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USE OF INFORMAtION tECHNOLOGIES IN INtEGRAtED PRODUCtION （IP） IN EUROPE:tHE ALMERIA’S CASE

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USE OF INFORMATION TECHNOLOGIES IN INTEGRATED PRODUCTION （I...

Preparation of microparticles and nanoparticles using membrane-assisted dispersion,micromixing,and evaporation processes

亚洲精细农业与计算机农业应用联合大会

作者： Martín M. Acebedo Vaz Samuel túnez fernando Bienvenido University of Almería Dept. Computer Languages and Sciences Almería Spain

Integrated Production is a production systems that accepted freely by farmers, assures the application of good agricultural practices, offering a quality label supported by the Ministry of Agriculture. Implementing this system requires a wide set of It tools in order to assure its application. In this paper, we discuss shortly main characteristics of IP and the different agents that participate in their implementation, describing briefly the different software systems used.

关键词： Integrated Production Sustainable Agriculture Plagues Control traceability

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Particuology 2024年第1期84卷 30-44页

作者： Goran t.Vladisavljevic Chemical Engineering Department Loughborough UniversityLoughboroughLeicestershire LE113TUUnited Kingdom

Synthetic microporous membranes are increasingly used for energy-efficient and controlled production of micro-and nanoparticles and micro-and nanoemulsions with tuneable morphology and physico-chemical properties through various micromixing,emulsification,and evaporation processes.In emul-sification processes,the membrane pores are used for dispersed phase injection and size-controlled generation of droplets and droplet-templated particles.In micromixing processes,membrane is utilised as a micromixer for mixing two miscible liquids,usually solvent and antisolvent-rich solutions,which leads to the creation of supersaturation and subsequent nanoprecipitation or crystallisation.In mem-brane evaporation processes,membrane is used to prevent phase dispersion while allowing efficient molecular diffusion of solvent and/or antisolvent vapour through gas-filled pores.Membrane dispersion processes can be operated continuously by decoupling shear stress on the membrane surface from cross flow using tube insets,flow pulsations,swirling flow,membrane oscillations or membrane rotations.Droplet generation and solidification can be performed continuously in a single pass by connecting membrane module with a downstream reactor.Membrane dispersion processes can be used for pro-duction of nanoparticles such as nanovesicles(liposomes,micelles,ethosomes,and niosomes),nanogels,polymeric,lipid and metallic nanoparticles,and nanocrystals.the main advantages of membrane-assisted particle generation are in low energy consumption,controlled geometry and hydrodynamic conditions at the microscale level,flexible throughput due to modular and scalable design of membrane devices,and a wide choice of available microporous membranes with various wall porosities,wetta-bilities,pore sizes,and pore morphologies to suit different applications.

关键词： Nanoparticles Microparticles Nanoemulsions Microemulsions Microporous membrane Crystallisation Flash nanoprecipitation Emulsification Zero liquid discharge

Most patients with non-hypertensive diseases at a critical care resuscitation unit require arterial pressure monitoring: a prospective observational study

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World Journal of Emergency Medicine 2023年第3期14卷 173-178页

作者： Emily Engelbrecht-Wiggans Jamie Palmer Grace Hollis fernando Albelo Afrah Ali Emily Hart Dominique Gelmann Iana Sahadzic James Gerding Quincy K.tran Daniel J.Haase University of Maryland School of Medicine Baltimore 21201USA the Research Associate Program in Emergency Medicine and Critical Care Department of Emergency MedicineUniversity of Maryland School of MedicineBaltimore 21201USA Department of Emergency Medicine University of Maryland School of MedicineBaltimore 21201USA Program in trauma the R Adams Cowley Shock Trauma CenterUniversity of Maryland School of MedicineBaltimore 21201USA

BACKGROUND:Blood pressure(BP)monitoring is essential for patient care.Invasive arterial BP(IABP)is more accurate than non-invasive BP(NIBP),although the clinical signifi cance of this diff erence is unknown.We hypothesized that IABP would result in a change of management(COM)among patients with non-hypertensive diseases in the acute phase of resuscitation.MEtHODS:this prospective study included adults admitted to the Critical Care Resuscitation Unit(CCRU)with non-hypertensive disease from February 1,2019,to May 31,2021.Management plans to maintain a mean arterial pressure>65 mmHg(1 mmHg=0.133 kPa)were recorded in real time for both NIBP and IABP measurements.A COM was defined as a discrepancy between IABP and NIBP that resulted in an increase/decrease or addition/discontinuation of a medication/infusion.Classification and regression tree analysis identified significant variables associated with a COM and assigned relative variable importance(RVI)values.RESULtS:Among the 206 patients analyzed,a COM occurred in 94(45.6%[94/206])patients.the most common COM was an increase in current infusion dosages(40 patients,19.4%).Patients receiving norepinephrine at arterial cannulation were more likely to have a COM compared with those without(45[47.9%]vs.32[28.6%],P=0.004).Receiving norepinephrine(relative variable importance[RVI]100%)was the most signifi cant factor associated with a COM.No complications were identifi ed with IABP use.CONCLUSION:A COM occurred in 94(45.6%)non-hypertensive patients in the CCRU.Receiving vasopressors was the greatest factor associated with COM.Clinicians should consider IABP monitoring more often in non-hypertensive patients requiring norepinephrine in the acute resuscitation phase.Further studies are necessary to confi rm the risk-to-benefi t ratios of IABP among these high-risk patients.

关键词： Non-hypertensive diseases Invasive arterial blood pressure Non-invasive blood pressure

Diabetic nephropathy,autophagy and proximal tubule protein endocytic transport:A potentially harmful relationship

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BIOCELL 2018年第2期42卷 35-40页

作者： Maximiliano GIRAUD-BILLOUD Claudio M.FADER Rocío AGÜERO fernando EZQUER Marcelo EZQUER IHEM Universidad Nacional de CuyoCONICETMendozaArgentina Universidad Nacional de Cuyo Facultad de Ciencias MédicasInstituto de FisiologíaCasilla de Correo 335500-MendozaArgentina Universidad Nacional de Cuyo Facultad de OdontologíaCasilla de Correo 335500-MendozaArgentina Centro de Medicina Regenerativa Facultad de Medicina Clínica AlemanaUniversidad del DesarrolloAvenida Las Condes 12438SantiagoChile

Diabetic nephropathy(DN)is the most frequent cause of chronic renal failure.Until now,the pathophysiological mechanisms that determine its development and progression have not yet been elucidated.In the present study,we evaluate the role of autophagy at early stages of DN,induced in type 2 diabetes mellitus(t2DM)mouse,and its association with proximal tubule membrane endocytic receptors,megalin and cubilin.In t2DM animals we observed a tubule-interstitial injury with significantly increased levels of urinary GGt and ALP,but an absence of tubulointerstitial fibrosis.Kidney proximal tubule cells of t2DM animals showed autophagic vesicles larger than those observed in the control group,and an increase in the number of these vesicles marked with LBPA by immunofluorescence.Furthermore,a significant decrease in the ratio of LC3II/LC3I isoforms and in p62 protein expression in DN affected animals is shown.Finally,we observed a marked increase in urinary albumin and vitamin D binding-protein levels in t2DM animals as well as a significant decrease in expression of megalin in the renal cortex.these results indicate an alteration of the tubular endocytic transporters in DN,which could be related to autophagic dysfunction,which would in turn result in impaired organelle recycling,thus contributing to the progression of this disease.

关键词： Megalin Cubilin type 2 diabetes mellitus

Optimization of an innovative approach involving mechanical activation and acid digestion for the extraction of lithium from lepidolite

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International Journal of Minerals,Metallurgy and Materials 2018年第1期25卷 11-19页

作者： Nathalia Vieceli Carlos A.Nogueira Manuel F.C.Pereira fernando O.Durao Carlos Guimaraes Fernanda Margarido Center for Innovation Technology and Po icy Research-IN+Instituto Superior T6cnicoUniversity of Lisbon1049-001 LisboaPortugal LNEG-Laborat6rio Nacional de Energia e Geologia I.P.Campus do Lumiar1649-038 LisboaPortugal CERENA-Centro de Recursos Naturais e Ambiente DECivilInstituto Superior T6cnicoUniversity of Lisbon1049-001 LisboaPortugal

the recovery of lithium from hard rock minerals has received increased attention given the high demand for this element. there- fore, this study optimized an innovative process, which does not require a high-temperature calcination step, for lithium extraction from le- pidolite. Mechanical activation and acid digestion were suggested as crucial process parameters, and experimental design and re- sponse-surface methodology were applied to model and optimize the proposed lithium extraction process. the promoting effect of amorphi- zation and the formation of lithium sulfate hydrate on lithium extraction yield were assessed. Several factor combinations led to extraction yields that exceeded 90%, indicating that the proposed process is an effective approach for lithium recovery.

关键词： lepidolite lithium mechanical activation acid digestion optimization extraction

Comparing the Soil Conservation Service model with new machine learning algorithms for predicting cumulative infiltration in semi-arid regions

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Pedosphere 2022年第5期32卷 718-732页

作者： Khabat KHOSRAVI Phuong t.t.NGO Rahim BARZEGAR John QUILtY Mohammad t.AALAMI Dieu t.BUI Department of Watershed Management Engineering Ferdowsi University of MashhadMashhad 93(Iran) Department of Earth and Environment Florida International UniversityMiami 33199(USA) Institute of Research and Development Duy Tan UniversityDa Nang 550000(Vietnam) Department of Bioresource Engineering McGill UniversitySte Anne de Bellevue QC H9X(Canada) Faculty of Civil Engineering University of TabrizTabriz 51(Iran) Department of Civil and Environmental Engineering University of WaterlooWaterloo N2L 3G1(Canada) Department of Business and It University of South-Eastern NorwayNotodden 3603(Norway)

Water infiltration into soil is an important process in hydrologic cycle;however,its measurement is difficult,time-consuming and costly.Empirical and physical models have been developed to predict cumulative infiltration(CI),but are often inaccurate.In this study,several novel standalone machine learning algorithms(M5Prime(M5P),decision stump(DS),and sequential minimal optimization(SMO))and hybrid algorithms based on additive regression(AR)(i.e.,AR-M5P,AR-DS,and AR-SMO)and weighted instance handler wrapper(WIHW)(i.e.,WIHW-M5P,WIHW-DS,and WIHW-SMO)were developed for CI prediction.the Soil Conservation Service(SCS)model developed by the United States Department of Agriculture(USDA),one of the most popular empirical models to predict CI,was considered as a benchmark.Overall,154 measurements of CI(explanatory/input variables)were taken from 16 sites in a semi-arid region of Iran(Illam and Lorestan provinces).Six input variable combinations were considered based on Pearson correlations between candidate model inputs(time of measuring and soil bulk density,moisture content,and sand,clay,and silt percentages)and CI.the dataset was divided into two subgroups at random:70%of the data were used for model building(training dataset)and the remaining 30%were used for model validation(testing dataset).the various models were evaluated using different graphical approaches(bar charts,scatter plots,violin plots,and taylor diagrams)and quantitative measures(root mean square error(RMSE),mean absolute error(MAE),Nash-Sutcliffe efficiency(NSE),and percent bias(PBIAS)).time of measuring had the highest correlation with CI in the study area.the best input combinations were different for different algorithms.the results showed that all hybrid algorithms enhanced the CI prediction accuracy compared to the standalone models.the AR-M5P model provided the most accurate CI predictions(RMSE=0.75 cm,MAE=0.59 cm,NSE=0.98),while the SCS model had the lowest performance(RMSE=4.77 cm,MAE=2.64 cm,NSE=0.23).the differences in RMSE between the best m

关键词： additive regression hybrid algorithms empirical model soil water infiltration weighted instances handler wrapper

Coherent-interface-induced strain in large lattice-mismatched materials:A new approach for modeling Raman shift

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Nano Research 2022年第3期15卷 2405-2412页

作者： Andrian V.Kuchuk fernando Mde Oliveira Pijush K.Ghosh Yuriy I.Mazur Hryhorii V.Stanchu Marcio D.teodoro Morgan E.Ware Gregory J.Salamo Institute for Nanoscience and Engineering University of ArkansasFayettevilleAR 72701USA Departamento de Física Universidade Federal de São CarlosSão CarlosSP 13565-905Brazil Department of Electrical Engineering University of ArkansasFayettevilleAR 72701USA

Strain engineering as one of the most powerful techniques for tuning optical and electronic properties of III-nitrides requires reliable methods for strain investigation.In this work,we reveal,that the linear model based on the experimental data limited to within a small range of biaxial strains(the non-destructive Raman study of strain with nanometer-scale spatial resolution is not valid for the binary wurtzite-structure group-III nitrides GaN and AlN.Importantly,we found that the discrepancy between the experimental values of strain and those calculated via Raman spectroscopy increases as the strain in both GaN and AlN increases.Herein,a new model has been developed to describe the strain-induced Raman frequency shift in GaN and AlN for a wide range of biaxial strains(up to 2.5%).Finally,we proposed a new approach to correlate the Raman frequency shift and strain,which is based on the lattice coherency in the epitaxial layers of superlattice structures and can be used for a wide range of materials.

关键词： Raman spectroscopy strain lattice coherency III-nitrides high-resolution X-ray diffraction(HRXRD)

Low hypoxia inducible factor-1α(HIF-1α)expression in testicular germ cell tumors--a major reason for enhanced chemosensitivity?

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Chinese Journal of Cancer Research 2017年第4期29卷 374-378页

作者： niraj shenoy roxana dronca fernando quevedo stephen a boorjian john cheville brian costello manish kohli thomas witzig lance pagliaro division of oncology mayo clinicRochesterMN 55905usa department of urology mayo clinicRochesterMN 55905usa division of clinical pathology mayo clinicRochesterMN 55905usa

the molecular basis for enhanced chemosensitivity of testicular germ cell tumors （GCt） has been an area of great interest, as it could potentially give us therapeutic leads in other resistant malignancies. thus far, however, the increased sensitivity of C＆t has been variously attributed to multiple factors -- an inability to detoxify cisplatin, a lack of export pumps, an inability to repair the DNA damage, an intact apoptotic cascade and lack of p53 mutation; but a unifying underlying etiology leading to the aforementioned processes and having a translational implication has so far been elusive. Herein, we offer evidence to support a potential significant role for the previously demonstrated low hypoxia inducible factor-la （HIF-la） expression in mediating the general exquisite chemosensitivity of testicular GCt, through the aforementioned processes. this molecular mechanism based hypothesis could have a significant translational implication in platinum refractory GCt as well as other platinum resistant malignancies.

关键词： Hypoxia inducible factor-la （HIF-la） testicular germ cell tumor chemosensitivity

Stem cell-based therapy for human diseases

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Signal transduction and targeted therapy 2022年第9期7卷 3242-3282页

作者： Duc M.Hoang Phuong t.Pham trung Q.Bach Anh t.L.Ngo Quyen t.Nguyen trang t.K.Phan Giang H.Nguyen Phuong t.t.Le Van t.Hoang Nicholas R.Forsyth Michael Heke Liem thanh Nguyen Department of Research and Development Vinmec Research Institute of Stem Cell and Gene TechnologyVinmec Healthcare SystemHanoiVietnam Department of Cellular therapy Vinmec High.Tech CenterVinmec Healthcare SsystemHanoiVietnam Institute for Science&technology in Medicine Keele UniversityKeeleUK a Department of Biology Stanford UniversityStanfordCAUSA

Recent advancements in stem cell technology open a new door for patients suffering from diseases and disorders that have yet to be treated.Stem cell-based therapy,including human pluripotent stem cells(hPsCs)and multipotent mesenchymal stem cells(MSCs),has recently emerged as a key player in regenerative medicine.hPSCs are defined as self-renewable cell types conferring the ability to differentiate into various cellular phenotypes of the human body,including three germ layers.MsCs are multipotent progenitor cells possessing self-renewal ability(limited in vitro)and differentiation potential into mesenchymal lineages,according to the International Society for Cell and Gene therapy(ISCt).this review provides an update on recent clinical applications using either hPSCs or MSCs derived from bone marrow(BM),adipose tissue(At),or the umbilical cord(UC)for the treatment of human diseases,including neurological disorders,pulmonary dysfunctions,metabolic/endocrine-related diseases,reproductive disorders,skin burns,and cardiovascular conditions.Moreover,we discuss our own clinical trial experiences on targeted therapies using MsCs in a clinical setting,and we propose and discuss the MSC tissue origin concept and how MSC origin may contribute to the role of MSCs in downstream applications,with the ultimate objective of facilitating translational research in regenerative medicine into clinical applications.the mechanisms discussed here support the proposed hypothesis that BM-MSCs are potentially good candidates for brain and spinal cord injury treatment,At-MSCs are potentially good candidates for reproductive disorder treatment and skin regeneration,and UC-MsCs are potentially good candidates for pulmonary disease and acute respiratory distress svndrometreatment.

关键词： diseases distress treatment