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Computers, Materials & Continua 2016年第3期51卷 203-215页

作者： J.Solórzano-López F.A.García-pastor Angélica Flores-Luna UNAM Facultad de QuímicaCiudad de MéxicoMéxico Cinvestav Unidad Saltillo CoahuilaMéxico TecNM Instituto Tecnológico de Tláhuac IIICiudad de MéxicoMéxico

Shot peening is a widely used technique to improve fatigue life in metallic *** processing technique introduces a subsurface compressive residual stress field through a plastic deformation of the surface caused by the impact of a large number of high-speed *** are a number of parameters that affect the residual stress field depth and *** effects of the impact angle,shot speed and shot geometry are currently being *** particular,substituting spherical cast shots by cylindrical cut wire shots is an attractive option,especially in terms of *** effect of shot geometry on residual stresses,however,needs to be further *** industrial-scale experimentation is costly and cumbersome,mathematical modeling offers a convenient alternative to carry out this type of *** present work shows a comparison between the residual stresses generated by the impact of spherical and cylindrical projectiles on a steel *** threedimensional model was developed using ABAQUS finite element commercial software(Release 6.12,Dassault Systémes,France).The results show that cylindrical shots generate residual stress fields t hat a re higher in magnitude than t hose generated by a spherical ***,the residual stress field of cylindrical shots impacting the surface at an oblique angle shows an important degree of *** effect is not found when spherical shots impact the surface at the same oblique angle.

关键词： Shot Peening Finite element method Residual Stresses

FRACTIONAL-STEP FINITE ELEMENT METHOD FOR CALCULATION OF 3-D FREE SURFACE PROBLEM USING LEVEL SET METHOD

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Journal of Hydrodynamics 2006年第6期18卷 742-747页

作者： ZHAO Lan-hao LI Tong-chun WANG Ling HERREROS M. I. pastor M. College of Water Conservancy and Hydropower Engineering Hohai University Naniing 210098 China Anhui Survey and Design Institute of Water Conservancy and Hydropower Hefei 230022 China CEDEX and E.T.S. de Caminos Madrid Spain

A two-step Taylor-Galerkin fractional-step finite element method, which is of second order accuracy in space and time, was proposed for the three-dimensional free surface problem. With this method, the intermediate velocity was explicitly obtained by neglecting pressure gradient term, and then the velocity was corrected by adding the effects of pressure once the pressure field had been obtained from the pressure Poisson equation. The level set approach was applied to track implicitly the free surface. In order to track the free surface, the transport equation of the level set function was solved at each time step and the level set function is reinitialized through iteration to maintain it as a distance function. The governing equations of the system were discretized by the two- step Taylor-Galerkin method, which is of high-order accuracy and easy to be used. The validity and reliability of this method in this article were proved by two numerical examples.

关键词： level set free surface two steps Taylor-Galerkin fractional step FEM

Temperature Responses to Infrared-Loading and Water Table Manipulations in Peatland Mesocosms

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Journal of Integrative Plant Biology 2008年第11期50卷 1484-1496页

作者： Jiquan Chen Scott Bridgham Jason Keller John pastor Asko Noormets Jake F.Weltzin Department of Environmental Sciences University of Toledo Center for Ecology and Evolutionary Biology University of Oregon Smithsonian Environmental Research Center Department of Biological Sciences University of Minnesota National Phenology Network

We initiated a multi-factor global change experiment to explore the effects of infrared heat loading （HT） and water table level （WL） treatment on soil temperature （T） in bog and fen peatland mesocosms. We found that the temperature varied highly by year, month, peatland type, soil depth, HT and WL manipulations. The highest effect of HT on the temperature at 25 cm depth was found in June for the bog mesocosms （3.34-4.27 ℃） but in May for the fen mesocosms （2.32-4.33 ℃） over the 2-year study period. The effects of WL in the bog mesocosms were only found between August and January, with the wet mesocosms warmer than the dry mesocosms by 0.48-2.03 ℃ over the 2-year study period. In contrast, wetter fen mesocosms were generally cooler by 0.16-3.87℃. Seasonal changes of temperatures elevated by the HT also varied by depth and ecosystem type, with temperature differences at 5 cm and 10 cm depth showing smaller seasonal fluctuations than those at 25 cm and 40 cm in the bog mesocosms. However, increased HT did not always lead to warmer soil, especially in the fen mesocosms. Both HT and WL manipulations have also changed the length of the non-frozen season.

关键词： global change infrared mesocosm peatlands warming experiment water table.

Neutrophil depletion-but not prevention of Kupffer cell activation-decreases the severity of cerulein-induced acute pancreatitis

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World Journal of Gastroenterology 2006年第8期12卷 1219-1224页

作者： Catherine M pastor Alain Vonlaufen Fabianna Georgi Antoine Hadengue Philippe Morel Jean-Louis Frossard Laboratoire de Physiopathologie Hépatique et Imagerie Moléculaire H■pitaux Universitaires de GenèveB■timent CRoom 6-79524 Rue Micheli-du-Crest1205 GenevaSwitzerland Division of Gastroentérologie et Hépatologie H■pitaux Universitaires de Genève24 Rue Micheli-du-Crest1205 GenevaSwitzerland Département APSI H■pitaux Universitaires de Genève24 Rue Micheli-du-Crest1205 GenevaSwitzerland Département de Chirurgie H■pitaux Universitaires de Genève24 Rue Micheli-du-Crest1205 GenevaSwitzerland

AIM： To determine whether neutrophil depletion and Kupffer cell inhibition might combine their protective effects to decrease the severity of acute pancreatitis. METHODS： Nice had cerulein administration to induce acute pancreatitis and were pretreated with either anti-mouse neutrophil serum or gadolinium chloride （GdCh） to prevent Kupffer cell activation, or both treatments. Injury was assessed in pancreas and lungs. Myeloperoxidases （MPO） assessed neutrophil infiltration. Interleukin-6 （IL-6） and IL-10 were measured in serum, pancreas, lungs and liver. RESULTS： In mice with acute pancreatitis, neutrophil depletion reduced the severity of pancreatitis and pancreatitis-associated lung injury. Kupffer cell inactivation by GdCh had less protective effect, although IL-6 and IL-10 concentrations were significantly decreased. The protective treatment brought by neutrophil depletion was not enhanced by Kupffer cell inactivation and both treatments did not combine their protective effects. CONCLUSION： Our results confirm the role of activated neutrophils in aggravating organ injury in acute pancreatitis while the role of Kupffer cell activation is less obvious.

关键词： Acute pancreatitis Cytokines Neutrophils Kupffer cells Pulmonary injury

Recent developments of generalized plasticity models for saturated and unsaturated soils

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Water Science and Engineering 2011年第3期4卷 329-344页

作者： Hong-en LI Yong-jun HE Guang-ya FAN Tong-chun LI Manuel pastor Dam Safety Management Department Nanjing Hydraulic Research Institute Nanjing 210029 P. R. China Dam Safety Management Center of Ministry of Water Resources Nanjing 210029 P. R. China College of Water Conservancy and Hydropower Engineering Hohai University Nanjing 210098 P. R. China Department of Applied Mathematics Technical University of Madrid Madrid 28040 Spain

Soil undergoes both elastic and plastic deformations under different loading conditions. A relatively accurate constitutive model of soil behaviors should be capable of predicting the elastic and plastic deformations properly. Among a large number of elastoplastic constitutive models developed over the last several decades, constitutive models based on generalized plasticity have been successfully utilized in modeling the mechanical behavior of various soils. This paper attempts to present a review of the most recent developments of generalized plasticity models for geotechnical problems. After a brief review of generalized plasticity theories and constitutive models, limitations of the original pastor-Zienkiewicz model in practical application are summarized. Afterwards, recent achievements in the generalized plasticity models for both saturated and unsaturated soils and their applicability are analyzed, and a general approach for modification of generalized plasticity models is highlighted.

关键词： generalized plasticity constitutive model pastor-Zienkiewicz model saturated and unsaturated soils

The sound of host-SARS-CoV-2 molecular interactions

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The Innovation 2021年第3期2卷 5-6页

作者： Joséde la Fuente Juan J.pastor Comín Christian Gortázar SaBio.Instituto de Investigación en Recursos Cinegéticos IREC-CSIC-UCLM-JCCM Ronda de Toledo s/n13005 Ciudad RealSpain Department of Veterinary Pathobiology Center for Veterinary Health SciencesOklahoma State UniversityStillwaterOK 74078USA Centro de Investigación y Documentación Musical CIDoM-UCLM-CSIC Facultad de Educación de Ciudad RealRonda Calatrava 313071 Ciudad RealSpain

Host-and virus-derived factors are key drivers of the COVID-19 pandemic(Gortázar et al.).1 The interaction between the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)spike glycoprotein(S)and host cell membrane angiotensin I converting enzyme 2(ACE2)receptor is highly dynamic,mediates virus infection,and is the main target for protective antibody response2.

关键词： ACE2 protective acute

Evaluating the potential of(epi)genotype‑by‑low pass nanopore sequencing in dairy cattle:a study on direct genomic value and methylation analysis

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Journal of Animal Science and Biotechnology 2023年第6期14卷 2276-2289页

作者： Oscar Gonzalez‑Recio Adrian Lopez‑Catalina Ramon Peiro‑pastor Alicia Nieto‑Valle Monica Castro Almudena Fernandez Dpt.Mejora Genetica Animal INIA-CSICCtra La Coruna Km 7.528040 MadridSpain. ETSIAAB Universidad Politecnica de Madrid.Ciudad Universitaria S/N28040 MadridSpain.

Background Genotype-by-sequencing has been proposed as an alternative to SNP genotyping arrays in genomic selection to obtain a high density of markers along the *** requires a low sequencing depth to be cost effective,which may increase the error at the genotype *** generation nanopore sequencing technology offers low cost sequencing and the possibility to detect genome methylation,which provides added value to *** aim of this study was to evaluate the performance of genotype-by-low pass nanopore sequencing for estimating the direct genomic value in dairy cattle,and the possibility to obtain methylation marks *** Latest nanopore chemistry(LSK14 and Q20)achieved a modal base calling accuracy of 99.55%,whereas previous kit(LSK109)achieved slightly lower accuracy(99.1%).The direct genomic value accuracy from genotype-by-low pass sequencing ranged between 0.79 and 0.99,depending on the trait(milk,fat or protein yield),with a sequencing depth as low as 2×and using the latest chemistry(LSK114).Lower sequencing depth led to biased estimates,yet with high rank *** LSK109 and Q20 achieved lower accuracies(0.57-0.93).More than one million high reliable methylated sites were obtained,even at low sequencing depth,located mainly in distal intergenic(87%)and promoter(5%)*** This study showed that the latest nanopore technology in useful in a LowPass sequencing framework to estimate direct genomic values with high *** may provide advantages in populations with no available SNP chip,or when a large density of markers with a wide range of allele frequencies is *** addition,low pass sequencing provided nucleotide methylation status of>1 million nucleotides at≥10×,which is an added value for epigenetic studies.

关键词： Genomic selection Genomic values Low pass sequencing Low sequencing imputation Polygenic risk score

Nanoparticles with high payloads of pipemidic acid, a poorly soluble crystalline drug: drug-initiated polymerization and self-assembly approach

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Acta Pharmaceutica Sinica B 2018年第3期8卷 420-431页

作者： Elisabetta Pancani Mario Menendez-Miranda Alexandra pastor Francois Brisset Marie-Francoise Bernet-Camard Didier Desmaele Ruxandra Gref Institut de Sciences Moléculaires d'Orsay(ISMO) Univ.of Paris-SudUniversitéParis-Saclay Institut Galien UMR8612 Univ.of Paris-SudUniversitéParis-Saclay Institut de Chimie Moléculaire et des Matériaux d'Orsay(ICMMO) Univ.of Paris-SudUniversitéParis-Saclay EA4043" UnitéBactéries Pathogènes et Santé"(UBaPS) Univ.of Paris-SudUniversitéParis-Saclay

Nowadays, biodegradable polymers such as poly(lactic acid)(PLA), poly(D,L-lactic-coglycolic acid)(PLGA) and poly(ε-caprolactone)(PCL) remain the most common biomaterials to produce drug-loaded nanoparticles(NPs). Pipemidic acid(PIP) is a poorly soluble antibiotic with a strong tendency to crystallize. PIP incorporation in PLA/PLGA NPs was challenging because of PIP crystals formation and burst release. As PIP had a poor affinity for the NPs, an alternative approach to encapsulation was used, consisting in coupling PIP to PCL. Thus, a PCL–PIP conjugate was successfully synthesized by an original drug-initiated polymerization in a single step without the need of ***–PIP was characterized by NMR, IR, SEC and mass spectrometry. PCL–PIP was used to prepare selfassembled NPs with PIP contents as high as 27%(w/w). The NPs were characterized by microscopy,DLS, NTA and TRPS. This study paves the way towards the production of NPs with high antibiotic payloads by drug-initiated polymerization. Further studies will deal with the synthesis of novel polymer–PIP conjugates with ester bonds between the drug and PCL. PIP can be considered as a model drug and the strategy developed here could be extended to other challenging antibiotics or anticancer drugs and employed to efficiently incorporate them in NPs.

关键词： Pipemidic acid Nanoparticle Antibiotic Nanoprecipitation Crystalline drug Drug-initiated polymerization

Role of vascular endothelial growth factor as a critical neurotrophic factor for the survival and physiology of motoneurons

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Neural Regeneration Research 2023年第8期18卷 1691-1696页

作者： Paula M.Calvo Rosendo G.Hernández Rosa R.de la Cruz Angel M.pastor Departamento de Fisiología Facultad de BiologíaUniversidad de SevillaSevillaSpain

Vascular endothelial growth factor(VEGF)was discovered by its angiogenic ***,during evolution,it appeared earlier as a neurotrophic factor required for the development of the nervous system in invertebrates lacking a circulatory *** aimed at reviewing recent evidence indicating that VEGF has neuroprotective effects in neurons exposed to a variety of *** particular interest is the link established between VEGF and motoneurons,especially after the design of the VEGFδ/δmutant *** mice are characterized by low levels of VEGF and develop muscle weakness and motoneuron degeneration resembling amyotrophic lateral *** administration of VEGF through several routes to animal models of amyotrophic lateral sclerosis delays motor impairment and motoneuron degeneration and increases life *** are new recent advances in the role of VEGF in the physiology of *** experimental aims use the extraocular(abducens)motoneurons lesioned by axotomy as a model for studying VEGF *** abducens motoneurons exhibit severe alterations in their discharge activity and a loss of synaptic *** exogenous administration of VEGF to axotomized abducens motoneurons,either from the transected nerve or intraventricularly,fully restores the synaptic and discharge properties of abducens motoneurons,despite being *** addition,when an anti-VEGF neutralizing antibody is delivered from the muscle to intact,uninjured abducens motoneurons,these cells display alterations in their discharge pattern and a loss of synaptic boutons that resemble the state of *** these data indicate that VEGF is an essential neurotrophic factor for motoneurons.

关键词： abducens nucleus amyotrophic lateral sclerosis cell death extracellular single-unit recordings eye movements neurodegeneration oculomotor trophic factors

Vascular endothelial growth factor：an essential neurotrophic factor for motoneurons？

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Neural Regeneration Research 2018年第7期13卷 1181-1182页

作者： Paula M.Calvo Angel M.pastor Rosa R.de la Cruz Departamento de Fisiologia Facultad de Biologia Universidad de Sevilla Sevilla Spain

Vascular endothelial growth factor（VEGF）,an angiogenic factor with neuroprotective effects：The VEGF was initially characterized by its vasculogenic and angiogenic activities and its capacity to promote vascular permeability（Yancopoulos et al.,2000）.VEGF is also known as VEGF-A and is the prototype member of a related group of five trophic factors,VEGF-B,VEGF-C,VEGF-D and placental growth factor（Pl GF;Lange et al.,2016）.

关键词： VEGFR Vascular endothelial growth factor:an essential neurotrophic factor for motoneurons