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Surgical and non-surgical risk factors affecting the insufficiency of ileocolic anastomosis after first-time surgery in Crohn’s disease patients

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World Journal of Gastrointestinal Surgery 2024年第10期16卷 3253-3260页

作者： Jaroslaw Cwaliński filip lorek Łukasz Mazurkiewicz MichałMazurkiewicz Wojciech Lizurej Jacek Paszkowski Hanna Cholerzyńska Wiktoria Zasada Department of General Endocrinological Surgery and Gastroenterological OncologyPoznan University of Medical SciencesPoznan 60-355Poland

BACKGROUND Crohn's disease(CD)often necessitates surgical intervention,particularly when it manifests in the terminal ileum and ileocecal *** undergoing radical surgery,a subset of patients experiences recurrent inflammation at the anasto-motic site,necessitating further medical *** To investigate the risk factors associated with anastomotic insufficiency following ileocecal resection in CD *** This study enrolled 77 patients who underwent open ileocolic resection with pri-mary stapled *** were stratified into two groups:Group I co-mprised individuals without anastomotic insufficiency,while Group II included patients exhibiting advanced anastomotic destruction observed endoscopically or those requiring additional surgery during the follow-up *** and non-surgical factors potentially influencing anastomotic failure were evaluated in both *** Anastomotic insufficiency was detected in 12 patients(15.6%),with a mean time interval of 30 months between the initial surgery and *** predomi-nant reasons for re-intervention included stenosis and excessive perianastomotic *** associated with a heightened risk of anastomotic failure encompassed prolonged postoperative obstruction,anastomotic bleeding,and clinically confirmed ***,patients in Group II exhibited preoperative malnutrition and early recurrence of symptoms related to *** Successful surgical outcomes hinge on the attainment of a fully functional anastomosis,optimal metabolic status,and clinical remission of the underlying *** endoscopic surveillance following primary resection facilitates the timely identification of anastomotic failure,thereby enabling noninvasive interventions.

关键词： Crohn’s disease Ileocolic resection Anastomotic insufficiency Endoscopic surveillance Surgery Risk factors

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Birds in rocky habitats of the Tatra Mountains (Carpathians)： species diversity and multiple ecological relationships

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Journal of Mountain Science 2016年第6期13卷 1078-1084页

作者： Michal CIACH filip KOWALSKI Department of Forest Biodiversity Institute of Forest Ecology and SilvicultureFaculty of ForestryUniversity of Agricultureal.29 Listopada 4531-425 KrakowPoland

Rocky habitats are regarded as biodiversity hot-spots. Along with high species diversity, diverse ecological relationships can be observed in these habitats. Large groups of bird species use rocks in various ways： as perching/roosting sites, breeding or foraging habitats, information exchange sites, display arenas or as sources of minerals and water. Because of the inaccessibility of these environments, their role and importance to animals has been underestimated. We evaluated the use of rocky habitats by birds in the Tatra Mountains （49°13′N; 19°57′E, Carpathians, central Europe）. Rocky habitats were used by 29 bird species, eight of which used cliffs directly （i.e. for nesting, foraging or resting）. The number of species recorded as using cliffs was correlated with the surface area of the cliff face. A total of 2o forms of rocky habitat use were recorded, in five behavioural categories： vocalization, foraging, perching, flight and nesting. Prevailing behaviours were flying by a rock face, circling above the face, and vocalization on a tree/shrub growing next to a rock. Rocks provide a nesting habitat for specialized petrophilic species and permit the existence of numerous ecological relations between species and habitats. The results of this study show that rocky habitats support the diversity of ecological relationships.

关键词： Bird community Rock Cliff Mountains Alpine species Ecological relationships

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Adaptive slices for acquisition of anisotropic BRDF

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Computational Visual Media 2018年第1期4卷 55-69页

作者： Radomfr Vavra Jiri filip Institute of Information Theory and Automation of the CAS Pod Vodarenskou vezi4185 08Praha 8Czech Republic

BRDF continues to be used as a fundamental tool for representing material appearance in computer graphics. In this paper we present a practical adaptive method for acquisition of anisotropic BRDF, based on sparse adaptive measurement of the complete four-dimensional BRDF space by means of one-dimensional slices, which form a sparse fourdimensional structure in the BRDF space, and can be measured by continuous movements of a light source and sensor. Such a sampling approach is advantageous especially for gonioreflectometer-based measurement devices where the mechanical travel of a light source and a sensor imposes a significant time constraint. In order to evaluate our method, we have performed adaptive measurements of three materials and we simulated adaptive measurements of thirteen others. This method has one quarter the reconstruction error of that resulting from regular non-adaptive BRDF measurements using the same number of measured samples. Our method is almost twice as good as a previous adaptive method, and it requires from two to five times fewer samples to achieve the same results as alternative approaches.

关键词： anisotropic BRDF slice sampling

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Comparative analysis of experimental testing procedures for the elicitation of rescue actions in ants

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Current Zoology 2022年第2期68卷 159-168页

作者： filip TURZA Krzysztof MILER Institute of Environmental Sciences Faculty of BiologyJagiellonian UniversityGronostajowa 7Krakow 30-387Poland Institute of Systematics and Evolution of Animals Polish Academy of SciencesStawkowska 17Krakow 31-016Poland

Rescue behavior is observed when 1 individual provides help to another individual in *** reports of rescue behavior concern ants(Formicidae),in which workers rescue each other from various types of *** of these entrapment situations can be simulated in the laboratory using an entrapment bioassay,in which ants confront a single endangered nest mate entrapped on a sandy arena by means of an artificial ***,we compared numerous characteristics of rescue actions(contact between individuals,digging around the entrapped individual,pulling at its body parts,transport of the sand covering it,and biting the snare entrapping it)in Formica cinerea *** performed entrapment tests in the field and in the laboratory,with the latter under varying conditions in terms of the number of ants potentially engaged in rescue actions and the arena substrate(marked or unmarked by ants'pheromones).Rescue actions were more probable and pronounced in the field than in the laboratory,regardless of the type of ***,different test types in the laboratory yielded inconsistent results and showed noteworthy variability depending on the tested characteristic of *** results illustrate the specifics of ant rescue actions elicited in the natural setting,which is especially important considering the scarcity of field ***,our results underline the challenges related to the comparison of results from different types of entrapment tests reported in the available ***,our study shows how animal behavior differs in differing experimental setups used to answer the same questions.

关键词： ants animal behavior entrapment bioassay Formica cinerea rescue behavior

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Image-based appearance acquisition of effect coatings

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Computational Visual Media 2019年第1期5卷 73-89页

作者： Jirí filip Radomír Vávra The Czech Academy of Sciences Institute of Information Theory and AutomationPod Vodárenskou vezı4185 08Praha 8Czech Republic

Paint manufacturers strive to introduce unique visual effects to coatings in order to visually communicate functional properties of products using value-added, customized design. However, these effects often feature complex, angularly dependent, spatiallyvarying behavior, thus representing a challenge in digital reproduction. In this paper we analyze several approaches to capturing spatially-varying appearances of effect coatings. We compare a baseline approach based on a bidirectional texture function(BTF) with four variants of half-difference parameterization. Through a psychophysical study, we determine minimal sampling along individual dimensions of this *** conclude that, compared to BTF, bivariate representations better preserve visual fidelity of effect coatings, better characterizing near-specular behavior and significantly the restricting number of images which must be captured.

关键词： effect coatings measurement bidirectional texture function(BTF) appearance psychophysical experiment

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The structural biology of ryanodine receptors

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Science China(Life Sciences) 2011年第8期54卷 712-724页

作者： Lynn KIMLICKA filip VAN PETEGEM University of British Columbia Department of Biochemistry and Molecular Biology

Ryanodine receptors are ion channels that allow for the release of Ca2+ from the endoplasmic or sarcoplasmic *** are expressed in many different cell types but are best known for their predominance in skeletal and cardiac myocytes,where they are directly involved in excitation-contraction *** molecular weights exceeding 2 MDa,Ryanodine Receptors are the largest ion channels known to date and present major challenges for structural *** their discovery in the 1980s,significant progress has been made in understanding their behaviour through multiple structural ***-electron microscopy reconstructions of intact channels depict a mushroom-shaped structure with a large cytoplasmic region that pre-sents many binding sites for regulatory *** region undergoes significant motions during opening and closing of the channel,demonstrating that the Ryanodine Receptor is a bona fide allosteric ***-resolution structures through X-ray crystallography and NMR currently cover～11% of the entire *** combination of high-and low-resolution methods allows us to build pseudo-atomic *** we present an overview of the electron microscopy,NMR,and crystallographic analyses of this membrane protein giant.

关键词： calcium release excitation-contraction coupling genetic disease structural biology calcium release channel ion channel

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Goal-Oriented Anisotropic hp-Adaptive Discontinuous Galerkin Method for the Euler Equations

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Communications on Applied Mathematics and Computation 2022年第1期4卷 143-179页

作者： Vít Dolejší filip Roskovec Faculty of Mathematics and Physics Charles UniversitySokolovská8318675 PragueCzech Republic

We deal with the numerical solution of the compressible Euler equations with the aid of the discontinuous Galerkin(DG)method with focus on the goal-oriented error estimates and *** analyse the adjoint consistency of the DG scheme where the adjoint problem is not formulated by the differentiation of the DG form and the target functional but using a suitable linearization of the nonlinear ***,we present the goal-oriented anisotropic hp-mesh adaptation method for the Euler *** theoretical results are supported by numerical experiments.

关键词： Euler equations Discontinuous Galerkin method Target functional Adjoint consistency Anisotropic hp-mesh adaptation

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A Multiscale Method for Damage Analysis of Quasi-Brittle Heterogeneous Materials

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Computer Modeling in Engineering & Sciences 2019年第7期120卷 123-156页

作者： filip Putar Jurica Soric Tomislav Lesicar Zdenko Tonkovic Faculty of Mechanical Engineering and Naval Architecture University of ZagrebIvana Lucica 5Zagreb 10000Croatia

A novel multiscale algorithm based on the higher-order continuum at both micro-and macrostructural level is proposed for the consideration of the quasi-brittle damage response of heterogeneous ***,the microlevel damage is modelled by the degradation of the homogenized stress and tangent stiffness tensors,which are then upscaled to govern the localization at the *** C^1 continuity finite element employing a modified case of Mindlin’s form II strain energy density is derived for the softening *** the authors’knowledge,the finite element discretization based on the strain gradient theory is applied for the modeling of damage evolution at the microstructural level for heterogeneous materials for the first *** advantage of the novel C1 finite element formulation in comparison with the standard finite element discretization in terms of the regularization efficiency as well as the objectivity has been *** isotropic damage law is used for the reduction of the constitutive and nonlocal material behaviour,which is necessary for the physically correct description of the localization formation in quasi-brittle *** capabilities of the derived finite element to capture the fully developed localization zones are tested on a random representative volume element(RVE)for several different loading *** employing the conventional second-order computational homogenization,the microstructural material constitutive response is averaged over the whole RVE *** order to model the loss of structural integrity when sharp localization is formed across RVE,the specific conditions which detect a completely formed localization zone are developed.A new failure criterion at the microstructural level has been *** derived finite element formulation,as well as the multiscale damage algorithm,are implemented into the finite element program *** capabilities of the presented multiscale scheme to capture the effects of the deformat

关键词： Multiscale analysis second-order computational homogenization damage,C^(1) continuity finite element quasi-brittle material

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Prenatal nicotine alters development of the laterodorsal tegmentum:Possible role for attention-deficit/hyperactivity disorder and drug dependence

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World Journal of Psychiatry 2022年第2期12卷 212-235页

作者： filip S Polli Kristi A Kohlmeier Drug Design and Pharmacology University of CopenhagenCopenhagen 2100Denmark

As we cycle between the states of wakefulness and sleep,a bilateral cholinergic nucleus in the pontine brain stem,the laterodorsal tegmentum(LDT),plays a critical role in controlling salience processing,attention,behavioral arousal,and electrophysiological signatures of the sub-and microstates of *** involving abnormal alterations in behavioral and motivated states,such as drug dependence,likely involve dysfunctions in LDT *** addition,as the LDT exhibits connectivity with the thalamus and mesocortical circuits,as well as receives direct,excitatory input from the prefrontal cortex,a role for the LDT in cognitive symptoms characterizing attention-deficit/hyperactivity disorder(ADHD)including impulsivity,inflexibility,and dysfunctions of attention is *** nicotine exposure(PNE)is associated with a higher risk for later life development of drug dependence and ADHD,suggesting alteration in development of brain regions involved in these *** has been shown to alter glutamate and cholinergic signaling within the *** glutamate and acetylcholine are major excitatory mediators,these alterations would likely alter excitatory output to target regions in limbic motivational circuits and to thalamic and cortical networks mediating executive ***,PNE alters neuronal development and transmission within prefrontal cortex and limbic areas that send input to the LDT,which would compound effects of differential processing within the PNE *** taken together,alterations in signaling in the LDT are likely to play a role in negative behavioral outcomes seen in PNE individuals,including a heightened risk of drug dependence and ADHD behaviors.

关键词： Prenatal nicotine exposure Pregnancy outcome Addiction risk Laterodorsal tegmentum Arousal Attention

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Poultry gut health and beyond

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Animal Nutrition 2023年第2期13卷 240-248页

作者： Richard Ducatelle Evy Goossens Venessa Eeckhaut filip Van Immerseel Livestock Gut Health Team Department of PathobiologyPharmacology and Zoological MedicineFaculty of Veterinary MedicineGhent UniversityBelgium

Intestinal health is critically important for the digestion and absorption of nutrients and thus is a key factor in determining *** health issues are very common in high performing poultry lines due to the high feed intake,which puts pressure on the physiology of the digestive *** nutrients which are not digested and absorbed in the small intestine may trigger dysbiosis,i.e.a shift in the microbiota composition in the intestinal *** as well as other stressors elicit an inflammatory response and loss of integrity of the tight junctions between the epithelial cells,leading to gut *** this paper,key factors determining intestinal health and the most important nutritional tools which are available to support intestinal health are reviewed.

关键词： Poultry Intestinal health Inflammation Gut leakage Microbiota Feed additive

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