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International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 2020年第4期9卷 178-185页

作者： Tamara Abaeva Zhanibek Muratov Rustam Tukhvatshin Zhypargul Abdullaeva Aziza Seitova Veronika Tursunova Mira Zhanganaeva Masalbek Satybaldiev Lazokatkhan Dzhumaeva Meerim Abdyraimova feruza mamasadykova Aiperi Alimbekova Department of Normal and Topographic Anatomy of I.K. Akhunbaev Kyrgyz State Medical Academy Bishkek Kyrgyzstan Department of Pathology Basic and Clinical Pharmacology International Medical Faculty Osh State University Osh Kyrgyzstan Department of Pathological Physiology I.K. Akhunbaev Kyrgyz State Medical Academy Bishkek Kyrgyzstan Department of Anatomy Histology and Normal Physiology International Medical Faculty Osh State University Osh Kyrgyzstan Science and Research Department Osh State University Osh Kyrgyzstan Department of Clinical Disciplines 2 International Medical Faculty Osh State University Osh Kyrgyzstan

This paper is describing a detailed study of morphological structures and characteristics newborns thymus in different climatic and geographical conditions of Kara-Balta, Cholpon-Ata, and Bishkek in Kyrgyzstan. Anatomical structure research done on 26 thymuses of newborn corpses. Research results showed that a significant amount of thymuses consisted of lobes with very thin connective tissues between them. It is observed that the Hassall cells were usually located in the medulla part of the thymus after using the coloring by Van-Gieson’s stain visible clear elastic and collagen fibers. In addition, cell population dynamics in a unit of conditional area of cortical substance thymus lobes in newborns determined.

关键词： Thymus Newborns Hassall Cells Climatic Conditions Histological Methods

Catamnestic Observation of Premature Newborns with Nervous System Injury in the Kyrgyz Republic

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Open Journal of Pediatrics 2021年第2期11卷 189-197页

作者： Aisuluu Omurzakova Aida Anarbaeva Zhainagul Abdirasulova feruza mamasadykova Zhazgul Eralieva Guldana Tashieva Kamchybek Uzakbaev Gulshat Matkasymova Akperi Gaipova Zhypargul Abdullaeva Aman Kumar Zia Ur Rahman Muhammed Abhishek Anand Department of Clinical Disciplines 2 International Medical Faculty Osh State University Osh Kyrgyzstan Department of Pediatric Surgery Medical Faculty Osh State University Osh Kyrgyzstan Maternity and Child Welfare National center under Ministry of Health Bishkek Kyrgyzstan Department of Surgical Disciplines and Traumatology International Medical Faculty Osh State University Osh Kyrgyzstan Science and Research Department Osh State University Osh Kyrgyzstan

Background: Recently, among child disability disorders nervous system diseases are prevailing 19.5%, while mental disorders are 14.3% and congenital malformations 21%. In most cases, children’s neurological disability is associated with pathology during the perinatal period, while 24% of patients have a cerebral impairment. Premature newborns perished 30 to 35 times more often than in-time newborns, and perinatal mortality in case of premature pregnancies is 30 to 40 times higher than in term delivery. Aim: This article is studying catamnestic observation of premature newborns with nervous system injury and with perinatal pathology in Kyrgyzstan for the period 2020-2021. Preterm newborns’ anthropometric characteristics and main diagnoses associated with diseases in the gestational period were shown. Methods: A comprehensive clinical and laboratory examination including premature newborns health dynamic monitoring with gestational age from 28 to 36 weeks, who were treated in the neonatal pathology department of the Regional Maternity Hospital in Osh for the period from 2020-2021 were carried out. Literature review analysis from PubMed database, MEDLINE, EMBASE, Science Direct, Google Scholar, and clinical trials performed. Results: after clinical examination, it was revealed that pregnancy and childbirth in all mothers of the studied group passed with complications. In mothers of the studying group, the most common pathologies during pregnancy were chronic fetal hypoxia 49 (58.4%), acute re

关键词： Catamnestic Observation Premature Newborns Nervous System Injury Pa-thology

A Comprehensive Analysis of Efficacy and Safety of Probiotics in Inflammatory Bowel Disease

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Open Journal of Gastroenterology 2024年第6期14卷 213-225页

作者： feruza Abraamyan Neeladri Misra Sutter Roseville Medical Center Roseville California USA

Introduction: Inflammatory bowel disease (IBD) affects approximately 7 million people worldwide. In the U.S. alone, per the CDC, 1.3% of adults, which is approximately 3,000,000 people, are diagnosed with inflammatory bowel disease-either, Crohn’s disease, or ulcerative colitis. The estimated cost of treatment can be close to $23,000 annually, with treatment regimens comprising biologic agents and anti-inflammatory therapies. Probiotics have recently gathered interest as a low-cost additional therapy option that, in addition to the current regimen of IBD management, allows for reductions in rates of IBD flare-ups by significantly reducing the number of emergency room visits and avoiding the need to constantly escalate treatment by addition of biologic agents in achieving remission. The Analysis Goal: Our research project aimed to see if there was a significant difference in the addition of probiotics to standard therapy in inflammatory bowel disease by comparing existing research studies and trials. We analyzed RCTs published in PubMed to assess the efficacy and safety of probiotics in patients with IBD in preventing frequent disease flare-ups and reducing the cost of care. Research Methods: We did a comparative analysis of available RCTs using a PubMed search and included studies that researched the addition of probiotic strains in patients with IBD (ulcerative colitis and Crohn’s disease). After reviewing the inclusion and exclusion criteria, the trials selected for analysis were reviewed by two independent reviewers. Results: We analyzed 21 RCTs, and 16 RCTs (76.2%) showed that probiotics are an effective therapy for IBD, inducing remission and reducing flare-up rates in patients on a standard treatment regimen. Conclusion: Probiotics given in combination with standard therapy in IBD are effective in decreasing disease activity rates and reducing remission rates. No significant adverse reactions to probiotics were noticed.

关键词： Probiotics Inflammatory Bowel Disease Crohn’s Disease Ulcerative Colitis Remission Rates

Advancements in Lynch Syndrome Management: Applying Immunotherapy for Therapeutic Success

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Open Journal of Gastroenterology 2024年第4期14卷 139-144页

作者： Abraamyan feruza Bobolis Kristie Gauchan Dron Sutter Roseville Medical Center Roseville CA USA

Lynch syndrome is the fourth most common cancer in the United States, with an early age of onset and poor prognosis. Here, we present a unique case of a patient with progressive colon cancer due to a late diagnosis of Lynch syndrome showing excellent response to immunotherapy. A 59-year-old male with a history of rectal cancer 30 years ago came to the hospital due to a fever and further found a large necrotic colon mass. Biopsy was positive for colorectal cancer;however, due to the size of the tumor, the patient was deemed not a surgical candidate and offered hospice with palliative chemotherapy. Based on further workup, the patient was diagnosed with Lynch syndrome, with colon cancer determined to be responsive to Immunotherapy. He was started on JEMPERLI (Dosterlimab-gxly), and after three cycles of therapy, imaging and PET scan were repeated, showing decreased activity and extent of the tumor—a tremendous success.

关键词： Lynch Syndrome Colon Cancer Genetics Immunotherapy Dostarlimab

Comparative Analysis of Continuous versus Intermittent Proton Pump Inhibitor Therapy in Patients with Upper Gastrointestinal Bleeding Due to Ulcers

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Open Journal of Gastroenterology 2024年第3期14卷 99-107页

作者： Abraamyan feruza Misra P. Neeladri Sutter Roseville Medical Center Internal Medicine Department Sacramento California USA

Upper gastrointestinal bleeding (UGIB) presents as a prevalent clinical challenge, with annual incidence rates ranging from 80 to 150 cases per 100,000 individuals. Guidelines for managing patients with UGIB due to bleeding ulcers recommend a continuous infusion of proton pump inhibitors (PPI). However, studies comparing intermittent dosing of PPI therapy show that this regimen achieves similar clinical benefits. If the clinical efficacy remains equivalent, intermittent dosing will be more cost-effective for patients and the health care system. Our research study aims to analyze the comparative effectiveness of intermittent versus continuous PPI therapy after endoscopic treatment in patients with UGIB, focusing on such endpoints as rebleeding risk at 3-and 7-day mortality rates. Methods: Resources searched included MEDLINE, EMBASE, PUBMED, and the Cochrane Central Register of Controlled Trials databases from January 2010 through December 2023 with the inclusion of meta-analysis, systematic review, review, or ACG guideline recommendations. Results of the analysis show how recommendations regarding high vs. low PPI regimen changed over time: from no difference in regimen in 2010 to recommending continuous regimen in 2012 to declaring insufficient evidence between choosing one regimen over another in 2013 to determine that both regimens were comparable to each other in 2014-2018 and finally to recommending both regimens in 2021. To conclude, our review shows that in patients with bleeding ulcers and high-risk endoscopic findings, intermittent PPI therapy is non-inferior to continuous PPI infusion for three days, seven days bleeding risk or mortality rates;however, it remains challenging to determine the most optimal intermittent regimen due to heterogeneity of RCTs included in meta-analyses, and further trials will need to be performed.

关键词： Upper Gastrointestinal Bleeding PPI Continuous Intermittent Bolus Regimens Review

Navigating Long-Term Management Challenges in Short Bowel Syndrome: A Case Report of Chronic Intestinal Failure Complicated by Kidney Dysfunction

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Open Journal of Internal Medicine 2024年第2期14卷 175-180页

作者： Abraamyan feruza Prasad Thajus Salk Spencer Mahmood Khalid Internal Medicine Department Sutter Roseville Medical Center Roseville California USA Idaho College of Osteopathic Medicine Idaho USA

The most common cause of intestinal failure is short bowel syndrome (SBS), occurring as a result of a small functional intestine length, usually less than 200 cm, leading to intestinal malabsorption. A 59-year-old female with a past medical history of Crohns disease status post total colectomy with ileostomy over 20 years ago came to the hospital due to progressive weakness. Despite medical management, the patient had high ileostomy output, leading to electrolyte disbalance, metabolic acidosis, dehydration, and progressive kidney decline. Due to the high dependence on continuous fluid supplementation, it was decided to place a port for parenteral hydration to maintain fluid replacements and homeostasis after discharge. Prompt initiation of parenteral fluid replacement and close follow-up on patients with ileostomy and intestinal failure is strongly recommended to avoid complications and prevent intestinal, liver, or kidney transplants.

关键词： Crohn’s Disease Intestinal Failure Short Bowel Syndrome High Ileostomy Output TPN

A Case of Esophageal Perforation Presenting as Cavitary Pneumonia: Diagnostic and Therapeutic Challenges

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Open Journal of Gastroenterology 2024年第7期14卷 241-247页

作者： feruza Abraamyan Harpreet Singh Vishal Raj Inder M. Singh Internal Medicine Department Sutter Roseville Medical Center Roseville CA USA Pulmonary Medicine Associates Sutter Roseville Medical Center Roseville CA USA Gastroenterology Department Sutter Roseville Medical Center Roseville CA USA

Esophageal perforation, a rare condition, can arise from iatrogenic, traumatic, or spontaneous origins. Even when therapy is initiated within the first 24 hours, it is associated with a mortality rate of up to 25%. Due to the varied initial presentation, treatment may be delayed, leading to poorer outcomes. Here, we present a unique case of a 27-year-old schizophrenic patient who initially presented with acute respiratory failure and septic shock and was ultimately diagnosed with cavitary pneumonia secondary to esophageal perforation.

关键词： Esophageal Perforation Foreign Body Esophageal Stent Cavitary Pneumonia Septic Shock Respiratory Failure

Challenges in Diagnosing and Managing Dieulafoy’s Lesions: A Case Report Highlighting the Importance of Clinical Suspicion and Multidisciplinary Approach in Obscure Gastrointestinal Bleeding

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Open Journal of Gastroenterology 2024年第3期14卷 80-86页

作者： feruza Abraamyan Neeladri Misra Kenneth Tran Khalid Mahmood Benjamin Coombs Shilpa Lingala Sutter Roseville Medical Center Roseville USA

Upper gastrointestinal bleeding remains a significant cause of hospital admissions. Even though the incidence of peptic ulcer disease and gastritis is decreasing, the incidence rates in neoplasm, Dieulafoy’s lesions, angiodysplasia, and esophagitis are trending up, which necessities physicians to be aware of those pathologies and their specifics. Here, we represent a case of a 62-year-old male on dual antiplatelet therapy who was transferred to our hospital due to severe melena with suspicion of upper gastrointestinal bleeding. Due to hemodynamic instability, the patient was intubated and started on vasopressors. However, several repeated EGDs and CTs of the abdomen with GI bleeding protocol did not reveal the location of active bleeding to stop it. At the same time, clinically, the patient was hemodynamically unstable with continued melena. On the last EGD, a small area of concern resembling gastric varix was clipped for identification purposes, and the patient underwent a selective angiogram with further diagnosis of Dieulafoy’s lesion, which was successfully embolized. Our case demonstrates that Dieulafoy’s lesions can present as severe life-threatening hemorrhage, hard to diagnose with traditional methods such as EGD or CTs, in which case it is recommended to proceed with an angiogram sooner rather than later for further diagnosis and treatment if needed.

关键词： Upper Gastrointestinal Bleeding Dieulafoy’s Lesion Angiodysplasia Melena Hematochezia EGD Angiogram Embolization

Catamnestic Observation of Premature Newborns with Nervous System Injury in the Kyrgyz Republic

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A Comprehensive Analysis of Efficacy and Safety of Probiotics in Inflammatory Bowel Disease

Open Journal of Pediatrics（儿科学期刊） 2021年第2期

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