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世界核心医学期刊文摘（妇产科学分册） 2006年第1期2卷 52-53页

作者： Elbaz G. ficha. Levy A. E. Sheiner 张旸 Department of Obstetrics and Gynecology Soroka University Medical Center P.O. Box 151 Beer-Sheva Israel

The present study investigates pregnancy outcome in women with IBD and examines the effect of pregnancy on the severity of IBD. Method: A case-control study comparing deliveries by mothers with IBD between January 1988 and January 2005 was performed. For every birth by a mother with IBD, four births by non- IBD mothers were randomly selected and adjusted for ethnicity and year of delivery. Result: During the study period there were 48 deliveries to patients with Crohn’ s disease and 79 deliveries to patients with ulcerative colitis. Higher rates of preterm delivery ( < 37 weeks) were found among patients with IBD as compared to the controls (odds ratios (OR) = 2.2; 95% confidence interval (CI) = 1.3- 3.8). This association remained significant after adjustment for labor induction and multiple gestations, using the Mantel-Haenszel technique (weighted OR = 2.1; 95% CI 1.3- 3.5 and weighted OR = 2.0; 95% CI 1.2- 3.5; P = 0.012; respectively). In addition, these patients had higher rates of fertility treatments (OR = 2.2; 95% CI = 1.1- 4.4). Using a multivariate analysis, controlling for maternal age and fertility treatments, preterm delivery was seen to be significantly associated with IBD (adjusted OR = 2.0; 95% CI = 1.2- 3.5). Perinatal outcomes, such as perinatal mortality, low Apgar scores, and congenital malformations, were comparable to the outcomes in the control group. Conclusion: Maternal IBD is an independent risk factor for preterm delivery. IBD is not associated with adverse perinatal outcome.

关键词：炎症性肠病 Mantel-Haenszel法早产低Apgar评分病例对照研究不良围生结局分娩情况溃疡性结肠炎 Crohn病围生儿死亡率

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