检索结果-南通市图书馆

Role of gut microbiota-immunity axis in patients undergoing surgery for colorectal cancer:Focus on short and long-term outcomes

引用

World Journal of Gastroenterology 2020年第20期26卷 2498-2513页

作者： Ilenia Bartolini Matteo Risaliti Maria Novella Ringressi filippo melli Giulia Nannini Amedeo Amedei Paolo Muiesan Antonio Taddei Department of Experimental and Clinical Medicine University of FlorenceFlorence 50134Italy

Human body is colonized by a huge amount of microorganisms mostly located in the gastrointestinal *** dynamic communities,the environment and their metabolites constitute the *** data suggests a causal role of a dysbiotic microbiota in several pathologies,such as metabolic and neurological disorders,immunity dysregulations and cancer,especially the well-studied colorectal cancer ***,many were preclinical studies and a complete knowledge of the pathogenetic mechanisms in humans is still *** gut microbiota can exert direct or indirect effects in different phases of colorectal cancer *** example,Fusobacterium nucleatum promotes cancer through cellular proliferation and some strains of Escherichia coli and Bacteroides fragilis produce ***,dysbiosis may also cause a proinflammatory state and the stimulation of a Th17 response with IL-17 and IL-22 secretion that have a pro-oncogenic activity,as demonstrated for Fusobacterium *** has a crucial role in several stages of postoperative course;dysbiosis in fact seems related with surgical site infections and Enterococcus faecalis(and other collagenase-producers microbes)are suggested as a cause of anastomotic ***,unbalanced presence of some species,together with altered immune response may also have a prognostic *** has also a substantial role in effectiveness of chemotherapy,chemoresistance and in the related side *** other words,a complete knowledge of the fine pathological mechanisms of gut microbiota may provide a wide range of new diagnostic tools other than therapeutic targets in the light of tailored medicine.

关键词： Intestinal microbiota Colorectal cancer Chemo-resistance Therapeutic strategies

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Evaluation of prognostic factors and clinicopathological patterns of recurrence after curative surgery for colorectal cancer

引用

World Journal of Gastrointestinal Surgery 2021年第1期13卷 50-75页

作者： filippo melli Ilenia Bartolini Matteo Risaliti Rosaria Tucci Maria Novella Ringressi Paolo Muiesan Antonio Taddei Amedeo Amedei Department of Clinical and Experimental Medicine University of FlorenceAzienda Ospedaliero-Universitaria CareggiFlorence 50134Italy

BACKGROUND Colorectal cancer is a common tumor with a quite high-related *** the used curative treatments,patients will develop cancer recurrence in up to 50%of the cases and/or other primary *** most of the recurrences are discovered within 3 years from the first treatment,a small percentage is found after 5 *** early detection of recurrence is crucial to allow further therapies improving patients’*** follow-up programs have been developed but the optimal one is far from being *** To evaluation of potential prognostic factors for timing and patterns of recurrence in order to plan tailored follow-up *** Perioperative and long-term data of all consecutive patients surgically treated with curative intent,from January 2006 to June 2009,for colorectal adenocarcinoma,were retrospectively reviewed to find potential prognostic factors associated with:(1)Recurrence incidence;(2)Incidence of an early(within 3 years from surgery)or late recurrence;and(3)Different sites of *** addition,the incidence of other primary neoplasms has been evaluated in a cohort of patients with a minimum potential follow-up of 10 *** Our study included 234 *** median follow-up period has been 119±46.2 *** recurrence rate has been 25.6%.Patients with a higher chance to develop recurrence had also the following characteristics:Higher levels of preoperative glycemia and carcinoembryonic antigen,highest anaesthesiologists Score score,occlusion,received a complex operation performed with an open technique,after a longer hospital stay,and showed advanced *** independent prognostic factors for recurrence were the hospital stay,N stage 2,and M stage 1(multivariate analysis).Younger ages were significantly associated with an early recurrence *** that received intermediate colectomies or segmental resections,having an N stage 2 or American Joint Committee on Cancer stage 3 tumors were al

关键词： Prognostic factors Recurrence Recurrence patterns Colorectal cancer Longterm follow-up Follow-up programs

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genome-wide investigation to assess copy number variants in the Italian local chicken population

引用

Journal of Animal Science and Biotechnology 2024年第2期15卷 563-577页

作者： filippo Cendron Martino Cassandro Mauro Penasa Department of Agronomy FoodNatural ResourcesAnimals and Environment(DAFNAE)University of PadovaViale Dell’Universita 1635020 LegnaroPDItaly Federazione Delle Associazioni Nazionali Di Razza E Specie Via XXIV Maggio 4300187 RomeItaly

Background Copy number variants(CNV)hold significant functional and evolutionary *** ongoing CNV studies aim to elucidate the etiology of human diseases and gain insights into the population structure of ***-density chips have enabled the detection of CNV with increased resolution,leading to the identification of even small *** study aimed to identify CNV in local Italian chicken breeds and investigate their distribution across the *** Copy number variants were mainly distributed across the first six chromosomes and primarily associated with loss type *** majority of CNV in the investigated breeds were of types 0 and 1,and the minimum length of CNV was significantly larger than that reported in previous ***,a high proportion of the length of chromosome 16 was covered by copy number variation regions(CNVR),with the major histocompatibility complex being the likely *** the genes identified within CNVR,only those present in at least five animals across breeds(n=95)were discussed to reduce the focus on redundant *** of these genes have been associated to functional traits in ***,several CNVR on different chromosomes harbor genes related to muscle development,tissue-specific biological processes,heat stress resistance,and immune *** trait loci(QTL)were also analyzed to investigate potential overlapping with the identified CNVR:54 out of the 95 gene-containing regions overlapped with 428 QTL associated to body weight and size,carcass characteristics,egg production,egg components,fat deposition,and feed *** The genomic phenomena reported in this study that can cause changes in the distribution of CNV within the genome over time and the comparison of these differences in CNVR of the local chicken breeds could help in preserving these genetic resources.

关键词： Chicken Copy number variant Conservation Local breed SNP

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A novel approach to the dynamic response analysis of Euler-Bernoulli beams resting on a Winkler soil model and subjected to impact loads

引用

Earthquake Engineering and Engineering Vibration 2024年第2期23卷 389-401页

作者： Adolfo Foriero filippo Santucci de Magistris Giovanni Fabbrocino Département de génie civil et de génie des eaux Pavillon Adrien-PouliotUniversitéLavalQuébecCanada Dipartimento di Bioscienze e Territorio Universitàdegli Studi del MoliseCampobassoItaly Construction Technologies Institute National Research CouncilITC-CNRL’AquilaItaly

This work presents a novel approach to the dynamic response analysis of a Euler-Bernoulli beam resting on a Winkler soil model and subjected to an impact *** approach considers that damping has much less importance in controlling the maximum response to impulsive loadings because the maximum response is reached in a very short time,before the damping forces can dissipate a significant portion of the energy input into the *** development of two sine series solutions,relating to different types of impulsive loadings,one involving a single concentrated force and the other a distributed line load,are *** study revealed that when a simply supported Euler-Bernoulli beam,resting on a Winkler soil model,is subject to an impact load,the resulting vertical displacements,bending moments and shear forces produced along the span of the beam are considerably *** particular,the quantification of this effect is best observed,relative to the corresponding static solution,via an amplification *** computed impact amplification factors,for the sub-grade moduli used in this study,were in magnitude greater than 2,thus confirming the multiple-degree-of-freedom nature of the problem.

关键词： beam-Winkler-soil model sub-grade moduli impact load impact distributed line load dynamic solution impact amplification factor

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Projected changes in Köppen-Trewartha climate zones under 1.5-4℃global warming targets over mid-high latitudes of Northern Asia using an ensemble of RegCM4 simulations

引用

Advances in Climate Change Research 2024年第2期15卷 185-196页

作者： Jie WU Xue-Jie GAO Xian-Bing TANG filippo GIORGI School of Geography and Environmental Engineering Gannan Normal UniversityGanzhou 341000China Climate Change Research Center Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science&TechnologyNanjing 210044China University of Chinese Academy of Sciences Beijing 100049China The Abdus Salam International Centre for Theoretical Physics Trieste 34100Italy

Mid-high latitude Northern Asia is one of the most vulnerable and sensitive areas to global warming,but relatively less studied *** used an ensemble of a regional climate model(RegCM4)projections to assess future changes in surface air temperature,precipitation and Köppen-Trewartha(K-T)climate types in Northern Asia under the 1.5-4℃global warming ***4 is driven by five CMIP5 global models over an East Asia domain at a grid spacing of 25 *** of the present day(1986-2005)simulations shows that the ensembles of RegCM4(ensR)and driving GCMs(ensG)reproduce the major characters of the observed temperature,precipitation and K-T climate zones reasonably *** and more realistic spatial detail is found in RegCM4 compared to the driving GCMs.A general warming and overall increases in precipitation are projected over the region,with these changes being more pronounced at higher warming *** projected warming by ensR shows different spatial patterns,and is in general lower,compared to ensG in most months of the year,while the percentage increases of precipitation are maximum during the cold *** future changes in K-T climate zones are characterized by a substantial expansion of Dc(temperature oceanic)and retreat of Ec(sub-arctic continental)over the region,reaching∼20%under the 4℃warming *** most notable change in climate types in ensR is found over Japan(∼60%),followed by Southern Siberia,Mongolia,and the Korean Peninsula(∼40%).The largest change in the K-T climate types is found when increasing from 2 to 3℃.The results will help to better assess the impacts of climate change and in implementation of appropriate adaptation measures over the region.

关键词： Mid-high latitudes of Northern Asia Köppen climate zones Global warming targets Regional climate model

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Towards hydrometeorological thresholds of reservoir-induced landslide from subsurface strain observations

引用

Science China(Technological Sciences) 2024年第6期67卷 1907-1922页

作者： YE Xiao ZHU HongHu WANG Jia ZHENG WanJi ZHANG Wei SCHENATO Luca PASUTO Alessandro CATANI filippo School of Earth Sciences and Engineering Nanjing UniversityNanjing210023China Department of Geosciences University of PadovaPadova35131Italy School of Geosciences and Info-Physics Central South UniversityChangsha410083China Department of Information Engineering University of PadovaPadova35131Italy National Research Council-Research Institute for Geo-Hydrological Protection(CNR-IRPI) Padova35127Italy

Synergistic multi-factor early warning of large-scale landslides is a crucial component of geohazard prevention and mitigation efforts in reservoir *** forecasting and early warning based on surface displacements have been widely ***,the lack of direct subsurface real-time observations limits our ability to predict critical hydrometeorological conditions that trigger landslide *** this paper,we leverage subsurface strain data measured by high-resolution fiber optic sensing nerves that were installed in a giant reservoir landslide in the Three Gorges Reservoir(TGR)region,China,spanning a whole hydrologic year since February *** spatiotemporal strain profile has preliminarily identified the slip zones and potential drivers,indicating that high-intensity short-duration rainstorms controlled the landslide kinematics from an observation *** the time lag effect,we reexamined and quantified potential controls of accelerated movements using a data-driven approach,which reveals immediate response of landslide deformation to extreme rainfall with a zero-day *** identify critical hydrometeorological rules in accelerated movements,accounting for the dual effect of rainfall and reservoir water level variations,we thus construct a landslide prediction model that relies upon the boosting decision tree(BDT)algorithm using a dataset comprising daily rainfall,rainfall intensity,reservoir water level,water level fluctuations,and slip zone strain time *** results indicate that landslide acceleration is most likely to occur under the conditions of mid-low water levels(i.e.,57.9 mm and rainfall intensity>24.4 mm/h).Moreover,this prediction model allows us to update hydrometeorological thresholds by incorporating the latest monitoring *** on the shoulder of this landslide case,our study informs a practical and reliable path

关键词： slow-moving landslide fiber-optic monitoring subsurface strain hydrometeorological threshold extreme weather

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Uncertainties of landslide susceptibility prediction: Influences of random errors in landslide conditioning factors and errors reduction by low pass filter method

引用

Journal of Rock Mechanics and Geotechnical Engineering 2024年第1期16卷 213-230页

作者： Faming Huang Zuokui Teng Chi Yao Shui-Hua Jiang filippo Catani Wei Chen Jinsong Huang School of Infrastructure Engineering Nanchang UniversityNanchang330031China State Key Laboratory of Geohazard Prevention and Geoenvironment Protection Chengdu University of TechnologyChengdu610059China Department of Geosciences University of PadovaPadovaItaly College of Geology and Environment Xi’an University of Science and TechnologyXi’an710054China Discipline of Civil Surveying and Conditioning EngineeringPriority Research Centre for Geotechnical Science and EngineeringUniversity of NewcastleNewcastleNSWAustralia

In the existing landslide susceptibility prediction(LSP)models,the influences of random errors in landslide conditioning factors on LSP are not considered,instead the original conditioning factors are directly taken as the model inputs,which brings uncertainties to LSP *** study aims to reveal the influence rules of the different proportional random errors in conditioning factors on the LSP un-certainties,and further explore a method which can effectively reduce the random errors in conditioning *** original conditioning factors are firstly used to construct original factors-based LSP models,and then different random errors of 5%,10%,15% and 20%are added to these original factors for con-structing relevant errors-based LSP ***,low-pass filter-based LSP models are constructed by eliminating the random errors using low-pass filter ***,the Ruijin County of China with 370 landslides and 16 conditioning factors are used as study *** typical machine learning models,*** perceptron(MLP),support vector machine(SVM)and random forest(RF),are selected as LSP ***,the LSP uncertainties are discussed and results show that:(1)The low-pass filter can effectively reduce the random errors in conditioning factors to decrease the LSP uncertainties.(2)With the proportions of random errors increasing from 5%to 20%,the LSP uncertainty increases continuously.(3)The original factors-based models are feasible for LSP in the absence of more accurate conditioning factors.(4)The influence degrees of two uncertainty issues,machine learning models and different proportions of random errors,on the LSP modeling are large and basically the same.(5)The Shapley values effectively explain the internal mechanism of machine learning model predicting landslide *** conclusion,greater proportion of random errors in conditioning factors results in higher LSP uncertainty,and low-pass filter can effectively reduce these random e

关键词： Landslide susceptibility prediction Conditioning factor errors Low-pass filter method Machine learning models Interpretability analysis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Multiple Detector-Row CT in Gastric Cancer Staging: Prospective Study

引用

Journal of Cancer Therapy 2014年第14期5卷 1438-1449页

作者： Lorenzo Bruno Lucia Barni Gaia Masini Sabrina Pacciani Edvige Lucarelli Antonella Masserelli Daniela Tomcykova filippo melli Luca Boni Giancarlo Freschi Paolo Bechi Surgery and Translational Medicine University of Florence Florence Italy Diagnostic Imaging 4 Azienda Ospedaliero-Universitaria Careggi Florence Italy Clinical Trials Coordinating Center Azienda Ospedaliero-Universitaria Careggi Florence Italy

The aim of this study was to evaluate the accuracy of multiple detector computed tomography (MDCT) in the preoperative staging of gastric cancer, prospectively comparing CT findings with pathological findings at surgery, in a single-center study. A total of 19 consecutive patients with primary cancer recruited between March and July 2014 were submitted to preoperative MDCT staging according to a standard protocol. All diagnostic procedures were performed by dedicated radiologists who were unaware of the final pathological results. Subsequently, 16 patients underwent surgical treatment and 15 were finally included in the study. The primary tumor was detected at CT in all 15 cases. CT results for T staging were in agreement with pathological findings in 12 of 15 cases, with overall accuracy of 80%. Stage-specific sensibility was high for advanced stages (sensibility for T1, T3, and T4 resulted 60%, 85.7%, and 100%, respectively), while earlier stages showed higher specificity (specificity for T1, T3, and T4 resulted 100%, 75%, and 91.7%, respectively). Overall N staging accuracy was 86.7%, with 13 of 15 patients correctly staged. Stage-specific sensibility was 75% for N0 and 100% for N3, while specificity was 100% for N0 and lower for advanced stages. Accuracy for peritoneal involvement was 100%. Our findings show a good performance of the diagnostic protocol performed with MDCT tested in this study.

关键词： Gastric Cancer MDCT Staging Oncologic Imaging

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Complications Following Surgery for Gastric Cancer: Analysis of Prospectively Collected Data

引用

Journal of Cancer Therapy 2014年第14期5卷 1454-1466页

作者： Lorenzo Bruno Lucia Barni Sabrina Pacciani Gaia Masini Lorenzo Tofani Federica Tofani filippo melli Antonio Taddei Manuela Andonova Miloeva Luca Boni Giancarlo Freschi Paolo Bechi Department of Surgery and Translational Medicine University of Florence Florence Italy Clinical Trials Coordinating Center Azienda Ospedaliero-Universitaria Careggi Florence Italy

Background and Aims: The complication rate after surgery for gastric cancer varies according to the particular definition of morbidity, so it’s necessary to report them using a standardized method, the Clavien-Dindo system. The purpose of this study was to prospectively analyze all post-gastrectomy complications in patients with gastric adenocarcinoma according to the severity grade using Clavien-Dindo system, in order to identify risk factors for postoperative complications and their prognostic significance on survival. Methods: This study is based on data from 90 consecutive patients who underwent gastrectomy for gastric neoplasia between January 2010 and February 2014 at the same unit. 15 patients were excluded (benign tumors, GISTs, missing data). Complications were categorized according to the Clavien-Dindo classification (uncomplicated patients vs patients classified ≥Grade I). The following risk factors were studied: age, BMI, sex, operation method, extent of resection, duration of surgery, transfusions, TNM staging, and lymph node ratio. Multivariate logistic regression was used to evaluate the association between risk factors and presence of complications. To assess the effect on overall survival, after selection of covariates using backward elimination, the Cox proportional hazard model was applied. Results: Among these patients, 49 (65.3%) developed complications, stratified as follows: Grade I, 6 (8%);Grade II, 24 (32%);Grade III, 6 (8%);Grade IV, 13 (17.3%). The laparoscopic technique (OR = 0.050;95% CI = 0.005 - 0.550, p = 0.0143) and no transfusions (OR = 0.219;95% CI = 0.058 - 0.827, p = 0.0251) were found to reduce the incidence of postoperative complications in the multivariate analysis. With regard to the survival analysis, lymph node ratio, malnutrition, extended resection and presence of complications were significant predictors of reduced survival in the multivariate analysis. Conclusions: Some variables can predict the risk of postoperative co

关键词： Gastric Cancer Complications Clavien-Dindo Classification Survival Probability

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A New Early Gastric Cancer after Subtotal Gastric Resection for Early Cancer: Case Report and Review of the Literature

引用

Journal of Cancer Therapy 2014年第14期5卷 1450-1453页

作者： Lorenzo Bruno Lucia Barni Gabriella Nesi Sabrina Pacciani Gaia Masini filippo melli Gherardo Maltinti Tiku Zalla Lorenzo Dioscoridi Antonio Taddei Giancarlo Freschi Paolo Bechi Department of Surgery and Translational Medicine University of Florence Florence Italy Division of Pathological Anatomy Department of Surgery and Translational Medicine University of Florence Florence Italy

Although the prognosis of early gastric cancer (EGC) is considered to be satisfactory, some patients experience tumor relapse after curative surgery. Both pathogenesis and risk factors of recurrence remain unclear. We describe a case report of a 49-year-old male who underwent subtotal gastric resection D2A for angular gastric cancer. Histological examination revealed gastric adenocarcinoma with low grade of differentiation and colloid areas, intramucosal, and absence of neoplastic proliferation in the surgical margins, in omental stroma and in the six examined lymph nodes (pT1, pN0). 11 years later, the same patient underwent D2 total gastrectomy for gastric cancer in the remnant stomach. New histological examination revealed again gastric adenocarcinoma, intramucosal, medium degree of differentiation, no documentable neoplastic proliferation within the limits of surgical resection, in the thirty-three examined lymph nodes and in the omentum (pT1, pN0).

关键词： Early Gastric Cancer Remnant Gastric Cancer Long Term Follow-Up

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：