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Stages of care for patients with chronic hepatitis C at a hospital in southern Brazil

世界肝病学杂志:英文版(电子版) 2023年第8期15卷 973-984页

作者： Manoela Badinelli Vaucher Camila Ubirajara silva Ivana Rosângela santos Varella Arthur Yu-Shin Kim Dimas Alexandre Kliemann department of Hepatology Universidade Federal de Ciências da Saúde de Porto AlegrePorto Alegre 90050-170Rio Grande do SulBrazil department of Medicine Universidade do Vale do TaquariLajeado 95914-014RSBrazil department of Application and Monitoring of Injectable Drugs Hospital Sanatório PartenonPorto Alegre 90650-000RSBrazil department of Epidemiology Hospital Nossa Senhora da ConceiçãoPorto Alegre 91350-200Rio Grande do SulBrazil department of Infectious Diseases Massachusetts General HospitalBostonMA 02114United States department of Medicine Harvard Medical SchoolBostonMA 02114United States departament of Infectious Diseases Hospital Nossa Senhora da ConceiçãoPorto Alegre 91350-200Rio Grande do SulBrazil

BACKGROUND Hepatitis C virus(HCV)is defined as a public health problem by the World Health Organization(WHO)and since then has defined targets through the HCV *** HCV cascade of care highlights the progress towards these goals and essential interventions that need to be delivered along this continuum *** To document the treatment cascade for patients with HCV infection at the Hospital Nossa Senhora da Conceição(HNSC),defining the percentage of antibody-positive patients who collected molecular biology tests(polymerase chain reaction),attended outpatient clinic assistance,underwent treatment,and achieved a virologic cure termed sustained virologic response(SVR).METHODS With the retrospective cohort design,patients diagnosed with HCV infection in the period between January 1,2015 and december 31,2020 were *** from HCV notification forms,electronic medical records,Computerized Laboratory Environment Manager System,and Medicine Administration System(evaluation of special medications)were collected in 2022 and all information up to that period was *** data were analyzed with IBM SPSS version 25,and Poisson regression with robust simple variance was performed for analysis of variables in relation to each step of the *** with Pded in the multivariate analysis with Pdered ***’s chi-square test was applied to compare the groups of patients who persisted in follow-up at the HNSC and who underwent follow-up at other *** Results were lower than expected by the WHO with only 49%of candidates receiving HCV treatment and only 29%achieving SVR,despite the 98%response rate to direct acting antivirals documented by follow-up *** city of origin and the place of follow-up were the variables associated with SVR and all other *** comparing the cascade of patients who remained assisted by the HNSC vs external patients,we observed superior data for HNSC patien

关键词： Cascade of care Elimination Hepatitis C virus Sustained virologic response

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Economic Feasibility Evaluation of the Use of Wind Microgenerator in Multifamily Building in Southern Brazil

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Journal of Civil Engineering and Architecture 2022年第10期16卷 513-518页

作者： Lauro AndréRibeiro Marcos Vinícius de Lima Wilson Levy Braga da silva Neto Marília Marton Correia Thaísa Leal da silva Postgraduation Program of Architecture and Urbanism School of Engineering and Applied SciencesATITUS EducaçãoRua Senador Pinheiro304Passo Fundo/RS 99070-220Brazil Postgraduation Program in Smart and Sustainable Cities at Universidade Nove de Julho Rua Vergueiro235/249-LiberdadeSão Paulo/SP 01525-000Brazil

There is a growing worldwide interest in the potential of using existing buildings to generate their own energy as a way to alleviate problems related to the exhaustion of energy resources,environmental degradation and the constant increase in energy-related *** the distributed electricity generation solutions on the market today,wind energy can be a solution for many existing city buildings ***,the objective of this article is to investigate the economic viability of generating wind energy in a multifamily building located in Southern Brazil,(city of Passo Fundo),seeking to supply the condominium electric energy for the period of one year of consumption with a renewable *** this end,the energy demand of the condominium and the energy generation of the wind turbine were taken into account to calculate the economic viability of the *** results showed a positive NPV(net present value)demonstrating the economic feasibility of carrying out such an *** IRR(internal rate of return)was 15.22%and the return on investment(payback)occurs in 7.88 years.

关键词： Wind energy microgeneration renewable energy economic analysis

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Application of advanced oxidation processes for removing salicylic acid from synthetic wastewaters

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Chinese Chemical Letters 2010年第1期21卷 101-104页

作者： Djalma Ribeiro da silva Carlos A.Martinez-Huítle Universidade Federal do Rio Grande do Norte CCET-Departamento de QuimicaLagoa Nova-CEP 59.072-970 Brazil Universidade Federal do Rio Grande do Norte CCET-Departamento de QuimicaLagoa Nova-CEP 59.072.970 Brazil University of Milan Department of ChemistryCeloria 220133 MilanItaly

In this study,advanced oxidation processes(AOPs) such as anodic oxidation(AO),UV/H_2O_2 and Fenton processes(FP) were investigated for the degradation of salicylic acid(sa) in lab-scale ***-doped diamond(BDD) film electrodes using Ta as substrates were employed for AO of *** the case of FP and UV/H_2O_2,most favorable experimental conditions were determined for each process and these were used for comparing with AO *** study showed that the FP was the most effective process under aci...

关键词： Advanced oxidation processes salicylic acid(sa) Anodic oxidation Ta/BDD Electrocatalytic activity

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Relationship between phase angle,steatosis,and liver fibrosis in patients coinfected with human immunodeficiency virus/hepatitis C virus

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World Journal of Hepatology 2022年第6期14卷 1173-1181页

作者： sabrina Alves Fernandes Cristiane Valle Tovo AndréLuiz Machado da silva Letícia Pereira Pinto Randhall B Carteri Angelo A Mattos Postgraduate Program in Hepatology Universidade Federal de Ciências da Saúde de Porto Alegre(UFCSPA)Porto Alegre 90050-170Brazil department of Infectology Service Hospital Nossa Senhora da ConceiçãoPorto Alegre 91350-200Brazil department of Nutrition Centro Universitário Metodista-IPAPorto Alegre 90420-060Brazil department of Nutrition Centro Universitário CESUCACachoeirinha 94935-630Brazil

BACKGROUND Malnutrition,lipodystrophy,and dyslipidemia are prevalent characteristics in patients with human immunodeficiency virus(HIV)infection with or without previous *** a clinical condition can lead to the hypothesis of the presence of hepatic steatosis with possible progression to fibrosis and the risk of hepatocellular ***,a low phase angle(PA),evaluated by bioelectrical impedance analysis(BIA),is an independent prognostic marker of clinical progression and survival in HIV-infected *** To evaluate the relationship between PA and body composition with steatosis and hepatic fibrosis in HIV/hepatitis C virus(HCV)-coinfected *** A retrospective observational study by convenience sampling of coinfected HIV/HCV patients,in which all patients underwent transient elastography(Fibroscan)and BIA ***’s t test was used for group comparisons,and Spearman’s or Pearson’s correlation test was used when *** significance level was set at 5%,and analyses were performed using SPSS version *** Forty-three patients who received antiretroviral therapy met the inclusion criteria,and 23(53.5%)were under treatment with protease inhibitors(PIs).There was no difference in PA between those who used PIs and those who did not(P=0.635).There was no correlation between fibrosis grade and PA(P=0.355)or lean mass(P=0.378).There was a significant inverse correlation between the controlled attenuation parameter(CAP)and lean mass(P=0.378),positive correlation between PA and lean mass(P=0.378),and negative correlation between PA and fatty mass(P=0.378),although the CAP and PA were not *** evaluated by sex,no significant correlations were *** PA determines the muscle function of HIV/HCV-coinfected patients,and the CAP values reinforce the association with lean mass,suggesting that patients require early nutritional interventions.

关键词： Phase angle Bioelectrical impedance Coinfection Human immunodeficiency virus Hepatitis C virus Nutrition

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Sex-specific effects of Eugenia punicifolia extract on gastric ulcer healing in rats

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World Journal of Gastroenterology 2018年第38期24卷 4369-4383页

作者： Larissa Lucena Périco Vinícius Peixoto Rodrigues Rie Ohara Gabriela Bueno Vania Vasti Alfieri Nunes Raquel Cássia dos santos Ana Carolina Lima Camargo Luis Antuio Justulin Joior Sérgio Faloni de Andrade Viviane Miranda Bispo Steimbach Luísa Mota da silva Lúcia Regina Machado da Rocha Wagner Vilegas Catarina dos santos Clélia Akiko Hiruma-Lima department of Physiology Institute of BiosciencesSa Paulo State University(UNESP)Botucatu 18618-970Sa PauloBrazil Laboratory of Bioactive Compounds Sao Francisco UniversityBraganca Paulista 12916-900Sa PauloBrazil department of Morphology Institute of BiosciencesSao Paulo State University(UNESP)Botucatu 18618-970Sao PauloBrazil Programa de Po-graduacao em Ciecias Farmaco-ticas Nuleo de Investigacoes Quiico-Farmaceticas(NIQFAR)Universidade do Vale do Itajai-UNIVALIItajai 88302-901Santa CatarinaBrazil Coastal Campus of sa Vicente Sa Paulo State University(UNESP)Sa Vicente 11330-900Sa PauloBrazil department of Biological Science Faculty of Sciences and LanguagesSa Paulo State University(UNESP)Assis 19806-900SaPauloBrazil

AIM To evaluate the sex-specific effects of a hydroalcoholic extract from Eugenia punicifolia(HEEP) leaves on gastric ulcer *** In this rat study involving males, intact(cycling) females, and ovariectomized females, gastric ulcers were induced using acetic acid. A vehicle, lansoprazole, or HEEP was administered for 14 d after ulcer induction. Body weight was monitored throughout the treatment period. At the end of treatment, the rats were euthanized and the following in vivo and in vitro investigations were performed: macroscopic examination of the lesion area and organ weights, biochemical analysis, zymography, and evaluation of protein expression levels. Additionally, the concentration-dependent effect of HEEP was evaluated in terms of subacute toxicity and *** Compared to the vehicle, HEEP demonstrated a great healing capacity by substantially reducing the ulcerative lesion area in males(52.44%), intact females(85.22%), and ovariectomized females(65.47%), confirming that HEEP accelerates the healing of acetic acidinduced gastric lesions and suggesting that this effect is modulated by female sex hormones. The antiulcer effect of HEEP was mediated by prostaglandin E2 only in male rats. Overall, the beneficial effect of HEEP was the highest in intact females. Notably, HEEP promoted the expression of vascular endothelial growth factor(intact vs ovariectomized females) and decreased the expression of Caspase-8 and Bcl-2(intact female vs male or ovariectomized female). Additionally, HEEP enhanced fibroblast proliferation and migration into a wounded area in vitro, confirming its healing effect. Finally, no sign of subacute toxicity or cytotoxicity of HEEP was *** In gastric ulcers, HEEP-induced healing(modulated by female sex hormones; in males, mediated by prostaglandin) involves extracellular matrix remodeling, with gastric mucosa cell proliferation and migration.

关键词： Eugenia punicifolia Gastric ulcer healing Acetic acid Sex difference Myrtaceae Toxicity

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The road to sustainable use and waste management of plastics in Portugal

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Frontiers of Environmental Science & Engineering 2022年第1期16卷 91-106页

作者： Joana C.Prata Ana LPatrício silva Armando CDuarte Teresa Rocha-santos Centre for Environmental and Marine Studies(CEsaM)&department of Chemistry University of Aveiro3810-193 AveiroPortugal Centre for Environmental and Marine Studies(CEsaM)&department of Biology University of Aveiro3810-193 AveiroPortugal

As a European Union(EU)member,Portugal must comply with reductions in plastic *** Portugal,the 330 items/100 m of beach litter,comprising up to 3.9 million pieces and of which 88%is plastic,is higher than the EU median(149 items/100 m)and must be reduced to 20 items/100 m(94%).Integrative measures are needed to reduce littering and improve plastics’use and disposal under the circular *** this 414 kt of plastic packaging waste,163 kt were declared plastic packaging,140 kt subjected to recycling,and 94 kt to energy *** current recycling rate of plastic packaging(34%)should be improved to reach EU recycling averages(42%)and goals and to provide widespread benefits,considering revenues of 167€/*** a net importer of waste,Portugal could benefit from the valorization of imported *** increased recycling,pyrolysis and gasification could provide short-term alternatives for producing value-added substances from plastic waste,such as hydrogen,consistent with the National Plan of Hydrogen and improving ongoing regulations on single-use *** manuscript provides an integrative view of plastics in Portugal,from use to disposal,providing specific recommendations under the circular economy.

关键词： Single-use plastics Plastic packaging Plastic waste Waste management Waste shipment Lightweight plastic bags

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Risk factors associated with inflammatory bowel disease: A multicenter case-control study in Brazil

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World Journal of Gastroenterology 2020年第25期26卷 3611-3624页

作者： Valéria Cristina Loureiro salgado Ronir Raggio Luiz Neio Lucio Fernandes Boéchat Isabella Sued Leao Bianca do Carmo Schorr JoséMiguel Luz Parente Daniela Calado Lima Eduardo santos Silveira Júnior Genoile Oliveira santana silva Neogélia Pereira Almeida Andrea Vieira Maria Luiza Queiroz de Bueno Júlio Maria Chebli érika Ruback Bertges Luísa Martins da Costa Brugnara Columbano Junqueira Neto Stefania Burjack Gabriel Campbell Luana Letiza Discacciati Joao Paulo silva Cézar Tiago Nunes Gilaad G Kaplan Cyrla Zaltman Division of Gastroenterology Department of Internal MedicineClementino Fraga Filho HospitalFederal University of Rio de JaneiroRio de Janeiro 21940-230Brazil Institute for Studies in Public Health Federal University of Rio de JaneiroRio de Janeiro 21940-230Brazil Multidisciplinary Research Laboratory Clementino Fraga Filho HospitalInstitute of Thoracic DiseasesFaculty of MedicineFederal University of Rio de JaneiroRio de Janeiro 21940-230Brazil Division of Gastroenterology Department of Internal MedicineHospital UniversityFaculty of MedicineFederal University of PiauíPiauí64049-550Brazil Almeida Division of GastroenterologyInflammatory Bowel Disease Outpatient ClinicRoberto Santos General Hospital(HGRS)of the Bahia State Department of HealthBahia 40110-060Brazil Division of Gastroenterology Inflammatory Bowel Disease Outpatient ClinicIrmandade Santa Casa da Misericórdia of São PauloSão Paulo 01221020Brazil Division of Gastroenterology Department of Internal MedicineHospital UniversityFaculty of MedicineFederal University of Juiz de ForaMinas Gerais 36036-247Brazil Division of Gastroenterology Inflammatory Bowel Disease Outpatient ClinicFederal District Base HospitalBrasília 70330-150Brazil Gastrointestinal Physiology Institute of Nutritional ScienceNestle Research CenterLausanne 1000Switzerland departments of Medicine and Community Health Sciences University of CalgaryCalgary T2N4Z6Canada

BACKGROUND The etiology of inflammatory bowel disease(IBD)is unknown,but it is believed to be *** hygiene hypothesis proposes that better hygiene conditions would lead to less infectious disease during childhood and favor the development of immune-mediated *** To test the hygiene hypothesis in IBD by assessing the environmental risk factors associated with IBD development in different regions of Brazil with diverse socioeconomic development *** A multicenter case-control study was carried out with 548 Crohn’s disease(CD)and 492 ulcerative colitis(UC)outpatients and 416 healthy controls,from six IBD centers within different Brazilian states at diverse socioeconomic development stages.A semi-structured questionnaire with 87 socioeconomic and environmental questions was *** regression model was created to assess the odds ratio(OR)with P value and 95%confidence intervals(CI).RESULTS Predictive variables for both diseases(CD and UC)were women[odd ratios(OR)=1.31;OR=1.69],low monthly family income(OR=1.78;OR=1.57),lower number of cohabitants(OR=1.70;OR=1.60),absence of vaccination(OR=3.11;OR=2.51),previous history of bowel infections(OR=1.78;OR=1.49),and family history of IBD(OR=5.26;OR=3.33).Associated risk factors for CD were age(18-39 years)(OR=1.73),higher educational level(OR=2.22),absence of infectious childhood diseases(OR=1.99).The UC predictive variables were living in an urban area(OR=1.62),inadequate living conditions(OR=1.48)and former smokers(OR=3.36).Appendectomy was a risk factor for CD(OR=1.58)with inverse association with UC(OR=4.79).Consumption of treated and untreated water was associated with risk of CD(OR=1.38)and UC(OR=1.53),*** This is the first examining environmental exposures as risk factors for inflammatory bowel disease in *** of the variables associated with disease risk support the role of the hygiene hypothesis in IBD development.

关键词： Crohn’s disease Ulcerative colitis Risk factors Environmental factors Hygiene hypothesis

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Rhino-Orbito-Cerebral Mucormycosis in a Diabetic Patient with Idiopathic CD4+Lymphocytopenia

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Advances in Infectious Diseases 2013年第4期3卷 248-252页

作者： Nuno Rocha Pereira Paulo Andrade Laura sa Candida Abreu Rita Figueiredo Roberto silva Antonio sarmento Infectious Diseases department Centro Hospitalar Sao Joao and Faculty of Medicine of Porto UniversityPortoPortugal Neuroradiology department Centro Hospitalar Sao JoaoPortoPortugal Pathology department Centro Hospitalar Sao Joao and Faculty of Medicine of Porto UniversityPortoPortugal

A 54-year-old diabetic male, with idiopathic CD4 + lymphocytopenia, was presented with a two-month history of headache and periocular pain followed by vertigo, left hypoacusia and left peripheral facial palsy and hypoesthesia. More than a month after admission, a palate ulcer appeared and Infectious Diseases consultation was required. Mucormycosis was suspected and the diagnosis was confirmed by histologic examination. despite early surgery and combination antifungal therapy, the patient did not survive. This case report illustrates the difficulty in diagnosing a rare condition with non-specific clinical manifestations and underlines the importance of a timely multidisciplinary approach in order to recognise this highly fatal disease earlier. It also describes a previously non-reported situation of mucormycosis in a patient with idiopathic CD4 + lymphocytopenia.

关键词： Mucormycosis Idiopathic CD4+Lymphocytopenia Diabetes Amphotericin B

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Influence of Helicobacter pylori oncoprotein CagA in gastric cancer:A critical-reflective analysis

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World Journal of Clinical Oncology 2022年第11期13卷 866-879页

作者： Fabrício Freire de Melo Hanna santos Marques samuel Luca Rocha Pinheiro Fabian Fellipe Bueno Lemos Marcel silva Luz Kádima Nayara Teixeira Cláudio Lima Souza Márcio Vasconcelos Oliveira Instituto Multidisciplinar em saúde Universidade Federal da BahiaVitória da Conquista 45029-094Brazil Campus Vitória da Conquista Universidade Estadual do Sudoeste da BahiaVitória da Conquista 45029-094Brazil Campus Toledo Universidade Federal do ParanáToledo 85919899Brazil

Gastric cancer is the fifth most common malignancy and third leading cancerrelated cause of death *** pylori is a Gram-negative bacterium that inhabits the gastric environment of 60.3%of the world’s population and represents the main risk factor for the onset of gastric *** is the most important virulence factor in ***,and is a translocated oncoprotein that induces morphofunctional modifications in gastric epithelial cells and a chronic inflammatory response that increases the risk of developing precancerous *** translocation and tyrosine phosphorylation,CagA moves to the cell membrane and acts as a pathological scaffold protein that simultaneously interacts with multiple intracellular signaling pathways,thereby disrupting cell proliferation,differentiation and *** these alterations in cell biology increase the risk of damaged cells acquiring pro-oncogenic genetic *** this sense,once gastric cancer sets in,its perpetuation is independent of the presence of the oncoprotein,characterizing a“hit-and-run”carcinogenic ***,this review aims to describe ***-and CagA-related oncogenic mechanisms,to update readers and discuss the novelties and perspectives in this field.

关键词： Helicobacter pylori Virulence factors CagA Gastric cancer EPIYA motifs Hit-and-run carcinogenesis

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Immune response to Helicobacter pylori infection and gastric cancer development

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World Journal of Meta-Analysis 2021年第3期9卷 257-276页

作者： Breno Bittencourt de Brito Fabian Fellipe Bueno Lemos Caroline da Mota Carneiro Andressa santos Viana Nilo Manoel Pereira Vieira Barreto Gabriela Alves de Souza Assis Barbara Dicarlo Costa Braga Maria Luísa Cordeiro santos Filipe Antônio França da silva Hanna santos Marques Natália Oliveira e silva Fabrício Freire de Melo Instituto Multidisciplinar em saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil Campus Vitória da Conquista Universidade Estadual do Sudoeste da BahiaVitória da Conquista 45031900BahiaBrazil

Gastric adenocarcinoma is a global health concern,and Helicobacter pylori(***)infection is the main risk factor for its *** note,the immune response against the pathogen seems to be a determining factor for gastric oncogenesis,and increasing evidence have emphasized several host and bacterium factors that probably influence in this *** development of an inflammatory process against *** involves a wide range of mechanisms such as the activation of pattern recognition receptors and intracellular pathways resulting in the production of proinflammatory cytokines by gastric epithelial *** process culminates in the establishment of distinct immune response profiles that result from the cytokine-induced differentiation of T naïve cells into specific T helper *** released from each type of T helper cell orchestrate the immune system and interfere in the development of gastric cancer in idiosyncratic ***,variants in genes such as single nucleotide polymorphisms have been associated with variable predispositions for the occurrence of gastric malignancy because they influence both the intensity of gene expression and the affinity of the resultant molecule with its *** addition,various repercussions related to some *** virulence factors seem to substantially influence the host immune response against the infection,and many of them have been associated with gastric tumorigenesis.

关键词： Gastric cancer Helicobacter pylori Immune response Virulence factors Polymorphisms

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