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Non-coding RNAs and other determinants of neuroinflammation and endothelial dysfunction:regulation of gene expression in the acute phase of ischemic stroke and possible therapeutic applications

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Neural Regeneration Research 2021年第11期16卷 2154-2158页

作者： Mario Daidone Marco Cataldi Antonio pinto Antonino Tuttolomondo Department of Health Promotion Maternal and Infant CareInternal Medicine and Medical Specialties“G.D’Alessandro”University of PalermoPiazza delle Cliniche n.2PalermoItaly

Ischemic stroke occurs under a variety of clinical conditions and has different pathogeneses,resulting in necrosis of brain *** pathogenesis is characterized by neuroinflammation and endothelial *** of the main processes triggered in the early stages of ischemic damage are the rapid activation of resident inflammatory cells(microglia,astrocytes and endothelial cells),inflammatory cytokines,and translocation of intercellular nuclear *** in stroke includes all the processes mentioned above,and it consists of either protective or detrimental effects concerning the“polarization”of these *** polarization comes out from the interaction of all the molecular pathways that regulate genome expression:the epigenetic *** recent years,new regulation mechanisms have been cleared,and these include non-coding RNAs,adenosine receptors,and the activity of mesenchymal stem/stromal cells and *** reviewed how long non-coding RNA and microRNA have emerged as an essential mediator of some neurological *** also clarified that their roles in cerebral ischemic injury may provide novel targets for the treatment of ischemic *** date,we do not have adequate tools to control pathophysiological processes associated with *** goal is to review the role of non-coding RNAs and innate immune cells(such as microglia and mesenchymal stem/stromal cells)and the possible therapeutic effects of their modulation in patients with acute ischemic stroke.A better understanding of the mechanisms that influence the“polarization”of the inflammatory response after the acute event seems to be the way to change the natural history of the disease.

关键词： acute phase cerebrovascular disease endothelial dysfunction epigenetics genetics neuroiflammation non-coding RNAs stroke

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Impact of nitrogen doping on growth and hydrogen impurity incorporation of thick nanocrystalline diamond films

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Chinese Physics B 2011年第5期20卷 433-438页

作者：顾利萍唐春玖江学范 J.L.pinto Department of Physics Jiangsu Key Laboratory for Advanced Functional MaterialsChangshu Institute of Technology Department of Physics I3N(Institute for NanostructuresNanomodelling and Nanofabrication)University of AveiroCampus Universita'rio de Santiago3810-193 AveiroPortugal

A much larger amount of bonded hydrogen was found in thick nanocrystalline diamond （NCD） films produced by only adding 0.24% N2 into 4% CH4/H2 plasma, as compared to the high quality transparent microcrystalline diamond （MCD） films, grown using the same growth parameters except for nitrogen. These experimental results clearly evidence that defect formation and impurity incorporation （for example, N and H） impeding diamond grain growth is the main formation mechanism of NCD upon nitrogen doping and strongly support the model proposed in the literature that nitrogen competes with CHx （x = 1, 2, 3） growth species for adsorption sites.

关键词： thick nanocrystalline diamond films nitrogen doping crystalline quality

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Giant appendiceal mucocele: Report of a case and brief review

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World Journal of Gastroenterology 2005年第30期11卷 4761-4763页

作者： Bernardino Rampone Franco Roviello Daniele Marrelli Enrico pinto Department of General Surgery and Surgical Oncology

Mucocele of the appendix is a rare lesion, characterized by distension of the lumen due to accumulation of mucoid substance. This disease is often asymptomatic and pre-operative diagnosis is rare. If untreated, one type of mucocele may rupture producing a potentially fatal entity known as pseudomyxoma peritonei. The type of surgical treatment is related to the dimensions and to histology of the mucocele. Appendectomy is used for simple mucocele or for cystadenoma. Right hemi-colectomy is recommended for cystadenocarcinoma. In this paper, we report a case of a 51-year-old woman with a mobile, painless mass in the right lower quadrant of abdomen caused by a giant appendiceal mucocele. Imaging showed a larger tubular, cystic structure extending below from the inferior wall of the cecum. Surgery revealed a giant retro-cecal appendix measuring 17 cm in length and 4 cm in diameter. The final pathologic diagnosis was mucocele caused by mucinous cystadenoma.

关键词： Appendix Mucocele Pseudomyxoma peritonei Surgical treatment

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Sifu-a cybersecurity awareness platform with challenge assessment and intelligent coach

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Cybersecurity 2018年第1期1卷 945-967页

作者： Tiago Espinha Gasiba Ulrike Lechner Maria pinto-Albuquerque Siemens AG Corporate Technology Otto-Hahn-Rin 681379 MunichBavariaGermany Universitat der Bundeswehr München MunichGermany Instituto Universitario de Lisboa(ISCTE-IUL) ISTAR-IULLisbonPortugal

Software vulnerabilities,when actively exploited by malicious parties,can lead to catastrophic *** handling of software vulnerabilities is essential in the industrial context,particularly when the software is deployed in critical ***,several industrial standards mandate secure coding guidelines and industrial software developers’training,as software quality is a significant contributor to secure *** Challenges(CSC)form a method that combines serious game techniques with cybersecurity and secure coding guidelines to raise secure coding awareness of software developers in the *** cybersecurity awareness events have been used with success in industrial ***,until now,these coached events took place *** the present work,we briefly introduce cybersecurity challenges and propose a novel platform that allows these events to take place *** introduced cybersecurity awareness platform,which the authors call Sifu,performs automatic assessment of challenges in compliance to secure coding guidelines,and uses an artificial intelligence method to provide players with solution-guiding ***,due to its characteristics,the Sifu platform allows for remote(online)learning,in times of social *** CyberSecurity Challenges events based on the Sifu platform were evaluated during four online real-life CSC *** report on three surveys showing that the Sifu platform’s CSC events are adequate to raise industry software developers awareness on secure coding.

关键词： Cybersecurity Awareness Training Artificial intelligence Serious games Secure coding Static application security testing Capture-the-flag Software development in industry

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Multiomic investigation of Sugarcane mosaic virus resistance in sugarcane

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The Crop Journal 2023年第6期11卷 1805-1815页

作者： Ricardo JoséGonzaga Pimenta Alexandre Hild Aono Roberto Carlos Villavicencio Burbano Marcel fernando da Silva Ivan Antônio dos Anjos Marcos Guimarães de Andrade Landell Marcos Cesar Gonçalves Luciana Rossini pinto Anete Pereira de Souza Centre for Molecular Biology and Genetic Engineering University of CampinasCampinasBrazil Gustavo Galindo Velasco Campus Littoral Polytechnic Superior SchoolGuayaquilEcuador Advanced Centre for Technological Research in Sugarcane Agribusiness Agronomic Institute of CampinasRibeirão PretoBrazil Plant Protection Research Centre Biological InstituteSão PauloBrazil Department of Plant Biology Institute of BiologyUniversity of CampinasCampinasBrazil

Sugarcane mosaic virus(SCMV)is the main etiological agent of sugarcane mosaic disease,which affects sugarcane and other grass *** the extensive characterization of quantitative trait loci controlling resistance to SCMV in maize,the genetic basis of this trait in sugarcane is largely ***,a genome-wide association study was performed and machine learning coupled with feature selection was used for genomic prediction of resistance to SCMV in a diverse sugarcane *** single-nucleotide polymorphisms(SNPs)explained up to 29.9%of the observed phenotypic variance and a 73-SNP set predicted resistance with high accuracy,precision,recall,and F1 scores(the harmonic mean of precision and recall).Both marker sets were validated in additional sugarcane genotypes,in which the SNPs explained up to 23.6%of the phenotypic variation and predicted resistance with a maximum accuracy of 69.1%.Synteny analyses suggested that the gene responsible for the majority of SCMV resistance in maize is absent in sugarcane,explaining why this major resistance source has not been identified in this ***,using sugarcane RNA-Seq data,markers associated with resistance to SCMV were annotated,and a gene coexpression network was constructed to identify the predicted biological processes involved in *** network allowed the identification of candidate resistance genes and confirmed the involvement of stress responses,photosynthesis,and the regulation of transcription and translation in resistance to *** results provide a practical marker-assisted breeding approach for sugarcane and identify target genes for future studies of SCMV resistance.

关键词： Saccharum SCMV GWAS Machine learning RNA-Seq

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巴西竹类生物多样性（英文）

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热带亚热带植物学报 2015年第1期23卷 1-16页

作者： Thiago Machado GRECO Moisés Medeiros pinto Antonio fernando Caetano TOMBOLATO 夏念和 Reitor Joao David Ferreira Lima 校区圣卡塔琳娜州联邦大学圣卡塔琳娜州FlorianópolisCEP 88040-900巴西巴西圣保罗州das Catléas 街240 号 CEP 18055-177巴西巴西农业研究所遗传研究中心圣保罗州Campinas 邮政信箱28 号 CEP 13020-902巴西中国科学院华南植物园、中国科学院植物资源保护与可持续利用重点实验室、广东省数字植物园重点实验室广州510650

巴西是全球生物多样性最丰富的地区,其竹类多样性也极为丰富。结合现存资料及野外调查,对巴西全境的竹类分布格局进行了讨论。巴西全国有原生竹亚科植物256种(含2亚种及3变种),北部地区草本竹类(莪莉竹族)最丰富,有61种,而东南部地区木... 详细信息

巴西是全球生物多样性最丰富的地区,其竹类多样性也极为丰富。结合现存资料及野外调查,对巴西全境的竹类分布格局进行了讨论。巴西全国有原生竹亚科植物256种(含2亚种及3变种),北部地区草本竹类(莪莉竹族)最丰富,有61种,而东南部地区木本竹类(箣竹族)最丰富,有96种。偏穗竹属(Merostachys)(43种)和丘斯夸竹属(Chusquea)(45种)是最常见的属,并是最具潜在经济利用的竹类。属种的特有性分别高达32.4%和68.8%。特有属有11个,分别为莪莉竹族的双药莪利草竹属(Diandrolyra)、独焰草竹属(Eremitis)、小百瑞草竹属(Parianella)、赖茨草竹属(Reitzia)、苏克蕾草竹属(Sucrea)和箣竹族的南美梨藤竹属(Alvimia)、离枝竹属(Apoclada)、密穗竹属(Athroostachys)、卡姆巴珠瓦竹属(Cambajuva)、菲尔盖拉斯竹属(Filgueirasia)、无枝竹属(Glaziophyton)。

关键词：竹亚科禾本科特有性地理分布

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促进慢性阻塞性肺疾病哮喘患者自我监控空气质量的护理干预措施:整合性综述（英文）

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International Journal of Nursing Sciences 2024年第1期 46-56页

作者： Bruna F.Sebasti?o Raquel M.Hortel?o Sara S.Granadas José M.Faria Joana R.pinto Helga Rafael Henriques Nursing School of Lisbon Hospital Center of Central Lisbon CUF Tejo Hospital University Hospital Center of Northern Lisbon Nursing Research Innovation and Development Centre of Lisbon (CIDNUR)

目的哮喘-慢性阻塞性肺疾病肺重叠症(Asthma-chronic obstructive pulmonary disease overlap,ACO)患者的生活质量较低,肺功能较差,病情经常加重。由于暴露于污染环境会加重其症状,增加发病率和病死率,环境管理对其至关重要。旨在通过... 详细信息

目的哮喘-慢性阻塞性肺疾病肺重叠症(Asthma-chronic obstructive pulmonary disease overlap,ACO)患者的生活质量较低,肺功能较差,病情经常加重。由于暴露于污染环境会加重其症状,增加发病率和病死率,环境管理对其至关重要。旨在通过系统性综述,寻找证据,以指导制订护理干预措施,促进ACO患者对空气质量的自我管理。方法 2023年3月,系统检索CINAHL、Medline、Academic Search Complete、Scopus、Web of Science、Cochrane图书馆、乔安娜布里格斯研究所(Joanna Briggs Institute,JBI)循证实践数据库,以及Google Scholar。对纳入研究进行数据提取和综合,并对护理干预措施进行分类。采用JBI研究质量评估工具进行方法学质量评估。结果共纳入5篇来自不同国家的研究。促进ACO患者自我监控空气质量的干预措施包括:警觉性干预措施(医务人员定期巡诊、进行症状评估),监测干预措施(监测室内外诱发因素),教育干预措施(空气质量警报、避免接触过敏原),以及相关政策的影响,如无烟政策和改善空气质量的综合战略。尽管这些研究报告了不同的干预措施,方法质量也存在差异,但这些干预措施显示了预防患者病情恶化、尽量减少急诊就诊和住院治疗的潜力。这些关键点可作为护理干预措施的关键组成部分。结论有必要采取全面措施,让护士参与促进患者自我监控空气质量的多学科团队、提高认识、制订和实施护理干预,从而使ACO患者受益。同时,需要进一步开展研究,以扩大证据基础并完善这些干预措施。

关键词：空气质量哮喘哮喘-慢阻肺重叠慢性病慢性阻塞性肺疾病护理自我管理

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Yield models for predicting aboveground ectomycorrhizal fungal productivity in Pinus sylvestris and Pinus pinaster stands of northern Spain

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Forest Ecosystems 2019年第4期6卷 414-426页

作者： Mariola Sánchez-González Sergio de-Miguel Pablo Martin-pinto fernando Martínez-Pe?a María Pasalodos-Tato Juan Andrés Oria-de-Rueda Juan Martínez de Aragón Isabel Ca?ellas José Antonio Bonet Spanish National Institute for Agricultural and Food Research and Technology (INIA)

Background: Predictive models shed light on aboveground fungal yield dynamics and can assist decision-making in forestry by integrating this valuable non-wood forest product into forest management planning. However, the currently existing models are based on rather local data and, thus, there is a lack of predictive tools to monitor mushroom yields on larger ***: This work presents the first empirical models for predicting the annual yields of ectomycorrhizal mushrooms and related ecosystem services in Pinus sylvestris and Pinus pinaster stands in northern Spain, using a long-term dataset suitable to account for the combined effect of meteorological conditions and stand *** were fitted for the following groups of fungi separately: all ectomycorrhizal mushrooms, edible mushrooms and marketed mushrooms. Our results show the influence of the weather variables(mainly precipitation) on mushroom yields as well as the relevance of the basal area of the forest stand that follows a right-skewed unimodal curve with maximum predicted yields at stand basal areas of 30–40 m2·***: These models are the first empirical models for predicting the annual yields of ectomycorrhizal mushrooms in Pinus sylvestris and Pinus pinaster stands in northern Spain, being of the highest resolution developed to date and enable predictions of mushrooms productivity by taking into account weather conditions and forests’ location, composition and structure.

关键词： Mushrooms Fungi Non-wood forest products Mixed models Hurdle models

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Introduction to the Special Issue on Mathematical Aspects of Computational Biology and Bioinformatics

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Computer Modeling in Engineering & Sciences 2023年第7期136卷 1-3页

作者： Dumitru Baleanu Carla M.A.pinto Sunil Kumar Department of Mathematics Cankaya UniversityBalgatAnkara06530Turkey Institute of Space Sciences Magurele-Bucharest077125Romania ISEP Instituto Superior de Engenharia do PortoRua Dr.António Bernardino de AlmeidaPorto4314249-015Portugal Department of Mathematics National Institute of TechnologyJamshedpurJharkhand831014India

The special issue presents new mathematical and computational approaches,to investigate some core problems of the computational biological *** topic presents a huge interest from both theoretical and applied *** content of this special issue was focused mainly to debate a wide range of the theory and applications of integer-order and fractional-order derivatives and fractional-order integrals in different directions of mathematical *** interdisciplinary groups reported their related results.

关键词： fractional integer Mathematical

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Updates on abdominal desmoid tumors

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World Journal of Gastroenterology 2007年第45期13卷 5985-5988页

作者： Bernardino Rampone Corrado Pedrazzani Daniele Marrelli Enrico pinto Franco Roviello Department of General Surgery and Surgical Oncology Unit of Surgical Oncology University of Siena Italy

Desmoid tumor is a monoclonal, f ibroblastic proliferation arising in musculoaponeurotic structures. This connective tissue hyperplasia inf iltrates locally, recurs frequently after resection but does not metastasize. Abdominal desmoid occurs sporadically, in association with some familial syndromes and often represents a clinical dilemma for surgeons. The enigmatic biology and anatomical location of abdominal desmoids make treatment recommendations diff icult. This distinct pathological entity is reviewed with a specif ic focus on aetiology and management.

关键词： Desmoid Abdomen Fibromatosis Familialadenomatous polyposis Gardner's syndrome

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