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How to boost the effects of exercise to favor traumatic brain injury outcome

Sports Medicine and Health Science 2022年第3期4卷 147-151页

作者： fernando gomez-pinilla Natosha M.Mercado Department of Integrative Biology&Physiology University of California at Los Angeles(UCLA)Los AngelesCA90095USA Department of Neurosurgery UCLA Brain Injury Research CenterUniversity of California at Los AngelesLos AngelesCA90095USA

Physical rehabilitation is an effective therapy to normalize weaknesses encountered with neurological disorders such as traumatic brain injury(TBI).However,the efficacy of exercise is limited during the acute period of TBI because of metabolic dysfunction,and this may further compromise neuronal function.Here we discuss the possibility to normalize brain metabolism during the early post-injury convalescence period to support functional plasticity and prevent long-term functional deficits.Although BDNF possesses the unique ability to support molecular events involved with the transmission of information across nerve cells through activation of its TrkB receptor,the poor pharmacokinetic profile of BDNF has limited its therapeutic applicability.The flavonoid derivative,7,8-dihydroxyflavone(7,8-DHF),signals through the same TrkB receptors and results in the activation of BDNF signaling pathways.We discuss how the pharmacokinetic limitations of BDNF may be avoided by the use of 7,8-DHF,which makes it a promising pharmacological agent for supporting activity-based rehabilitation during the acute post-injury period after TBI.In turn,docosahexaenoic acid(C22:6n-3;DHA)is abundant in the phospholipid composition of plasma membranes in the brain and its action is important for brain development and plasticity.DHA is a major modulator of synaptic membrane fluidity and function,which is fundamental for supporting cell signaling and synaptic plasticity.Exercise influences DHA function by normalizing DHA content in the brain,such that the collaborative action of exercise and DHA can be instrumental to boost BDNF function with strong therapeutic potential for reducing the deleterious effects of TBI on synaptic plasticity and cognition.

关键词： Exercise Traumatic brain injury Brain Synaptic plasticity DHA BDNF

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Fast and reliable identification of atomically thin layers of TaSe2 crystals

引用

Nano Research 2013年第3期6卷 191-199页

作者： Andres Castellanos-gomez Efren Navarro-Moratalla Guillermo Mokry Jorge Quereda Elena pinilla-Cienfuegos Nicolas Agrait Herre S. J. van der Zant Eugenio Coronado Gary A. Steele Gabino Rubio-Bollinger Kavli Institute of Nanoscience Delft University of Technology Lorentzweg 1 2628 CJ Delft The Netherlands Instituto Ciencia Molecular (ICMol) Univ. Valencia C/Catedrdtico Jose Beltrdn 2 E-46980 Paterna Spain Departamento de Fisica de la Materia Condensada (C-III). UniversidadAutonoma de Madrid Campus de Cantoblanco 28049 Madrid Spain Instituto Madrileno de Estudios Avanzados en Nanociencia IMDEA-Nanociencia E-28049 Madrid Spain

Deposition of clean and defect-free atomically thin two-dimensional crystalline flakes on surfaces by mechanical exfoliation of layered bulk materials has proven to be a powerful technique, but it requires a fast, reliable and non-destructive way to identify the atomically thin flakes among a crowd of thick flakes. In this work, we provide general guidelines to identify ultrathin flakes of TaSe2 by means of optical microscopy and Raman spectroscopy. Additionally, we determine the optimal substrates to facilitate the optical identification of atomically thin TaSe2 crystals. Experimental realization and isolation of ultrathin layers of TaSe2 enables future studies on the role of the dimensionality in interesting phenomena such as superconductivity and charge density waves.

关键词：光谱识别超薄层原子晶体光学显微镜电荷密度波超薄片散装物料

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