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Biosynthetic scaffolds for partial meniscal loss:A systematic review from animal models to clinical practice

Bioactive Materials 2021年第11期6卷 3782-3800页

作者： F.Veronesi B.Di Matteo N.D.Vitale g.filardo A.Visani E.Kon M.Fini Complex Structure of Surgical Sciences and Technologies IRCCS Istituto Ortopedico RizzoliBolognaItaly Humanitas University Department of Biomedical SciencesVia Rita Levi Montalcini 420090Pieve EmanueleMilanItaly IRCCS Humanitas Research Hospital Via Manzoni 5620089RozzanoMilanItaly Applied and Translational Research Center IRCCS Istituto Ortopedico RizzoliBolognaItaly Orthopaedic and Traumatology Unit Ospedale Regionale di LuganoEOCLuganoSwitzerland Faculty of Biomedical Sciences Universit`a della Svizzera ItalianaLuganoSwitzerland First Moscow State Medical University-Sechenov University Bol’shaya Pirogovskaya Ulitsa19c1119146MoscowRussia

Acute or degenerative meniscus tears are the most common knee *** provides symptomatic relief and functional recovery only in the short-to mid-term follow-up but significantly increases the risk of *** this reason,preserving the meniscus is key,although it remains a *** transplants present many disadvantages,so during the last 20 years preclinical and clinical research focused on developing and investigating meniscal *** aim of this systematic review was to collect and evaluate all the available evidence on biosynthetic scaffolds for meniscus regeneration both in vivo and in clinical *** databases were searched:46 in vivo preclinical studies and 30 clinical ones were *** natural,15 synthetic,and 15 hybrid scaffolds were studied in *** them,only 2 were translated into clinic:the Collagen Meniscus Implant,used in 11 studies,and the polyurethane-based scaffold Actifit®,applied in 19 *** positive outcomes were described in the short-to mid-term,the number of concurrent procedures and the lack of randomized trials are the major limitations of the available clinical *** in vivo studies also combined the use of cells or growth factors,but these augmentation strategies have not been applied in the clinical practice *** solutions offer a significant but incomplete clinical improvement,and the regeneration potential is still *** upon the overall positive results of these“old”technologies to address partial meniscal loss,further innovation is urgently needed in this field to provide patients better joint sparing treatment options.

关键词： Meniscal scaffold Meniscectomy Osteoarthritis Regenerative medicine Collagen Polyurethane

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Platelet rich plasma versus viscosupplementation for knee osteoarthritis

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中华物理医学与康复杂志 2015年第9期37卷 677-677页

作者： filardo g Di Matteo B Di Martino A

BACKgROUND AND OBJECTIVE Osteoarthritis （OA） of the knee is a common condition that can result in pain and decreased functional capacity. Among new treatments for OA are biologic treatments including platelet rich plasma （ PRP）. This study evaluated the benefit of PRP as compared to that of hyaluronic acid （HA） for the treatment of OA.

关键词：摘要编辑部编辑工作读者作者

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基质辅助自体软骨细胞移植治疗髌股关节软骨损伤——髌骨与滑车损伤修复疗效对比

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中国骨科临床与基础研究杂志 2015年第1期7卷 60-60页

作者： filardo g Kon E Andriolo L 沈洪园章莹

由于自身愈合能力有限，软骨损伤修复一直以来都具有临床挑战性。膝关节软骨损伤患病率高，尤以髌股关节软骨损伤最为多见。基质辅助自体软骨细胞移植（matrix-assisted autologous chondrocyte transplantation，MACT）中期随访显示出... 详细信息

由于自身愈合能力有限，软骨损伤修复一直以来都具有临床挑战性。膝关节软骨损伤患病率高，尤以髌股关节软骨损伤最为多见。基质辅助自体软骨细胞移植（matrix-assisted autologous chondrocyte transplantation，MACT）中期随访显示出良好疗效，但对于不同患者及不同损伤类型，治疗结果各异。本研究的目的在于对同一手术团队采取同一术式治疗的髌股关节软骨缺损的中期疗效进行前瞻性队列研究，明确髌骨和滑车软骨缺损治疗后是否存在临床愈合结果的差异。

关键词：自体软骨细胞移植膝关节软骨损伤骨损伤修复移植治疗中期疗效基质辅助滑车髌骨

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Infectious burden and atherosclerosis: A clinical issue

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World Journal of Clinical Cases 2014年第7期2卷 240-249页

作者： Rosa Sessa Marisa Di Pietro Simone filardo Ombretta Turriziani Department of Public Health and Infectious Diseases "Sapienza" University Department of Molecular Medicine "Sa-pienza" University

Atherosclerotic cardiovascular diseases, chronic inflam-matory diseases of multifactorial etiology, are the lead-ing cause of death worldwide. In the last decade, more infectious agents, labeled as "infectious burden", rather than any single pathogen, have been showed to con-tribute to the development of atherosclerosis through different mechanisms. Some microorganisms, such as Chlamydia pneumoniae(C. pneumoniae), human cytomegalovirus, etc. may act directly on the arterial wall contributing to endothelial dysfunction, foam cell formation, smooth muscle cell proliferation, platelet ag-gregation as well as cytokine, reactive oxygen specie, growth factor, and cellular adhesion molecule produc-tion. Others, such as Helicobacter pylori(H. pylori), in-fluenza virus, etc. may induce a systemic inflammation which in turn may damage the vascular wall(e.g., by cytokines and proteases). Moreover, another indirect mechanism by which some infectious agents(such as H. pylori, C. pneumoniae, periodontal pathogens, etc.) may play a role in the pathogenesis of atherosclero-sis is molecular mimicry. given the complexity of the mechanisms by which each microorganism may con-tribute to atherosclerosis, defining the interplay of moreinfectious agents is far more difficult because the pro-atherogenic effect of each pathogen might be ampli-fied. Clearly, continued research and a greater aware-ness will be helpful to improve our knowledge on the complex interaction between the infectious burden and atherosclerosis.

关键词： Infectious burden Atherosclerosis Bacteria Virus Pathogenetic mechanisms

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Biologic agents for anterior cruciate ligament healing: a systematic review

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World Journal of Orthopedics 2016年第9期7卷 592-603页

作者： Berardo Di Matteo Markus Loibl Luca Andriolo giuseppe filardo Johannes Zellner Matthias Koch Peter Angele ⅠOrthopaedic and Traumatologic Clinic - Biomechanics and Technology Innovation Laboratory Rizzoli Orthopaedic Institute Department of Trauma Surgery University Regensburg Medical Centre Sporthopaedicum Regensburg

AIM To systematically review the currently available literature concerning the application of biologic agents such as platelet-rich plasma(PRP) and stem cells to promote anterior cruciate ligament(ACL) *** A systematic review of the literature was performed on the use of biologic agents(i.e., PRP or stem cells) to favor ACL healing during reconstruction or repair. The following inclusion criteria for relevant articles were used: Clinical reports of any level of evidence, written in English language, on the use of PRP or stem cells during ACL reconstruction/repair. Exclusion criteria were articles written in other languages, reviews, or studies analyzing other applications of PRP/stem cells in knee surgery not related to promoting ACL *** The database search identified 394 records that were screened. A total of 23 studies were included in the final analysis: In one paper stem cells were applied for ACL healing, in one paper there was a concomitant application of PRP and stem cells, whereas in the remaining21 papers PRP was used. Based on the ACL injury pattern, two papers investigated biologic agents in ACL partial tears whereas 21 papers in ACL *** at the quality of the available literature, 17 out of 21 studies dealing with ACL reconstruction were randomized controlled trials. Both studies on ACL repair were case *** There is a paucity of clinical trials investigating the role of stem cells in promoting ACL healing both in case of partial and complete tears. The role of PRP is still controversial and the only advantage emerging from the literature is related to a better graft maturation over time, without documenting beneficial effects in terms of clinical outcome, bone-graft integration and prevention of bony tunnel enlargement.

关键词： Platelet-rich plasma growth factors Stem cells Anterior cruciate ligament reconstruction Anterior cruciate ligament repair Anterior cruciate ligament healing Sports medicine Regenerative medicine

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论通货紧缩的成本：历史回顾

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国际金融研究 2015年第8期 3-14页

作者： Claudio Borio Magdalena Erdem Andrew filardo Boris Hofmann 韩丽颖瞿亢刘兰兰国际清算银行(BIS) 中国银行总行风险管理部中国银行伦敦分行英国诺丁汉大学

当商品和服务的价格出现持续下降时,货币成本随之上升,因此会引发关于通货紧缩的担忧。本文基于1870-2013年期间38个经济体的数据,从实证角度检验了经济增长和通货紧缩之间的历史关系。实证结果表明,通货紧缩与经济增速放缓之间的关系... 详细信息

当商品和服务的价格出现持续下降时,货币成本随之上升,因此会引发关于通货紧缩的担忧。本文基于1870-2013年期间38个经济体的数据,从实证角度检验了经济增长和通货紧缩之间的历史关系。实证结果表明,通货紧缩与经济增速放缓之间的关系非常薄弱,并且这一关系主要存在于大萧条时期。然而我们发现,经济增长和资产价格下跌之间具有密切的联系,这一关系在第二次世界大战后的房地产市场尤为明显。我们并未发现高负债会引起商品和服务成本的提高,即债务通货紧缩。其中的例外是,房地产价格和私人债务之间相互影响引起的经济下滑。

关键词：通货紧缩经济增长资产价格

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论通货紧缩的成本:历史回顾

论通货紧缩的成本:历史回顾

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作者： Claudio Borio Magdalena Erdem Andrew filardo Boris Hofmann 韩丽颖瞿亢刘兰兰国际清算银行(BIS) 中国银行总行风险管理部中国银行伦敦分行英国诺丁汉大学

关键词：通货紧缩经济增长资产价格

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高影响力医学期刊中第一作者为女性的发展趋势与比较：观察性研究（19942014年）

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英国医学杂志中文版 2016年第12期19卷 681-681页

作者： giovanni filardo Briget da graca Danielle M Sass Benjamin D Pollock Emma B Smith Melissa Ashley-MarieMartinez 王强徐静 Department of Epidemiology Office of the Chief Quality Officer Baylor Scott & White Health 8080 North Central Expressway Dallas TX 75206. USA Center for Clinical Effectiveness Office of the Chief Quality Officer Baylor Scott & White Health Dallas Yale University NewHaven CT 06520USA University of NewMexico School ofMedicine Albuquerque NM87131 USA 武汉市黄陂区中医院病理科中华心血管病杂志编辑部

目的以1994--2014年影响力较大的综合性医学期刊上发表的原创性研究为对象，调查其中第一作者为女性的变化情况及其在期刊间的差异。设计观察性研究。

关键词：综合性医学期刊期刊编辑工作规范写作方法

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