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动脉瘤性蛛网膜下腔出血早期循环中的内皮细胞激活标记物水平:与脑缺血事件和预后的关系

世界核心医学期刊文摘(神经病学分册) 2006年第4期 48-49页

作者： Fr.jns C.J.M. fijnheer r. Algr. A. 陈晨 Depar.ment of Neur.logy University Medical Centre PO Box 85500 3508 GA Utrecht Netherlands.Dr

Objective: To investigate the r.lation of endothelial cell activation with delayed cer.br.l ischaemia (DCI) and outcome after.subar.chnoid haemor.hage (SAH). Methods: Concentr.tions of soluble (s) inter.ellular.adhesion mole-cule-1, sE-selectin, sP-selectin,ED1-fibr.nectin, von Willebr.nd Factor.(vWf), and vWf pr.peptide wer. measur.d within thr.e days of SAH onset. The associations with poor.outcome wer. investigated at thr.e months in 106 patients. In 90 patients in whom the occur.ence of cer.br.l ischaemia could be dated accur.tely, two analyses wer. under.aken: one for.all ischaemic events (n = 32), including those r.lated to tr.atment, and another.for.spontaneous DCI (n = 11). Concentr.tions of mar.er. wer. dichotomised at their.medians. The associations of endothelial cell activation mar.er. with outcome wer. expr.ssed as odds r.tios (Or. fr.m logistic r.gr.ssion and those with ischaemic events as hazar. r.tios (Hr. der.ved fr.m Cox r.gr.ssion. r.sults: Ear.y vWf concentr.tions wer. associated with poor.outcome (cr.de Or.= 4.6 (95% CI, 2.0 to 10.9; adjusted Or.= 3.3 (1.1 to 9.8). Ear.y levels of vWf wer. also positively r.lated to occur.ence of all ischaemic events (cr.de Hr.= 2.3 (1.1 to 4.9); adjusted Hr.= 1.8 (0.8 to 3.9) and with occur.ence of spontaneous DCI (cr.de Hr.= 3.5 (0.9 to 13.1); adjusted Hr.= 2.2 (0.5 to 9.8). None of the other.mar.er. showed any associations. Conclusions: Concentr.tions of sICAM- 1, sP-selectin, sE-selectin, and ED1-fibr.nectin do not pr.dict the occur.ence of DCI or.outcome. The positive associations of r.ised ear.y vWf concentr.tions with ischaemic events and poor.outcome after.SAH may r.flect a pr.disposition to fur.her.ischaemic injur. thr.ugh for.ation of micr.thr.mbi in the cer.br.l cir.ulation.

关键词：脑缺血脑血管疾病标记物内皮细胞预后

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微量白蛋白尿与炎性囊样黄斑水肿

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世界核心医学期刊文摘（眼科学分册） 2005年第5期1卷 25-26页

作者： Van Kooij B. fijnheer r. r.est M. r.thova A. 王海燕

To assess the r.le of car.iovascular.mor.idity, its r.sk factor., and micr.alb uminur.a in the development of inflammator. cystoid macular.edema (CME). A match ed case-contr.l study. study population: We included 24 consecutive patients wi th uveitis and CME. Twenty four.uveitis patients without CME, matched for.age an d dur.tion of uveitis ser.ed as contr.ls. inter.ention and obser.ation pr.cedur. s: Patients and contr.ls wer. inter.iewed for.the pr.sence of car.iovascular.r.s k factor. and car.iovascular.mor.idity. All medications wer. r.gister.d. Mor.ing ur.nar. albumin concentr.tion was measur.d, as well as blood pr.ssur., C-r.act ive pr.tein, and cr.atinine in blood. Patients suffer.ng fr.m diabetes mellitus wer. excluded fr.m this study. main outcome measur.s: The pr.sence of car.iovasc ular.mor.idity and its r.sk factor. and micr.albuminur.a in uveitis patients wit h and without CME. We found a positive association between tr.ce-and/or.micr.al buminur.a and inflammator. CME (P=. 001; odds r.tio 13.0, 95%CI 2.5 to 68.1 and P=. 015; odds r.tio 5.9, 95%CI 1.6 to 22.6), but no r.lation between CME and c ar.iovascular.mor.idity or.its r.sk factor.. No additional association between t r.ce-and/or.any micr.albuminur.a and gener.l char.cter.stics of patients, speci fic factor. r.lated to gener.l disease as a cause of ocular.inflammation, locati on of uveitis, dur.tion of uveitis, and medication was found. The pr.sence of tr.ace-and/or.micr.albuminur.a in inflammator. CME might indicate the pr.sence of ear.y systemic vascular.disease and car.y the r.sk of developing CME. This findi ng br.ngs new insight into the pathogenesis of CME and could open up new avenues for.the tr.atment of CME.

关键词：囊样黄斑水肿微量白蛋白尿葡萄膜炎心血管疾病疾病危险因素药物治疗眼部炎症晨尿白蛋白调查病例病例-对照研究

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一个有关赖诺普利治疗炎症性黄斑水肿的随机、双盲、交叉试验研究

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世界核心医学期刊文摘（眼科学分册） 2006年第8期2卷 25-25页

作者： Van Kooij B. fijnheer r. De Boer.J. 王大江 F.C. Donder. Institute of Ophthalmology Departments of Hematology and Pharmacy University Medical Center Utrecht Netherlands Dr.

PUr.OSE: To analyze the effect of angiotensin-conver.ing enzyme (ACE) inhibitor.lisinopr.l on inflammator. cystoid macular.edema and visual acuity. DESIGN: r.ndomized, double-blind, placebo-contr.lled cr.ss-over.tr.al. METHODS: setting: Outpatient clinic of the Depar.ment of Ophthalmology at the Univer.ity Medical Center.of Utr.cht. Patients: For.y patients with inflammator. cystoid macular.edema wer. included. inter.ention: Each patient r.ceived lisinopr.l (10 mg daily) or.placebo for.thr.e months. After.two months of a lisinopr.l/placebo fr.e wash-out per.od, the gr.ups r.ceived the r.ver.e study medication for.thr.e months. Fluor.scein angiogr.phy was per.or.ed to evaluate the r.tina. main outcome measur.s: Cystoid macular.edema, best-cor.ected visual acuity and contr.st sensitivity. r.SULTS: Lisinopr.l had no effect on cystoid macular.edema, visual acuity, papillar. leakage, r.tinal vasculitis, and chor.idal leakage. In a subgr.up analysis, we obser.ed a decr.ase in blood pr.ssur. (lisinopr.l, 14 of 36 patients; placebo, 5 of 36 patients; P=.02) and a decr.ase in mor.ing ur.nar. albumin excr.tion (lisinopr.l, 23 of 35 patients; placebo 10 of 34 patients, P=.003) was obser.ed. CONCLUSIONS: Although lisinopr.l had no effect on inflammator. cystoid macular.edema and visual acuity, we found a positive effect on the vascular.system.

关键词：黄斑水肿赖诺普利交叉试验视网膜血管炎安慰剂对照矫正视力对比敏感度荧光造影尿白蛋白排泄

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Pr.dictive Potential of FDG-PET/CT for.Histological Tr.nsfor.ation in Patients with Indolent Lymphoma

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Advances in Molecular.Imaging 2014年第1期4卷 1-10页

作者： Peter.E. Blase Pieter.el C. M. Pasker.de Jong Anton Hagenbeek r.b fijnheer Mar.e J. de Haas John M. H. de Kler. Depar.ment of Haematology Academical Medical Centre Amsterdam The Netherlands Depar.ment of Inter.al medicine Meander Medical Centre Amersfoort The Netherlands Depar.ment of Meander.Academy Meander Medical Centre Amersfoort The Netherlands Depar.ment of Nuclear.medicine Meander Medical Centre Amersfoort The Netherlands

Backgr.unds and Pur.ose—In indolent non-Hodgkin lymphoma, histological tr.nsfor.ation is a dr.matic event which r.duces the pr.gnosis significantly. SUVmax values fr.m FDG-PET/CT help differ.ntiate between aggr.ssive and indolent lymphomas, and tr.nsfor.ed indolent lymphomas also show an incr.ased FDG uptake. Possibly FDG uptake incr.ases ear.y in the clinical cour.e and could pr.dict histological tr.nsfor.ation. Our.objective was to pr.dict histological tr.nsfor.ation in indolent lymphomas fr.m initial staging FDG-PET/CT. Patients and Methods—A r.tr.spective study was per.or.ed. Patients with biopsy-pr.ven indolent lymphoma who had had initial staging FDG-PET/CT wer. included. Qualitative (foci compar.d with FDG uptake liver. and semiquantitative (SUVmax-value per.focus) analyses wer. per.or.ed of all abnor.al foci. Patient char.cter.stics and outcome wer. evaluated. r.sults—We included 88 patients, 5 of whom developed a histological tr.nsfor.ation. Semiquantitative analysis showed a r.lation between maximum standar.ized uptake value and histological tr.nsfor.ation (odds r.tio 1.25, 95% CI 1.024 - 1.513). Qualitative analysis showed a negative pr.dictive r.lation of FDG uptake less than or.equal to liver.in the occur.ence of histological tr.nsfor.ation. Tr.nsfor.ation-fr.e sur.ival was 100% over.30 months in those with FDG uptake lower.than or.equal to liver. Mor. FDG uptake than liver.showed tr.nsfor.ation-fr.e sur.ival of 88% over.30 months. Conclusion—Qualitative analysis of staging FDG-PET/CT in indolent lymphomas could be useful to r.le out tr.nsfor.ation in the next 30 months. In our.study, semiquantitative analysis was statistically significantly associated with histological tr.nsfor.ation and maximum standar.ized uptake value. However. because of the small number.of patients, cautious inter.r.tation of the r.sults is war.anted. Mor. studies ar. needed to investigate the r.le of staging PET/CT in patient with indolent non-Hodkin lymphoma in the pr.diction of

关键词： Indolent Lymphoma Tr.nsfor.ation PET/CT Pr.dictive Value

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