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Relation of Biochemical Parameters with Flow-mediated Dilatation in Patients with Metabolic Syndrome

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Chinese Medical Journal 2017年第13期130卷 1564-1569页

作者： Nurver Turfaner Sipahioglu Barls Ilerigelen Zeynep B. Gungor Gulsel Ayaz Hakan Ekmekci Cigdem Bayram Gurel Gunay Can Huseyin Sonmez Turgut Ulutin fikret Sipahioglu Department of Family Medicine Cerrahpasa Medical Faculty Istanbul University Istanbu134303 Turkey Department of Cardiology Cerrahpasa Medical Faculty Istanbul University Istanbul 34303 Turkey Department of Biochemistry Cerrahpasa Medical Faculty Istanbul University Istanbu134303 Turkey Department of Medical Biology Cerrahpasa Medical Faculty Istanbul University Istanbul 34303 Turkey Department of Public Health Cerrahpasa Medical Faculty Istanbul University Istanbul 34303 Turkey Department of Internal Medicine Cerrahpasa Medical Faculty Istanbul University Istanbul 34303 Turkey

Background： Metabolic syndrome （MetS） is one of the high cardiovascular （CV） situations. Endothelial dysfunction, which is a common finding in patients with MetS, is related with increased CV risk. In patients with MetS, the effect of the major CV risk factors, not included in the MetS definition, on endothelial dysfunction is not well known. The aim of this study was to determine the effect of major CV risk factors such as gender, smoking, family history, and biochemical parameters on endothelial dysfunction in patients with MetS. Methods： The study was performed between December 2010 and August 2014. A total of 55 patients （ 15 females and 40 males） with MetS and 81 healthy controls （37 females and 44 males） with a body mass index 〈25 kg/m2 were enrolled in the study. Endothelial dysfunction was measured by flow-mediated dilatation （FMD）, oxidative stress parameters; high-sensitivity C-reactive protein （hs-CRP）, oxidized low-density lipoprotein （ox-LDL）, endothelial nitric oxide synthase （e-NOS）, nitric oxide, and cell adhesion markers; yon Willebrand factor, and e-selectin. Platelet aggregation （endothelial adenosine diphosphate）, total platelet count, and mean platelet volume were additionally analyzed and demographic parameters were explored. Student＇s t-test, Mann-Whitney U-test, and Chi-square test were used to analyze the results. Results： The fasting blood glucose （z = 3.52, P = 0.001 ）, hs-CRP （z - 3.23, P = 0.004）, ox-LDL （z = 2.62, P= 0,013）, and e-NOS （z = 2.22, P = 0.026） levels and cardiac risk score （z - 5.23, P 〈 0.001） were significantly higher in patients with MetS compared with the control group. Smoking was correlated with decreased FMD （χ2 = 9.26, P = 0.002） in MetS patients but not in the control group. Conclusions： Increased ox-LDL, hs-CRP, and e-NOS are likely to be a result of oxidative stress, a condition in which an imbalance occurs between the production and inactivation of reactive nitrogen and oxygen species. In addition, in patients w

关键词： Endothelial Dysfunction Metabolic Syndrome Oxidative Stress Smoking

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煤炭脱硫的微生物方法

环境科学与管理 1988年第3期 14-18页

作者： fikret Kargi 王保军

由于酸雨带来的恶果,近年来,煤炭脱硫问题已愈来愈为人们所关注。煤炭脱硫的微生物学方法,较之化学和物理方法有明显的优势,目前,已经发展了许多新的菌种与处理方法。本文概述了在煤炭脱硫中所采用的微生物工艺及菌种的特性。

关键词：煤炭脱硫菌种兼性微生物法硫杆菌自养菌有机硫化合物黄铁矿硫

The Study of Inhibition Effect of Rhenium Thioacetic and Dithiocarbonic Acids in Oxidation Reaction

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Advances in Chemical Engineering and Science 2015年第3期5卷 338-344页

作者： Fakhriyya M. Nasiri fikret A. Kuliev Arif J. Efendy Lyudmila I. Kojarova Farida A. Abdullayeva Irada H. Melikova Natevan F. Aykan Institute of Catalysis and Inorganic Chemistry Named after Academician M.F.Nagiyev of Azerbaijan Baku Azerbaijan Azerbaijan Medical University Baku Azerbaijan

Antioxidant activity of interaction products of the studied compounds with tret-Butyl hydroperoxide is studied. New, more active acceptors of free radicals are formed in the process of oxidative transformations of initial compounds. It is investigated that the products have high inhibiting properties. The parameter fk, characterizing inhibitory effect of an inhibitor is studied.

关键词： Synthesis Phenylthioacetic and Dithiocarbonic Acids Hydroperoxide Inhibitor

Closer look at white-coat hypertension

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World Journal of Methodology 2014年第3期4卷 144-150页

作者： Nurver Turfaner Sipahioglu fikret Sipahioglu Department of Internal Medicine Cerrahpasa Medical Faculty Istanbul University

This review aims to clarify novel concepts regarding the clinical and laboratory aspects of white-coat hypertension(WCHT). Recent studies on the clinical and biological implications of WCHT were compared with existing knowledge. Studies were included if the WCHT patients were defined according to the 2013 European Society of Hypertension guidelines, i.e., an office blood pressure(BP) of ≥ 140/90 mm Hg, a home BP of ≤ 135/85 mm Hg, and a mean 24-h ambulatory BP of ≤ 130/80 mm Hg. WCHT studies published since 2000 were selected, although a few studies performed before 2000 were used for comparative purposes. True WCHT was defined as normal ABPM and home BP readings, and partial WCHT was defined as an abnormality in one of these two readings. The reported prevalence of WCHT was 15%-45%. The incidence of WCHT tended to be higher in females and in non-smokers. Compared with normotensive(NT) patients, WCHT was associated with a higher left ventricular mass index, higher lipid levels, impaired fasting glucose, and decreased arterial compliance. The circadian rhythm in WCHT patients was more variable than in NT patient's, with a higher pulse pressure and non-dipping characteristics. Compared with sustained hypertension patients, WCHT patients have a better 10-year prognosis; compared with NT patients, WCHT patients have a similar stroke risk, but receivemore frequent drug treatment. There are conflicting results regarding WCHT and markers of endothelial damage, oxidative stress and inflammation, and the data imply that WCHT patients may have a worse prognosis. Nitric oxide levels are lower, and oxidative stress parameters are higher in WCHT patients than in NT patients, whereas the antioxidant capacity is lower in WCHT patients than in NT patients. Clinicians should be aware of the risk factors associated with WCHT and patients should be closely monitored especially to identify target organ damage and metabolic syndrome.

关键词： White-coat hypertension Ambulatory blood pressure Target organ damage Glucose dysregulation

北方高纬度地区生态系统动态、生物多样性管理及社会政策

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AMBIO－人类环境杂志 2004年第6期33卷 328-333页

作者： Thomas Elmqvist fikret Berkes Carl Folke Per Angelstam Anne-Sophie Crépin Jari Niemel 韩海东 Department of Systems Ecology Stockholm University

由于受到众多因素大规模作用的影响,高纬度地区生态系统的变化异常活跃。这些地区的生态系统非常脆弱,各种全球变化过程都在影响着可更新林木资源持续生产和当地社会赖以生存的动植物资源丰度。本文对于北半球高纬度地区生态系统的一些... 详细信息

由于受到众多因素大规模作用的影响,高纬度地区生态系统的变化异常活跃。这些地区的生态系统非常脆弱,各种全球变化过程都在影响着可更新林木资源持续生产和当地社会赖以生存的动植物资源丰度。本文对于北半球高纬度地区生态系统的一些新认识及其(所包含的)意义进行了讨论,并对提高生态系统的恢复力所采取的必要管理措施进行了探讨。认为在生态系统面临各种变化和干扰时系统管理的焦点应该从系统的恢复转移到系统功能的维系上来。生物多样性的作用是确保生态系统在经历干扰和重组时能够进行重组和发展,这一作用应该在系统管理与相关的方针政策中得到重视。强调应重新考虑现在的生态保护区的概念以发展一些动态的管理方法,使生态系统在面临环境变化时能够进行可持续的管理。而高纬度地区一些土著人习惯性的生态保护区的特点与那些对保护区进行动态保护的观点往往是一致的。针对高纬度地区动态景观中的生物多样性管理我们提出了新的发展方向,并从非传统的观点方面为其提供了经验例证。这些非传统的观点与看法可能会有助于提高生物多样性可持续管理和生态系统功能发挥的潜力。

关键词：高纬度地区生态系统生物多样性北方持续生产林木资源可持续管理动态发展系统管理

Current status and trends in forest genomics

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Forestry Research 2022年第1期2卷 99-120页

作者： Dulal Borthakur Victor Busov Xuan Hieu Cao Qingzhang Du Oliver Gailing fikret Isik Jae-Heung Ko Chenghao Li Quanzi Li Shihui Niu Guanzheng Qu Thi Ha Giang Vu Xiao-Ru Wang Zhigang Wei Lin Zhang Hairong Wei Department of Molecular Biosciences and Bioengineering University of Hawaii at Manoa1955 East-West RoadHonoluluHI 96822USA College of Forest Resources and Environmental Science Michigan Technological UniversityHoughtonMI 49931USA Forest Genetics and Forest Tree Breeding Faculty for Forest Sciences and Forest EcologyUniversity of GöttingenBüsgenweg 237077 GöttingenGermany National Engineering Research Center of Tree Breeding and Ecological Restoration College of Biological Sciences and TechnologyBeijing Forestry UniversityBeijing 100083P.R.China Cooperative Tree Improvement Program North Carolina State UniversityRaleighNC 27695USA Department of Plant&Environmental New Resources Kyung Hee University1732 Deogyeong-daeroYongin 17104Republic of Korea State Key Laboratory of Tree Genetics and Breeding Northeast Forestry UniversityHarbin 150040P.R.China State Key Laboratory of Tree Genetics and Breeding Chinese Academy of ForestryBeijing 100093P.R.China Department of Ecology and Environmental Science UmeåPlant Science CentreUmeåUniversityUmeå90187Sweden College of Life Sciences Heilongjiang UniversityHarbin 150080P.R.China Key Laboratory of Cultivation and Protection for Non-Wood Forest Trees Ministry of EducationCentral South University of Forestry and TechnologyChangsha 410004Hunan ProvinceP.R.China

Forests are not only the most predominant of the Earth's terrestrial ecosystems,but are also the core supply for essential products for human ***,global climate change and ongoing population explosion severely threatens the health of the forest ecosystem and aggravtes the deforestation and forest *** genomics has great potential of increasing forest productivity and adaptation to the changing *** the last two decades,the field of forest genomics has advanced quickly owing to the advent of multiple high-throughput sequencing technologies,single cell RNA-seq,clustered regularly interspaced short palindromic repeats(CRISPR)-mediated genome editing,and spatial transcriptomes,as well as bioinformatics analysis technologies,which have led to the generation of multidimensional,multilayered,and spatiotemporal gene expression *** technologies,together with basic technologies routinely used in plant biotechnology,enable us to tackle many important or unique issues in forest biology,and provide a panoramic view and an integrative elucidation of molecular regulatory mechanisms underlying phenotypic changes and *** this review,we recapitulated the advancement and current status of 12 research branches of forest genomics,and then provided future research directions and focuses for each ***,a shift from simple biotechnology-based research to advanced and integrative genomics research,and a setup for investigation and interpretation of many spatiotemporal development and differentiation issues in forest genomics have just begun to emerge.

关键词： forest routine biotechnology

复发性前列腺癌患者血清PSA水平、Gleason评分与68Ga-PSMA PET/CT显像的关系

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中华核医学与分子影像杂志 2018年第5期38卷 380-380页

作者：李慧玲兰晓莉 Yasemin Sanli Serkan Kuyumcu Oner Sanli fikret Buyukkaya Ayca Iribas Goksel Alcin Emin Darendeliler Yasemin Ozluk Sevda Ozel Yildiz Cüneyt Turkmen 华中科技大学同济医学院附属协和医院核医学科 Department of Nuclear Medicine Istanbul Faculty of MedicineIstanbul University

目的探讨复发性前列腺癌(PCa)患者血清前列腺特异性抗原(PSA)水平、Gleason评分与68Ga-前列腺特异性膜抗原(PSMA)PET/CT显像的关系。方法纳入109例患者(中位年龄为71岁,范围48～89岁),所有患者均为根治手术和(或)激素治疗和(或)放疗后PS... 详细信息

目的探讨复发性前列腺癌(PCa)患者血清前列腺特异性抗原(PSA)水平、Gleason评分与68Ga-前列腺特异性膜抗原(PSMA)PET/CT显像的关系。方法纳入109例患者(中位年龄为71岁,范围48～89岁),所有患者均为根治手术和(或)激素治疗和(或)放疗后PSA复发的患者。记录局部复发、淋巴结转移[盆腔、腹部和(或)膈上]、骨转移(单处转移、多处转移)和其他部位转移(肺、肝、脑等)。结果在91例(83.4%)患者中,68Ga-PSMA PET/CT至少检测到1处PCa病灶。血清总PSA(tPSA)中位值为6.5(0.2～640)μg/L。68Ga-PSMA PET/CT阳性与阴性患者血清tPSA差异有统计学意义,而Gleason评分差异无统计学意义。56例患者有局部复发,46例有淋巴结转移。盆腔淋巴结转移最常见,其次是腹部和膈上淋巴结。55例患者存在骨转移(20例为单发,35例为多处转移)。受试者工作特征曲线分析示血清tPSA区分阳性和阴性68Ga-PSMA PET/CT显像的最佳临界值为0.67μg/L,曲线下面积为0.952(95%CI:0.911～0.993)。结论68Ga-PSMA PET/CT是一种有效检测PCa复发的方法。尽管Gleason评分和68Ga-PSMA PET/CT显像之间无明显相关性,血清tPSA可用于预估68Ga-PSMA PET/CT阳性的可能性。

关键词： 68Ga-PSMA 复发性前列腺癌 PSA值 Gleason评分

ITMA 2015--纺织品整理趋势:可持续发展、数码印花新时代、工业4.0即将到来

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国际纺织导报 2017年第1期45卷 34-36,38-40页

作者： m.rabe b.karmann f.terzioglu j.schrick 黄明(译) 胡筱(译) 罗艳(校) 下莱茵应用科学大学纺织服装技术学院德国不详

随着来自46个参展国(地区)1 691家参展商的到来,2015年国际纺织机械展览会(ITMA 2015)开创了自1951年展会成立以来的新纪录。与往届相同,纺织品整理部分也有很好展示:前处理、染色和后整理领域的303家参展商及占据了总展厅面积43%的另外... 详细信息

随着来自46个参展国(地区)1 691家参展商的到来,2015年国际纺织机械展览会(ITMA 2015)开创了自1951年展会成立以来的新纪录。与往届相同,纺织品整理部分也有很好展示:前处理、染色和后整理领域的303家参展商及占据了总展厅面积43%的另外113家印花公司。如ITMA 2011,许多参展商特别重视可持续发展性。展台上的设计也证明了这点:绿色和木制品随处可见,甚至展会地图上纺织品整理部分呈现的也是春意盎然的绿色。直到进入18号展厅,其在展会地图上才以鲜艳的橙色标记,与印花产品丰富的色彩相呼应。相比于ITMA 2011,数码印花在加工速度、加工安全性和颜色质量方面都获得了极大提升,目前已达到圆网印花的水平。虽然关于工业4.0的创新已告一段落,但最为重要的是,测量控制技术与软件的供应商已经意识到提升的潜力,并就机械工程合作提出了有效的解决方案。

关键词： 2015年国际纺织机械展览会(ITMA 2015) 纺织品整理数码印花工业4.0

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建设恢复力和适应性以对付北极的变化

AMBIO－人类环境杂志 2006年第4期35卷 198-202页

作者： F.Stuart Chapin Ⅲ Michael Hoel Steven R.Carpenter Jane Lubchenco Brian Walker Terry V.Callaghan Carl Folke Simon A.Levin Karl-Gran Mler Christer Nilsson Scott Barrett fikret Berkes Anne-Sophie Crépin Kjell Danell Thomas Rosswall David Starrett Anastasios Xepapadeas Sergey A.Zimov 陈卓天 Institute of Arctic Biology University of Alaska Department of Economics University of Oslo Center for Limnology University of Wisconsin Department of Zoology Oregon State University CSIRO Sustainable Ecosystems Abisko Scientific Research Station Department of Systems Ecology and Centre for Transdisciplinary Environmental Research Stockholm University Department of Ecology and Evolutionary Biology Princeton University The Beijer Institute Landscape Ecology Group Department of Ecology and Environmental Science Ume University School of Advanced International Studies Johns Hopkins University Natural Resources Institute University of Manitoba Department of Animal Ecology Swedish University of Agricultural Sciences International Council for Science Department of Economics Stanford University Department of Economics University Crete Northeast Science Station Pacific Institute for GeographyFar-East BranchRussian Academy of SciencesRepublic Sakha(Yakutia)

人类行为引起的空前的全球变化挑战着社会支撑我们这颗行星保持自身优点的能力。这就要求对变化进行主动的管理以培养地球的恢复力——维持在变化的情况下对社会很重要的一些属性,和适应性——发展新的社会生态构造以便在新的条件下有... 详细信息

人类行为引起的空前的全球变化挑战着社会支撑我们这颗行星保持自身优点的能力。这就要求对变化进行主动的管理以培养地球的恢复力——维持在变化的情况下对社会很重要的一些属性,和适应性——发展新的社会生态构造以便在新的条件下有效地发挥作用。北极的广大地区仍然完整地保留着原型的生态及社会过程及反馈,这为我们为变化预先做出计划提供了可能是最后一个实验的机会。如果该策略的可行性在北极可以被证实,我们对于变化的动态所得到的进一步的理解就可以实施到那些被人类较大地改变了的地区中。现在执行管理北极变化的政策的条件可能很理想,因为近来的研究提供了极其重要的科学知识,合适的国际机制也已各就各位,而且,如果北极地区的国家选择这样做的话,他们具备实行必要改变的财力。

关键词：北极地区适应性恢复力社会生态人类行为全球变化社会过程科学知识