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Six-year outcomes in neovascular age-related macular degeneration with ranibizumab

International Journal of Ophthalmology(English edition) 2017年第1期10卷 81-90页

作者： Julie Jacob Heidi Brié Anita Leys Laurent Levecq filip mevgaerts Kris Denhaerynck Stefaan Vancayzeele Eline Van Craeyveld Ivo Abraham Karen MacDonald Leuven University Eye Hospital Kapucijnenvoer 33Leuven B-3000Belgium Novartis Pharma Medialaan 40Vilvoorde B-1800Belgium Catholic University of Louvain CHU UCL NamurYvoirB-5530Belgium Medisch Centrum Aarschot Langdorpsesteenweg 129Aarschot B-3200Belgium Matrix45 6159 W Sunset RdTucsonAZ 85743USA Center for Health Outcomes and Pharmacoeconomic Research University of ArizonaTucsonAZ 85721USA

AIM： To evaluate the outcomes of （6y ranibizumab therapy in neovascular age-related macular degeneration （AMD）.METHODS： HELIX was a retrospective, observational effectiveness study using medical records of patients treated in three clinics in Belgium. Patients had neovascular AMD and were initially treated with intravitreal ranibizumab （0.5 mg） between November 1, 2007 and October 31, 2008, had （6y of data available, and were treated on an ongoing, as-needed basis. Outcomes included best-corrected visual acuity （BCVA） and central retinal thickness （CRT）.RESULTS： The sample consisted of 88 eyes from 69 patients. Mean age was 76.4±6.5y, most patients were female （62.3%）. Most eyes （62.5%） were treatment-naive, 33 previously treated eyes had received predominantly other anti-vascular endothelial growth factor agents and verteporfin. Mean baseline BCVA was 57.4±12.7 ETDRS letters and CRT was 291.5±86.1 （m. On average, patients received 20.6±11.9 ranibizumab injections over the （6y. Intervals between injections were on average 12.7±16.1wk. Mean change in BCVA from baseline to last observation for the sample was less than one letter （-0.9±17.3 letters）, with an average loss of -3.2±15.6 letters in previously treated eyes versus a gain of 0.6±18.4 letters in treatment-na？ve eyes. When considering a loss of 〈15 letters over 6y as stabilization of disease, 75.9% of all eyes showed a positive （improvement or stabilization） outcome. Mean change in CRT from baseline to last observation for the sample was -26.9±148.4 （m with the greatest reduction observed in treatment-naive ***： This retrospective study of 69 neovascular AMD patients treated for （6y with ranibizumab demonstrates long-term visual stabilization. In light of the natural evolution of the disease, these data confirm that ranibizumab is effective long-term under real-world conditions of heterogeneity of patients, clinicians, and centers.

关键词： ranibizumab age-related macular degeneration visual acuity central retinal thickness optical coherence tomography visual function, long-term outcome

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Birds in rocky habitats of the Tatra Mountains (Carpathians)： species diversity and multiple ecological relationships

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Journal of Mountain Science 2016年第6期13卷 1078-1084页

作者： Michal CIACH filip KOWALSKI Department of Forest Biodiversity Institute of Forest Ecology and SilvicultureFaculty of ForestryUniversity of Agricultureal.29 Listopada 4531-425 KrakowPoland

Rocky habitats are regarded as biodiversity hot-spots. Along with high species diversity, diverse ecological relationships can be observed in these habitats. Large groups of bird species use rocks in various ways： as perching/roosting sites, breeding or foraging habitats, information exchange sites, display arenas or as sources of minerals and water. Because of the inaccessibility of these environments, their role and importance to animals has been underestimated. We evaluated the use of rocky habitats by birds in the Tatra Mountains （49°13′N; 19°57′E, Carpathians, central Europe）. Rocky habitats were used by 29 bird species, eight of which used cliffs directly （i.e. for nesting, foraging or resting）. The number of species recorded as using cliffs was correlated with the surface area of the cliff face. A total of 2o forms of rocky habitat use were recorded, in five behavioural categories： vocalization, foraging, perching, flight and nesting. Prevailing behaviours were flying by a rock face, circling above the face, and vocalization on a tree/shrub growing next to a rock. Rocks provide a nesting habitat for specialized petrophilic species and permit the existence of numerous ecological relations between species and habitats. The results of this study show that rocky habitats support the diversity of ecological relationships.

关键词： Bird community Rock Cliff Mountains Alpine species Ecological relationships

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Structural and functional aspects of the liver and liver sinusoidal cells in relation to colon carcinoma metastasis

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World Journal of Gastroenterology 2005年第33期11卷 5095-5102页

作者： Katrien Vekemans filip Braet Centre of Experimental Surgery and Anaesthesia Abdominal Transplant Surgery Department Catholic University of Leuven (KUL)Herestraat 49 3000 Leuven Belgium Australian Key Centre for Microscopy and Microanalysis Electron Microscopy Unit The University of SydneySydney 2006NSWAustralia

Nowadays, liver metastasis remains difficult to cure. When tumor cells escape and arrive in the liver sinusoids, they encounter the local defense mechanism specific to the liver. The sinusoidal cells have been widely described in physiologic conditions and in relation to metastasis during the past 30 years. This paper provides an “overview” of how these cells function in health and in diseases such as

关键词： Metastasis Liver Colon carcinoma Sinusoidalcells Kupffer cells Liver sinusoidal endothelial cells Hepatic NK cells

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Adaptive slices for acquisition of anisotropic BRDF

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Computational Visual Media 2018年第1期4卷 55-69页

作者： Radomfr Vavra Jiri filip Institute of Information Theory and Automation of the CAS Pod Vodarenskou vezi4185 08Praha 8Czech Republic

BRDF continues to be used as a fundamental tool for representing material appearance in computer graphics. In this paper we present a practical adaptive method for acquisition of anisotropic BRDF, based on sparse adaptive measurement of the complete four-dimensional BRDF space by means of one-dimensional slices, which form a sparse fourdimensional structure in the BRDF space, and can be measured by continuous movements of a light source and sensor. Such a sampling approach is advantageous especially for gonioreflectometer-based measurement devices where the mechanical travel of a light source and a sensor imposes a significant time constraint. In order to evaluate our method, we have performed adaptive measurements of three materials and we simulated adaptive measurements of thirteen others. This method has one quarter the reconstruction error of that resulting from regular non-adaptive BRDF measurements using the same number of measured samples. Our method is almost twice as good as a previous adaptive method, and it requires from two to five times fewer samples to achieve the same results as alternative approaches.

关键词： anisotropic BRDF slice sampling

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Multifaceted nature of membrane microdomains in colorectal cancer

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World Journal of Gastroenterology 2011年第6期17卷 681-690页

作者： Kristina A Jahn filip Braet Australian Centre for Microscopy and Microanalysis The University of Sydney

Membrane microdomains or lipid rafts are known to be highly dynamic and to act as selective signal transduction mediators that facilitate interactions between the cell's external and internal *** rafts play an important mediating role in the biology of cancer:they have been found in almost all existing experimental cancer models,including colorectal cancer (CRC),and play key regulatory roles in cell migration,metastasis,cell survival and tumor *** paper explores the current state of knowledge in this field by highlighting some of the pioneering and recent lipid raft studies performed on different CRC cell lines and human tissue *** this literature review,it becomes clear that membrane microdomains appear to be implicated in all key intracellular signaling pathways for lipid metabolism,drug resistance,cell adhesion,cell death,cell proliferation and many other processes in *** signal transduction pathways seem to originate directly from those peculiar lipid islands,thereby orchestrating the colon cancer cells' state and *** confirmed by recent animal and preclinical studies in different CRC models,continuing to unravel the structure and function of lipid rafts-including their associated complex signaling pathways-will likely bring us one step closer to better monitoring and treating of colon cancer patients.

关键词： Actin Caveolae Cytoskeleton Combined imaging Detergent-resistant membranes Drug targeting Electron microscopy Lipid domains Membrane rafts Prognosis Staging Tomography Lipid-mediated therapy

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Comparative analysis of experimental testing procedures for the elicitation of rescue actions in ants

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Current Zoology 2022年第2期68卷 159-168页

作者： filip TURZA Krzysztof MILER Institute of Environmental Sciences Faculty of BiologyJagiellonian UniversityGronostajowa 7Krakow 30-387Poland Institute of Systematics and Evolution of Animals Polish Academy of SciencesStawkowska 17Krakow 31-016Poland

Rescue behavior is observed when 1 individual provides help to another individual in *** reports of rescue behavior concern ants(Formicidae),in which workers rescue each other from various types of *** of these entrapment situations can be simulated in the laboratory using an entrapment bioassay,in which ants confront a single endangered nest mate entrapped on a sandy arena by means of an artificial ***,we compared numerous characteristics of rescue actions(contact between individuals,digging around the entrapped individual,pulling at its body parts,transport of the sand covering it,and biting the snare entrapping it)in Formica cinerea *** performed entrapment tests in the field and in the laboratory,with the latter under varying conditions in terms of the number of ants potentially engaged in rescue actions and the arena substrate(marked or unmarked by ants'pheromones).Rescue actions were more probable and pronounced in the field than in the laboratory,regardless of the type of ***,different test types in the laboratory yielded inconsistent results and showed noteworthy variability depending on the tested characteristic of *** results illustrate the specifics of ant rescue actions elicited in the natural setting,which is especially important considering the scarcity of field ***,our results underline the challenges related to the comparison of results from different types of entrapment tests reported in the available ***,our study shows how animal behavior differs in differing experimental setups used to answer the same questions.

关键词： ants animal behavior entrapment bioassay Formica cinerea rescue behavior

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Image-based appearance acquisition of effect coatings

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Computational Visual Media 2019年第1期5卷 73-89页

作者： Jirí filip Radomír Vávra The Czech Academy of Sciences Institute of Information Theory and AutomationPod Vodárenskou vezı4185 08Praha 8Czech Republic

Paint manufacturers strive to introduce unique visual effects to coatings in order to visually communicate functional properties of products using value-added, customized design. However, these effects often feature complex, angularly dependent, spatiallyvarying behavior, thus representing a challenge in digital reproduction. In this paper we analyze several approaches to capturing spatially-varying appearances of effect coatings. We compare a baseline approach based on a bidirectional texture function(BTF) with four variants of half-difference parameterization. Through a psychophysical study, we determine minimal sampling along individual dimensions of this *** conclude that, compared to BTF, bivariate representations better preserve visual fidelity of effect coatings, better characterizing near-specular behavior and significantly the restricting number of images which must be captured.

关键词： effect coatings measurement bidirectional texture function(BTF) appearance psychophysical experiment

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The role of interleukin-6 in central nervous system demyelination

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Neural Regeneration Research 2016年第12期11卷 1922-1923页

作者： filip Petkovic Bernardo Castellano Department of Cell Biology Physiology and Immunology Institute of Neuroscience Universitat Autonoma de Barcelona Bellaterra Spain Department of Immunology Institute for Biological Research "Sinisa Stankovic" Belgrade Serbia

Demyelination of the central nervous system（CNS）is a hallmark of multiple sclerosis（MS）,chronic inflammatory and neurodegenerative *** demyelination favors neurodegeneration of denuded axons,which is a major cause... 详细信息

关键词： interleukin disability neuronal irreversible despite microglia cytokine astrocyte maturation understood

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The structural biology of ryanodine receptors

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Science China(Life Sciences) 2011年第8期54卷 712-724页

作者： Lynn KIMLICKA filip VAN PETEGEM University of British Columbia Department of Biochemistry and Molecular Biology

Ryanodine receptors are ion channels that allow for the release of Ca2+ from the endoplasmic or sarcoplasmic *** are expressed in many different cell types but are best known for their predominance in skeletal and cardiac myocytes,where they are directly involved in excitation-contraction *** molecular weights exceeding 2 MDa,Ryanodine Receptors are the largest ion channels known to date and present major challenges for structural *** their discovery in the 1980s,significant progress has been made in understanding their behaviour through multiple structural ***-electron microscopy reconstructions of intact channels depict a mushroom-shaped structure with a large cytoplasmic region that pre-sents many binding sites for regulatory *** region undergoes significant motions during opening and closing of the channel,demonstrating that the Ryanodine Receptor is a bona fide allosteric ***-resolution structures through X-ray crystallography and NMR currently cover～11% of the entire *** combination of high-and low-resolution methods allows us to build pseudo-atomic *** we present an overview of the electron microscopy,NMR,and crystallographic analyses of this membrane protein giant.

关键词： calcium release excitation-contraction coupling genetic disease structural biology calcium release channel ion channel

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Goal-Oriented Anisotropic hp-Adaptive Discontinuous Galerkin Method for the Euler Equations

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Communications on Applied Mathematics and Computation 2022年第1期4卷 143-179页

作者： Vít Dolejší filip Roskovec Faculty of Mathematics and Physics Charles UniversitySokolovská8318675 PragueCzech Republic

We deal with the numerical solution of the compressible Euler equations with the aid of the discontinuous Galerkin(DG)method with focus on the goal-oriented error estimates and *** analyse the adjoint consistency of the DG scheme where the adjoint problem is not formulated by the differentiation of the DG form and the target functional but using a suitable linearization of the nonlinear ***,we present the goal-oriented anisotropic hp-mesh adaptation method for the Euler *** theoretical results are supported by numerical experiments.

关键词： Euler equations Discontinuous Galerkin method Target functional Adjoint consistency Anisotropic hp-mesh adaptation

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