检索结果-南通市图书馆

Starch Orodispersible Film Loaded with Melatonin for Human Supplementation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Renewable Materials 2024年第7期12卷 1343-1354页

作者： Fabio Tamanini Tatiane Zucchini de souza Creusa Sayuri Tahara Amaral Antônio joséFelix Carvalho Eliane Trovatti department of Health and Biological Sciences University of Araraquara(UNIARA)São Paulo14801-340Brazil department of Materials Engineering São Carlos School of EngineeringUniversity of São PauloSão Paulo13563-120Brazil

An innovative pharmaceutical form for administering melatonin,based on starch orodispersibleﬁlm(ODF),was designed and *** composition of the ODF included starch as the polymer matrix,the active drug melatonin,and a ***,a natural hormone produced by the pineal gland in the brain,can be absorbed by passive diffusion across the mucous membrane,resulting in improved bioavailability when compared to conventional oral *** study shows a simple and efﬁcient method for preparing melatonin-loaded orodispersibleﬁlms with a physically stable and commercially viable matrix,suitable for use in the pharmaceutical ***ﬁlms were prepared by treating the starch with microwave irradiation,followed by plasticization with glycerol,melatonin loading and drying by solvent *** tests showed theﬁlms’robustness,with a modulus of approximately 97 MPa,indicating good handling *** uptake analysis showed fast water absorption,reaching about 150%within 2 min,indicating its fast oral disintegration *** tests in artiﬁcial saliva and dissolution studies indicated the release of the drug in min-utes,indicating the potential properties of theﬁlm for oral drug *** the best of our knowledge,there is no melatonin ODF based on starch described in the literature.

关键词： Starch orodispersibleﬁlm melatonin drug delivery

What is the effect of Tribulus terrestris on testicular morphology and sperm production?An experimental study in the rat model

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2024年第1期26卷 67-70页

作者： Marcello Henrique Araujo Da Silva Gabriela Faria Buys-Goncalves Joao Henrique Duque Reis Estrada Francisco jose Barcellos Sampaio Diogo Benchimol de souza Urogenital Research Unit Rio de Janeiro State UniversityRio de Janeiro 20551-030RJBrazil

The objective of this study was to investigate whether treatment with Tribulus terrestris(Tt)has any impact on the testicular morphology and function in a rodent *** male rats were divided into a control group and a group receiving 100 mg kg^(-1) body weight of Tt *** 4o days of experiment,the animals were submitted to euthanasia;epididymal tail spermatozoa were collected;and spermatozoa concentration,motility,and viability were *** addition,testicles were collected and processed for histomorphometrical *** were compared using the Student's t-test and considered significant when Pdensity,seminiferous epithelium surface density,and intertubular compartment surface density were statistically similar between the ***,seminiferous epithelium height and tubular lumen surface density were augmented in animals treated with *** with Tt does not cause a major impact on testicular morphology,promoting only subtle *** difference on spermatozoa parameters was observed.

关键词： morphometry testicle Tribulus terrestris

Study of the Conversion of Postconsumer Polystyrene on CeO₂/HZSM-5 Type Materials

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Materials Science and Chemical Engineering 2024年第4期12卷 29-41页

作者： Mirna Oliveira Sant’Ana Anne Michelle Garrido Pedrosa Marcelo josé Barros de souza Graduate Program in Chemical Engineering at UFS Federal University of Sergipe (UFS) S&#227o Crist&#243v&#227o Brazil department of Chemistry Federal University of Sergipe S&#227o Crist&#243v&#227o Brazil

The catalytic conversion of polystyrene (PS) was studied in the presence of the materials type HZSM-5, CeO2, 10% CeO2/HZSM-5 and 20% CeO2/HZSM-5, which were characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD) and nitrogen adsorption at 77K. The catalytic tests were performed via thermogravimetric analysis (TG) at heating rates of 5, 10 and 20˚C min−1 in a temperature range from 30˚C to 900˚C. For the tests, a ratio of 30% by mass of each catalytic material mixed with PS was used and the activation energy of the degradation process was determined by the Vyazovkin method. The obtained results showed that the addition of the catalyst to the PS in general reduced its degradation temperature. The 10% CeO2/HZSM-5 catalyst showed greater efficiency, as it resulted in lower activation energy for PS degradation. Thus, the combination of CeO2 with HZSM-5 resulted in materials with potential for application in the catalytic degradation of polystyrene and the results indicate that the production of a composite material can be a good strategy to generate an increase in catalytic activity and a decrease in energy process activation.

关键词： HZSM-5 Zeolite Cerium Oxide Polystyrene Pyrolysis

Prevalence of Human Leukocyte Antigen HLA-B*5701 in HIV-1 Infected Individuals in Brazil

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Genetics 2014年第1期4卷 56-62页

作者： Claudinéia de Araújo Cristina Valetta de Carvalho Miriam Estela de souza Freire Amanda Yamaguti Ivens Cuiabano Scaff fernando josé de souza Flávia Galindo Silvestre Silva Ricardo Sobhie Diaz Ismael Dale Cotrim Guerreiro da Silva department of Gynecology Molecular Gynecology Laboratory Federal University of S&atildeo Paulo S&atildeo Paulo Brazil State department of Health of Mato Grosso Cuiabá Brazil Unirondon University Cuiabá Brazil Infectious Diseases Division Federal University of Mato Grosso Cuiabá Brazil Imunogenetics Laboratory General University Hospital Cuiabá Brazil

This study was designed to establish the prevalence of HLA-B*5701 at HIV-1 infected individuals in Brazil. A total of 517 consecutive individuals were followed in this study from February 2009 through July 2011. The presence of HLA-B*5701 was determined by Nested-PCR with HLA-B*57 and HLA-B*5701 sequence-specific primers (PCR-SSP). The expression of HLA-B*57 was negative in the 385 (74.5%) and positive in the 103 (19.9%) of infected individuals. Among these, the expression of HLA-B5701 was positive in the 29 (5.6%) of individuals. No demographic or ethnic differences were found between HLA-B*57/HLA-B*5701 HIV-1 negative patients, with a prevalence of Caucasians (57.1%) individuals. During the period of study, 68 patients were submited to an abacavir contain- ing regimen. The HLA-B*5701 allele was observed in 7 (10.3%) patients, with a significant incidence of Hypersensitivity reactions at 4 of them (p < 0.001). Conclusions: Although Brazilian population consists of a mixture of individuals of Caucasian, African and Native American genetic background, prevalence of HLA-B*5701 in this population is similar to the one found in pure Caucasians.

关键词： Immunogenetics Human Immunodeficiency Virus HLA-B*5701 Antigen Human Abacavir

Rifaximin on epigenetics and autophagy in animal model of hepatocellular carcinoma secondary to metabolic-dysfunction associated steatotic liver disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Hepatology 2024年第1期16卷 75-90页

作者： Matheus Truccolo Michalczuk Larisse Longo Melina Belén Keingeski Bruno de souza Basso Gabriel Tayguara Silveira Guerreiro Jessica T Ferrari joséEduardo Vargas Cláudia P Oliveira Carolina Uribe-Cruz Carlos Thadeu Schmidt Cerski Eduardo Filippi-Chiela Mário ReisÁlvares-da-Silva Division of Gastroenterology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil Graduate Program in Gastroenterology and Hepatology Universidade Federal do Rio Grande do SulPorto Alegre 90035-003Rio Grande do SulBrazil Experimental Laboratory of Hepatology and Gastroenterology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil Laboratory of Inflammatory and Neoplastic Cells Universidade Federal do ParanáParaná81530900Brazil department of Gastroenterology(LIM07) Faculdade de Medicina da Universidade de São PauloSão Paulo 01246903Brazil Facultad de Ciencias de la Salud Universidad Católica de las MisionesPosadasMisiones 3300Argentina Unit of Surgical Pathology Hospital de Clinicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil Center of Biotechnology Universidade Federal do Rio Grande do SulPorto Alegre 90035-003Rio Grande do SulBrazil department of Morphological Sciences Universidade Federal do Rio Grande do SulPorto Alegre 90.050-170Rio Grande do SulBrazil Conselho Nacional de desenvolvimento Científico e Tecnológico(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico(CNPq)ResearcherBrasília 71.605-001Brazil

BACKGROUND Prevalence of hepatocellular carcinoma(HCC)is increasing,especially in patients with metabolic dysfunctionassociated steatotic liver disease(MASLD).AIM To investigate rifaximin(RIF)effects on epigenetic/autophagy markers in *** Adult Sprague-Dawley rats were randomly assigned(n=8,each)and treated from 5-16 wk:Control[standard diet,water plus gavage with vehicle(Veh)],HCC[high-fat choline deficient diet(HFCD),diethylnitrosamine(deN)in drinking water and Veh gavage],and RIF[HFCD,deN and RIF(50 mg/kg/d)gavage].Gene expression of epigenetic/autophagy markers and circulating miRNAs were *** All HCC and RIF animals developed metabolic-dysfunction associated steatohepatitis fibrosis,and cirrhosis,but three RIF-group did not develop *** animals who developed HCC with those who did not,miR-122,miR-34a,tubulin alpha-1c(Tuba-1c),metalloproteinases-2(Mmp2),and metalloproteinases-9(Mmp9)were significantly higher in the *** opposite occurred with Becn1,coactivator associated arginine methyltransferase-1(Carm1),enhancer of zeste homolog-2(Ezh2),autophagy-related factor LC3A/B(Map1 Lc3b),and p62/sequestosome-1(p62/SQSTM1)-*** with controls,Map1 Lc3b,Becn1 and Ezh2 were lower in HCC and RIF-groups(P0.05).miR-122 was higher in HCC,and miR-34a in RIF compared to controls(P0.05).CONCLUSION RIF might have a possible beneficial effect on preventing/delaying liver carcinogenesis throu

关键词： Animal model Autophagy Epigenetic Hepatocellular carcinoma Metabolic dysfunction-associated steatotic liver disease Rifaximin

Litter decomposition and nutrient release for two tropical N-fixing species in Rio de Janeiro,Brazil

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Forestry Research 2022年第2期33卷 487-496页

作者： David Pessanha Siqueira Giovanna Campos Mamede Weiss de Carvalho joséGabriel de souza Silva Marcos Vinicius Winckler Caldeira deborah Guerra Barroso Laboratório de Fitotecnia Universidade Estadual do Norte Fluminense Darcy RibeiroAvenida Alberto Lamego2000Campos dos GoytacazesRio de JaneiroBrazil departamento de Ciências Florestais e da Madeira Universidade Federal do Espírito SantoAvenida Governador Lindenberg316Jerônimo MonteiroEspírito SantoBrazil department of Geosciences and Natural Resources Management University of CopenhagenRolighedsvej 23Frederisksberg CDenmark

Litter production and decomposition are critical to forest productivity,nutrient cycling,and carbon seques-tration in tropical woody ***,nutrient release and leaf litter stoichiometry in tropical legume tree plantations over the long term after outplanting are poorly understood or even *** improving our under-standing of the pattern of changes in the decomposition of N-fixing leaf litters and their possible impact on carbon stor-age,we measured litter production,mass loss and nutrient release for 240 d during litter decomposition for two tropical legume tree species(Plathymenia reticulata and Hymenaea courbaril),in Rio de Janeiro,*** production for *** was 5.689 kg ha^(−1) a^(−1) and 3.231 kg ha^(−1) a^(−1) for *** patterns of mass loss rates were similar;however,nutrient release was greater for ***,while *** showed immobilization of nutrients,especially for N,which increased by almost 20%in the early phase of decomposition followed by gradual *** from the N-fixing species did differ in nutrient chemistries over time,which was not surprising given that initial nutrient concentrations varied broadly,except for C and *** of the nutrient concentrations increased as the remaining litter mass decreased in both species,except for C and *** C:N and N:P ratios differed between the species,but N:P did not correlate to mass *** species had N-rich leaves,but *** decomposition was very likely P-limited,while *** seemed to be co-limited by N and *** results showed different patterns in nutrient release and the stoichi-ometry involved in the decomposition dynamics of the two tropical N-fixing species,even though they have similar litter decay *** species,but especially ***,may help re-establish nutrient cycling in disturbed ecosystems.

关键词： Nutrient dynamics Legume species Litter chemistry Ecological stoichiometry Tropical forest

Vegetative propagation of Apuleia leiocarpa(Vogel)***

在线全文

学校读者我要写书评

暂无评论

Journal of Forestry Research 2022年第2期33卷 455-462页

作者： joséGabriel de souza Silva Diêgo Faustolo Alves Bispo David Pessanha Siqueira Giovanna Campos Mamede Weiss de Carvalho deborah Guerra Barroso Laboratório de Fitotecnia Universidade Estadual do Norte Fluminense Darcy RibeiroAvenida Alberto LamegoCampos dos GoytacazesRJ 2000Brazil

Apuleia leiocarpa is an environmentally and economically significant Atlantic Forest species threat-ened by ongoing *** vegetative propagation of the species could be a step forward to enable implanta-tion of clonal seed orchards and multiplication of selected trees but remains unknown to *** study assessed the mini-cutting technique for propagation of *** and determined the time required for rooting and viable mini-cutting type and *** results show that it is possible to propagate *** with mini-cuttings derived from mini-stumps produced with seeds;the mini-stumps pre-sented regrowth capacity and remained constantly produc-tive for 1 year;10-cm *** mini-cuttings should remain under misting conditions for at least 40 days,and the vegetative propagation of *** with intermediate 7-to 10-cm mini-cuttings resulted in more vigorous clonal seedlings than smaller mini-cuttings.

关键词： Mini-cutting Tropical woody species Adventitious rooting Fabaceae

Multiomic investigation of Sugarcane mosaic virus resistance in sugarcane

在线全文

学校读者我要写书评

暂无评论

The Crop Journal 2023年第6期11卷 1805-1815页

作者： Ricardo joséGonzaga Pimenta Alexandre Hild Aono Roberto Carlos Villavicencio Burbano Marcel fernando da Silva Ivan Antônio dos Anjos Marcos Guimarães de Andrade Landell Marcos Cesar Gonçalves Luciana Rossini Pinto Anete Pereira de souza Centre for Molecular Biology and Genetic Engineering University of CampinasCampinasBrazil Gustavo Galindo Velasco Campus Littoral Polytechnic Superior SchoolGuayaquilEcuador Advanced Centre for Technological Research in Sugarcane Agribusiness Agronomic Institute of CampinasRibeirão PretoBrazil Plant Protection Research Centre Biological InstituteSão PauloBrazil department of Plant Biology Institute of BiologyUniversity of CampinasCampinasBrazil

Sugarcane mosaic virus(SCMV)is the main etiological agent of sugarcane mosaic disease,which affects sugarcane and other grass *** the extensive characterization of quantitative trait loci controlling resistance to SCMV in maize,the genetic basis of this trait in sugarcane is largely ***,a genome-wide association study was performed and machine learning coupled with feature selection was used for genomic prediction of resistance to SCMV in a diverse sugarcane *** single-nucleotide polymorphisms(SNPs)explained up to 29.9%of the observed phenotypic variance and a 73-SNP set predicted resistance with high accuracy,precision,recall,and F1 scores(the harmonic mean of precision and recall).Both marker sets were validated in additional sugarcane genotypes,in which the SNPs explained up to 23.6%of the phenotypic variation and predicted resistance with a maximum accuracy of 69.1%.Synteny analyses suggested that the gene responsible for the majority of SCMV resistance in maize is absent in sugarcane,explaining why this major resistance source has not been identified in this ***,using sugarcane RNA-Seq data,markers associated with resistance to SCMV were annotated,and a gene coexpression network was constructed to identify the predicted biological processes involved in *** network allowed the identification of candidate resistance genes and confirmed the involvement of stress responses,photosynthesis,and the regulation of transcription and translation in resistance to *** results provide a practical marker-assisted breeding approach for sugarcane and identify target genes for future studies of SCMV resistance.

关键词： Saccharum SCMV GWAS Machine learning RNA-Seq

Near-infrared leaf reflectance modeling of Annona emarginata seedlings for early detection of variations in nitrogen concentration

在线全文

学校读者我要写书评

暂无评论

Journal of Forestry Research 2023年第1期34卷 269-282页

作者： Rafaela Lancas Gomes Marília Caixeta Sousa Felipe Girotto Campos Carmen Sílvia Fernandes Boaro josé Raimundo de souza Passos Gisela Ferreira Bioestatistic Plant BiologyParasitology and Zoology DepartmentBioscience Institute(IBB)Universidade Estadual Paulista(UNESP)BotucatuSao PauloBrazil

Nitrogen(N)monitoring is essential in nurseries to ensure the production of high-quality *** spectroscopy(NIRS)is an instantaneous,nondestructive method to monitor *** data such as NIRS can also provide the basis for developing a new vegetation spectral index(VSI).Here,we evaluated whether NIRS combined with statistical modeling can accurately detect early variations in N concentration in leaves of young plants of Annona emargiaata and developed a new VSI for this *** were grown in a hydroponics system with 0,2.75,5.5or 11 mM N for 45 *** we measured gas exchange,chlorophylla fluorescence,and pigments in leaves;analyzed complete leaf nutrients,and recorded spectral data for leaves at 966 to 1685 nm using *** a statistical learning approach,the dimensionality of the spectral data was reduced,then models were generated using two classes(N deficiency,N)or four classes(0,2.75,5.5,11 mM N).The best combination of techniques for dimensionality reduction and classification,respectively,was stepwise regression(PROC STEPDISC)and linear discriminant *** was possible to detect N deficiency in seedlings leaves with 100%precision,and the four N concentrations with93.55%accuracy before photosynthetic damage to the plant ***,NIRS combined with statistical modeling of multidimensional data is effective for detecting N variations in seedlings leaves of ***.

关键词： Mineral nutrition of plants Near-infrared spectroscopy Spectral vegetation index Digital signature Statistical learning Fluorescence of chlorophylla