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Preface to the Special Topic on Ocean, Sea Ice and Northern Hemisphere Climate:In Remembrance of Professor Yongqi GAO's Key Contributions

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Advances in Atmospheric Sciences 2024年第8期41卷 1463-1464页

作者： noel KEENLYSIDE Shengping HE Fei LI Geophysical Institute University of Bergen and Bjerkenes Centre for Climate ResearchBergen 5007Norway Nansen Environmental and Remote Sensing Center Bergen 5007Norway Nansen-Zhu International Research Center Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China

This special issue commemorates the life work of Prof. Yongqi GAO who passed away in July 2021, his time cut short by illness. He had many great achievements, but still much more to contribute. The seven articles in this special issue are from research areas where he contributed, and they illustrate how his close colleagues are continuing his work.

关键词： Ice Hemisphere Climate

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Highly toxic Aβ begets more Aβ

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Neural Regeneration Research 2024年第9期19卷 1871-1872页

作者： Merc M.Kemeh noel D.Lazo Gustaf H.Carlson School of Chemistry and Biochemistry Clark UniversityWorcesterMAUSA

Alzheimer’s disease(AD)is the most common form of dementia-the 7th leading cause of death *** the tissue level,AD is characterized by the presence of extracellular amyloid plaques that are comprised primarily of the amyloid-βpeptide(Aβ),and by intraneuronal neurofibrillary tangles composed of *** genetics of early-onset AD and longitudinal brain-imaging studies of late-onset AD indicate that extracellular Aβdeposition,in general,precedes neurofibrillary tangle formation in neurons(Hampel et al.,2021;Young-Pearse et al.,2023).

关键词： Aβ tau Alzheimer death

Projecting Spring Consecutive Rainfall Events in the Three Gorges Reservoir Based on Triple-Nested Dynamical Downscaling

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Advances in Atmospheric Sciences 2024年第8期41卷 1539-1558页

作者： Yanxin ZHENG Shuanglin LI noel KEENLYSIDE Shengping HE Lingling SUO Department of Atmospheric Science CMA-CUG Joint Centre for Severe Weather and Climate and Hydro-geological HazardsChina University of GeosciencesWuhan 430074China Institute of Atmospheric Physics and Climate Change Research Center Chinese Academy of SciencesBeijing 100029China Three Gorges National Climatological Observatory Yichang 443099China Geophysical Institute University of Bergen and Bjerknes Centre for Climate ResearchBergen 5007Norway Nansen Environmental and Remote Sensing Center and Bjerknes Centre for Climate Research Bergen 5007Norway Nansen-Zhu International Research Centre Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China

Spring consecutive rainfall events(CREs) are key triggers of geological hazards in the Three Gorges Reservoir area(TGR), China. However, previous projections of CREs based on the direct outputs of global climate models(GCMs) are subject to considerable uncertainties, largely caused by their coarse resolution. This study applies a triple-nested WRF(Weather Research and Forecasting) model dynamical downscaling, driven by a GCM, MIROC6(Model for Interdisciplinary Research on Climate, version 6), to improve the historical simulation and reduce the uncertainties in the future projection of CREs in the TGR. Results indicate that WRF has better performances in reproducing the observed rainfall in terms of the daily probability distribution, monthly evolution and duration of rainfall events, demonstrating the ability of WRF in simulating CREs. Thus, the triple-nested WRF is applied to project the future changes of CREs under the middle-of-the-road and fossil-fueled development scenarios. It is indicated that light and moderate rainfall and the duration of continuous rainfall spells will decrease in the TGR, leading to a decrease in the frequency of CREs. Meanwhile, the duration, rainfall amount, and intensity of CREs is projected to regional increase in the central-west TGR. These results are inconsistent with the raw projection of MIROC6. Observational diagnosis implies that CREs are mainly contributed by the vertical moisture advection. Such a synoptic contribution is captured well by WRF, which is not the case in MIROC6,indicating larger uncertainties in the CREs projected by MIROC6.

关键词： triple-nested downscaling Three Gorges Reservoir area consecutive rainfall events geological hazards projection

Arctic Sea Ice Variations in the First Half of the 20th Century:A New Reconstruction Based on Hydrometeorological Data

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Advances in Atmospheric Sciences 2024年第8期41卷 1483-1495,1686-1693页

作者： Vladimir A.SEMENOV Tatiana A.ALDONINA Fei LI noel Sebastian KEENLYSIDE Lin WANG A.M.Obukhov Institute of Atmospheric Physics RAS Moscow 119017Russia Institute of Geography RAS Moscow 119017Russia Geophysical Institute University of Bergen and Bjerknes Centre for Climate ResearchBergen 5007Norway Nansen Environmental and Remote Sensing Center Bergen 5007Norway Center for Monsoon System Research Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China

The shrinking Arctic sea-ice area(SIA) in recent decades is a striking manifestation of the ongoing climate *** of the Arctic sea ice have been continuously observed by satellites since 1979, relatively well monitored since the 1950s, but are highly uncertain in the earlier period due to a lack of observations. Several reconstructions of the historical gridded sea-ice concentration(SIC) data were recently presented based on synthesized regional sea-ice observations or by applying a hybrid model–empirical approach. Here, we present an SIC reconstruction for the period1901–2019 based on established co-variability between SIC and surface air temperature, sea surface temperature, and sea level pressure patterns. The reconstructed sea-ice data for March and September are compared to the frequently used Had ISST1.1 and SIBT1850 datasets. Our reconstruction shows a large decrease in SIA from the 1920 to 1940 concurrent with the Early 20th Century Warming event in the Arctic. Such a negative SIA anomaly is absent in Had ISST1.1 data. The amplitude of the SIA anomaly reaches about 0.8 mln km^(2) in March and 1.5 mln km^(2) in September. The anomaly is about three times stronger than that in the SIBT1850 dataset. The larger decrease in SIA in September is largely due to the stronger SIC reduction in the western sector of the Arctic Ocean in the 70°–80°N latitudinal zone. Our reconstruction provides gridded monthly data that can be used as boundary conditions for atmospheric reanalyses and model experiments to study the Arctic climate for the first half of the 20th century.

关键词： Arctic sea ice Arctic climate early 20th century warming climate variability

Management of early oesophageal cancer:An overview

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World Journal of Gastrointestinal Surgery 2024年第5期16卷 1255-1258页

作者： Gavin G Calpin Matthew G Davey noel E Donlon Department of Surgery Royal College of Surgeons in IrelandDublin D2Ireland Department of Upper Gastrointestinal Surgery Beaumont HospitalDublin D09V2N0Ireland

The incidence of esophageal cancer,namely the adenocarcinoma subtype,continues to increase exponentially on an annual *** indolent nature of the disease renders a significant proportion inoperable at first presentation,however,with the increased utilisation of endoscopy,many early lesions are now being identified which are suitable for endotherapeutic *** article details the options available for dealing with early esophageal cancer by endoscopic mean obviating the need for surgery thereby avoiding the potential morbidity and mortality of such intervention.

关键词： Esophageal cancer Endotherapy Endoscopic submucosal resection Endoscopic mucosal resection Endoscopy

Go-Ahead Element of Domestic Architecture:Socio-Economic and Cultural Characteristics of the Residents in Benin

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Journal of Civil Engineering and Architecture 2024年第6期18卷 296-310页

作者： Ekhaese Eghosa noel Department of Architecture School of Environmental StudiesCovenant UniversityOta 112104OgunNigeria

The domestic architecture of a traditional settlement is greatly influenced by the socio-economic and socio-cultural characteristics of its *** City which is the focus of the paper is a case of a traditional settlement undergoing domestic architectural evolution with the changing times influenced by factors of growth and *** paper has examined the effect of socio-economic and socio-cultural characteristics as factors that partly determine the design,style,pattern,space use,organization,location and meaning as well as land use of the domestic architecture of *** study employed the use of questionnaire administered to residents across the cross-section of the *** the end,descriptive frequency tables were used to analyse the data collected from the residential zones in *** research has been able to corroborate the theory that socio-economic and socio-cultural factors are some of the determinants/elements of domestic architecture of a people.

关键词： Go-ahead element domestic architecture socio-economic and socio-cultural characteristics

Overview on signal transduction cascades regulation roles of garlic and its bioactive constituents

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Food Science and Human Wellness 2024年第5期13卷 2353-2362页

作者： Ammad Ahmad Farooqi Iqra Mobeen Rukset Attar Khalida I.noel Baojun Xu William C.Cho Institute of Biomedical and Genetic Engineering(IBGE) Islamabad 44000Pakistan Khursheed Rasheed Hospital Lahore Lahore 53720Pakistan Department of Obstetrics and Gynecology Yeditepe UniversityAtaşehir 34755Turkey Human Anatomy Department College of MedicineAl-Mustansiriyah UniversityBaghdad 10036Iraq Food Science and Technology Program Department of Life SciencesBNU-HKBU United International CollegeZhuhai 519087China Department of Clinical Oncology Queen Elizabeth HospitalHong Kong G514TFChina

High-throughput technologies in combination with modern exciting advancements in mass spectrometry-based proteomics and data analysis pipelines have empowered comprehensive characterization of disease phenotypes and their mechanistic regulation by dietary agents and bioactive molecules at unprecedented dimensionality and ***-ordinary breakthroughs in the field of nutrigenomics have leveraged our understanding altogether to a new level of *** researchers have extensively analyzed health promoting and pharmacologically significant properties of garlic(Allium sativum).Importantly,garlic and its biologically active chemicals targeted oncogenic signaling *** this mini-review we have attempted to summarize how garlic and its bioactive constituents regulated signal transduction cascades in cell culture studies and tumor-bearing mice.

关键词： Cancer Nutrigenomics Signaling Apoptosis Allium sativum

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江南造山带东段地区三堡铅锌矿床花岗闪长斑岩的形成年代、地球化学特征及成矿指示

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大地构造与成矿学 2024年第4期48卷 879-898页

作者：侯舒雅张达玉张飞雷行行胡梦祥翁望飞 noel C White 合肥工业大学资源与环境工程学院安徽合肥230009 安徽省地质矿产勘查局332地质队安徽黄山245000

三堡铅锌矿床位于江南古陆北部,其成矿作用与花岗闪长斑岩密切相关。本文在地质特征和岩相学认识基础上,对与三堡铅锌矿床相关的花岗闪长斑岩开展了锆石LA-ICP-MS U-Pb同位素年代学、全岩地球化学和Sr-Nd同位素分析。结果显示,三堡花岗... 详细信息

三堡铅锌矿床位于江南古陆北部,其成矿作用与花岗闪长斑岩密切相关。本文在地质特征和岩相学认识基础上,对与三堡铅锌矿床相关的花岗闪长斑岩开展了锆石LA-ICP-MS U-Pb同位素年代学、全岩地球化学和Sr-Nd同位素分析。结果显示,三堡花岗闪长斑岩锆石U-Pb年龄为154.8±1.8 Ma,为晚侏罗世。三堡花岗闪长斑岩SiO_(2)含量为63.75%~67.47%,Na_(2)O+K_(2)O为3.92%~7.34%,为高钾钙碱性、准铝质‒弱过铝质的I型花岗岩;且样品富集轻稀土元素(LREE/HREE=10.50~11.29)、显示弱负Eu异常(δEu=0.68~0.77),富集Rb、Th、U、K等大离子亲石元素,亏损P、Ti、Yb等高场强元素。花岗闪长斑岩(^(87)Sr/^(86)Sr)i值为0.71028~0.71320,ε_(Nd)(t)值在-6.57~-5.55之间。岩石地球化学特征显示,三堡花岗闪长斑岩熔体来自壳幔混合源区,上升过程中经历了显著的结晶分异作用。结合区域资料对比显示,三堡铅锌矿床为江南造山带东段地区燕山期早阶段(177~153 Ma)铜铅锌成矿作用的重要组成部分,该花岗闪长斑岩所呈现的中低结晶温度、较低分异程度、较高氧逸度与水含量是该区中酸性岩浆岩的成矿专属性指标。

关键词：花岗闪长斑岩成岩年代岩石成因成矿专属性江南造山带东段地区

Physical and Chemical Properties of Horns Sheaths Particles for the Manufacture of Composite Materials

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Journal of Materials Science and Chemical Engineering 2024年第5期12卷 1-9页

作者： Tawe Laynde Zakari Yaou Karga Tapsia Lionel Konai noel Danwe Raidandi Department of Wood Construction University Institute for Wood Technology University of Yaounde 1 Yaounde Cameroon Department of Industrial and Mechanical Engineering National Advance School of Engineering University of Yaounde 1 Yaounde Cameroon Department of Mechanical Petroleum and Gas Engineering National Advance School of Mines and Petroleum Industries University of Maroua Maroua Cameroon

Salvaged cow horns from slaughterhouses have been transformed into fine particles for a physical characterization that has led us to determine the humidity rate (2.34% ± 0.054%), the actual density situated between 0.586 g/cm3 and 0.732 g/cm3, the swelling rate (12%), and one chemical characterization that permitted us to determine the rate of dry matters (97.05%), of mineral matters (2.5%), of protein matters (94.52%). From these weak values, it can easily be seen that cow horn case doesn’t absorb much water and improve the mechanical characteristics of the composite;the high rate of protein shows that keratin which is the structural molecule favors its gripping as reinforcing element in the manufacturing of composite materials.

关键词： Horns Fibers Polymer Loads Physical Properties Chemical Composition