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Antiasthmatic Effect of Eugenol （4-Allyl-2-Methoxyophenol） Mediated by Both Bronchodilator and Immunomodulatory Properties

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Journal of Pharmacy and Pharmacology 2014年第1期2卷 38-49页

作者： Campos Keina Maciele Teixeira Tatiane Oliveira Cerqueira-Lima Ana Tereza Costa Ryan Santos CarneiroTamires Cana Brasil Silva Darizy Faivia Barreto Mauricio Lima Pontes-de-Carvalho Lain Carlos Alcantatara-Neves Neuza Maria figueiredo camila alexandrina Instituto de CiOncias da Saude Universidade Federal da Bahia Salvador Bahia 41110-100 Brazil lnstituto de Saftde Coletiva Universidade Federal de Bahia Rua Basilio da Gama s/n Canela Salvador Bahia 41110-040 Brazil Centro de pesquisa Gongalo Moniz Fundacao Oswaldo Cruz Salvador Bahia 40296-710 Brazil

Eugenol, an aromatic product, exhibits anti-inflammatory properties, however, little is known about its effect in allergic inflammation mediated by Th2-type cells and cytokines. We examined the pharmacological potential of this compound in a murine model of respiratory allergy to Bt （Blomia tropicalis）. For this, AJ mice were sensitized （100μg/animal s.c.） and challenged （10 μg/animal i.n.） with Bt mite extract. Sensitized animals were treated or not with eugenol （20, 40 or 80 mg/kg） and the following parameters were analyzed： number of total cells in BAL （bronchoalveolar lavage）; EPO （eosinophil peroxidase activity） and histopathological changes in the lungs; serum level of specific IgE, IgG1 and IgG2a and; concentration of Th2 cytokines on BAL and spleen cultures. In addition, the capability ofeugenol in relaxing tracheal smooth muscle was also evaluated. Our results showed that treatment with eugenol significantly reduced the airway inflammation, decreasing the cellular infiltrate, EPO and mucus in the lungs, as well as the production of Th2 cytokines. It was also demonstrated a dilator effect of eugenol observed by the relaxation of normal and hyper-reactivity isolated trachea upon carbachol stimulation. These results suggest that eugenol has potential as an anti-asthmatic drug by both bronchodilator and immunomodulatory properties.

关键词： Asthma BIomia tropicalis, natural products, eugenol.

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Hereditary Angioedema in Pregnancy and Management without Recombinant Human C1-INH

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Open Journal of Obstetrics and Gynecology 2021年第11期11卷 1470-1476页

作者： Natália Paseto Pilati Maria alexandrina Zanatta Daniele camila Maltauro Gabrielle Behenck Edimárlei Gonsales Valério Fernanda Oliveira Castilhos Eduardo Vettorazzi-Stuczynski Daniela Vanessa Vettori Janete Vettorazzi Postgraduation Program in Health Sciences: Gynecology and Obstetrics (PPGGO) Faculdade de Medicina (FAMED) Universidade Federal do Rio Grande do Sul (UFRGS) Porto Alegre Rio Grande do Sul Brazil Service of Gynecology Hospital de Clinicas de Porto Alegre Porto Alegre Brazil Hospital Geral de Caxias do Sul e Faculdade de Medicina da Universidade de Caxias do Sul Caxias do Sul Brazil

A pregnant woman diagnosed with type 1 angioedema seeks care at a public hospital for planning the delivery. This report presents ways to prevent and manage an acute HAE crisis during childbirth and early postpartum w... 详细信息

关键词： Hereditary Angioedema (HAE) C1-Inhibitor High-Risk Pregnancy Prophylaxis

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