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Music therapy and pediatric palliative care:songwriting with children in the end-of-life

World Journal of Pediatrics 2022年第10期18卷 695-699页

作者： filippo giordano Chiara Rutigliano Mariagrazia Baroni Massimo Grassi Paola Muggeo Nicola Santoro Department of Emergency and Organ Transplants University of Bari Aldo MoroPiazza G.Cesare 1170124BariItaly Section of Pediatric Hematology-Oncology University Hospital of BariBariItaly Hospice Madonna Dell’Uliveto AlbineaREItaly

Children's needs in pediatric palliative care(PPC)are complex and are determined by age,the course of the disease,family structure,and cultural background[1].The child's family system also has multiple needs which mus... 详细信息

关键词： pediatric assessed palliative

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Music therapy in children affected by brain tumors

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World Journal of Pediatric Surgery 2021年第3期4卷 44-45页

作者： filippo giordano Raffaella Messina Anna Riefolo Chiara Rutigliano Teresa Perillo Massimo Grassi Nicola Santoro Francesco Signorelli School of Medicine University of BariBariItaly Department of Basic Medical Sciences Neurosciences and Sense OrgansDivision of NeurosurgeryUniversity of BariBariPugliaItaly Anesthesia and Intensive Care Unit Azienda Ospedaliero-Universitaria Consorziale Policlinico di BariBariPugliaItaly Pediatric Hemathology-Oncology Policlinico di Bari Ospedale Giovanni XXIIIBariPugliaItaly

Children affected by brain tumors experi-ence significant levels of anxiety,nervousness,and fear regarding surgery,especially in the preoperative *** operating room can be an intimidating environment for them,and preoperative anxiety can adversely affect postoperative pain.1 Interest is growing in finding non-pharmacological means that may be used to reduce these symptoms.

关键词： tumors surgery dating

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Endozepine-4 levels are increased in hepatic coma

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World Journal of Gastroenterology 2015年第30期21卷 9103-9110页

作者： Giulia Malaguarnera Marco Vacante filippo Drago Gaetano Bertino Massimo Motta Maria giordano Michele Malaguarnera Research Center "The Great Senescence" Hospital of Cannizzaro University of Catania Department of Clinical and Experimental Medicine University of Catania Department of Biomedical and Biotechnological Sciences Section of PharmacologySchool of MedicineUniversity of Catania Gerontology and Bone Metabolic Disease Section Department of Medical SciencesUniversity of Torino

AIM:To evaluate the serum levels of endozepine-4,their relation with ammonia serum levels,the grading of coma and the severity of cirrhosis,in patients with hepatic coma. METHODS:In this study we included 20 subjects with Hepatic coma,20 subjects with minimal hepatic encephalopathy(MHE) and 20 subjects control. All subjects underwent blood analysis,Child Pugh and Model for End- stage liver disease(MELD) assessment,endozepine-4 analysis. RESULTS:Subjects with hepatic coma showed significant difference in endozepine-4(P < 0.001) and NH3 levels(P < 0.001) compared both to MHE and controls patients. Between NH3 and endozepine-4 we observed a significant correlation(P = 0.009; Pearson correlation 0.570). There was a significant correlation between endozepine-4 and MELD(P = 0.017; Pearsoncorrelation = 0.529). In our study blood ammonia concentration was noted to be raised in patients with hepatic coma,with the highest ammonia levels being found in those who were comatose. We also found a high correlation between endozepine-4 and ammonia(P < 0.001). In patients with grade Ⅳ hepatic coma,endozepine levels were significantly higher compared to other groups. CONCLUSION:This study suggests that an increased level of endozepine in subjects with higher levels of MELD was observed. In conclusion,data concerning involvement of the GABA-ergic system in HE coma could be explained by stage-specific alterations.

关键词： Endozepine-4 Hepatic encephalopathy Hepatic coma Cirrhosis, Benzodiazepine Peripheralbenzodiazepine receptor Model for End - stage liverdisease Glutamate-related neurotoxicity which in turnmay alter the γ-aminobutyric acid

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Nano albumin bound-paclitaxel in pancreatic cancer: Current evidences and future directions

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World Journal of Gastroenterology 2017年第32期23卷 5875-5886页

作者： Guido giordano Massimo Pancione Nunzio Olivieri Pietro Parcesepe Marianna Velocci Tania Di Raimo Luigi Coppola Giuseppe Toffoli Mario Rosario D’Andrea Medical Oncology Unit San Filippo Neri Hospital CRO Aviano National Cancer Institute Department of Sciences and Technologies University of Sannio Department of Biochemistry and Molecular Biology II Faculty of PharmacyComplutense University Department of Biology University of Naples Department of Pathology and Diagnostics University of Verona Strada Anatomic Pathology Unit San Filippo Neri00135 RomaItaly Experimental and Clinical Pharmacology Unit CRO-National Cancer Institute Via F

Pancreatic cancer(PDAC) is an aggressive and chemoresistant disease, representing the fourth cause of cancer related deaths in western countries. Majority of patients have unresectable, locally advanced or metastatic disease at time of diagnosis and the 5-year survival rate in these conditions is extremely low. For more than a decade gemcitabine has been the cornerstone of metastatic PDAC treatment, although survival benefit was very poor. PDAC cells are surrounded by an intense desmoplastic reaction that may create a barrier to the drugs penetration within the tumor. Recently PDAC stroma has been addressed as a potential therapeutic target. Nano albumin bound(Nab)-paclitaxel is an innovative molecule depleting tumor stroma, through interaction between albumin and secreted protein acidic and rich in cysteine. Addition of nab-paclitaxel to gemcitabine has showed activity and efficacy in metastatic PDAC first-line treatment improving survival and overall response rate vs gemcitabine alone in the MPACT phase Ⅲ study. This combination represents one of the standards of care in advanced PDAC therapy and is suitable to a broader spectrum of patients compared to other schedules. Nab-paclitaxel is under investigation as a backbone of chemotherapy in novel combinations with target agents or immunotherapy in locally advanced or metastatic PDAC. In this article, we provide an updated and critical overview about the role of nab-paclitaxel in PDAC treatment based on the latest advances in preclinical and clinical research. Furthermore, we focus on the use of nab-paclitaxel within the context of metastatic PDAC treatment landscape and we discuss about future implications in the light of current clinical ongoing trials.

关键词： Nano albumin bound-paclitaxel Pancreatic cancer Metastatic disease Gemcitabine Folfirinox

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