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Plasma Lysophosphatidylcholine and Phospholipase A2 Activity in Chagas Disease Patients: A Comparative Analysis

Advances in Bioscience and Biotechnology 2024年第8期15卷 462-473页

作者： Maria Fernanda Carvalho de araujo Bruna Maria Ferreira Iaciura fillipe araujo de sá Georgia Correa Atella Laboratrio de Bioqumica de Lipdios e Lipoprotenas Instituto de Bioqumica Mdica Leopoldo de Meis Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil Instituto Nacional de Cincia e Tecnologia em Entomologia Molecular (INCT-EM) Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil Laboratrio de sinalizao Celular Instituto de Bioqumica Mdica Leopoldo de Meis Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil

Chagas disease (CD) affects 21 countries in the Americas and is caused by the parasite Trypanosoma cruzi. A key molecule involved in CD is lysophosphatidylcholine (LPC), which has been studied in various contexts: in the saliva of insect vectors, during the establishment of infection in the vertebrate host, and for the parasite itself. This lipid can be produced by the action of phospholipases A2 (PLA2), enzymes that catalyze the hydrolysis of phospholipids releasing fatty acids and lysophospholipids, such as LPC. This study investigates LPC levels and PLA2 activities in the plasma of CD patients and compares these levels with those in healthy individuals and patients with idiopathic dilated cardiomyopathy (IDCM). Plasma from 64 CD patients, 54 healthy individuals, and 16 IDCM patients were analyzed. LPC levels and the activity of two types of phospholipase A2: secreted (sPLA2) and lipoprotein-associated (Lp-PLA2) were measured. LPC levels and sPLA2 activity were similar between CD patients and the control groups. However, there were notable differences in LPC levels and sPLA2 activity between subgroups of CD patients and IDCM patients. This study is the first to identify LPC in patients with CD across various stages of the disease. It also offers new insights into the biochemical changes observed in the plasma of patients with IDCM.

关键词： Lysophosphatidylcholine Phospholipase A2 Plasma Chagas Disease Idiopathic Dilated Cardiomyopathy

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