterization, a principal component analysis (PCA) was performed inorder to evaluate the established interactions between the used formulation variables and the obtained polyolproperties. The PCA analysis allowed to clarify the interactions between PFS and PO contents and the finalbiopolyol properties (PPO, IOH, V and UR). This approach showed to be a simple method to rationally analyzethe influence of the input formulation variables on the final polyol properties.

关键词： Principal components analysis Brazilian pine-fruit shell (PFS) oxypropylation polyols

A novel STK11 gene mutation (c.388dupG,***130Glyfs∗33) in a Peutz-Jeghers family and evidence of higher gastric cancer susceptibility associated with alterations in STK11 region aa 107-170

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genes & Diseases 2022年第2期9卷 288-291页

作者： Giovanna Forte filomena Cariola Katia De Marco Andrea Manghisi filomena Anna Guglielmi Raffaele Armentano Giuseppe Lippolis Pietro Giorgio Cristiano Simone Vittoria Disciglio Medical Genetics National Institute of Gastroenterology“S.de Bellis”Research HospitalCastellana GrotteBari 70013Italy Histopathology Unit National Institute of Gastroenterology“S.de Bellis”Research HospitalCastellana GrotteBari 70013Italy Department of General Surgery National Institute of Gastroenterology“S.de Bellis”Research HospitalCastellana GrotteBari 70013Italy Gastroenterology and Digestive Endoscopy Unit National Institute of Gastroenterology“S.de Bellis”Research HospitalCastellana GrotteBari 70013Italy Department of Biomedical Sciences and Human Oncology(DIMO) Medical GeneticsUniversity of Bari Aldo MoroPiazza Umberto IBari 70124Italy

Peutz-Jeghers syndrome(PJS)is a rare autosomal dominant disorder characterized by mucocutaneous pigmentation and gastrointestinal(GI)hamartomatous polyposis and is associated with an increased risk of gastrointestinal,breast,gynecologic and other extra-GI *** serine/threonine kinase 11(STK11)gene has been identi-fied as a pathogenic factor in ***11 is a tumor sup-pressor gene located on chromosome 19p13.3 and includes 9 coding exons.1 The STK11 protein is composed of 433 amino acids(aa)and comprises a kinase catalytic region(aa 49e309)as well as N-and C-terminal regulatory domains.

关键词： STK11 Jeghers alterations

Mycorrhizal synthesis between Pisolithus arhizus and adult clones of Arbutus unedo in vitro and in nursery

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Forestry Research 2013年第4期24卷 659-670页

作者： filomena Gomes Helena Machado Esteban San Martin A.Portugal Jorge M.Canhoto filomena Gomes.CERNAS Dep.Recursos FlorestaisEscola Superior Agrária Coimbra INIAV Instituto Nacional de Investigao Agráriae VeterináriaIP.Av.República Centre of Functional Ecology Department of Life SciencesUniversity of Coimbra

Arbutoid mycorrhizae were synthesized between adult se- lected clones of Arbutus unedo L. and Pisolithus arhizus. Two micro- propagated clones were tested： ALl, in vitro and C1 （acclimatized plants） in nursery and later in a field trial. In vitro, rooted shoots were trans- ferred to test tubes containing the substrate previously inoculated with mycelium cultured on agar. In the nursery, two inoculation treatments were tested （vegetative inocula or dry sporocarps） and compared to con- trol plants. In the field trial, plants from nursery inoculation treatments were compared and an additional control treatment using seedlings was implemented. Plant height was evaluated 4 months later in the nursery and 20 months later in the field trial.

关键词： arbutoid mycorrhizae Ericaceae field plants Arbutus unedoor strawberry tree