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Investigation of Galactic open cluster remnants： the case of NGC 7193

Research in Astronomy and Astrophysics 2017年第1期17卷 31-54页

作者： Mateus de Souza Angelo Joao Francisco Coelho dos Santos Jr Wagner Jose Barbosa Corradi Francisco ferreira de Souza Maia Andres Eduardo Piatti Departamento de Fisica ICEx Universidade Federal de Minas Gerais Av. Antonio Carlos 6627 31270-901 Belo Horizonte MG Brazil Observatorio Astronomico Universidad Nacional de Cordoba Laprida 854 5000 Cordoba Argentina Consejo Nacional de Investigaciones Cientificas y Tecnicas Av. Rivadavia 1917 C1033AAJ Buenos AiresArgentina

Galactic open clusters （OCs） that survive the early gas-expulsion phase are gradually de- stroyed over time by the action of disruptive dynamical processes. Their final evolutionary stages are characterized by a poorly populated concentration of stars called an open cluster remnant （OCR）. This study is devoted to assessing the real physical nature of the OCR candidate NGC 7193. GMOS/Gemini spectroscopy of 53 stars in the inner target region were obtained to derive radial velocities and at- mospheric parameters. We also employed photometric and proper motion data. The analysis method consists of the following steps：（i） analysis of the statistical resemblance between the cluster and a set of field samples with respect to the sequences defined in color-magnitude diagrams （CMDs）; （ii） a 5-dimensional iterative exclusion routine was employed to identify outliers from kinematical and posi- tional data; （iii） isochrone fitting to thes× （J - Ks） CMD of the remaining stars and the dispersion of spectral types along empirical sequences in the （J - H） × （H - Ks） diagram were checked. A group of stars was identified for which the mean heliocentric distance is compatible with that obtained via isochrone fitting and whose metallicities are compatible with each other. Fifteen of the member stars observed spectroscopically were identified together with another 19 probable members. Our results indi- cate that NGC 7193 is a genuine OCR, of a once very populous OC, for which the following parameters were derived： d = 501±46 pc, t = 2.5±1.2 Gyr, （[Fe/H]） = -0.17±0.23 and E（B-v） = 0.05±0.05. Its luminosity and mass functions show depletion of low mass stars, confirming the OCR is in a dynam- ically evolved state.

关键词： open cluster remnants - Galactic open clusters

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Effect of operational parameters on the performance of an anaerobic sequencing batch reactor(AnSBR)treating protein-rich wastewater

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Environmental Science and Ecotechnology 2024年第1期17卷 89-99页

作者： Zhe Deng Julian Muñoz Sierra Ana Lucia Morgado ferreira Daniel Cerqueda-Garcia Henri Spanjers Jules B.van Lier Delft University of Technology Faculty of Civil Engineering and GeosciencesStevinweg 12628 CNDelftthe Netherlands veolia Water Technologies Techno Center Netherlands B.v.-Biothane Tanthofdreef 212623 EWDelftthe Netherlands KWR Water Research Institute Groningenhaven 7P.O.Box 10723430 BBNieuwegeinthe Netherlands Institute of Ecology.A.C Cluster Cientifico y Tecnologico BioMimic®Carretera Antigua a Coatepec 351El Haya91073XalapaVeracruzMexico

Treating protein-rich wastewater using cost-effective and simple-structured single-stage reactors presents several *** this study,we applied an anaerobic sequencing batch reactor(AnSBR)to treat protein-rich wastewater from a *** focused on identifying the key factors influencing the removal of chemical oxygen demand(COD)and the settling performance of the *** AnSBR achieved a maximum total COD removal of 90%,a protein degradation efficiency exceeding 80%,and a COD to methane conversion efficiency of over 70%at organic loading rates of up to 6.2 g COD L^(-1)d^(-1).We found that the variations in both the organic loading rate within the reactor and the hydraulic retention time in the buffer tank had a significant effect on COD *** hydraulic retention time in the buffer tank and the reactor,which determined the ammonification efficiencies and the residual carbohydrate concentrations in the reactor liquid,affected the sludge ***,the genus Clostridium sensu stricto 1,known as protein-and lipids-degraders,was predominant in the *** analysis showed a significant correlation between the core microbiome and ammonification efficiency,highlighting the importance of protein degradation as the governing process in the *** results will provide valuable insights to optimise the design and operation of AnSBR for efficient treatment of protein-rich wastewater.

关键词： Anaerobic digestion Anaerobic sequencing batch reactor (AnSBR) Protein Microbial community Slaughterhouse wastewater

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Investigation of possible relationship between atopic dermatitis and salivary biomarkers,stress,and sleep disorders

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World Journal of Clinical Cases 2023年第17期11卷 3958-3966页

作者： Juliany Estefan Dennis de Carvalho ferreira Fernanda Sampaio Cavalcante Kátia Regina Netto dos Santos Marcia Ribeiro Dermatologia Pediátrica Universidade Federal do Rio de JaneiroRio de Janeiro 21941630Brazil Faculdade de Enfermagem Departamento de Fundamentos de EnfermagemUniversidade do Estado do Rio de JaneiroRio de Janeiro 20551030Brazil Departamento de Clínica Médica Instituto de Ciências MédicasUniversidade Federal do Rio de JaneiroCampus MacaéRio de Janeiro 27930-560Brazil Departamento de Microbiologia Médica Instituto de Microbiologia Paulo de GóesUniversidade Federal do Rio de JaneiroRio de Janeiro 21941630Brazil Genética médica Instituto de Puericultura e Pediatria Martagão Gesteira/Universidade Federal do Rio de JaneiroRio de Janeiro 21941630Brazil

Atopic dermatitis(AD)is a chronic,relapsing,multifactorial inflammatory disease with genetic,environmental,and immunological *** quality of life and sleep of patients and their families are affected by AD,which triggers stress,described as one of the factors that worsens *** biomarkers such as cortisol,alpha-amylase,chromogranin A,and melatonin have been associated with stress and sleep ***,the evaluation of stress and sleep disorders using salivary biomarkers in AD patients is *** review aims to describe the possible relationship between atopic dermatitis and stress,sleep disorders,and salivary biomarkers,seeking to contribute to better understanding and clinical management of *** descriptive study is characterized as a narrative literature review.A literature search was conducted of studies published in English and Portuguese between January 2012 and October 2022 that are available in electronic media from various databases,such as Scientific Electronic Library Online,Latin American and Caribbean Literature on Health Sciences,and *** is associated with different degrees of impact on the lives of individuals who present with the *** stress may induce changes in saliva composition and worsen AD;at the same time,the severity of the disease may be associated with emotional *** studies are needed to assess and correlate AD severity,stress,and sleep disturbances with salivary biomarkers in order to better understand this association.

关键词： Atopic dermatitis Sleep Psychological stress Chromogranin A Melatonin Cortisol

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Interrelationship between chromosome 8 aneuploidy,C-MYC amplification and increased expression in individuals from northern Brazil with gastric adenocarcinoma

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World Journal of Gastroenterology 2006年第38期12卷 6207-6211页

作者： Danielle Queiroz Calcagno Mariana ferreira Leal Aline Damaceno Seabra Andre Salim Khayat Elizabeth Suchi Chen Samia Demachki Paulo Pimentel Assumpcao Mario Henrique Girao Faria Silvia Helena Barem Rabenhorst Márcia valéria Pitombeira ferreira Marília de Arruda Cardoso Smith Rommel Rodríguez Burbano Human Cytogenetics and Toxicological Genetics Laboratory Department of BiologyCenter of Biological SciencesFederal University of ParáBelémPABrazil Genetics Division Department of Morphology Federal University of Sao PauloSao PauloSPBrazil Department of Pathology and Surgery Service Federal University of ParáBelémPABrazil Joao de Barros Barreto University Hospital Federal University of ParáBelémPABrazil Molecular Genetics Laboratory Department of Pathology Medical SchoolFederal University of CearáFortalezaCEBrazil

AIM: To investigate chromosome 8 numerical aberra- tions, C-MYC oncogene alterations and its expression in gastric cancer and to correlate these findings with histo- pathological characteristics of gastric tumors. METHODS: Specimens were collected surgically from seven patients with gastric adenocarcinomas. Immu- nostaining for C-MYC and dual-color fluorescence in situ hybridization (FISH) for C-MYC gene and chromosome 8 centromere were performed. RESULTS: All the cases showed chromosome 8 aneu- ploidy and C-MYC amplification, in both the diffuse and intestinal histopathological types of Lauren. No significant difference (P ved between the level ofchromosome 8 ploidy and the site, stage or histological type of the adenocarcinomas. C-MYC high amplification, like homogeneously stained regions (HSRs) and double minutes (DMs), was observed only in the intestinal-type. Structural rearrangement of C-MYC, like translocation, was observed only in the diffuse type. Regarding C-MYC gene, a significant difference (P ved between the two histological types. The C-MYC protein was expressed in all the studied cases. In the intestinal- type the C-MYC immunoreactivity was localized only in the nucleus and in the diffuse type in the nucleus and cytoplasm. CONCLUSION: Distinct patterns of alterations between intestinal and diffuse types of gastric tumors support the hypothesis that these types follow different genetic path- ways.

关键词： Chromosome 8 aneuploidy C-MYC amplification Immunostaining Gastric adenocarcinoma

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Blue LED as a new treatment to vaginal stenosis due pelvic radiotherapy:Two case reports

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World Journal of Clinical Cases 2021年第23期9卷 6839-6845页

作者： Daniela Barros Cecília Alvares Teresa Alencar Priscila Baqueiro Augusto Marianno Rafael Alves Juliana Lenzi Laura ferreira Rezende Patricia Lordelo Oncology Department Hospital Santa IzabelSalvador 40290-000Brazil Pelvic Floor Care Center(CAAP)and Postgraduate Bahiana School of Medicine and Public HealthSalvador 40290-000Brazil Oncology Department NOB/Grupo OncoclinicasSalvador 40290-000Brazil Pelvic Floor Care Center(CAAP) University Center of the Associated Teaching FacultiesCampinas 40000000Brazil Physiotherapy Instituto Patrícia Lordelo-IPLSalvador 40290-000Brazil

BACKGROUND Currently,the advancement cancer treatment technology improves overall survival,however,adverse events are still a challenge for health *** syndrome of menopause and vaginal stenosis are conditions that impact the quality of life of patients undergoing *** present two such cases in patients with previous cervical and endometrial *** conditions were handled with an innovative method using an energy-based device with blue light emitting diode for concomitant vaginal and vulvar *** impact in clinical findings,cytologic changes,and referred symptoms were *** SUMMARY One patient diagnosed with vaginal severe vaginal stenosis with previous cervix cancer treatment and other patient diagnosed with mild stenosis with severe dyspareunia and recent endometrium cancer treatment were considered for vulvovaginal treatment with weekly blue led device and closely evaluated with repeated validated questionnaires and cytological *** This innovative technique showed an improvement in all areas of the examiner's criteria,the cytological criteria,and most bothered symptoms.

关键词： Radiotherapy Atrophic vaginitis vaginal diseases Laser therapy Semiconductor diode lasers Nonhormonal vaginal therapy Case report

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A Resource Allocation Scheme with Delay Optimization Considering mmWave Wireless Networks

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International Journal of Communications, Network and System Sciences 2020年第7期13卷 105-119页

作者： Marcus v. G. ferreira Flávio H. T. vieira Marcos N. L. Carvalho Instituto de Informática Universidade Federal de Goiás Goiania Goiás Brasil Escola de Engenharia Elétrica Mecanica e de Computa&#231 o Universidade Federal de Goiás Goiania Goiás Brasil

This paper presents a resource allocation scheme for wireless networks, aiming at optimizing the users’ data delay. It is proposed to provide optimal delay al-location by solving an optimization problem using idle state prediction and considering 5G characteristics such as mmWave propagation. The perfor-mance of the resource allocation algorithm is verified and compared with oth-ers from the literature using computational simulations in terms of Quality of Service (QoS) parameters such as throughput, delay, fairness index, loss rate and computational complexity. In these simulations, it is also considered the mmWave propagation and carrier aggregation technology for wireless next generation systems, in order to verify the system performance in a high data rate scenario.

关键词： Delay QoS mmWave Carrier Aggregation 5G

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Helicobacter pylori infection:How does age influence the inflammatory pattern?

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World Journal of Gastroenterology 2022年第4期28卷 402-411页

作者： Glauber Rocha Lima Araújo Hanna Santos Marques Maria Luísa Cordeiro Santos filipe Antônio França daSilva Breno Bittencourt da Brito Gabriel Lima Correa Santos Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094Brazil Campus vitória da Conquista Universidade Estadual do Sudoeste da BahiaVitória da Conquista 45083-900Brazil

The inflammatory pattern during Helicobacter pylori(***)infection is changeable and *** childhood,it is possible to observe a predominantly regulatory response,evidenced by high concentrations of key cytokines for the maintenance of Treg responses such as TGF-β1 and IL-10,in addition to high expression of the transcription factor *** the other hand,there is a predominance of cytokines associated with the Th1 and Th17 responses among ***-positive *** the last few years,the participation of the Th17 response in the gastric inflammation against *** infection has been highlighted due to the high levels of TGF-β1 and IL-17 found in this infectious scenario,and growing evidence has supported a close relationship between this immune response profile and unfavorable outcomes related to the ***,this cytokine profile might play a pivotal role in the effectiveness of *** *** is evident that age is one of the main factors influencing the gastric inflammatory pattern during the infection with ***,and understanding the immune response against the bacterium can assist in the development of alternative prophylactic and therapeutic strategies against the infection as well as in the comprehension of the pathogenesis of the outcomes related to that microorganism.

关键词： Helicobacter pylori Inflammation Treg response Th1 response Th17 response Gastric diseases

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Sedation in gastrointestinal endoscopy: Where are we at in 2014?

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World Journal of Gastrointestinal Endoscopy 2015年第2期7卷 102-109页

作者： Alexandre Oliveira ferreira Marília Cravo Serviço de Gastrenterologia Centro Hospitalar do AlgarveUnidade Hospitalar de Portimão8500 PortimãoPortugal Serviço de Gastrenterologia Hospital BeatrizÂngelo2674-514 LouresPortugal

Gastrointestinal endoscopies are invasive and unpleasant procedures that are increasingly being used worldwide. The importance of high quality procedures(especially in colorectal cancer screening), the increasing patient awareness and the expectation of painless examination, increase the need for procedural sedation. The best single sedation agent for endoscopy is propofol which, due to its' pharmacokinetic/dynamic profile allows for a higher patient satisfaction and procedural quality and lower induction and recovery times, while ma-intaining the safety of traditional sedation. Propofol is an anesthetic agent when used in higher doses than those needed for endoscopy. Because of this important feature it may lead to cardiovascular and respiratory depression and, ultimately, to cardiac arrest and death. Fueled by this argument, concern over the safety of its administration by personnel without general anesthesia training has arisen. Propofol usage seems to be increasing but it's still underused. It is a safe alternative for simple endoscopic procedures in low risk patients even if administered by non-anesthesiologists. Evidence on propofol safety in complex procedures and high risk patients is less robust and in these cases, the presence of an anesthetist should be considered. We review the existing evidence on the topic and evaluate the regional differences on sedation practices.

关键词： Hypnotics and sedatives Propofol Conscious sedation Endoscopy Gastrointestinal

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Molecular docking of DS-3032B,a mouse double minute 2 enzyme antagonist with potential for oncology treatment development

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World Journal of Clinical Oncology 2022年第6期13卷 496-504页

作者： vítor Hugo Sales da Mota Fabrício Freire de Melo Breno Bittencourt de Brito filipe Antônio França da Silva Kádima Nayara Teixeira Campus Toledo Universidade Federal do ParanáToledo 85.919-899ParanáBrazil Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil

BACKGROUND It is known that p53 suppression is an important marker of poor prognosis of cancers,especially in solid tumors of the breast,lung,stomach,and esophagus;liposarcomas,glioblastomas,and *** p53 has mouse double minute 2(MDM2)as its primary negative regulator,this molecular docking study seeks to answer the following hypotheses:Is the interaction between DS-3032B and MDM2 stable enough for this drug to be considered as a promising neoplastic inhibitor?AIM To analyze,in silico,the chemical bonds between the antagonist DS-3032B and its binding site in *** For molecular docking simulations,the file containing structures of MDM2(receptor)and the drug DS-3032B(ligand)were *** three-dimensional structure of MDM2 was obtained from Protein Data Bank,and the one for DS-3032B was obtained from PubChem *** location and dimensions of the Grid box was determined using AutoDock Tools *** this case,the dimensions of the Grid encompassed the entire *** ligand DS-3032B interacts with the MDM2 receptor in a physiological environment with pH 7.4;thus,to simulate more reliably,its interaction was made with the calculation for the prediction of its protonation state using the MarvinSketch®*** ligands,with and without the protonation,were prepared for molecular docking using the AutoDock Tools *** software detects the torsion points of the drug and calculates the angle of the *** docking simulations were performed using the tools of the AutoDock platform connected to the vina *** analyses of the amino acid residues involved in the interactions between the receptor and the ligand as well as the twists of the ligand,atoms involved in the interactions,and type,strength,and length of the interactions were performed using the PyMol software(***/2)and Discovery Studio from BIOvIA®.RESULTS The global alignment indicated crystal structure 5SWK was more suitable for docking simulati

关键词： DS-3032B Mouse double minute 2 antagonist Molecular docking Tumor suppressor p53

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Autoimmune hepatitis in childhood: The role of genetic and immune factors

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World Journal of Gastroenterology 2013年第28期19卷 4455-4463页

作者： Priscila Menezes Ferri Liu Débora Marques de Miranda Eleonora Druve Tavares Fagundes Alexandre Rodrigues ferreira Ana Cristina Simoes e Silva Department of Pediatrics Interdisciplinary Laboratory of Medical Investigation Federal University of Minas Gerais Belo Horizonte Minas Gerais 30130-100 Brazil National Institute of Science and Technology of Molecular Medicine (INCT-MM) CNPq-FAPEMIG Federal University of Minas Gerais Belo Horizonte Minas Gerais 30130-100 Brazil

Autoimmune hepatitis (AIH) is a rare chronic inflammatory disease of the liver, which affects a group of patients who lost their immunological tolerance to antigens of the liver. It is clinically characterized by hypergammaglobulinemia, elevated liver enzymes, presence of autoantibodies and histological changes. Although being rare in children, it represents a serious cause of chronic hepatic disease that can lead to cirrhosis and hepatic failure. Clinical findings, exclusion of more common liver disorders and the detection of antibodies antinuclear antibodies, smooth muscle antibodies and anti-LKM1 are usually enough for diagnosis on clinical practice. The pathogenic mechanisms that lead to AIH remain obscure, but some research findings suggest the participation of immunologic and genetic factors. It is not yet knew the triggering factor or factors that stimulate inflammatory response. Several mechanisms proposed partially explain the immunologic findings of AIH. The knowledge of immune factors evolved might result in better markers of prognosis and response to treatment. In this review, we aim to evaluate the findings of research about genetic and immune markers and their perspectives of application in clinical practice especially in pediatric population.

关键词： Autoimmune hepatitis Genetics Clinical practice Immunophenotype

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