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COX-2 as a potential biomarker and therapeutic target in melanoma

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Cancer Biology & Medicine 2020年第1期17卷 20-31页

作者： Diana Valentina Tudor Ioana Baldea Mihai Lupu Teodor Kacso Eniko Kutasi Andreea Hopartean Roland Stretea Adriana Gabriela filip Department of Physiology University of Medicine and Pharmacy"Iuliu Ha(t)ieganu"Cluj-Napoca 400000Romania

With a constantly increasing incidence,cutaneous melanoma has raised the need for a better understanding of its complex microenvironment that may further guide therapeutic *** is a model tumor in *** represents an important hallmark of cancer capable of inducing and sustaining tumor *** inflammatory process also orchestrates the adaptative immunosuppression of tumor cells that helps them to evade immune *** its role in proliferation,angiogenesis,and apoptosis,cyclooxygenase-2(COX-2)is a well-known promoter of immune suppression in ***-2 inhibitors are closely involved in this *** review attempts to answer two controversial questions:is COX-2 a valuable prognostic factor?Among all COX-2 inhibitors,is celecoxib a suitable adjuvant in melanoma therapy?

关键词： Melanoma inflammation,COX-2 COX-2 inhibitors celecoxib

A miniaturized assay to quantify effects of chemicals or physical stimuli upon locust activity

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Insect Science 2006年第5期13卷 401-407页

作者： BRUNO HOSTE filip SAS TIM VANDERSMISSEN ARNOLD DE LOOF MICHAEL BREUER JURGEN HUYBRECHTS Laboratory for Developmental Physiology Genomics and Proteomics Zoological Insitute K.U. Leuven Leuven Belgium

Solitary and gregarious locusts differ in many traits, such as body color, morphometrics and behavior. With respect to behavior, solitary animals shun each other, while gregarious animals seek each other＇s company, hence their crowding behavior. General activity, depending on the temperature, occurs throughout the day but is much lower in solitary locusts. Solitary locusts occasionally fly by night while gregarious locusts fly regularly during daytime （swarming）. In search of new assays to identify substances that control or modify aspects of （phase） behavior, we designed a simple activity assay, meant to complement existing behavioral measurement tools. The general activity is reflected in the number of wall hits, that is, the number of contacts between the locust and the vertical walls of a small arena. Using this single parameter we were able to quantify differences in total activity of both nymphs and adults of isolation-reared （solitary）, regrouped- and crowdreared （gregarious） locusts under different conditions. Furthermore, we demonstrate that there are inter- and intra-phase dependent differences in activities of 5th instar nymphs afar injections of the three different adipokinetic hormones.

关键词： AKH locomotion Locusta migratoria neurohormones phase transition Schistocerca gregaria

The effect of powder size on the mechanical and corrosion properties and the ignition temperature of WE43 alloy prepared by spark plasma sintering

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Journal of Magnesium and Alloys 2021年第4期9卷 1356-1369页

作者： Drahomír Dvorský JiríKubásek Michaela Roudnická filip Pruša David Necas Peter Minárik Jitka Stráská Dalibor Vojtech University of Chemistry and Technology Faculty of Chemical TechnologyDepartment of Metals and Corrosion EngineeringTechnická516628 Praha 6–DejvicePragueCzech Republic Institute of Physics Czech Academy of ScienceNa Slovance 1999/218221 Praha 8PragueCzech Republic Department of Physics of Materials Charles UniversityKe Karlovu 5Prague 12116Czech Republic

Powder metallurgy is a powerful method for the preparation of materials with superior *** work aimed to investigate the effect of powder size on the microstructure,mechanical,and corrosion properties of advanced WE43(Mg-4Y-3REE-Zr)alloy prepared by spark plasma sintering(SPS).At the same time,the effect of HF pre-treatment of the powder on the properties of final compacted products is *** powder particles yielded microstructure with more interfaces formed by Y_(2)O_(3),or MgF_(2) and YF_(3).These interfaces work as barriers against corrosion,which greatly improves corrosion *** suggested pre-treatment of powder in HF further reduced the corrosion rate of the compacted *** the contrary,fragile interfaces of YF_(3) decreased mechanical properties as the crack primarily propagates through these *** original powder containing the mixture of all powder fractions exerted the best combination of mechanical *** size has also shown to affect ignition *** highest ignition temperature was measured for the finest powder fraction.

关键词： Powder metallurgy Mechanical properties Corrosion Interface SPS

Challenges of Business in Poland in Old and New EU Policy Fields： Analytical Approach

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International Relations and Diplomacy 2016年第7期4卷 434-440页

作者： Jarostaw filip Czub University of Warsaw Warsaw Poland

Representation of Polish Business Groups in the Institutional System of the European Union

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International Relations and Diplomacy 2016年第3期4卷 177-188页

作者： Jaroslaw filip Czub University of Warsaw Warsaw Poland

Sucrose Induction of Anthocyanin Biosynthesis Mediated by DELLA

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Molecular Plant 2014年第3期7卷 570-572页

作者： Yi Li Wire Van den Ende filip Rolland Laboratory of Molecular Plant Biology KU Leuven Department of Biology Kasteelpark Arenberg 31 B-3001 Leuven Belgium

Dear Editor, While they affect all aspects of plant life, the exact molecu- lar mechanisms involved in sugar sensing and signaling are still mostly unknown. However, using the induction of antho- cyanin biosynthesis as a convenient readout and tool, the DELLA proteins can be identified as key positive regulators in sucrose-specific signaling and a point of integration of diverse metabolic and hormonal signals.

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Structural and functional aspects of the liver and liver sinusoidal cells in relation to colon carcinoma metastasis

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World Journal of Gastroenterology 2005年第33期11卷 5095-5102页

作者： Katrien Vekemans filip Braet Centre of Experimental Surgery and Anaesthesia Abdominal Transplant Surgery Department Catholic University of Leuven (KUL)Herestraat 49 3000 Leuven Belgium Australian Key Centre for Microscopy and Microanalysis Electron Microscopy Unit The University of SydneySydney 2006NSWAustralia

Nowadays, liver metastasis remains difficult to cure. When tumor cells escape and arrive in the liver sinusoids, they encounter the local defense mechanism specific to the liver. The sinusoidal cells have been widely described in physiologic conditions and in relation to metastasis during the past 30 years. This paper provides an 'overview' of how these cells function in health and in diseases such as liver metastasis.

关键词：肝窦状细胞肝功能结肠癌肿瘤转移

Business Groups and the Europe 2020 Strategy： Problem Analysis

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International Relations and Diplomacy 2017年第1期5卷 34-45页

作者： Jaroslaw filip Czub University of Warsaw Warsaw Poland

Pancreatic Castleman disease treated with laparoscopic distal pancreatectomy

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Hepatobiliary & Pancreatic Diseases International 2013年第3期12卷 332-334页

作者： filip ecka Alexander Ferko Bohumil Jon Zdeněk ubrt Petra Kaparová Rudolf Repák Department of Surgery Faculty of Medicine and University Hospital Hradec Králové Department of Field Surgery Military Health Science Faculty Hradec Králové Defence University Brno Fingerland Department of Pathology Faculty of Medicine and University Hospital Hradec Králové Second Department of Internal Medicine Faculty of Medicine and University Hospital Hradec Králové

BACKGROUND: Castleman disease is an uncommon lympho-proliferative disorder most frequently occurring in the mediastinum. Abdominal forms are less frequent, with pancreatic localization of the disease in particular being extremely rare. Only seventeen cases have been described in the world literature. METHOD: This report describes an interesting and unusual case of pancreatic Castleman disease treated with laparoscopic resection. RESULTS: A 48-year-old woman presented with epigastric pain. CT scan showed a well-encapsulated mass on the ventral border of the pancreas. Endosonography with fine needle aspiration biopsy was performed. Biopsy showed lymphoid elements and structures of a normal lymph node. The patient was treated with laparoscopic distal pancreatectomy. The pancreas was transected with a Ligasure device and the pancreatic stump was secured with a manual suture. One year after surgery the patient was complaint-free and showed no signs of recurrence of the disease. CONCLUSIONS: Laparoscopic distal pancreatectomy is a feasible and safe method for the treatment of lesions in the body and tail of the pancreas. Transection of the pancreas with a Ligasure device offers the advantages of low bleeding and low risk of pancreatic fistula.

关键词： Castleman disease pancreas laparoscopic distal pancreatectomy Ligasure