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Recent trends in rapid dereplication of natural product extracts:an update

Journal of Coastal Life Medicine 2015年第3期3卷 178-182页

作者： fikre mammo Milkyas Endale Department of Chemistry College of Natural and Computational SciencesHawassa UniversityP.0.Box 05HawassaEthiopia

Natural products are the prominent sources of drugs to combat various infectious *** rapid progress of multi-resistance and pan-resistant pathogens to various medicines represents today a major *** search for novel natural products requires a quick and efficient approach to distinguish novel compounds from the known ones,a process called *** strategy is generic and time-saving,avoids isolation/purification of known compounds,enables an efficient liquid chromatography peak annotation of most of the studied compounds and can be well adapted for plant chemotaxonomy,phytochemical screening and metabolite *** this review,recent developments of hyphenated techniques towards dereplication of active compounds,chemotaxonomy,metabolite profiling and rapid detection of novel compounds in medicinal plant extracts are presented.

关键词： Dereplication Phytochemical screening Metabolite profiling Hyphenated techniques

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A coniferyl alcohol derivative from the roots of Zanthoxylum chalybeum

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Journal of Coastal Life Medicine 2014年第12期 970-974页

作者： Mathewos Anza Erimias Haile Sisay Tadesse fikre mammo Milkyas Endale Department of Chemistry College of Natural and Computational SciencesHawassa UniversityP.O.Box 05HawassaEthiopia

Objective:To isolate and characterize chemical constituents of the roots of Zanthoxylumchalybeum(***).Methods:A number of phytochemical tests were applied to identify the class of compounds present in the CH_(2)Cl_(2)/CH_(3)OH(1:1)root *** chromatographic separation technique was applied to separate the constituents of the CH_(2)Cl_(2)/CH_(3)OH(1:1)root extract and various spectroscopic techniques[UV-vis,infrared radiation,nuclear magnetic resonance(NMR)(^(1)H-NMR,^(13)C NMR,DEPT-135,COSY,gHSQC and gHMBC)]were used to determine the structures of pure ***:Phytochemical screening of the CH_(2)Cl_(2)/CH_(3)OH(1:1)root extract of *** revealed the presence of alkaloids,flavonoids,terpenoids,tannins and *** chromatographic separation of the extract yielded a new coniferyl alcohol derivative,2,3-epoxy-6,7-methylenedioxyconiferyl alcohol(1)together with the known alkaloid,dihydrochelerythrine(2).Conclusions:The present work conducted on the CH2Cl2:CH3OH(1:1)root extract of *** identified various class of compounds present in the root *** characterization of two compounds were done using spectroscopic techniques of which a coniferyl alcohol derivative(1)was identified for the first time.

关键词： Z.chalybeum Rutaceae Alkaloid Coniferyl alcohol derivative

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