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Perimesencephalic Subarachnoid Hemorrhage in Pregnancy: A Case Report

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Maternal-Fetal Medicine 2022年第4期4卷 290-292页

作者： Stefania Ruggieri Maurizia Gatto Maria Annunziata Gentile Salvatore D'Oria filippo Tamma Domenico Caringella Alessandra Giocolano Chiara Taccalti Maurizio Guido Department of Obstetrics and Gynecology Catholic University of theSacred HeartPoliclinico Agostino Gemell iRCCSRome 00168Italy Department of Obstetrics and Gynecology General Regional Hospital"F.Miull"Acquaviva delle Fonti 70021Italy Department of Neurology General Regional Hospital"F.Miuli"AcquavivadelleFonti70021litaly Department of Neuroradiology General Regional Hospital“F.Miulli"Acquaviva delle Fonti 70021Italy Department of Neurosurgery General Regional Hospital"F.Miulli"Acquavivadelle Fonti 70021Italy MeSVA Department University of L'AquilaL'Aquila 67100Italy

Perimesencephalic subarachnoid hemorrhage (P-SAH) is a benign subset of subarachnoid hemorrhage. Only two cases of P-SAH during pregnancy have been reported in the literature. We describe a case of P-SAH detected at 29 weeks’ gestation, arose with severe bilateral frontal headache, neck rigidity, and vomiting. A diagnosis of P-SAH was confirmed on magnetic resonance angiography with no evidence of vascular malformation or bleeding sources and conservatively treated. Hemorrhage, vasospasm, and cerebellar edema observed on initial magnetic resonance angiography resolved after two months. The clinical course of P-SAH during pregnancy appears to be favorable. Our case shows for the first time in literature that magnetic resonance angiography is a valid diagnostic test for P-SAH during pregnancy that circumvents radiological risk associated with conventional imaging.

关键词： Subarachnoid hemorrhage Cerebrovascular diseases Headache Magnetic resonance angiography Pregnancy

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Plaque imaging with CT coronary angiography:Effect of intra-vascular attenuation on plaque type classification

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World Journal of Radiology 2012年第6期4卷 265-272页

作者： Erica Maffei Chiara Martini Teresa Arcadi Alberto Clemente Sara Seitun Alessandra Zuccarelli Tito Torri Nico R Mollet Alexia Rossi Onofrio Catalano Giancarlo Messalli filippo Cademartiri Cardiovascular Imaging Unit Giovanni XXIII Hospital31050 Monastier di TrevisoTrevisoItaly Department of Radiology Academic Hospital of Parma43100 ParmaItaly Department of Radiology Ospedale di Carrara54033 CarraraItaly Department of Radiology Erasmus Medical Center University3015 CE RotterdamThe Netherlands Filippo Cademartiri Department of Radiology SDN FoundationIRCCS80143 NaplesItaly Department of Radiology Erasmus Medical Center University3015 CE RotterdamThe Netherlands

AIM: To assess the attenuation of non-calcified atherosclerotic coronary artery plaques with computed tomography coronary angiography (CTCA). METHODS: Four hundred consecutive patients underwent CTCA (Group 1: 200 patients, Sensation 64 Cardiac, Siemens; Group 2: 200 patients, VCT GE Healthcare, with either Iomeprol 400 or Iodixanol 320, respectively) for suspected coronary artery disease (CAD). CTCA was performed using standard protocols. Image quality (score 0-3), plaque (within the accessible non-calcified component of each non-calcified/mixed plaque) and coronary lumen attenuation were measured. Data were compared on a per-segment/per-plaque basis. Plaques were classified as fibrous vs lipid rich based on different attenuation thresholds. A P < 0.05 was considered significant. RESULTS: In 468 atherosclerotic plaques in Group 1 and 644 in Group 2, average image quality was 2.96 ± 0.19 in Group 1 and 2.93 ± 0.25 in Group 2 (P ≥ 0.05). Coronary lumen attenuation was 367 ± 85 Hounsfield units (HU) in Group 1 and 327 ± 73 HU in Group 2 (P < 0.05); non-calcified plaque attenuation was 48 ± 23 HU in Group 1 and 39 ± 21 HU in Group 2 (P < 0.05). Overall signal to noise ratio was 15.6 ± 4.7 in Group 1 and 21.2 ± 7.7 in Group 2 (P < 0.01). CONCLUSION: Higher intra-vascular attenuation modifies significantly the attenuation of non-calcified coronary plaques. This results in a more difficult characterization between lipid rich vs fibrous type.

关键词： Computed tomography coronary angiography Coronary artery plaque Plaque characterization Contrast material Lumen enhancement

Complications Following Surgery for Gastric Cancer: Analysis of Prospectively Collected Data

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Journal of Cancer Therapy 2014年第14期5卷 1454-1466页

作者： Lorenzo Bruno Lucia Barni Sabrina Pacciani Gaia Masini Lorenzo Tofani Federica Tofani filippo Melli Antonio Taddei Manuela Andonova Miloeva Luca Boni Giancarlo Freschi Paolo Bechi Department of Surgery and Translational Medicine University of Florence Florence Italy Clinical Trials Coordinating Center Azienda Ospedaliero-Universitaria Careggi Florence Italy

Background and Aims: The complication rate after surgery for gastric cancer varies according to the particular definition of morbidity, so it’s necessary to report them using a standardized method, the Clavien-Dindo system. The purpose of this study was to prospectively analyze all post-gastrectomy complications in patients with gastric adenocarcinoma according to the severity grade using Clavien-Dindo system, in order to identify risk factors for postoperative complications and their prognostic significance on survival. Methods: This study is based on data from 90 consecutive patients who underwent gastrectomy for gastric neoplasia between January 2010 and February 2014 at the same unit. 15 patients were excluded (benign tumors, GISTs, missing data). Complications were categorized according to the Clavien-Dindo classification (uncomplicated patients vs patients classified ≥Grade I). The following risk factors were studied: age, BMI, sex, operation method, extent of resection, duration of surgery, transfusions, TNM staging, and lymph node ratio. Multivariate logistic regression was used to evaluate the association between risk factors and presence of complications. To assess the effect on overall survival, after selection of covariates using backward elimination, the Cox proportional hazard model was applied. Results: Among these patients, 49 (65.3%) developed complications, stratified as follows: Grade I, 6 (8%);Grade II, 24 (32%);Grade III, 6 (8%);Grade IV, 13 (17.3%). The laparoscopic technique (OR = 0.050;95% CI = 0.005 - 0.550, p = 0.0143) and no transfusions (OR = 0.219;95% CI = 0.058 - 0.827, p = 0.0251) were found to reduce the incidence of postoperative complications in the multivariate analysis. With regard to the survival analysis, lymph node ratio, malnutrition, extended resection and presence of complications were significant predictors of reduced survival in the multivariate analysis. Conclusions: Some variables can predict the risk of postoperative co

关键词： Gastric Cancer Complications Clavien-Dindo Classification Survival Probability

Management of Phylloid Sarcomas: A Retrospective Study of 12 Cases

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Advances in Breast Cancer Research 2021年第2期10卷 25-33页

作者： Kanta Ka Abdoul Halim Bague Ibrahim Mounkeila Mamadou Lassana Foba N. Zongo Davide Soldato filippo Dall’Olio Mamadou Moustapha Dieng Papa Macoumba Gaye Daniele Presti Radiotherapy Department Centre Hospitalier National Universitaire Dalal Jamm de Guédiawaye Guédiawaye Senegal School of Cancer Sciences Paris Sud Orsay French Unité D’oncologie Chirurgicale CHU Yalgado Ouedraogo Ouagadougou Burkina Faso Servie d’Oncologie Institut Joliot Curie Centre Hospitalier Universitaire Aristide Le Dantec Dakar Senegal Department of Plastic Surgery Aristide Le Dantec University Hospital Dakar Senegal University Cheikh Anta Diop of Dakar Dakar Senegal Medical Oncology Service ICS Maugeri IRCCS SpA University of Pavia Pavia Italy

Background: Phylloid sarcomas are rare. There is not enough data to codify the management. Objectives: The objective was to study the clinical and therapeutic aspects and the fate of patients after a follow-up of at least 4 years. Thus contributing to the limited body of knowledge on these tumors. Methods: a retrospective analysis of the files from 2013 to 2017 was carried out and patients were followed up until 2021at Hassan II Hospital. Epidemiological, clinical and therapeutic aspects were studied. Survival was calculated using the Kaplan-Meier method. Results: We collected 12 charts of patients treated for phyllodeal sarcoma from 2013 to 2017. The median age was 43 years. The circumstance of discovery was marked by the presence of nodule in all patients. The coupled echo-mammography examination classified the nodules, ACR 4 in 7 patients and ACR 3 in 3 and ACR 5 in 2 patients. Histological examination revealed a phylloid sarcoma in 11 patients and a borderline phylloid tumor in 1 patient. All patients had radical surgery with positive margins in 2 patients, 16.66%. One patient had revision surgery. Histological examination of the surgical specimens showed phylloid sarcoma on all specimens. All patients had adjuvant radiotherapy with doses of 50 Gy in 25 fractions of 2 Gy and a boost of 10 Gy was done in one patient. The median spread of radiotherapy was 37 days. Grade 1 and 2 skin toxicities were noted in 5 and 3 patients respectively. The median time from surgery to radiotherapy was 2.95 months. 3 patients relapsed after 13.6 months of follow-up. The recurrence-free survival at 1 and 3 years was 83% and

关键词： Phylloid Sarcoma Radiotherapy Survival

灵性工业朋克——宝山再生能源利用中心概念展示馆

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中国建筑装饰装修 2020年第11期 34-39页

作者： Andrea Destefanis filippo Gabbiani 陆恬曲昊张虔希 Frances Arnold Kokaistudios Kokaistudios设计事务所

宝山再生能源利用中心概念展示馆是宝武集团和上实集团联合开创多功能空间项目的首个里程碑,它保留了宝武上海罗泾基地的工业遗产,同时也为其未来的功能拓展奠定了基础。通过在原有建筑中置入新的体量,以及内置灵活性,Kokaistudios为这...

宝山再生能源利用中心概念展示馆是宝武集团和上实集团联合开创多功能空间项目的首个里程碑,它保留了宝武上海罗泾基地的工业遗产,同时也为其未来的功能拓展奠定了基础。通过在原有建筑中置入新的体量,以及内置灵活性,Kokaistudios为这个里程碑式的项目开创了先河。该项目的主体是位于上海宝山罗泾的再生能源利用中心,通过垃圾焚烧进行发电,环境公园和教育展示中心等组成的多元景观。在园区整体施工之前,

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Adjuvant chemotherapy for resected colorectal cancermetastases:literature review and meta-analysis

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World Journal of Gastroenterology 2016年第2期22卷 519-533页

作者： Giovanni Brandi Stefania De Lorenzo Margherita Nannini Stefania Curti Marta Ottone filippo Gustavo Dall’Olio Maria Aurelia Barbera Maria Abbondanza Pantaleo Guido Biasco Department of Experimental Diagnostic and Specialty MedicineSant’Orsola-Malpighi Hospital and“G.Prodi”Interdepartmental Center for Cancer ResearchBologna University40138 BolognaItaly Department of Experimental Diagnostic and Specialty MedicineSant’Orsola-Malpighi HospitalUniversity of Bologna40138 BolognaItaly Department of Medical and Surgical Sciences Bologna University40138 BolognaItaly

Surgical resection is the only option of cure for patients with metastatic colorectal cancer(CRC). However, the risk of recurrence within 18 mo after metastasectomy is around 75% and the liver is the most frequent site of relapse. The current international guidelines recommend an adjuvant therapy after surgical resection of CRC metastases despite the lower level of evidence(based on the quality of studies in this setting). However, there is still no standard treatment and the effective role of an adjuvant therapy remains controversial. The aim of this review is to report the state-of-art of systemic chemotherapy and regional chemotherapy with hepatic arterial infusion in the management of patients after resection of metastases from CRC, with a literature review and meta-analysis of the relevant randomized controlled trials.

关键词： Liver metastases Adjuvant chemotherapy Metastasectomy Colorectal cancer Adjuvant hepaticartery infusion

全球变暖背景下中国区域不同强度降水事件变化的高分辨率数值模拟

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气候变化研究进展 2010年第3期6卷 164-169页

作者：石英高学杰 filippo Giorgi 宋瑞艳吴佳董文杰中国科学院大气物理研究所北京100029 中国科学院研究生院北京100049 中国气象局国家气候中心北京100081 The Abdus Salam International Centre for Theoretical Physics TriesteItaly 天津市气象局天津300074 北京师范大学全球变化与地球系统科学研究院北京100875

对一个20km高水平分辨率区域气候模式(RegCM3)所模拟的全球变暖背景下,中国区域未来不同强度降水事件变化进行了分析。以日降水量的大小,将降水划分为不同等级。首先检验了模式对当代(1961—1990年)各等级降水日数的模拟能力,结果表明,... 详细信息

对一个20km高水平分辨率区域气候模式(RegCM3)所模拟的全球变暖背景下,中国区域未来不同强度降水事件变化进行了分析。以日降水量的大小,将降水划分为不同等级。首先检验了模式对当代(1961—1990年)各等级降水日数的模拟能力,结果表明,与观测相比,模式模拟的小雨事件偏多而大雨事件在南方过少。21世纪末(2071—2100年)在IPCC SRES A2温室气体排放情景下,中国区域不同强度降水的变化在各地表现不同,同时其对各个地区降水总量变化的贡献也表现出较大不同,但在大部分地区,模式给出了未来强降水事件将增加的结果。

关键词：气候变化区域气候模式降水极端事件

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Electrical Storms after Levonorgestrel (Synthetic Progestin)-Releasing Intra-Vaginal Device Insertion. A Case Report and a Short Review of Literature

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Open Journal of Obstetrics and Gynecology 2018年第4期8卷 338-343页

作者： Sergio Fasullo Giorgio Maringhini Piero Fasullo filippo Ganci Arcangelo Giamporcaro Sebastiano Scalzo Fernanda Pipitone Vito Pinto Graziella Vetrano Gabriella Terrazzino Stefania Davì Nicolò Renda Antonio Maiorana Division of Cardiology “Paolo Borsellino” G.F. Ingrassia Hospital Palermo Italy Operative Unit of Gynecology S. Antonio Abate Hospital Trapani Italy Chemistry and Pharmaceutical Technologies University of Palermo Palermo Italy Psychiatry CTA La Rinascita Palermo Italy Operative Unit of Gynecology ARNAS Civico Palermo Italy

We report a case of arrhythmic storm in a patient with recent vaginal insertion of a device with release of levonorgestrel (synthetic progestin). A woman of 60 years was hospitalized for runs of monomorphic sustained ventricular tachycardia. She received a vaginal device levonorgestrel-releasing 2 days before admission. No history of associated cardiovascular or thyroid disease or risk factors was reported. Laboratory parameters as well as ECG and echocardiogram were normal. After 48 hours from removal of the vaginal device, the patient was asymptomatic and showed only single ectopic beats, sometimes in pairs. The subsequent coronary angiography, electrophysiological study and cardiac magnetic resonance resulted negative.

关键词： Levonorgestrel Progesterone Ventricular Arrhythmias

A New Early Gastric Cancer after Subtotal Gastric Resection for Early Cancer: Case Report and Review of the Literature

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Journal of Cancer Therapy 2014年第14期5卷 1450-1453页

作者： Lorenzo Bruno Lucia Barni Gabriella Nesi Sabrina Pacciani Gaia Masini filippo Melli Gherardo Maltinti Tiku Zalla Lorenzo Dioscoridi Antonio Taddei Giancarlo Freschi Paolo Bechi Department of Surgery and Translational Medicine University of Florence Florence Italy Division of Pathological Anatomy Department of Surgery and Translational Medicine University of Florence Florence Italy

Although the prognosis of early gastric cancer (EGC) is considered to be satisfactory, some patients experience tumor relapse after curative surgery. Both pathogenesis and risk factors of recurrence remain unclear. We describe a case report of a 49-year-old male who underwent subtotal gastric resection D2A for angular gastric cancer. Histological examination revealed gastric adenocarcinoma with low grade of differentiation and colloid areas, intramucosal, and absence of neoplastic proliferation in the surgical margins, in omental stroma and in the six examined lymph nodes (pT1, pN0). 11 years later, the same patient underwent D2 total gastrectomy for gastric cancer in the remnant stomach. New histological examination revealed again gastric adenocarcinoma, intramucosal, medium degree of differentiation, no documentable neoplastic proliferation within the limits of surgical resection, in the thirty-three examined lymph nodes and in the omentum (pT1, pN0).

关键词： Early Gastric Cancer Remnant Gastric Cancer Long Term Follow-Up