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Nanocellulose-based porous materials: Regulation and pathway to commercialization in regenerative medicine

Bioactive Materials 2023年第11期29卷 151-176页

作者： filipe v.ferreira Alana G.Souza Rubina Ajdary Lucas P.de Souza Jo˜ao H.Lopes Daniel S.Correa Gilberto Siqueira Hernane S.Barud Derval dos S.Rosa Luiz H.C.Mattoso Orlando J.Rojas Nanotechnology National Laboratory for Agriculture(LNNA) Embrapa Instrumentation-Rua XV de Novembro1452S˜ao CarlosSP13560-979Brazil Center for Engineering Modelingand Applied Social Sciences(CECS)Federal University of ABC(UFABC)Santo Andr´eBrazil Department of Bioproducts and Biosystems School of Chemical EngineeringAalto UniversityP.O.Box 16300AaltoEspooFIN-00076Finland College of Engineering and Physical Sciences Aston Institute of Materials ResearchAston UniversityBirminghamUK Department of Chemistry Division of Fundamental Sciences(IEF)Technological Institute of Aeronautics(ITA)S˜ao Jose dos CamposSPBrazil Laboratory for Cellulose&Wood Materials Empa-Swiss Federal Laboratories for Materials Science and TechnologyÜberlandstrasse 1298600DübendorfSwitzerland Biopolymers and Biomaterials Laboratory(BIOPOLMAT) University of Araraquara(UNIARA)Araraquar114801-340S˜ao PauloBrazil Bioproducts Institute Department of Chemical&Biological EngineeringDepartment of Chemistry andDepartment of Wood ScienceThe University of British Columbi12360 East MallVancouverBCV6T 1Z3Canada

We review the recent progress that have led to the development of porous materials based on cellulose nanostructures found in plants and other resources. In light of the properties that emerge from the chemistry, shape and structural control, we discuss some of the most promising uses of a plant-based material, nanocellulose, in regenerative medicine. Following a brief discussion about the fundamental aspects of self-assembly of nanocellulose precursors, we review the key strategies needed for material synthesis and to adjust the architecture of the materials (using three-dimensional printing, freeze-casted porous materials, and electrospinning) according to their uses in tissue engineering, artificial organs, controlled drug delivery and wound healing systems, among others. For this purpose, we map the structure-property-function relationships of nanocellulose-based porous materials and examine the course of actions that are required to translate innovation from the laboratory to industry. Such efforts require attention to regulatory aspects and market pull. Finally, the key challenges and opportunities in this nascent field are critically reviewed.

关键词： Cellulose nanofibrils Cellulose nanocrystals Regenerative medicine Biomaterial Sustainable materials Green nanomaterials

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Contribution of inrush current to mechanical failure of power transformers windings

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High voltage 2019年第4期4卷 300-307页

作者： Rafael M.R.Barros Edson Gda Costa Jalberth F.Araujo filipe L.Mde Andrade Tarso v.ferreira Department of Electrical Engineering Federal University of Campina GrandeAprigio Veloso St.882Campina GrandeBrazil

This work presents a study regarding the contribution of inrush current to the occurrence of mechanical fatigue in windings of a power transformer and,consequently,the impact of that phenomenon on the equipment's *** order to perform the study,electromagnetic transient simulations were used to determine the inrush current in a three-phase transformer ***,three-dimensional simulations,based on the finite element method,were performed to determine the electromechanical stresses in the equipment windings,under the effect of the inrush ***,the methods of critical plans and Palmgren–Miner were applied to perform the fatigue *** the results,the impact of inrush current on the integrity of the transformer's windings was determined,as well as,to estimate the reduction of lifespan of the equipment due to inrush *** number of inrushes needed for the total reduction of lifespan of the equipment due to mechanical fatigue was also *** results can be used in the transformers design stage,with the purpose of assisting the evaluation of mechanical withstand of equipment,which can minimise the possibility of failure and increase its lifespan.

关键词： winding fatigue power

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Laser texturing of piston ring for tribological performance improvement

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Friction 2023年第10期11卷 1895-1905页

作者： Rita ferreira Óscar CARvALHO Luís SOBRAL Sandra CARvALHO filipe SILvA CMEMS-UMinho University of MinhoGuimarães 4800058Portugal LABBELS-Associate Laboratory Guimarães 4800058Portugal CEMMPRE-Center for Mechanical Engineering Materials and ProcessesUniversity of CoimbraRua Luís Reis SantosCoimbra 3030-788Portugal MAHLE Componentes de MotoresS.A.Núcleo Industrial de MurtedeCantanhede 3060-372Portugal

The radial surface coating layer of compression piston rings is used to improve their wear resistance during the internal combustion engine ***,at top dead centers,the friction coefficient of the piston ring–cylinder liner pair is detrimental to the engine’s tribological *** this work,dimples with different texture dimensions and densities were tested in a home-developed *** friction coefficient was measured for all samples,and for those with the best results,their wear resistance was *** texture with an aspect ratio of 0.25 and a density area of 15%reported the best tribological results.

关键词： piston ring surface texture friction wear

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Insights into the oxidation resistance mechanism and tribological behaviors of multilayered TiSiN/CrvxN hard coatings

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International Journal of Minerals,Metallurgy and Materials 2023年第12期30卷 2459-2468页

作者： Hongbo Ju Moussa Athmani Jing Luan Abbas AL-Rjoub Albano Cavaleiro Talha Bin Yaqub Abdelouahad Chala Fabio ferreira filipe Fernandes School of Materials Science and Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China Laboratory of Physics of Thin Films and Applications University of Mohamed KhiderBP 145 RPBiskra 07000Algeria CEMMPRE ARISEDepartment of Mechanical EngineeringUniversity of CoimbraCoimbra 3030-788Portugal IPN-LED&MAT-Instituto Pedro Nunes Laboratory of TestsWear and MaterialsCoimbra 3030-199Portugal ISEP Polytechnic of PortoRua Dr.António Bernardino de AlmeidaPorto 4249-015Portugal

In the last decades,vanadium alloyed coatings have been introduced as potential candidates for self-lubrication due to their perfect tribological *** this work,the influence of v incorporation on the wear performance and oxidation resistance of TiSiN/CrN film coatings deposited by direct current(DC)reactive magnetron sputtering is *** results show that vanadium incorporation significantly decreases the oxidation resistance of the *** general,two layers are formed during the oxidation process:i)Ti(v)O_(2) on top,followed by a protective layer,which is subdivided into two layers,Cr_(2)O_(3) and ***)The diffusion of v controls the oxidation of v-containing *** addition of vanadium improves the wear resistance of coatings,and the wear rate decreases with increasing v content in the coatings;however,the friction coefficient is independent of the chemical composition of the *** wear of the v-containing coatings is driven by polishing wear.

关键词： DC magnetron sputtering TiSiN/CrvxN multilayer coatings oxidation resistance tribology wear rate

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Modelling the role of ground-true riparian vegetation for providing regulating services in a Mediterranean watershed

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International Soil and Water Conservation Research 2023年第1期11卷 159-168页

作者： Bruno A.Aparício João Pedro Nunes Léonard Bernard-Jannin Luis filipe Dias Andre Fonseca Teresa ferreira cE3c-Centre for Ecology Evolution and Environmental Changes&CHANGE-Global Change and Sustainability InstituteFaculty of SciencesUniversity of LisbonLisbonPortugal Forest Research Centre&Laboratory TERRA School of AgricultureUniversity of LisbonLisbonPortugal Soil Physics and Land Management Group Wageningen University and ResearchWageningenNetherlands Longline Environment Ltd LondonUK

Intensive agricultural and industrial activities are often considered major sources of water ***,riparian vegetation(Rv)is increasingly being promoted as a solution to balance the potentially adverse effects that agriculture may have on water ***,existing Rv is often overlook in recent modelling efforts,failing to capture the current amount of ecosystem services ***,we used the Soil and Water Assessment Tool ecohydrological model to simulate the influence of ground-true Rv on i)nutrient(nitrate and total phosphorus)and sediment exports from agricultural areas and ii)its effect for in-stream *** results are further compared against a set of hypothetical scenarios of different Rv widths and different *** results point to a great rele-vance of existing Rv in controlling in-stream concentration of sediments and nutrients where pressure from agriculture is highest,preventing them to surpass limits set in the EU Water Framework *** the other hand,in areas with industry discharges,the role of Rv is limited and model results suggest that restoring Rv would have limited *** illustrate how existing Rv may already provide strong but not acknowledged water quality regulation services,how these services can differ substantially between nearby streams,and that effective strategies to improve water quality using Rv must acknowledge existing patterns of vegetation,land use and contamination sources.

关键词： Agricultural pollution Riparian vegetation Ecosystem services Hydrological services Mediterranean region

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Analysis of alternative parameters of dynamic resistance measurement in high voltage circuit breakers

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High voltage 2019年第3期4卷 197-202页

作者： Herbet filipe dos Santos Sousa Adriano Costa de Oliveira George victor Rocha Xavier Henrique Nunes de Santana Edson Guedes da Costa Tarso vilela ferreira Federal University of Campina Grande Campina GrandeBrazil Federal University of Sergipe AracajuBrazil

Throughout its lifetime,high-voltage circuit breaker(HvCB)contacts suffer from inevitable degradation processes,especially during the formation of electric *** degraded contacts can reduce the current interruption capacity and increase the chances of operational faults,which might lead to considerable financial ***,the use of efficient evaluating techniques is a key factor to achieve systems *** dynamic resistance measurement(DRM)is a technique that can be used to evaluate the degradation level of HvCB'*** stands out from the usual technique,static resistance measurement,by allowing the assessment of both the main contacts and the arcing contacts(ACs).Usually,the mean resistance or the area under the DRM curve is used to estimate the AC ***,DRM is a non-standardised technique and there are no specified parameters to evaluate the real wear ***,an analysis of alternative parameters extractible from the DRM technique is presented in this study,such as amplitude and variance of the DRM *** results attest the possible use of more than one parameter for the continuous evaluation of HvCB ACs,characterising the DRM as a more complete and precise diagnosis tool.

关键词： resistance parameters dynamic

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Paternal physical exercise modulates global DNA methylation status in the hippocampus of male rat offspring

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Neural Regeneration Research 2019年第3期14卷 491-500页

作者： Christiano Spindler Ethiane Segabinazi Andre Luis ferreira de Meireles Francele valente Piazza filipe Mega Gabriela dos Santos Salvalaggio Matilde Achaval viviane Rostirola Elsner Simone Marcuzzo Programa de Pos-Graduacao em Neurociencias Instituto de Ciencias Basicas da Saude Universidade Federal do Rio Grande do Sul Laboratorio de Histofisiologia Comparada Departamento de Ciencias Morfologicas Instituto de Ciencias Basicas da Saude Universidade Federal do Rio Grande do Sul Programa de Pos-Graduacao em Biociências e Reabilitacao Centro Universitario Metodista-IPA

It is widely known that maternal physical exercise is able to induce beneficial improvements in offspring cognition; however, the effects of paternal exercise have not been explored in detail. The present study was designed to evaluate the impact of paternal physical exercise on memory and learning, neuroplasticity and DNA methylation levels in the hippocampus of male offspring. Adult male Wistar rats were divided into two groups: sedentary or exercised fathers. The paternal preconception exercise protocol consisted of treadmill running, 20 minutes daily, 5 consecutive days per week for 22 days, while the mothers were not trained. After mating, paternal sperm was collected for global DNA methylation analysis. At postnatal day 53, the offspring were euthanized, and the hippocampus was dissected to measure cell survival by 5-bromo-2′-deoxiuridine and to determine the expression of synaptophysin, reelin, brain-derived neurotrophic factor and global DNA methylation levels. To measure spatial memory and learning changes in offspring, the Morris water maze paradigm was used. There was an improvement in spatial learning, as well as a significant decrease in hippocampal global DNA methylation levels in the offspring from exercised fathers compared with those from sedentary ones; however, no changes were observed in neuroplasticity biomarkers brain-derived neurotrophic factor, reelin and 5-bromo-2′-deoxiuridine. Finally, the global DNA methylation of paternal sperm was not significantly changed by physical exercise. These results suggest a link between paternal preconception physical activity and cognitive benefit, which may be associated with hippocampal epigenetic programming in male offspring. However, the biological mechanisms of this modulation remain unclear.

关键词： epigenetics preconception methylation learning treadmill running fetal programming inheritance sperm nerve regeneration

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Enhancing production monitoring: A back allocation methodology to estimate well flow rates and assist well test scheduling

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Petroleum Research 2024年第3期9卷 369-379页

作者： G.S.Chaves v.J.M.ferreira Filho Universidade Federal Do Rio de Janeiro Brazil

Production flow rates are crucial to make operational decisions,monitor,manage,and optimize oil and gas *** rates also have a financial importance to correctly allocate production to fiscal purposes required by regulatory agencies or to allocate production in fields owned by multiple *** its significance,usually only the total field production is measured in real time,which requires an alternative way to estimate wells'*** address these challenges,this work presents a back allocation methodology that leverages real-time instrumentation,simulations,algorithms,and mathe-matical programming modeling to enhance well monitoring and assist in well test *** methodology comprises four modules:simulation,classification,error calculation,and *** modules work together to characterize the flowline,wellbore,and reservoir,verify simulation outputs,minimize errors,and calculate flow rates while honoring the total platform flow *** well status generated through the classification module provides valuable information about the current condition of each well(*** the well is deviating from the latest well test parameters),aiding in decision-making for well testing scheduling and *** effectiveness of the methodology is demonstrated through its application to a representative offshore oil field with 14 producing wells and two years of daily production *** results highlight the robustness of the methodology in properly classifying the wells and obtaining flow rates that honor the total platform flow ***,the methodology supports well test scheduling and provides reliable indicators for well *** uti-lizing real-time data and advanced modeling techniques,this methodology enhances production monitoring and facilitates informed operational decision-making in the oil and gas industry.

关键词： Production estimation Real-time production Production monitoring Back allocation Well test scheduling Flow rate estimation

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Co-expression of HBZ,TAX and FOXp3 and HTLv-1-associated myelopathy/tropical spastic paraparesis development in HTLv-1-infected individuals:A systematic review

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Asian Pacific Journal of Tropical Medicine 2021年第8期14卷 333-340页

作者： Ana Carolina Marinho Monteiro Lima Greice Carolina Santos da Silva Fernanda Khouri Barreto filipe ferreira de Almeida Rego Luana Leandro Gois Luciane Amorim Santos Catholic University of Salvador SalvadorBahiaBrazil Multidisciplinary Institute in Health Federal University of BahiaVitoria da ConquistaBahiaBrazil Bahia School of Medicine and Public Health SalvadorBahiaBrazil Postgraduate Program in Health Sciences Faculty of Medicine of BahiaFederal University of BahiaSalvadorBahiaBrazil

Human T-cell lymphotropic virus type 1(HTLv-1)is associated with the development of HTLv-1-associated myelopathy/tropical spastic paraparesis(HAM/TSP).It has been reported that the HTLv-1 proteins(specifically TAX and HBZ)can modulate FOXp3,resulting in an immune imbalance that can favor the progression of HAM/*** review aims to summarize the literature in order to clarify the relationship between the expression of HTLv-1 m RNAs and/or viral proteins(TAX and HBZ)with the expression of mRNA and/or protein FOXp3 and their correlation with HAM/TSP *** systematic review was conducted according to the recommendations of the Preferred Reporting Items for Systematic Reviews and *** search strategy was performed on the Medical Literature Analysis and Retrieval System Online and Latin American and Caribbean Literature in Health Sciences Platform using subject *** screening,six articles were included in this *** studies suggested that TAX and HBZ have a directly proportional correlation with FOXp3 in individuals with HAM/TSP,which also presented an increased expression of FOXp3 compared to asymptomatic controls and/or healthy *** systematic review indicates that TAX and HBZ can interact with FOXp3 and that interaction may influence HAM/TSP development.

关键词： HTLv-1 HTLv-1-associated myelopathy/tropical spastic paraparesis(HAM/TSP) FOXp3 HBZ TAX

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The use of Artificial Neural Networks to estimate seismic damage and derive vulnerability functions for traditional masonry

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Frontiers of Structural and Civil Engineering 2020年第3期14卷 609-622页

作者： Tiago Miguel ferreira Joao ESTEvAO Rui MAIO Romeu vICENTE ISISE Institute of Science and Innovation for Bio-Sustainability(IB-S)Department of Civil EngineeringUniversity of MinhoGuimaraes 4800-058Portugal Department of Civil Engineering University of AlgarveFaro 8005-139Portugal RISCO Department of Civil EngineeringUniversity of AveiroAveiro 3810-193Portugal

ABSTRACT This paper discusses the adoption of Artificial Intelligence-based techniques to estimate seismic damage,not with the goal of replacing existing approaches,but as a mean to improve the precision of empirical *** such,damage data collected in the aftermath of the 1998 Azores earthquake(Portugal)is used to develop a comparative analysis between damage grades obtained resorting to a classic damage formulation and an innovative approach based on Artificial Neural Networks(ANNs).The analysis is carried out on the basis of a vulnerability index computed with a hybrid seismic vulnerability asssment methodology,which is subsequently used as input to both *** results obtained are then compared with real post-earthquake damage observation and critically discussed taking into account the level of adjustment achieved by each ***,a computer routine that uses the ANN as an approximation function is developed and applied to derive a new vulnerability curve *** general terms,the ANN developed in this study allowed to obtain much better approximations than those achieved with the original vulnerability approach,which has revealed to be quite ***,the proposed vulnerability curve expression was found to provide a more accurate damage prediction than the traditional analytical expressions.

关键词： Artificial Neural Networks seismic vulnerability masonry buildings damage estimation,vulnerability curves

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